{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:12:01Z","timestamp":1768972321808,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672315"],"award-info":[{"award-number":["81672315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072577"],"award-info":[{"award-number":["82072577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2017KY256"],"award-info":[{"award-number":["2017KY256"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.cca.2021.11.024","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T20:31:44Z","timestamp":1637958704000},"page":"34-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Lipid profiling in malignant mesothelioma reveals promising signatures for diagnosis and prognosis: A plasma-based LC-MS lipidomics study"],"prefix":"10.1016","volume":"524","author":[{"given":"Zhongjian","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cca.2021.11.024_b0005","first-page":"402","article-title":"Mesothelioma Scientific clues for prevention, diagnosis, and therapy","volume":"69","author":"Carbone","year":"2019","journal-title":"CA: Cancer J. Clinicians"},{"issue":"2","key":"10.1016\/j.cca.2021.11.024_b0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0013-9351(81)90028-1","article-title":"Mechanisms of asbestos carcinogenesis","volume":"25","author":"Mossman","year":"1981","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0015","doi-asserted-by":"crossref","first-page":"361","DOI":"10.21147\/j.issn.1000-9604.2017.04.09","article-title":"Epidemiology and trend analysis on malignant mesothelioma in China","volume":"29","author":"Zhao","year":"2017","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.cca.2021.11.024_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/1310478","article-title":"Malignant mesothelioma, BAP1 immunohistochemistry, and VEGFA: does BAP1 have potential for early diagnosis and assessment of prognosis?","volume":"2017","author":"Pulford","year":"2017","journal-title":"Dis. Markers"},{"issue":"11","key":"10.1016\/j.cca.2021.11.024_b0025","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.tibs.2016.08.010","article-title":"Lipidomics: techniques, applications, and outcomes related to biomedical sciences","volume":"41","author":"Yang","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cmet.2019.11.010","article-title":"Greasing the wheels of the cancer machine: the role of lipid metabolism in cancer","volume":"31","author":"Snaebjornsson","year":"2020","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4292\/wjgpt.v4.i4.97","article-title":"Metabolomics as a diagnostic tool in gastroenterology","volume":"4","author":"Preter","year":"2013","journal-title":"World J. Gastrointestinal Pharmacol. Therap."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0040","article-title":"Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2021.11.024_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/823849","article-title":"Serum lipid profiles and cancer risk in the context of obesity: four meta-analyses","volume":"2013","author":"Melvin","year":"2013","journal-title":"J. Cancer Epidemiol."},{"issue":"5","key":"10.1016\/j.cca.2021.11.024_b0050","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ajg.2013.64","article-title":"The association of serum lipids with colorectal adenomas","volume":"108","author":"Yang","year":"2013","journal-title":"Am. J. Gastroenterol."},{"issue":"24","key":"10.1016\/j.cca.2021.11.024_b0055","doi-asserted-by":"crossref","first-page":"36622","DOI":"10.18632\/oncotarget.9124","article-title":"Plasma lipidomics profiling identified lipid biomarkers in distinguishing early-stage breast cancer from benign lesions","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2021.11.024_b0060","doi-asserted-by":"crossref","first-page":"113069","DOI":"10.1016\/j.jpba.2019.113069","article-title":"Metabolic and lipidomic characterization of malignant pleural effusion in human lung cancer","volume":"180","author":"Yang","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"10","key":"10.1016\/j.cca.2021.11.024_b0065","doi-asserted-by":"crossref","first-page":"e46091","DOI":"10.1371\/journal.pone.0046091","article-title":"Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool","volume":"7","author":"Ostroff","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.cca.2021.11.024_b0070","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1158\/1055-9965.EPI-20-0543","article-title":"Verification of a Blood-Based Targeted Proteomics Signature for Malignant Pleural Mesothelioma","volume":"29","author":"Cerciello","year":"2020","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"12","key":"10.1016\/j.cca.2021.11.024_b0075","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1158\/1078-0432.CCR-15-1130","article-title":"HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients","volume":"22","author":"Napolitano","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0080","doi-asserted-by":"crossref","first-page":"e18232","DOI":"10.1371\/journal.pone.0018232","article-title":"Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma","volume":"6","author":"Santarelli","year":"2011","journal-title":"PLoS One"},{"issue":"7-8","key":"10.1016\/j.cca.2021.11.024_b0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.clinbiochem.2012.02.009","article-title":"Clinical significance of circulating miR-126 quantification in malignant mesothelioma patients","volume":"45","author":"Tomasetti","year":"2012","journal-title":"Clin. Biochem."},{"issue":"12","key":"10.1016\/j.cca.2021.11.024_b0090","doi-asserted-by":"crossref","first-page":"e114483","DOI":"10.1371\/journal.pone.0114483","article-title":"Combination of MiR-103a-3p and mesothelin improves the biomarker performance of malignant mesothelioma diagnosis","volume":"9","author":"Weber","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.cca.2021.11.024_b0095","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3390\/diagnostics11071281","article-title":"Combination of Plasma-Based Metabolomics and Machine Learning Algorithm Provides a Novel Diagnostic Strategy for Malignant Mesothelioma","volume":"11","author":"Li","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"10.1016\/j.cca.2021.11.024_b0100","first-page":"778","article-title":"Lipid metabolism and carcinogenesis, cancer development","volume":"8","author":"Long","year":"2018","journal-title":"Am. J. Cancer Res."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40169-018-0199-0","article-title":"Lipidomics: a promising cancer biomarker","volume":"7","author":"Yan","year":"2018","journal-title":"Clin. Trans. Med."},{"key":"10.1016\/j.cca.2021.11.024_b0110","article-title":"Circulating Phospholipids as Biomarkers of Breast Cancer: A Review","volume":"10","author":"Mistry","year":"2016","journal-title":"Breast Cancer: Basic Clin. Res."},{"issue":"5","key":"10.1016\/j.cca.2021.11.024_b0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10719-017-9790-7","article-title":"Glycosaminoglycans and glycolipids as potential biomarkers in lung cancer","volume":"34","author":"Li","year":"2017","journal-title":"Glycoconjugate J."},{"issue":"2","key":"10.1016\/j.cca.2021.11.024_b0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00216-010-4290-7","article-title":"Shotgun lipidomics for candidate biomarkers of urinary phospholipids in prostate cancer","volume":"399","author":"Min","year":"2011","journal-title":"Analy. Bioanaly. Chem."},{"issue":"1-2","key":"10.1016\/j.cca.2021.11.024_b0125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2119\/molmed.2010.00115","article-title":"Identification of phospholipid scramblase 1 as a biomarker and determination of its prognostic value for colorectal cancer","volume":"17","author":"Kuo","year":"2011","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2021.11.024_b0135","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.semcancer.2015.02.006","article-title":"Sustained proliferation in cancer: Mechanisms and novel therapeutic targets","volume":"35","author":"Feitelson","year":"2015","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0140","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2188\/jea.JE20150086","article-title":"The associations between smoking habits and serum triglyceride or hemoglobin A1c levels differ according to visceral fat accumulation","volume":"26","author":"Koda","year":"2016","journal-title":"J. Epidemiol."},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0145","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/jamaoncol.2016.5487","article-title":"Association of asbestos exposure with malignant mesothelioma incidence in Eastern China","volume":"3","author":"Mao","year":"2017","journal-title":"JAMA Oncol."},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0150","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jtho.2016.12.006","article-title":"Improving the accuracy of mesothelioma diagnosis in China","volume":"12","author":"Guo","year":"2017","journal-title":"J. Thoracic Oncol."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-physiol-020518-114444","article-title":"Phospholipid remodeling in physiology and disease","volume":"81","author":"Wang","year":"2019","journal-title":"Annu. Rev. Physiol."},{"issue":"9","key":"10.1016\/j.cca.2021.11.024_b0160","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-6-17","article-title":"Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status","volume":"6","author":"Taylor","year":"2007","journal-title":"Lipids Health Dis."},{"issue":"5","key":"10.1016\/j.cca.2021.11.024_b0170","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/ijms20051149","article-title":"An updated review of lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3B","key":"10.1016\/j.cca.2021.11.024_b0175","first-page":"1587","article-title":"Application of 31P NMR spectroscopy in clinical analysis of changes of serum phospholipids in leukemia, lymphoma and some other non-haematological cancers","volume":"16","author":"Kuliszkiewicz-Janus","year":"1996","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.cca.2021.11.024_b0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/nbm.758","article-title":"31P NMR spectroscopy of blood plasma: determination and quantification of phospholipid classes in patients with renal cell carcinoma","volume":"15","author":"S\u00fcllentrop","year":"2002","journal-title":"NMR Biomed.: Int. J. Devoted Dev. Appl. Magnetic Resonance In Vivo"},{"key":"10.1016\/j.cca.2021.11.024_b0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2010.05554.x","article-title":"Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model","volume":"1203","author":"Hillegass","year":"2010","journal-title":"Ann. New York Acad. Sci."},{"issue":"9","key":"10.1016\/j.cca.2021.11.024_b0190","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1194\/jlr.M800500-JLR200","article-title":"Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1","volume":"50","author":"Harayama","year":"2009","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.cca.2021.11.024_b0195","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1183\/09031936.95.08030403","article-title":"Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma","volume":"8","author":"Shijubo","year":"1995","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.cca.2021.11.024_b0200","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/ajplegacy.1972.223.3.715","article-title":"Surface active materials from dog lung. II. Composition and physiological correlations","volume":"223","author":"King","year":"1972","journal-title":"Am. J. Physiol.-Legacy Content"},{"issue":"4","key":"10.1016\/j.cca.2021.11.024_b0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.trsl.2009.01.004","article-title":"Asbestos-induced lung diseases: an update","volume":"153","author":"Kamp","year":"2009","journal-title":"Trans. Res."},{"issue":"22","key":"10.1016\/j.cca.2021.11.024_b0210","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1073\/pnas.1307237110","article-title":"Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids","volume":"110","author":"Kamphorst","year":"2013","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121004149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898121004149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:05:04Z","timestamp":1762113904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898121004149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":42,"alternative-id":["S0009898121004149"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2021.11.024","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid profiling in malignant mesothelioma reveals promising signatures for diagnosis and prognosis: A plasma-based LC-MS lipidomics study","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2021.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}