{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:41:21Z","timestamp":1788432081190,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cca.2021.05.006","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T03:31:17Z","timestamp":1620703877000},"page":"214-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Nephrogenic syndrome of inappropriate antidiuresis \u2013 An ethnically, genetically and phenotypically diverse disorder: First report in a Chinese adult and review of published cases"],"prefix":"10.1016","volume":"519","author":[{"given":"Hok Fung","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Tik Stella","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Hei Toby","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi Ning","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Lai Tony","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak Lam Sammy","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2021.05.006_b0005","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1056\/NEJMcp066837","article-title":"The Syndrome of Inappropriate Antidiuresis","volume":"356","author":"Ellison","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2021.05.006_b0010","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1258\/000456307781646030","article-title":"Vasopressin and disorders of water balance: the physiology and pathophysiology of vasopressin","volume":"44","author":"Ball","year":"2007","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.cca.2021.05.006_b0015","article-title":"Vasopressin Function in the Syndrome of Inappropriate Antidiuresis","volume":"315\u201327","author":"Zerbe","year":"1980","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cca.2021.05.006_b0020","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1056\/NEJMoa042743","article-title":"Nephrogenic Syndrome of Inappropriate Antidiuresis","volume":"352","author":"Feldman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2021.05.006_b0025","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1681\/ASN.2018121268","article-title":"Germline-Derived Gain-of-Function Variants of Gs\u03b1-Coding GNAS Gene Identified in Nephrogenic Syndrome of Inappropriate Antidiuresis","volume":"30","author":"Miyado","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cca.2021.05.006_b0030","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/cen.13011","article-title":"Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2","volume":"85","author":"Powlson","year":"2016","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.cca.2021.05.006_b0035","first-page":"17","article-title":"Adult female with symptomatic AVPR2-related nephrogenic syndrome of inappropriate antidiuresis (NSIAD)","volume":"2018","author":"Hague","year":"2018","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"10.1016\/j.cca.2021.05.006_b0040","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1258\/acb.2007.007211","article-title":"Intermittent severe, symptomatic hyponatraemia due to the nephrogenic syndrome of inappropriate antidiuresis","volume":"45","author":"Soule","year":"2008","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.cca.2021.05.006_b0045","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1681\/ASN.2006090987","article-title":"Nephrogenic Syndrome of Inappropriate Antidiuresis in Adults: High Phenotypic Variability in Men and Women from a Large Pedigree","volume":"18","author":"Decaux","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cca.2021.05.006_b0050","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2362.2011.02576.x","article-title":"Lack of responsiveness to 1-desamino-d arginin vasopressin (desmopressin) in male patients with nephrogenic syndrome of inappropriate antidiuresis: from bench to bedside","volume":"42","author":"Vandergheynst","year":"2012","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cca.2021.05.006_b0055","doi-asserted-by":"crossref","first-page":"c168","DOI":"10.1159\/000338539","article-title":"Long-Term Treatment of Hyponatremic Patients with Nephrogenic Syndrome of Inappropriate Antidiuresis: Personal Experience and Review of Published Case Reports","volume":"120","author":"Vandergheynst","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"10.1016\/j.cca.2021.05.006_b0060","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00467-006-0344-7","article-title":"Hyponatremia resulting from Arginine Vasopressin Receptor 2 gene mutation","volume":"22","author":"Bes","year":"2007","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cca.2021.05.006_b0065","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1007\/s00467-008-0913-z","article-title":"Neonatal onset of nephrogenic syndrome of inappropriate antidiuresis","volume":"23","author":"Marcialis","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cca.2021.05.006_b0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/EJE-09-0246","article-title":"Thirst perception and arginine vasopressin production in a kindred with an activating mutation of the type 2 vasopressin receptor: the pathophysiology of nephrogenic syndrome of inappropriate antidiuresis","volume":"161","author":"Gupta","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.cca.2021.05.006_b0075","doi-asserted-by":"crossref","first-page":"E37","DOI":"10.1210\/jc.2009-2524","article-title":"Familial Nephrogenic Syndrome of Inappropriate Antidiuresis: Dissociation between Aquaporin-2 and Vasopressin Excretion","volume":"95","author":"Ranchin","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2021.05.006_b0080","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1053\/j.ajkd.2011.09.026","article-title":"A Family With Hyponatremia and the Nephrogenic Syndrome of Inappropriate Antidiuresis","volume":"59","author":"Bockenhauer","year":"2012","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cca.2021.05.006_b0085","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1681\/ASN.2012010077","article-title":"Identification and Characterization of an Activating F229V Substitution in the V2 Vasopressin Receptor in an Infant with NSIAD","volume":"23","author":"Carpentier","year":"2012","journal-title":"J. Am. Soc. Nephrol. JASN."},{"key":"10.1016\/j.cca.2021.05.006_b0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1687-9856-2012-3","article-title":"Persistent elevation of urine aquaporin-2 during water loading in a child with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) caused by a R137L mutation in the V2 vasopressin receptor","volume":"2012","author":"Cheung","year":"2012","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.cca.2021.05.006_b0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000381586","article-title":"Nephrogenic Syndrome of Inappropriate Antidiuresis in a Female Neonate: Review of the Clinical Presentation in Females","volume":"84","author":"Brachet","year":"2015","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.cca.2021.05.006_b0100","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/ki.2015.181","article-title":"Mutation in the V2 vasopressin receptor gene, AVPR2, causes nephrogenic syndrome of inappropriate diuresis","volume":"88","author":"Erd\u00e9lyi","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2021.05.006_b0105","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1210\/me.2016-1002","article-title":"Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking","volume":"30","author":"Tiulpakov","year":"2016","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cca.2021.05.006_b0110","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/imj.14284","article-title":"Nephrogenic syndrome of inappropriate antidiuresis","volume":"49","author":"Hayat","year":"2019","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.cca.2021.05.006_b0115","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1124\/mol.109.061804","article-title":"Functional characterization of vasopressin type 2 receptor substitutions (R137H\/C\/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments","volume":"77","author":"Rochdi","year":"2010","journal-title":"Mol. Pharmacol."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121001558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121001558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:03:55Z","timestamp":1762113835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898121001558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":23,"alternative-id":["S0009898121001558"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2021.05.006","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nephrogenic syndrome of inappropriate antidiuresis \u2013 An ethnically, genetically and phenotypically diverse disorder: First report in a Chinese adult and review of published cases","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2021.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}