{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:35:17Z","timestamp":1775147717919,"version":"3.50.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Institute of Technology, Calicut and Department of Biotechnology","award":["BT\/PR16307\/MED\/30\/1729\/2016"],"award-info":[{"award-number":["BT\/PR16307\/MED\/30\/1729\/2016"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.cca.2020.06.047","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T21:14:21Z","timestamp":1593724461000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Liquid biopsy in ovarian cancer"],"prefix":"10.1016","volume":"510","author":[{"given":"Boddapati Kalyani","family":"Bhardwaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-8799","authenticated-orcid":false,"given":"Sanu","family":"Thankachan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thejaswini","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmanaban S.","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2020.06.047_b0005","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1039\/C3NR05042D","article-title":"Targeting of follicle stimulating hormone peptide-conjugated dendrimers to ovarian cancer cells","volume":"6","author":"Modi","year":"2014","journal-title":"Nanoscale"},{"key":"10.1016\/j.cca.2020.06.047_b0010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijpharm.2013.06.038","article-title":"Targeted paclitaxel nanoparticles modified with follicle-stimulating hormone \u03b2 81\u201395 peptide show effective antitumor activity against ovarian carcinoma","volume":"453","author":"Zhang","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.cca.2020.06.047_b0015","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/PGP.0000000000000274","article-title":"An immunohistochemical algorithm for ovarian carcinoma typing","volume":"35","author":"K\u00f6bel","year":"2016","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.cca.2020.06.047_b0020","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1159\/000345182","article-title":"Circulating tumor cells in lung cancer","volume":"56","author":"Young","year":"2012","journal-title":"Acta Cytol."},{"key":"10.1016\/j.cca.2020.06.047_b0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201010021","article-title":"Circulating tumor cells: approaches to isolation and characterization","volume":"192","author":"Yu","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cca.2020.06.047_b0030","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/jnci\/djq016","article-title":"Circulating tumor cells: will they be clinically useful?","volume":"102","author":"Nelson","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.cca.2020.06.047_b0035","article-title":"Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology","volume":"10","author":"Palmirotta","year":"2018","journal-title":"Therapeutic Adv. Med. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0040","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ygyno.2011.05.028","article-title":"Circulating tumor cells predict progression free survival and overall survival in patients with relapsed\/recurrent advanced ovarian cancer","volume":"122","author":"Poveda","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0045","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/labmed\/lmx084","article-title":"Assessment of circulating tumor cells as a predictive biomarker of histology in women with suspected ovarian cancer","volume":"49","author":"Lou","year":"2018","journal-title":"Lab. Med."},{"key":"10.1016\/j.cca.2020.06.047_b0050","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygyno.2013.08.006","article-title":"Predictive value of circulating tumor cells (CTCs) in newly-diagnosed and recurrent ovarian cancer patients","volume":"131","author":"Liu","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0055","doi-asserted-by":"crossref","first-page":"102735","DOI":"10.1007\/s00404-020-05477-7","article-title":"Clinical relevance of circulating tumor cells in ovarian, fallopian tube and peritoneal cancer","volume":"301","author":"Banys-Paluchowski","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.cca.2020.06.047_b0060","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2407-9-244","article-title":"Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer","volume":"9","author":"Li","year":"2009","journal-title":"BMC Cancer."},{"key":"10.1016\/j.cca.2020.06.047_b0065","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/1471-2407-10-666","article-title":"Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients","volume":"10","author":"Obermayr","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0070","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.molonc.2016.04.002","article-title":"Gene expression profiling of single circulating tumor cells in ovarian cancer - establishment of a multi-marker gene panel","volume":"10","author":"Blassl","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0075","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00432-008-0533-9","article-title":"Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer","volume":"135","author":"Fan","year":"2009","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ygyno.2008.09.021","article-title":"Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer","volume":"112","author":"Fan","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0085","doi-asserted-by":"crossref","unstructured":"X. Cheng, L. Zhang, Y. Chen, C. Qing, Circulating cell-free DNA and circulating tumor cells, the \u201cliquid biopsies\u201d in ovarian cancer 10 (2017) 75.","DOI":"10.1186\/s13048-017-0369-5"},{"key":"10.1016\/j.cca.2020.06.047_b0090","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrc3066","article-title":"Cell-free nucleic acids as biomarkers in cancer patients","volume":"11","author":"Schwarzenbach","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0095","first-page":"181","article-title":"Circulating nucleic acids (CNAs) and cancer\u2013a survey","volume":"1775","author":"Fleischhacker","year":"2007","journal-title":"BBA"},{"key":"10.1016\/j.cca.2020.06.047_b0100","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1002\/1097-0142(19830601)51:11<2116::AID-CNCR2820511127>3.0.CO;2-S","article-title":"Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease","volume":"51","author":"Shapiro","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0105","first-page":"241","article-title":"Les acides nucleiques du plasma sanguin chez l\u2019 homme","volume":"142","author":"Mandel","year":"1948","journal-title":"C. R. Seances Soc. Biol. Fil."},{"key":"10.1016\/j.cca.2020.06.047_b0110","first-page":"646","article-title":"Free DNA in the serum of cancer patients and the effect of therapy","volume":"37","author":"Leon","year":"1977","journal-title":"Cancer Res."},{"key":"10.1016\/j.cca.2020.06.047_b0115","doi-asserted-by":"crossref","first-page":"e0155495","DOI":"10.1371\/journal.pone.0155495","article-title":"Circulating cell free DNA as the diagnostic marker for ovarian cancer: a systematic review and meta-analysis","volume":"11","author":"Zhou","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cca.2020.06.047_b0120","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.3892\/ol.2015.3771","article-title":"Quantitative analysis of cell-free DNA in ovarian cancer","volume":"10","author":"Shao","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cca.2020.06.047_b0125","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/cncr.24997","article-title":"Plasma cell-free DNA in ovarian cancer","volume":"116","author":"Kamat","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0130","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.ejca.2014.06.022","article-title":"Prognostic importance of cell-free DNA in chemotherapy resistant ovarian cancer treated with bevacizumab","volume":"50","author":"Steffensen","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0135","first-page":"9","article-title":"Direct detection of early-stage cancers using circulating tumor","author":"Phallen","year":"2017","journal-title":"DNA"},{"key":"10.1016\/j.cca.2020.06.047_b0140","doi-asserted-by":"crossref","unstructured":"Y.M. Kim, S.W. Lee, Prospective study of the efficacy and utility of TP53 mutations in circulating tumor DNA as a non-invasive biomarker of treatment response monitoring in patients with high-grade serous ovarian carcinoma 30 (2019) e32.","DOI":"10.3802\/jgo.2019.30.e32"},{"key":"10.1016\/j.cca.2020.06.047_b0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/ijgc-00009577-200405000-00006","article-title":"Detection of p53 mutations in the plasma DNA of patients with ovarian cancer","volume":"14","author":"Otsuka","year":"2004","journal-title":"Int. J. Gynecol. Cancer Off. J. Int. Gynecol. Cancer Soc."},{"key":"10.1016\/j.cca.2020.06.047_b0150","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ajog.2005.01.054","article-title":"Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer","volume":"193","author":"Swisher","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2020.06.047_b0155","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/biores.2019.0031","article-title":"Comparison of somatic mutation profiles between formalin-fixed paraffin embedded tissues and plasma cell-free DNA from ovarian cancer patients before and after surgery","volume":"9","author":"Jagelkova","year":"2020","journal-title":"Biores. Open Access"},{"key":"10.1016\/j.cca.2020.06.047_b0160","first-page":"181","article-title":"Enrichment and Analysis of ctDNA","volume":"215","author":"Gilson","year":"2020","journal-title":"Recent results in cancer research Fortschritte der Krebsforschung Progres dans les recherches sur le cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0165","first-page":"2713","article-title":"Changes in the gene mutation profiles of circulating tumor DNA detected using CAPP-Seq in neoadjuvant chemotherapy-treated advanced ovarian cancer","volume":"19","author":"Noguchi","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cca.2020.06.047_b0170","doi-asserted-by":"crossref","unstructured":"K.K. Lin, M.I. Harrell, A.M. Oza, A. Oaknin, I. Ray-Coquard, A.V. Tinker, et al. BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma 9 (2019) 210\u2013219.","DOI":"10.1158\/2159-8290.CD-18-0715"},{"key":"10.1016\/j.cca.2020.06.047_b0175","first-page":"263","article-title":"Dynamic Treatment Stratification Using ctDNA","volume":"215","author":"Vidal","year":"2020","journal-title":"Recent results in cancer research Fortschritte der Krebsforschung Progres dans les recherches sur le cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0180","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12916-016-0667-6","article-title":"Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening","volume":"14","author":"Cohen","year":"2016","journal-title":"BMC Med."},{"key":"10.1016\/j.cca.2020.06.047_b0185","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1001\/jama.2015.7120","article-title":"Noninvasive prenatal testing and incidental detection of occult maternal malignancies","volume":"314","author":"Bianchi","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.cca.2020.06.047_b0190","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ygyno.2018.05.026","article-title":"ESR1 methylation in primary tumors and paired circulating tumor DNA of patients with high-grade serous ovarian cancer","volume":"150","author":"Giannopoulou","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0195","doi-asserted-by":"crossref","first-page":"21429","DOI":"10.18632\/oncotarget.15249","article-title":"RASSF1A promoter methylation in high-grade serous ovarian cancer: A direct comparison study in primary tumors, adjacent morphologically tumor cell-free tissues and paired circulating tumor DNA","volume":"8","author":"Giannopoulou","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2020.06.047_b0200","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ygyno.2011.08.029","article-title":"Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer","volume":"123","author":"Bondurant","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0205","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.7314\/APJCP.2014.15.3.1171","article-title":"Aberrant methylation of RASSF2A in tumors and plasma of patients with epithelial ovarian cancer","volume":"15","author":"Wu","year":"2014","journal-title":"Asian Pacific J. Cancer Prevent. APJCP"},{"key":"10.1016\/j.cca.2020.06.047_b0210","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1158\/0008-5472.CAN-04-1529","article-title":"Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients","volume":"64","author":"Ibanez de Caceres","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.cca.2020.06.047_b0215","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1158\/1078-0432.CCR-03-0732","article-title":"The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients","volume":"10","author":"Gifford","year":"2004","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.cca.2020.06.047_b0220","doi-asserted-by":"crossref","first-page":"29831","DOI":"10.1038\/srep29831","article-title":"Quantification of somatic chromosomal rearrangements in circulating cell-free DNA from ovarian cancers","volume":"6","author":"Harris","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2020.06.047_b0225","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cca.2020.06.047_b0230","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/1471-2407-12-627","article-title":"Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer","volume":"12","author":"Kan","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0235","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ygyno.2008.08.036","article-title":"The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform","volume":"112","author":"Resnick","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0240","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1177\/0300060513487652","article-title":"Serum microRNA-92 expression in patients with ovarian epithelial carcinoma","volume":"41","author":"Guo","year":"2013","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.cca.2020.06.047_b0245","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/0300060513475759","article-title":"Prognostic significance of serum microRNA-221 expression in human epithelial ovarian cancer","volume":"41","author":"Hong","year":"2013","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.cca.2020.06.047_b0250","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7314\/APJCP.2013.14.2.1057","article-title":"Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancer","volume":"14","author":"Xu","year":"2013","journal-title":"Asian Pacific J. Cancer Prevent. APJCP"},{"key":"10.1016\/j.cca.2020.06.047_b0255","doi-asserted-by":"crossref","first-page":"89811","DOI":"10.18632\/oncotarget.20688","article-title":"A combination of circulating miRNAs for the early detection of ovarian cancer","volume":"8","author":"Yokoi","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2020.06.047_b0260","doi-asserted-by":"crossref","first-page":"e0225249","DOI":"10.1371\/journal.pone.0225249","article-title":"Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass","volume":"14","author":"Oliveira","year":"2019","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cca.2020.06.047_b0265","doi-asserted-by":"crossref","first-page":"731479","DOI":"10.1155\/2015\/731479","article-title":"Challenges in using circulating miRNAs as cancer biomarkers","volume":"2015","author":"Tiberio","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cca.2020.06.047_b0270","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1600-0854.2005.00302.x","article-title":"Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells","volume":"6","author":"Nickel","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.cca.2020.06.047_b0275","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.cca.2020.06.047_b0280","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.omtn.2017.11.014","article-title":"Exosomes in cancer liquid biopsy: a focus on breast cancer","volume":"10","author":"Halvaei","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.cca.2020.06.047_b0285","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13048-017-0368-6","article-title":"A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies","volume":"10","author":"Cheng","year":"2017","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.cca.2020.06.047_b0290","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jprot.2012.12.029","article-title":"Characterization and proteomic analysis of ovarian cancer-derived exosomes","volume":"80","author":"Liang","year":"2013","journal-title":"J. Proteomics"},{"issue":"Suppl 4","key":"10.1016\/j.cca.2020.06.047_b0295","first-page":"3","article-title":"Exosomes in plasma of patients with ovarian carcinoma: potential biomarkers of tumor progression and response to therapy","author":"Szajnik","year":"2013","journal-title":"Gynecol. Obstet."},{"key":"10.1016\/j.cca.2020.06.047_b0300","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1582-4934.2011.01316.x","article-title":"Secretion of annexin A3 from ovarian cancer cells and its association with platinum resistance in ovarian cancer patients","volume":"16","author":"Yin","year":"2012","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cca.2020.06.047_b0305","doi-asserted-by":"crossref","first-page":"16923","DOI":"10.18632\/oncotarget.7850","article-title":"Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer","volume":"7","author":"Meng","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2020.06.047_b0310","doi-asserted-by":"crossref","first-page":"43076","DOI":"10.18632\/oncotarget.9246","article-title":"Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages","volume":"7","author":"Ying","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2020.06.047_b0315","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ebiom.2018.11.004","article-title":"Exosomal miRNA confers chemo resistance via targeting Cav1\/p-gp\/M2-type macrophage axis in ovarian cancer","volume":"38","author":"Kanlikilicer","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cca.2020.06.047_b0320","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-019-1095-1","article-title":"Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype","volume":"38","author":"Zhu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cca.2020.06.047_b0325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.canlet.2017.02.009","article-title":"TWEAK-stimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA","volume":"393","author":"Hu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cca.2020.06.047_b0330","doi-asserted-by":"crossref","unstructured":"In \u2018t Veld SGJG, Wurdinger T. Tumor-educated platelets, Blood 33 (2019) 2359\u20132364.","DOI":"10.1182\/blood-2018-12-852830"},{"key":"10.1016\/j.cca.2020.06.047_b0335","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ccell.2015.09.018","article-title":"RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics","volume":"28","author":"Best","year":"2015","journal-title":"Cancer Cell"},{"issue":"Suppl 4","key":"10.1016\/j.cca.2020.06.047_b0340","article-title":"EP457 Assessment of ovarian tumors with tumor educated platelets (TEPs). International Journal of Gynecologic","volume":"29","author":"Piek","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.cca.2020.06.047_b0345","doi-asserted-by":"crossref","first-page":"e11481-e","DOI":"10.1097\/MD.0000000000011481","article-title":"Altered long noncoding RNAs and survival outcomes in ovarian cancer: A systematic review and meta-analysis (PRISMA Compliant)","volume":"97","author":"Ning","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.cca.2020.06.047_b0350","doi-asserted-by":"crossref","first-page":"xi9","DOI":"10.1093\/annonc\/mdz447.027","article-title":"Antoneeva I. 29P - Expression profiles of serum long non-coding RNA in ovarian cancer patients receiving platinum-containing chemotherapy","volume":"30","author":"Gening","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cca.2020.06.047_b0355","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180936","article-title":"LINK-A lncRNA promotes migration and invasion of ovarian carcinoma cells by activating TGF-\u03b2 pathway","volume":"38","author":"Ma","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.cca.2020.06.047_b0360","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.12659\/MSM.913609","article-title":"LINK-a Long Non-Coding RNA (lncRNA) participates in metastasis of ovarian carcinoma and upregulates hypoxia-inducible factor 1 (HIF1\u03b1)","volume":"25","author":"Zhang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.cca.2020.06.047_b0365","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.2147\/OTT.S220533","article-title":"Circulating serum exosomal aHIF is a novel prognostic predictor for epithelial ovarian cancer","volume":"12","author":"Tang","year":"2019","journal-title":"OncoTargets Therapy"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898120303119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898120303119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:04:11Z","timestamp":1762113851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898120303119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":73,"alternative-id":["S0009898120303119"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2020.06.047","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid biopsy in ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2020.06.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}