{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:11:55Z","timestamp":1783523515850,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cca.2021.11.007","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T10:35:32Z","timestamp":1636367732000},"page":"519-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Biological variation of thyroid function biomarkers over 24\u00a0hours"],"prefix":"10.1016","volume":"523","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Hai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Rui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2021.11.007_b0005","series-title":"The Thyroid and Its Diseases: A Comprehensive Guide for the Clinician","first-page":"75","article-title":"Epidemiology of thyroid disorders","author":"Vanderpump","year":"2019"},{"key":"10.1016\/j.cca.2021.11.007_b0010","doi-asserted-by":"crossref","first-page":"106389","DOI":"10.1016\/j.domaniend.2019.106389","article-title":"Short-term biological variation of serum thyroid hormones concentrations in clinically healthy cats","volume":"71","author":"Prieto","year":"2020","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.cca.2021.11.007_b0015","first-page":"926","article-title":"Study on biological variation of routine biochemical test items","volume":"35","author":"Chen","year":"2012","journal-title":"Chin. J. Lab. Med."},{"key":"10.1016\/j.cca.2021.11.007_b0020","first-page":"107","article-title":"Establishment and verification of personalized reference interval of blood cells","volume":"35","author":"Yue","year":"2017","journal-title":"Chin. J. Clin. Lab."},{"issue":"3","key":"10.1016\/j.cca.2021.11.007_b0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/00365510410004885","article-title":"The reference change value: a proposal to interpret laboratory reports in serial testing based on biological variation","volume":"64","author":"Ric\u00f3s","year":"2004","journal-title":"Scand. J. Clin Lab. Invest."},{"key":"10.1016\/j.cca.2021.11.007_b0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1373\/clinchem.2004.039354","article-title":"Estimate of biological variation of laboratory analytes based on third national health and nutrition examination survey","volume":"51","author":"Lacher","year":"2005","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2021.11.007_b0035","doi-asserted-by":"crossref","unstructured":"G. Cooper, N. DeJonge, S. Ehrmeyer, J. Yundt-Pacheco, R. Jansen, C. Ric\u00f3s, M. Plebani, Collective opinion paper on findings of the 2010 convocation of experts on laboratory quality, Clin. Chem. Lab. Med. 49 (2011) 793\u2013802. https:\/\/doi.org\/10.1515\/CCLM.2011.149.","DOI":"10.1515\/CCLM.2011.149"},{"key":"10.1016\/j.cca.2021.11.007_b0040","doi-asserted-by":"crossref","unstructured":"T. Badrick, Biological variation: Understanding why it is so important? Pract. Lab. Med. 23 (2021) e00199. https:\/\/doi.org\/10.1016\/j.plabm.2020.e00199.","DOI":"10.1016\/j.plabm.2020.e00199"},{"key":"10.1016\/j.cca.2021.11.007_b0045","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1373\/clinchem.2017.281808","article-title":"The biological variation data critical appraisal checklist: a standard for evaluating studies on biological variation","volume":"64","author":"Aarsand","year":"2018","journal-title":"Clin Chem."},{"key":"10.1016\/j.cca.2021.11.007_b0050","unstructured":"A.K. Aarsand, P. Fernandez-Calle, C. Webster, A. Coskun, E. Gonzales-Lao, J. Diaz-Garzon, N. Jonker, J. Minchinela, M. Simon, F. Braga, C. Perich, B. Boned, T. Roraas, F. Marques-Garcia, A. Carobene, B. Aslan, W.A. Barlett, S. Sandberg, The EFLM Biological Variation Database. https:\/\/biologicalvariation.eu\/ (accessed 7 May 2021)."},{"key":"10.1016\/j.cca.2021.11.007_b0055","first-page":"1582","article-title":"Influence of gender, age and season on thyroid hormone reference interval","volume":"98","author":"Qiu","year":"2018","journal-title":"Zhonghua Yi Xue Za Zhi."},{"key":"10.1016\/j.cca.2021.11.007_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4106816","article-title":"Challenges in interpreting thyroid stimulating hormone results in the diagnosis of thyroid dysfunction","volume":"2019","author":"Razvi","year":"2019","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.cca.2021.11.007_b0065","series-title":"Papers Compilation of the 5th Chinese Congress of Clinical Microbiology & Microbiology and Immunology Forum across the Taiwan Strait","article-title":"Correlation analysis of serum thyroid stimulating hormone concentration and body mass index in healthy adults. Commemorate the 5th Anniversary of the Chinese Society for Microbiology Clinical Microbiology Specialized Committee -","author":"Zhang","year":"2014"},{"issue":"3","key":"10.1016\/j.cca.2021.11.007_b0070","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1210\/jcem.87.3.8165","article-title":"Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease","volume":"87","author":"Andersen","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2021.11.007_b0075","first-page":"135","article-title":"Value of using reference change factor to evaluate the results of continuous monitoring of thyroid function indicators in thyroid diseases","volume":"34","author":"Zhang","year":"2019","journal-title":"J. Modern Lab. Med."},{"issue":"6","key":"10.1016\/j.cca.2021.11.007_b0080","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/cen.12824","article-title":"Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee","volume":"84","author":"Okosieme","year":"2016","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.cca.2021.11.007_b0085","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1530\/EJE-16-0031","article-title":"Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method","volume":"174","author":"Hoermann","year":"2016","journal-title":"Eur. J. Endocrinol."},{"issue":"7","key":"10.1016\/j.cca.2021.11.007_b0090","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1210\/jc.2005-0375","article-title":"Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism","volume":"90","author":"D\u00edez","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2021.11.007_b0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-4682-11-35","article-title":"The homeostatic set point of the hypothalamus-pituitary-thyroid axis\u2013maximum curvature theory for personalized euthyroid targets","volume":"11","author":"Leow","year":"2014","journal-title":"Theor. Biol. Med. Model."},{"key":"10.1016\/j.cca.2021.11.007_b0100","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/cen.12527","article-title":"Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment","volume":"81","author":"Hoermann","year":"2014","journal-title":"Clin. Endocrinol. (Oxf)"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121003909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121003909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:06:35Z","timestamp":1757862395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898121003909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":20,"alternative-id":["S0009898121003909"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2021.11.007","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological variation of thyroid function biomarkers over 24\u00a0hours","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2021.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}