{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:08:58Z","timestamp":1771297738603,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.cca.2020.08.014","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T21:18:04Z","timestamp":1597180684000},"page":"515-521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use"],"prefix":"10.1016","volume":"510","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-664X","authenticated-orcid":false,"given":"Christopher D.","family":"Koch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna A.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-6201","authenticated-orcid":false,"given":"John D.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin R.","family":"Bunch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-9540","authenticated-orcid":false,"given":"Joe M.","family":"El-Khoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2020.08.014_b0005","article-title":"Impact of Cannabinoids on Symptoms of Refractory Gastroparesis: A Single-center Experience","volume":"11","author":"Barbash","year":"2019","journal-title":"Cureus"},{"issue":"CD012182","key":"10.1016\/j.cca.2020.08.014_b0010","article-title":"Cannabis-based medicines for chronic neuropathic pain in adults","volume":"3","author":"Mucke","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.cca.2020.08.014_b0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000481089","article-title":"Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients","volume":"78","author":"Schimrigk","year":"2017","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.cca.2020.08.014_b0020","doi-asserted-by":"crossref","DOI":"10.1136\/tsaco-2019-000391","article-title":"Matched pilot study examining cannabis-based dronabinol for acute pain following traumatic injury","volume":"5","author":"Schneider-Smith","year":"2020","journal-title":"Trauma Surg. Acute Care Open"},{"key":"10.1016\/j.cca.2020.08.014_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10030161","article-title":"Efficacy of Dronabinol for Acute Pain Management in Adults with Traumatic Injury: Study Protocol of A Randomized Controlled Trial","volume":"10","author":"Swartwood","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.cca.2020.08.014_b0030","unstructured":"Alkem Laboratories Limited. MARINOL (dronabinol) [package insert]. U.S. Food and Drug Administration website. www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/018651s029lbl.pdf. Revised August 2017. Accessed March 31, 2020."},{"key":"10.1016\/j.cca.2020.08.014_b0035","unstructured":"Benuvia Therapeutics, Inc. SYNDROS (dronabinol) [package insert]. U.S. Food and Drug Administration website. www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/205525s007lbl.pdf. Revised September 2018. Accessed March 31, 2020."},{"key":"10.1016\/j.cca.2020.08.014_b0040","doi-asserted-by":"crossref","first-page":"469","DOI":"10.20452\/pamw.741","article-title":"2009 Clinical Guidelines from the American Pain Society and the American Academy of Pain Medicine on the use of chronic opioid therapy in chronic noncancer pain: what are the key messages for clinical practice?","volume":"119","author":"Chou","year":"2009","journal-title":"Pol. Arch. Med. Wewn."},{"key":"10.1016\/j.cca.2020.08.014_b0045","doi-asserted-by":"crossref","unstructured":"M. ElSohly WG, Constituents of cannabis sativa. Oxford University Press, Oxford, 2014.","DOI":"10.1093\/acprof:oso\/9780199662685.003.0001"},{"key":"10.1016\/j.cca.2020.08.014_b0050","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jat\/25.7.565","article-title":"\u03949-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study","volume":"25","author":"ElSohly","year":"2001","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.cca.2020.08.014_b0055","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/jat\/23.3.222","article-title":"Delta 9-tetrahydrocannabivarin (\u0394 9-THCV) as a marker for the ingestion of cannabis versus Marinol","volume":"23","author":"ElSohly","year":"1999","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.cca.2020.08.014_b0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.drugalcdep.2009.07.021","article-title":"\u03949-tetrahydrocannabivarin testing may not have the sensitivity to detect marijuana use among individuals ingesting dronabinol","volume":"106","author":"Levin","year":"2010","journal-title":"Drug Alcohol. Depend."},{"key":"10.1016\/j.cca.2020.08.014_b0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.chroma.2016.05.024","article-title":"Quantification of cannabinoids and their free and glucuronide metabolites in whole blood by disposable pipette extraction and liquid chromatography-tandem mass spectrometry","volume":"1453","author":"Scheidweiler","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.cca.2020.08.014_b0070","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1007\/s00216-016-9765-8","article-title":"Simultaneous quantification of 11 cannabinoids and metabolites in human urine by liquid chromatography tandem mass spectrometry using WAX-S tips","volume":"408","author":"Andersson","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cca.2020.08.014_b0075","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/dta.2230","article-title":"Optimization of recombinant beta-glucuronidase hydrolysis and quantification of eight urinary cannabinoids and metabolites by liquid chromatography tandem mass spectrometry","volume":"10","author":"Sempio","year":"2018","journal-title":"Drug Test Anal."},{"key":"10.1016\/j.cca.2020.08.014_b0080","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/FTD.0000000000000583","article-title":"Simultaneous Quantification of 13 Cannabinoids and Metabolites in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry in Adult Epilepsy Patients","volume":"41","author":"Roslawski","year":"2019","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.cca.2020.08.014_b0085","unstructured":"CLSI, Mass Spectrometry in the Clinical Laboratory: General Principles and Guidance, 1st Edition. CLSI Document C50-A. Wayne, PA: Clinical and Laboratory Standards Institute, 2007."},{"key":"10.1016\/j.cca.2020.08.014_b0090","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cca.2018.08.009","article-title":"Investigation of transition ion ratio variation for liquid chromatography-tandem mass spectrometry: A case study approach","volume":"486","author":"Bunch","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2020.08.014_b0095","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1089\/can.2016.0020","article-title":"Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography\/Photodiode Array-Mass Spectrometry","volume":"1","author":"Wang","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.cca.2020.08.014_b0100","first-page":"408","article-title":"Detection of cannabigerol and its presumptive metabolite in human urine after Cannabis consumption","volume":"65","author":"Hidvegi","year":"2010","journal-title":"Pharmazie"},{"key":"10.1016\/j.cca.2020.08.014_b0105","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1007\/s00216-013-6837-x","article-title":"Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine","volume":"405","author":"Bergamaschi","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cca.2020.08.014_b0110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1373\/clinchem.2013.214106","article-title":"Urinary cannabinoid disposition in occasional and frequent smokers: is THC-glucuronide in sequential urine samples a marker of recent use in frequent smokers?","volume":"60","author":"Desrosiers","year":"2014","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2020.08.014_b0115","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1373\/clinchem.2016.263475","article-title":"Free and Glucuronide Whole Blood Cannabinoids' Pharmacokinetics after Controlled Smoked, Vaporized, and Oral Cannabis Administration in Frequent and Occasional Cannabis Users: Identification of Recent Cannabis Intake","volume":"62","author":"Newmeyer","year":"2016","journal-title":"Clin. Chem."},{"issue":"1691428","key":"10.1016\/j.cca.2020.08.014_b0120","article-title":"Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, Cancer","volume":"2018","author":"Pellati","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cca.2020.08.014_b0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.forsciint.2018.12.021","article-title":"A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC- and CBD-acids","volume":"295","author":"Hadener","year":"2019","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.cca.2020.08.014_b0130","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jchromb.2006.12.045","article-title":"Development of a LC\/MS\/MS method for the analysis of cannabinoids in human EDTA-plasma and urine after small doses of Cannabis sativa extracts","volume":"850","author":"Grauwiler","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.cca.2020.08.014_b0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1373\/clinchem.2013.216507","article-title":"Phase I and II cannabinoid disposition in blood and plasma of occasional and frequent smokers following controlled smoked cannabis","volume":"60","author":"Desrosiers","year":"2014","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2020.08.014_b0140","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/dta.1998","article-title":"Simultaneous quantification of major cannabinoids and metabolites in human urine and plasma by HPLC-MS\/MS and enzyme-alkaline hydrolysis","volume":"9","author":"Aizpurua-Olaizola","year":"2017","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.cca.2020.08.014_b0145","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1515\/cclm-2019-0119","article-title":"THC and CBD concentrations in blood, oral fluid and urine following a single and repeated administration of \u201clight cannabis\u201d","volume":"58","author":"Pacifici","year":"2020","journal-title":"Clin. Chem. Lab. Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812030396X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812030396X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:00:34Z","timestamp":1757862034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989812030396X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":29,"alternative-id":["S000989812030396X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2020.08.014","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2020.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}