{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:51:04Z","timestamp":1792792264188,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071656"],"award-info":[{"award-number":["82071656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1002900"],"award-info":[{"award-number":["2018YFC1002900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.cca.2022.01.012","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T10:52:20Z","timestamp":1642675940000},"page":"16-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Prenatal diagnosis and outcome of fetal hyperechogenic kidneys in the era of antenatal next-generation sequencing"],"prefix":"10.1016","volume":"528","author":[{"given":"Linbei","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8429","key":"10.1016\/j.cca.2022.01.012_b0005","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(85)92154-3","article-title":"Antenatal diagnosis of surgical disorders by ultrasonography","volume":"325","author":"Hutson","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2022.01.012_b0010","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1542\/peds.78.5.879","article-title":"Prenatal diagnosis of urinary tract abnormalities by ultrasound","volume":"78","author":"Helin","year":"1986","journal-title":"Pediatrics"},{"issue":"7","key":"10.1016\/j.cca.2022.01.012_b0015","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/uog.3856","article-title":"Differential diagnosis of fetal hyperechogenic cystic kidneys unrelated to renal tract anomalies: A multicenter study","volume":"28","author":"Chaumoitre","year":"2006","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.cca.2022.01.012_b0020","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1701-2163(16)34480-2","article-title":"Maternal fetal medicine committee; infectious diseases committee. Cytomegalovirus infection in pregnancy","volume":"32","author":"Yinon","year":"2010","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.cca.2022.01.012_b0025","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1046\/j.1471-0528.2002.02055.x","article-title":"Prenatal diagnosis of bilateral isolated fetal hyperechogenic kidneys. Is it possible to predict long term outcome?","volume":"109","author":"Tsatsaris","year":"2002","journal-title":"BJOG"},{"issue":"10","key":"10.1016\/j.cca.2022.01.012_b0030","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00467-018-3998-z","article-title":"Prenatal hyperechogenic kidneys in three cases of infantile hypercalcemia associated with SLC34A1 mutations","volume":"33","author":"Hureaux","year":"2018","journal-title":"Pediatr. Nephrol."},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0035","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s40746-019-00166-3","article-title":"Congenital Anomalies of the Kidney and Urinary Tract: A Clinical Review","volume":"5","author":"Stonebrook","year":"2019","journal-title":"Curr. Treat Options Pediatr."},{"key":"10.1016\/j.cca.2022.01.012_b0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/bs.ctdb.2015.10.010","article-title":"Development of the Mammalian Kidney","volume":"117","author":"McMahon","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0045","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1681\/ASN.2017080887","article-title":"Conserved and Divergent Features of Human and Mouse Kidney Organogenesis","volume":"29","author":"Lindstr\u00f6m","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cca.2022.01.012_b0050","first-page":"13","article-title":"Prenatal diagnosis of urinary tract abnormalities with ultrasound. A review","volume":"137","author":"Townsend","year":"1991","journal-title":"Scand. J. Urol. Nephrol. Suppl."},{"issue":"6","key":"10.1016\/j.cca.2022.01.012_b0055","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0022-5347(17)38570-1","article-title":"A prospective study of urologist-performed sonographic evaluation of the urinary tract in patients with prostatism","volume":"145","author":"Reisman","year":"1991","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bpobgyn.2014.01.009","article-title":"Ultrasound diagnosis of fetal renal abnormalities","volume":"28","author":"Dias","year":"2014","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"9","key":"10.1016\/j.cca.2022.01.012_b0065","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/pd.5418","article-title":"Prenatal detection of isolated bilateral hyperechogenic kidneys: Etiologies and outcomes","volume":"39","author":"Shuster","year":"2019","journal-title":"Prenat. Diagn."},{"issue":"7","key":"10.1016\/j.cca.2022.01.012_b0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/pd.1185","article-title":"Fetal hyperechogenic kidney with normal amniotic fluid volume: a diagnostic dilemma","volume":"25","author":"Mashiach","year":"2005","journal-title":"Prenat. Diagn."},{"issue":"12","key":"10.1016\/j.cca.2022.01.012_b0075","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrneph.2015.140","article-title":"Genetic, environmental, and epigenetic factors involved in CAKUT","volume":"11","author":"Nicolaou","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.cca.2022.01.012_b0080","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/nep.12414","article-title":"Pattern of clinical presentation of congenital anomalies of the kidney and urinary tract among infants and children","volume":"20","author":"Soliman","year":"2015","journal-title":"Nephrology (Carlton)"},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0085","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00003081-199309000-00008","article-title":"Prenatal diagnosis: choices women make about pursuing testing and acting on abnormal results","volume":"36","author":"Pryde","year":"1993","journal-title":"Clin. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.cca.2022.01.012_b0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"ACMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"issue":"4","key":"10.1016\/j.cca.2022.01.012_b0095","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41436-019-0731-7","article-title":"ACMG Professional Practice and Guidelines Committee. The use of fetal exome sequencing in prenatal diagnosis: a points to consider document of the American College of Medical Genetics and Genomics (ACMG)","volume":"22","author":"Monaghan","year":"2020","journal-title":"Genet. Med."},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0100","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2214\/ajr.157.3.1872242","article-title":"Normal length of fetal kidneys: sonographic study in 397 obstetric patients","volume":"157","author":"Cohen","year":"1991","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.cca.2022.01.012_b0105","first-page":"540","article-title":"Amniotic fluid volume assessment with the four-quadrant technique at 36\u201342 weeks' gestation","volume":"32","author":"Phelan","year":"1987","journal-title":"J. Reprod. Med."},{"issue":"5","key":"10.1016\/j.cca.2022.01.012_b0110","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/0002-9378(90)90009-V","article-title":"The amniotic fluid index in normal human pregnancy","volume":"162","author":"Moore","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.cca.2022.01.012_b0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10654-019-00576-5","article-title":"A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research","volume":"35","author":"Muka","year":"2020","journal-title":"Eur. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.cca.2022.01.012_b0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1469-0705.1991.01020115.x","article-title":"The differential diagnosis of enlarged hyperechogenic kidneys with normal or increased liquor volume: report of five cases and review of the literature","volume":"1","author":"Chitty","year":"1991","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.cca.2022.01.012_b0125","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00005392-199502000-00051","article-title":"Prenatally diagnosed bilateral hyperechoic kidneys with normal amniotic fluid: postnatal outcome","volume":"153","author":"Carr","year":"1995","journal-title":"J. Urol."},{"issue":"845","key":"10.1016\/j.cca.2022.01.012_b0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1259\/bjr.71.845.9691894","article-title":"A 10 year audit of antenatal ultrasound detection of renal disease","volume":"71","author":"Dillon","year":"1998","journal-title":"Br. J. Radiol."},{"issue":"1","key":"10.1016\/j.cca.2022.01.012_b0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/uog.1098","article-title":"Prenatal sonographic patterns in autosomal dominant polycystic kidney disease: a multicenter study","volume":"24","author":"Brun","year":"2004","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0140","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1681\/ASN.2006091057","article-title":"Anomalies of the TCF2 gene are the main cause of fetal bilateral hyperechogenic kidneys","volume":"18","author":"Decramer","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cca.2022.01.012_b0145","first-page":"236","article-title":"Prenatal diagnosis and clinical prognosis of fetal hyperechogenic kidneys","volume":"42","author":"Li","year":"2007","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.cca.2022.01.012_b0150","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jgyn.2010.07.012","article-title":"Prenatal diagnosis of hyperechogenic kidneys: A study of 17 cases","volume":"39","author":"Emmanuelli","year":"2010","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"6","key":"10.1016\/j.cca.2022.01.012_b0155","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2215\/CJN.06810909","article-title":"Spectrum of HNF1B mutations in a large cohort of patients who harbor renal diseases","volume":"5","author":"Heidet","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11","key":"10.1016\/j.cca.2022.01.012_b0160","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/pd.4926","article-title":"Prenatal diagnosis of 17q12 deletion syndrome: from fetal hyperechogenic kidneys to high risk for autism","volume":"36","author":"Gilboa","year":"2016","journal-title":"Prenat. Diagn."},{"issue":"10","key":"10.1016\/j.cca.2022.01.012_b0165","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00467-016-3421-6","article-title":"Hyperechogenic kidneys and polyhydramnios associated with HNF1B gene mutation","volume":"31","author":"Gondra","year":"2016","journal-title":"Pediatr. Nephrol."},{"issue":"3","key":"10.1016\/j.cca.2022.01.012_b0170","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/01443615.2018.1519693","article-title":"Prenatal diagnosis of 17q12 deletion syndrome: a retrospective case series","volume":"39","author":"Jing","year":"2019","journal-title":"J. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.cca.2022.01.012_b0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/uog.1086","article-title":"Antenatal renal sonographic anomalies and postnatal follow-up of renal involvement in Bardet-Biedl syndrome","volume":"24","author":"Cassart","year":"2004","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.cca.2022.01.012_b0180","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ccr3.859","article-title":"Prenatal diagnosis of Bardet-Biedl syndrome in a case of hyperechogenic kidneys: Clinical use of DNA sequencing","volume":"5","author":"Garcia-Tizon Larroca","year":"2017","journal-title":"Clin Case Rep"},{"issue":"2","key":"10.1016\/j.cca.2022.01.012_b0185","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/jmg.10.2.180","article-title":"Trisomy 9 mosaicism with multiple congenital anomalies","volume":"10","author":"Haslam","year":"1973","journal-title":"J. Med. Genet."},{"issue":"5","key":"10.1016\/j.cca.2022.01.012_b0190","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/ajmg.a.33928","article-title":"Presenting physical characteristics, medical conditions, and developmental status of long-term survivors with trisomy 9 mosaicism","volume":"155","author":"Bruns","year":"2011","journal-title":"Am J Med Genet A"},{"issue":"5","key":"10.1016\/j.cca.2022.01.012_b0195","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/ajmg.a.36977","article-title":"Twenty-five additional cases of trisomy 9 mosaic: Birth information, medical conditions, and developmental status","volume":"167","author":"Bruns","year":"2015","journal-title":"Am J Med Genet A"},{"issue":"1","key":"10.1016\/j.cca.2022.01.012_b0200","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00442081","article-title":"Multiple acyl-CoA dehydrogenation deficiency (glutaric aciduria type II), congenital polycystic kidneys, and symmetric warty dysplasia of the cerebral cortex in two brothers. I. Clinical, metabolical, and biochemical findings","volume":"139","author":"Lehnert","year":"1982","journal-title":"Eur. J. Pediatr."},{"issue":"2","key":"10.1016\/j.cca.2022.01.012_b0205","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ajhg.2015.07.001","article-title":"Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development","volume":"97","author":"Vivante","year":"2015","journal-title":"Am. J. Hum. Genet."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122000213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122000213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:02:31Z","timestamp":1757862151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898122000213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":41,"alternative-id":["S0009898122000213"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2022.01.012","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal diagnosis and outcome of fetal hyperechogenic kidneys in the era of antenatal next-generationsequencing","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2022.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}