{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:04Z","timestamp":1791925684754,"version":"4.3.4"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2018DK51707"],"award-info":[{"award-number":["2018DK51707"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.cca.2020.03.024","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T11:26:08Z","timestamp":1584185168000},"page":"196-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["COX-2 in liver fibrosis"],"prefix":"10.1016","volume":"506","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-7278","authenticated-orcid":false,"given":"Hu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xuefeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Shandong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Jianhua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cca.2020.03.024_b0005","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hep.22437","article-title":"The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis","volume":"48","author":"Perugorria","year":"2008","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0010","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00000658-199206000-00001","article-title":"Prostaglandin E2 production during hepatic regeneration downregulates Kupffer cell IL-6 production","volume":"215","author":"Goss","year":"1992","journal-title":"Ann. Surg."},{"issue":"11","key":"10.1016\/j.cca.2020.03.024_b0015","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1080\/15548627.2017.1356550","article-title":"Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling","volume":"13","author":"Chen","year":"2017","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0020","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0025","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.bbalip.2013.04.005","article-title":"Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts","volume":"1831","author":"Martien","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1194\/jlr.M080028","article-title":"Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice","volume":"59","author":"Li","year":"2018","journal-title":"J. Lipid Res."},{"issue":"3\u20134","key":"10.1016\/j.cca.2020.03.024_b0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10555-007-9096-5","article-title":"Cyclooxygenases, prostanoids, and tumor progression","volume":"26","author":"Wang","year":"2007","journal-title":"Cancer Metastas. Rev."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0040","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0014-5793(93)80263-T","article-title":"Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues","volume":"330","author":"O'Neill","year":"1993","journal-title":"FEBS Lett."},{"issue":"6827","key":"10.1016\/j.cca.2020.03.024_b0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/35068566","article-title":"Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity","volume":"410","author":"Samad","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0050","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbamcr.2014.10.010","article-title":"Biphasic effects of luteolin on interleukin-1 beta-induced cyclooxygenase-2 expression in glioblastoma cells","volume":"1853","author":"Lamy","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0055","first-page":"1081","article-title":"Retinoids suppress phorbol ester- mediated induction of cyclooxygenase-2","volume":"57","author":"Mestre","year":"1997","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.cca.2020.03.024_b0060","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1158\/0008-5472.CAN-04-1107","article-title":"Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma","volume":"65","author":"von Rahden","year":"2005","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0065","first-page":"1276","article-title":"Expression of cyclooxygenase-2 in human gastric carcinoma","volume":"57","author":"Ristimaki","year":"1997","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0070","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1158\/0008-5472.CAN-16-2400","article-title":"Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 Signaling","volume":"77","author":"Henry","year":"2017","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11060-015-1976-x","article-title":"Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma","volume":"126","author":"Oksuz","year":"2016","journal-title":"J. Neurooncol."},{"issue":"Pt 3","key":"10.1016\/j.cca.2020.03.024_b0080","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1042\/bj3020723","article-title":"Structure of the human cyclo-oxygenase-2 gene","volume":"302","author":"Appleby","year":"1994","journal-title":"Biochem. J."},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0085","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1007\/s12035-015-9355-3","article-title":"Pathophysiological roles of cyclooxygenases and prostaglandins in the central nervous system","volume":"53","author":"Yagami","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"6610","key":"10.1016\/j.cca.2020.03.024_b0090","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/384644a0","article-title":"Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents","volume":"384","author":"Kurumbail","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cca.2020.03.024_b0095","doi-asserted-by":"crossref","unstructured":"G. Shaw, R. Kamen, Pillars article: a conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation, Cell 46 (1986) 659\u2013667 J. Immunol., 189(1) (2012):5\u201313.","DOI":"10.1093\/jimmunol\/189.1.5"},{"issue":"6460","key":"10.1016\/j.cca.2020.03.024_b0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/367243a0","article-title":"The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1","volume":"367","author":"Picot","year":"1994","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/cea.12697","article-title":"Cyclooxygenase 2: its regulation, role and impact in airway inflammation","volume":"46","author":"Rumzhum","year":"2016","journal-title":"Clin. Exp. Allergy"},{"issue":"9","key":"10.1016\/j.cca.2020.03.024_b0110","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.bbadis.2016.06.009","article-title":"Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice","volume":"1862","author":"Motino","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.bjp.0701112","article-title":"Selective induction of cyclo- oxygenase-2 activity in the permanent human endothelial cell line HUV-EC-C: biochemical and pharmacological characterization","volume":"121","author":"Miralpeix","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cca.2020.03.024_b0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/OARRR.S14568","article-title":"Combination therapy versus celecoxib, a single selective COX-2 agent, to reduce gastrointestinal toxicity in arthritic patients: patient and cost-effectiveness considerations","volume":"3","author":"Scolnik","year":"2011","journal-title":"Open Access Rheumatol."},{"issue":"4","key":"10.1016\/j.cca.2020.03.024_b0125","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/hep.21108","article-title":"COX-2 induction in mice with experimental nutritional steatohepatitis: role as pro-inflammatory mediator","volume":"43","author":"Yu","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2020.03.024_b0130","first-page":"9(10)","article-title":"Animal models of nonalcoholic fatty liver disease-a starter's guide","author":"Van Herck","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.cca.2020.03.024_b0135","first-page":"88","article-title":"MAPK-activated protein kinases (MKs): novel insights and challenges","volume":"3","author":"Gaestel","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cca.2020.03.024_b0140","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1038\/ncomms10879","article-title":"A conserved motif in JNK\/p38- specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation","volume":"7","author":"Liu","year":"2016","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.cca.2020.03.024_b0145","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1096\/fj.12-216382","article-title":"Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways","volume":"26","author":"Ayroldi","year":"2012","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"50","key":"10.1016\/j.cca.2020.03.024_b0155","doi-asserted-by":"crossref","first-page":"49954","DOI":"10.1074\/jbc.M307964200","article-title":"Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors","volume":"278","author":"Bradbury","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0160","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neulet.2006.03.026","article-title":"The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2","volume":"401","author":"Inoue","year":"2006","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0165","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1038\/s41598-018-26473-7","article-title":"Protein kinase Cepsilon regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression","volume":"8","author":"Nakano","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0170","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/00005344-199905000-00016","article-title":"Bradykinin-dependent cardioprotective effects of losartan against ischemia and reperfusion in rat hearts","volume":"33","author":"Zhu","year":"1999","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0175","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MOH.0000000000000444","article-title":"Subverting bradykinin-evoked inflammation by co-opting the contact system: lessons from survival strategies of Trypanosoma cruzi","volume":"25","author":"Scharfstein","year":"2018","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.cca.2020.03.024_b0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2017.03.003","article-title":"Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-kappaB in human rheumatoid arthritis synovial fibroblasts","volume":"132","author":"Yang","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cca.2020.03.024_b0185","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.12659\/MSM.908592","article-title":"Propofol promotes ankle fracture healing in children by inhibiting inflammatory response","volume":"24","author":"Zhou","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.cca.2020.03.024_b0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.taap.2018.05.011","article-title":"Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts","volume":"351","author":"Munoz-Rodriguez","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"13","key":"10.1016\/j.cca.2020.03.024_b0195","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1158\/1078-0432.CCR-17-2725","article-title":"COX-2\/PGE2 axis regulates HIF2alpha activity to promote hepatocellular carcinoma hypoxic response and reduce the sensitivity of sorafenib treatment","volume":"24","author":"Dong","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"22","key":"10.1016\/j.cca.2020.03.024_b0200","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1111\/bph.13326","article-title":"Mevastatin ameliorates sphingosine1- phosphate-induced COX-2\/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation","volume":"172","author":"Hsu","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.cca.2020.03.024_b0205","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jgh.12021","article-title":"Forkhead box class O transcription factors in liver function and disease","volume":"28","author":"Tikhanovich","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1\u20132","key":"10.1016\/j.cca.2020.03.024_b0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mce.2013.12.014","article-title":"Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis","volume":"384","author":"Fujimori","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0215","doi-asserted-by":"crossref","first-page":"11033","DOI":"10.1038\/s41598-018-29349-y","article-title":"Cyclooxygenase-2 up-regulates hepatic somatostatin receptor 2 expression","volume":"8","author":"Lu","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cca.2020.03.024_b0220","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1136\/gut.2003.036053","article-title":"Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma","volume":"53","author":"Reynaert","year":"2004","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0225","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1083\/jcb.149.3.667","article-title":"Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation","volume":"149","author":"Choy","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cca.2020.03.024_b0230","first-page":"183","article-title":"TGF beta regulation of epithelial cell proliferation: role of tumor suppressor genes","volume":"22","author":"Moses","year":"1991","journal-title":"Princess Takamatsu Symp."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0235","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.1038\/s41598-017-09062-y","article-title":"Silencing of TGF-beta1 in tumor cells impacts MMP-9 in tumor microenvironment","volume":"7","author":"Moore-Smith","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0240","doi-asserted-by":"crossref","first-page":"E1217","DOI":"10.1210\/jc.2013-4100","article-title":"TGF-beta1 induces COX-2 expression and PGE2 production in human granulosa cells through Smad signaling pathways","volume":"99","author":"Fang","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0245","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.ki.5001626","article-title":"TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells","volume":"70","author":"Rodriguez-Barbero","year":"2006","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/j.cca.2020.03.024_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076346","article-title":"TGF-beta1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-beta1","volume":"8","author":"Takai","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0255","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1128\/IAI.02975-14","article-title":"Transforming growth factor beta2 promotes transcription of COX2 and EP4, leading to a prostaglandin E2-driven autostimulatory loop that enhances virulence of Theileria annulata-transformed macrophages","volume":"83","author":"Haidar","year":"2015","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.cca.2020.03.024_b0260","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1386-6346(03)00155-4","article-title":"Loss of endogenous TGF-beta effect induces mouse hepatoma malignancy by correlation with cyclooxygenase-2 and VEGF","volume":"26","author":"Kim","year":"2003","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.cca.2020.03.024_b0265","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-019-1607-3","article-title":"Inducing and exploiting vulnerabilities for the treatment of liver cancer","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0270","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/gast.2000.9374","article-title":"Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT\/enhancer-binding proteins","volume":"119","author":"Callejas","year":"2000","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.cca.2020.03.024_b0275","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1096\/fj.01-0158fje","article-title":"Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy","volume":"15","author":"Casado","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.cca.2020.03.024_b0280","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cellimm.2017.08.004","article-title":"Immune response involved in liver damage and the activation of hepatic progenitor cells during liver tumorigenesis","volume":"326","author":"Hou","year":"2018","journal-title":"Cell Immunol."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0285","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","article-title":"Helicobacter pylori-induced gastric inflammation and gastric cancer","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0290","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2298\/VSP1302170D","article-title":"Correlation of inflammation parameters and biochemical markers of cholestasis with the intensity of lipid peroxidation in patients with choledocholithiasis","volume":"70","author":"Damnjanovic","year":"2013","journal-title":"Vojnosanit Pregl."},{"issue":"10","key":"10.1016\/j.cca.2020.03.024_b0295","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1295","article-title":"Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms","volume":"11","author":"Shibata","year":"2005","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0300","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nri2075","article-title":"Innate immunity of the newborn: basic mechanisms and clinical correlates","volume":"7","author":"Levy","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0305","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/sj.bjp.0702196","article-title":"Expression of cyclooxygenase-2 in foetal rat hepatocytes stimulated with lipopolysaccharide and pro-inflammatory cytokines","volume":"125","author":"Martin-Sanz","year":"1998","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0310","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fasebj.8.2.8119492","article-title":"Bacterial endotoxin: molecular relationships of structure to activity and function","volume":"8","author":"Rietschel","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.cca.2020.03.024_b0315","doi-asserted-by":"crossref","first-page":"45006","DOI":"10.1038\/srep45006","article-title":"Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4\/NF-kappaBp65\/MAPKs signaling cascade","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2020.03.024_b0320","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.28","article-title":"Negative regulatory approaches to the attenuation of Toll-like receptor signaling","volume":"45","author":"Anwar","year":"2013","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0325","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1097-2765(00)80136-7","article-title":"MyD88 is an adaptor protein in the hToll\/IL-1 receptor family signaling pathways","volume":"2","author":"Medzhitov","year":"1998","journal-title":"Mol. Cell"},{"issue":"2\u20133","key":"10.1016\/j.cca.2020.03.024_b0330","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2003.09.034","article-title":"Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation","volume":"481","author":"Hattori","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0335","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide- and Abeta-mediated microglial inflammation by inhibiting the TLR4\/NF-kappaB\/STAT signaling cascade","volume":"120","author":"Capiralla","year":"2012","journal-title":"J. Neurochem."},{"issue":"13","key":"10.1016\/j.cca.2020.03.024_b0340","first-page":"3477","article-title":"Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase","volume":"60","author":"Holmes-McNary","year":"2000","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0345","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1038\/s41598-018-28408-8","article-title":"Synergy of physico-chemical and biological experiments for developing a cyclooxygenase-2 inhibitor","volume":"8","author":"Singh","year":"2018","journal-title":"Sci. Rep."},{"issue":"1\u20132","key":"10.1016\/j.cca.2020.03.024_b0350","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ijpharm.2016.11.002","article-title":"Encapsulation of NSAIDs for inflammation management: overview, progress, challenges and prospects","volume":"515","author":"Badri","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0355","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jsb.2014.11.005","article-title":"The structure of ibuprofen bound to cyclooxygenase-2","volume":"189","author":"Orlando","year":"2015","journal-title":"J. Struct. Biol."},{"issue":"11","key":"10.1016\/j.cca.2020.03.024_b0360","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1080\/15384101.2015.1038685","article-title":"Autophagy and apoptosis in liver injury","volume":"14","author":"Wang","year":"2015","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0365","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.33594\/000000093","article-title":"ROS generated by upconversion nanoparticle- mediated photodynamic therapy induces autophagy via PI3K\/AKT\/ mTOR Signaling Pathway in M1 Peritoneal Macrophage","volume":"52","author":"Han","year":"2019","journal-title":"Cell Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0370","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.jhep.2011.07.010","article-title":"A role for autophagy during hepatic stellate cell activation","volume":"55","author":"Thoen","year":"2011","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.cca.2020.03.024_b0375","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41418-018-0221-5","article-title":"Recruitment of LC3 to damaged Golgi apparatus","volume":"26","author":"Gomes-da-Silva","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cca.2020.03.024_b0380","first-page":"1","article-title":"GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia","author":"Han","year":"2019","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.cca.2020.03.024_b0385","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1159\/000495713","article-title":"Cr(VI)-induced autophagy protects L-02 hepatocytes from apoptosis through the ROS-AKT-mTOR Pathway","volume":"51","author":"Liang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0390","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta1\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cca.2020.03.024_b0395","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/15548627.2015.1058473","article-title":"Macrophage autophagy protects against liver fibrosis in mice","volume":"11","author":"Lodder","year":"2015","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0400","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.26598","article-title":"Cannabinoid receptor 2 counteracts interleukin- 17-induced immune and fibrogenic responses in mouse liver","volume":"59","author":"Guillot","year":"2014","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0405","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1080\/15548627.2018.1458172","article-title":"A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo","volume":"14","author":"Cassidy","year":"2018","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0410","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/jcb.25750","article-title":"Sucrose, but not glucose, Blocks IL1-beta-Induced inflammatory response in human chondrocytes by inducing autophagy via AKT\/mTOR Pathway","volume":"118","author":"Khan","year":"2017","journal-title":"J. Cell Biochem."},{"issue":"10","key":"10.1016\/j.cca.2020.03.024_b0415","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1007\/s12035-018-0950-y","article-title":"Inhibition of cyclooxygenase-2 (COX-2) initiates autophagy and potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson's Disease","volume":"55","author":"Niranjan","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.cca.2020.03.024_b0420","doi-asserted-by":"crossref","first-page":"529","DOI":"10.5483\/BMBRep.2016.49.10.115","article-title":"Mitophagy: a balance regulator of NLRP3 inflammasome activation","volume":"49","author":"Kim","year":"2016","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0425","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2013.02.016","article-title":"Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy","volume":"59","author":"Hernandez-Gea","year":"2013","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0430","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jhep.2017.10.011","article-title":"Galpha12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells","volume":"68","author":"Kim","year":"2018","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.cca.2020.03.024_b0435","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ccell.2016.09.004","article-title":"p62\/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer","volume":"30","author":"Duran","year":"2016","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0440","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ccell.2016.04.006","article-title":"p62, Upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-Initiating Cells","volume":"29","author":"Umemura","year":"2016","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0445","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1159\/000491904","article-title":"Activation of Cyclooxygenase-2 by ATF4 During endoplasmic reticulum stress regulates kidney podocyte autophagy induced by lupus nephritis","volume":"48","author":"Jin","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.cca.2020.03.024_b0450","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ecoenv.2018.11.120","article-title":"The regulatory role of COX-2 in the interaction between Cr(VI)-induced endoplasmic reticulum stress and autophagy in DF-1 cells[J]","volume":"170","author":"Chen","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0455","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.78","article-title":"Endoplasmic reticulum stress eIF2alpha-ATF4 pathway- mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney","volume":"7","author":"Luo","year":"2016","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0460","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051018","article-title":"Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis","volume":"18","author":"Iorga","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cca.2020.03.024_b0465","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1002\/hep.29759","article-title":"Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury","volume":"67","author":"Sun","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0470","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jhep.2015.08.019","article-title":"Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1beta","volume":"64","author":"Ilyas","year":"2016","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0475","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-kappaB restricts inflammasome activation via elimination of damaged Mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006819","article-title":"Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia","volume":"13","author":"Cho","year":"2017","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0485","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2015.10.008","article-title":"Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency","volume":"64","author":"Farah","year":"2016","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.cca.2020.03.024_b0490","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1159\/000430167","article-title":"Inhibition of notch signaling promotes the adipogenic differentiation of mesenchymal stem cells through autophagy activation and PTEN-PI3K\/AKT\/mTOR Pathway","volume":"36","author":"Song","year":"2015","journal-title":"Cell Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0495","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.4161\/auto.28768","article-title":"Suppression of MAPK\/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells","volume":"10","author":"Basu","year":"2014","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.cca.2020.03.024_b0500","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10522-018-9785-1","article-title":"Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K\/Akt\/mTOR pathway and induces senescent cell death by regulation of Bax\/Bcl-2 pathway","volume":"20","author":"Kumar","year":"2019","journal-title":"Biogerontology"},{"issue":"3","key":"10.1016\/j.cca.2020.03.024_b0505","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10522-008-9204-0","article-title":"p53 and ATF-2 partly mediate the overexpression of COX-2 in H(2)O (2)-induced premature senescence of human fibroblasts","volume":"10","author":"Zdanov","year":"2009","journal-title":"Biogerontology"},{"key":"10.1016\/j.cca.2020.03.024_b0510","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2018.4462","article-title":"High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma","author":"Shi","year":"2018","journal-title":"Int. J. Oncol."},{"issue":"12","key":"10.1016\/j.cca.2020.03.024_b0515","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.mad.2008.09.003","article-title":"Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner","volume":"129","author":"Kim","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cca.2020.03.024_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108669","article-title":"Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2","volume":"112","author":"Feng","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cca.2020.03.024_b0525","doi-asserted-by":"crossref","first-page":"114","DOI":"10.18632\/aging.101127","article-title":"Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis","volume":"9","author":"Mellone","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"10.1016\/j.cca.2020.03.024_b0530","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112275","article-title":"Modulation of the senescence-associated inflammatory phenotype in human fibroblasts by olive phenols","volume":"18","author":"Menicacci","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cca.2020.03.024_b0535","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/0022034510387794","article-title":"Molecular inflammation as an underlying mechanism of the aging process and age-related diseases","volume":"90","author":"Chung","year":"2011","journal-title":"J. Dent. Res."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898120301261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898120301261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:55:48Z","timestamp":1777402548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898120301261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":107,"alternative-id":["S0009898120301261"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2020.03.024","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COX-2 in liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2020.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}