{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:58:35Z","timestamp":1758052715253,"version":"3.44.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.cca.2021.07.003","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T02:36:32Z","timestamp":1625625392000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Serum HDL-C values: An extremely useful marker for differentiating homozygous lipoprotein lipase deficiency from severe hypertriglyceridemia with other causes in Japan"],"prefix":"10.1016","volume":"521","author":[{"given":"Junji","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Minamizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Koshizaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Maezawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiraku","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-4813","authenticated-orcid":false,"given":"Koutaro","family":"Yokote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2021.07.003_b0005","unstructured":"J.R. Burnett, A.J. Hooper, R.A. Hegele, Familial Lipoprotein Lipase Deficiency. 1999 Oct 12 [updated 2017 Jun 22], in: M.P. Adam, H.H. Ardinger, R.A. Pagon, S.E. Wallace, L.J.H. Bean, G. Mirzaa, A. Amemiya, (Eds.), GeneReviews\u00ae [Internet], University of Washington, Seattle (WA), 1993\u20132021."},{"key":"10.1016\/j.cca.2021.07.003_b0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1172\/JCI115624","article-title":"Molecular studies on primary lipoprotein lipase (LPL) deficiency. One base deletion (G916) in exon 5 of LPL gene causes no detectable LPL protein due to the absence of LPL mRNA transcript","volume":"89","author":"Takagi","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cca.2021.07.003_b0015","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0022-2275(20)39947-8","article-title":"A newly identified heterozygous lipoprotein lipase gene mutation (Cys239\u2013>stop\/TGC972\u2013>TGA; LPL obama) in a patient with primary type IV hyperlipoproteinemia","volume":"35","author":"Takagi","year":"1994","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2021.07.003_b0020","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1006\/bbrc.1994.2694","article-title":"A naturally occurring mutation at the second base of codon asparagine 43 in the proposed N-linked glycosylation site of human lipoprotein lipase: in vivo evidence that asparagine 43 is essential for catalysis and secretion","volume":"205","author":"Kobayashi","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cca.2021.07.003_b0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(99)00060-1","article-title":"A novel frameshift mutation in exon 6 (the site of Asn 291) of the lipoprotein lipase gene in type I hyperlipidemia","volume":"285","author":"Kobayashi","year":"1999","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2021.07.003_b0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0925-4439(00)00067-3","article-title":"A newly identified lipoprotein lipase (LPL) gene mutation (F270L) in a Japanese patient with familial LPL deficiency","volume":"1502","author":"Takagi","year":"2000","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"10.1016\/j.cca.2021.07.003_b0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9150(01)00510-X","article-title":"No evidence of accelerated atherosclerosis in a 66-yr-old chylomicronemia patient homozygous for the nonsense mutation (Tyr61\u2013>stop) in the lipoprotein lipase gene","volume":"159","author":"Ebara","year":"2001","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.cca.2021.07.003_b0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1507\/endocrj.48.113","article-title":"Severe hypercholesterolemia in a double heterozygote for lipoprotein lipase deficiency (LPL(Arita)) and apolipoprotein epsilon4: a report of a family with LPL(Arita)","volume":"48","author":"Ando","year":"2001","journal-title":"Endocr. J."},{"key":"10.1016\/j.cca.2021.07.003_b0045","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0022-2275(20)31596-0","article-title":"Novel compound heterozygous mutations for lipoprotein lipase deficiency. A G-to-T transversion at the first position of exon 5 causing G154V missense mutation and a 5' splice site mutation of intron 8","volume":"42","author":"Ikeda","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2021.07.003_b0050","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1365-2362.2003.01129.x","article-title":"Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis","volume":"33","author":"Saika","year":"2003","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cca.2021.07.003_b0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2005.02.025","article-title":"The recovery of dysfunctional lipoprotein lipase (Asp204-Glu) activity by modification of substrate","volume":"183","author":"Murano","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cca.2021.07.003_b0060","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cca.2007.08.011","article-title":"A 60-y-old chylomicronemia patient homozygous for missense mutation (G188E) in the lipoprotein lipase gene showed no accelerated atherosclerosis","volume":"386","author":"Ebara","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2021.07.003_b0065","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2169\/internalmedicine.55.5239","article-title":"Lipoprotein Lipase Deficiency (R243H) in a Type 2 Diabetes Patient with Multiple Arterial Aneurysms","volume":"55","author":"Suzuki","year":"2016","journal-title":"Intern. Med."},{"key":"10.1016\/j.cca.2021.07.003_b0070","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.atherosclerosis.2017.11.006","article-title":"Molecular and functional characterization of familial chylomicronemia syndrome","volume":"269","author":"Teramoto","year":"2018","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.cca.2021.07.003_b0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2169\/internalmedicine.0952-18","article-title":"Lipoprotein Lipase Deficiency Arising in Type V Dyslipidemia","volume":"58","author":"Tanaka","year":"2019","journal-title":"Intern. Med."},{"key":"10.1016\/j.cca.2021.07.003_b0080","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cca.2020.07.031","article-title":"Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency - Effects of pemafibrate treatment","volume":"510","author":"Minamizuka","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2021.07.003_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5551\/jat.10702","article-title":"Research Committee for Primary Hyperlipidemia, Research on Measures against Intractable Diseases by the Ministry of Health, Labour and Welfare in Japan. Diagnosis and management of type I and type V hyperlipoproteinemia","volume":"19","author":"Gotoda","year":"2012","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.cca.2021.07.003_b0090","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.5551\/jat.51540","article-title":"Variants of Lipid-Related Genes in Adult Japanese Patients with Severe Hypertriglyceridemia","volume":"27","author":"Matsunaga","year":"2020","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.cca.2021.07.003_b0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12933-017-0602-y","article-title":"Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor alpha modulator for management of atherogenic dyslipidaemia","volume":"16","author":"Fruchart","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cca.2021.07.003_b0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2008.11.146","article-title":"Formation of prebeta1-HDL during lipolysis of triglyceride-rich lipoprotein","volume":"379","author":"Miyazaki","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cca.2021.07.003_b0105","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1210\/js.2019-00214","article-title":"Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles","volume":"3","author":"O'Dea","year":"2019","journal-title":"J. Endocr. Soc."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121002345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121002345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:59:17Z","timestamp":1757861957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898121002345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":21,"alternative-id":["S0009898121002345"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2021.07.003","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum HDL-C values: An extremely useful marker for differentiating homozygous lipoprotein lipase deficiency from severe hypertriglyceridemia with other causes in Japan","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2021.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}