{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:19:14Z","timestamp":1792412354257,"version":"4.4.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873943"],"award-info":[{"award-number":["81873943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000100"],"award-info":[{"award-number":["2016YFC1000100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.cca.2022.04.234","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T10:53:22Z","timestamp":1650279202000},"page":"265-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"special_numbering":"C","title":["Immune regulation in polycystic ovary syndrome"],"prefix":"10.1016","volume":"531","author":[{"given":"Ying-yi","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-qiu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-hong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2022.04.234_b0005","first-page":"2434","article-title":"A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain","volume":"85","author":"Asuncion","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2022.04.234_b0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.cca.2022.04.234_b0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1530\/REP-15-0352","article-title":"Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment","volume":"151","author":"D\u0103neas\u0103","year":"2016","journal-title":"Reproduction"},{"issue":"7","key":"10.1016\/j.cca.2022.04.234_b0020","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.3390\/ijms22073789","article-title":"Chronic Low Grade Inflammation in Pathogenesis of PCOS","volume":"22","author":"Rudnicka","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cca.2022.04.234_b0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.15171\/jnp.2017.04","article-title":"Relationship between IL-17 serum level and ambulatory blood pressure in women with polycystic ovary syndrome","volume":"6","author":"Foroozanfard","year":"2017","journal-title":"J Nephropathol"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/1043659619856670","article-title":"Cultural Experiences, Patterns, and Practices of American Indian Women With Polycystic Ovary Syndrome: An Ethnonursing Study","volume":"31","author":"Carron","year":"2020","journal-title":"J Transcult Nurs"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0035","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1210\/jc.2010-1290","article-title":"Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance","volume":"96","author":"Manner\u00e5s-Holm","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2022.04.234_b0040","doi-asserted-by":"crossref","unstructured":"Qi X, Zhang B, Zhao Y, Li R, Chang HM, Pang Y, Qiao J. Hyperhomocysteinemia Promotes Insulin Resistance and Adipose Tissue Inflammation in PCOS Mice Through Modulating M2 Macrophage Polarization via Estrogen Suppression. Endocrinology 2017;158:1181\u20131193.","DOI":"10.1210\/en.2017-00039"},{"key":"10.1016\/j.cca.2022.04.234_b0045","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13048-020-00670-3","article-title":"Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review","volume":"13","author":"He","year":"2020","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.cca.2022.04.234_b0050","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S0954422416000287","article-title":"Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges","volume":"30","author":"Jeanes","year":"2020","journal-title":"Nutr Res Rev"},{"key":"10.1016\/j.cca.2022.04.234_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00575","article-title":"Guizhi Fuling Wan, Chinese Herbal Medicine, Ameliorates Insulin Sensitivity in PCOS Model Rats With Insulin Resistance via Remodeling Intestinal Homeostasis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"10.1016\/j.cca.2022.04.234_b0060","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/jcm9051399","article-title":"Activation of Systemic Inflammation and Oxidative Stress in Adolescent Girls with Polycystic Ovary Syndrome in Combination with Metabolic Disorders and Excessive Body Weight","volume":"9","author":"Khashchenko","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.cca.2022.04.234_b0065","first-page":"1","article-title":"Mesenchymal Stem Cells Alleviate DHEA-Induced Polycystic Ovary Syndrome (PCOS) by Inhibiting Inflammation in Mice","volume":"2019","author":"Xie","year":"2019","journal-title":"Stem Cells Int"},{"issue":"3","key":"10.1016\/j.cca.2022.04.234_b0080","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/01443615.2011.553693","article-title":"Polycystic ovary syndrome and the peripheral blood white cell count","volume":"31","author":"Herlihy","year":"2011","journal-title":"J Obstet Gynaecol"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0085","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4049\/jimmunol.1100588","article-title":"Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling","volume":"187","author":"Delano","year":"2011","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40618-015-0335-2","article-title":"The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome","volume":"39","author":"Yilmaz","year":"2016","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.cca.2022.04.234_b0095","article-title":"Correlation of platelet to lymphocyte and neutrophil to lymphocyte ratio with hormonal and metabolic parameters in women with PCOS. Horm Mol Biol","volume":"34","author":"Pergialiotis","year":"2018","journal-title":"Clin Investig"},{"key":"10.1016\/j.cca.2022.04.234_b0100","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1530\/EJE-07-0822","article-title":"Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?","volume":"158","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.cca.2022.04.234_b0105","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cellimm.2018.06.001","article-title":"Bone marrow-derived inflammatory and steady state DCs are different in both functions and survival","volume":"331","author":"Zhang","year":"2018","journal-title":"Cell Immunol"},{"key":"10.1016\/j.cca.2022.04.234_b0110","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3389\/fimmu.2018.01768","article-title":"Uncovering the Mysteries of Langerhans Cells, Inflammatory Dendritic Epidermal Cells, and Monocyte-Derived Langerhans Cell-Like Cells in the Epidermis","volume":"9","author":"Otsuka","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.cca.2022.04.234_b0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molimm.2020.07.006","article-title":"Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation","volume":"126","author":"Rodrigues","year":"2020","journal-title":"Mol Immunol"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0120","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.1000325","article-title":"Dendritic cell apoptosis: regulation of tolerance versus immunity","volume":"185","author":"Kushwah","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2022.04.234_b0125","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3389\/fimmu.2019.00775","article-title":"Metabolic Control of Dendritic Cell Functions: Digesting Information","volume":"10","author":"Wculek","year":"2019","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.cca.2022.04.234_b0130","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00281-011-0263-y","article-title":"Immunotherapy with pluripotent stem cell-derived dendritic cells","volume":"33","author":"Senju","year":"2011","journal-title":"Semin Immunopathol"},{"issue":"3","key":"10.1016\/j.cca.2022.04.234_b0135","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12717","article-title":"Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome","volume":"78","author":"Zhang","year":"2017","journal-title":"Am J Reprod Immunol"},{"issue":"7","key":"10.1016\/j.cca.2022.04.234_b0140","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1210\/me.2013-1400","article-title":"Ovarian dendritic cells act as a double-edged pro-ovulatory and anti-inflammatory sword","volume":"28","author":"Cohen-Fredarow","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2826.1996.tb00682.x","article-title":"Immunohistochemical, morphological and ultrastructural resemblance between dendritic cells and folliculo-stellate cells in normal human and rat anterior pituitaries","volume":"8","author":"Allaerts","year":"1996","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/41.2.8419456","article-title":"Immunocytochemical evidence that S-100-positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity","volume":"41","author":"Vankelecom","year":"1993","journal-title":"J Histochem Cytochem"},{"issue":"4","key":"10.1016\/j.cca.2022.04.234_b0155","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/cyto.b.20410","article-title":"Dendritic cell subsets in the peritoneal fluid and peripheral blood of women suffering from ovarian cancer","volume":"74B","author":"Wertel","year":"2008","journal-title":"Cytometry B Clin Cytom"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0160","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000125097","article-title":"Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system","volume":"49","author":"Vankelecom","year":"1989","journal-title":"Neuroendocrinology"},{"issue":"3","key":"10.1016\/j.cca.2022.04.234_b0165","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.fertnstert.2011.12.030","article-title":"CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins","volume":"97","author":"Fainaru","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.cca.2022.04.234_b0170","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3389\/fimmu.2019.02278","article-title":"NK Cell Metabolism and Tumor Microenvironment","volume":"10","author":"Terr\u00e9n","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.cca.2022.04.234_b0175","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3389\/fimmu.2019.01414","article-title":"What Defines NK Cell Functional Fate: Phenotype or Metabolism?","volume":"10","author":"Poznanski","year":"2019","journal-title":"Front Immunol"},{"issue":"18","key":"10.1016\/j.cca.2022.04.234_b0180","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.3390\/ijms20184514","article-title":"NK Cell Hyporesponsiveness: More Is Not Always Better","volume":"20","author":"Frutoso","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.cca.2022.04.234_b0185","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41577-019-0139-2","article-title":"Immunometabolism and natural killer cell responses","volume":"19","author":"O\u2019Brien","year":"2019","journal-title":"Nat Rev Immunol."},{"key":"10.1016\/j.cca.2022.04.234_b0190","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/JIR.S260770","article-title":"Peripheral Blood Inflammatory-Immune Cells as a Predictor of Infertility in Women with Polycystic Ovary Syndrome","volume":"13","author":"He","year":"2020","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.cca.2022.04.234_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2018.08.003","article-title":"Killer-cell immunoglobulin-like receptors associated with polycystic ovary syndrome","volume":"130","author":"Sala Elpidio","year":"2018","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.cca.2022.04.234_b0200","doi-asserted-by":"crossref","unstructured":"Matteo M, Serviddio G, Massenzio F, Scillitani G, Castellana L, Picca G, Sanguedolce F, Cignarelli M, Altomare E, Bufo P, et al. Reduced percentage of natural killer cells associated with impaired cytokine network in the secretory endometrium of infertile women with polycystic ovary syndrome. Fertil Steril 2010; 94:2222\u20137, 2227.e1\u20133.","DOI":"10.1016\/j.fertnstert.2010.01.049"},{"issue":"8","key":"10.1016\/j.cca.2022.04.234_b0205","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/09513590.2018.1428301","article-title":"Association between Th1\/Th2 immune imbalance and obesity in women with or without polycystic ovary syndrome","volume":"34","author":"Gong","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.cca.2022.04.234_b0210","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe drived butyraye inducecs the differentiation of colonic regulationry T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cca.2022.04.234_b0215","first-page":"1","article-title":"The story of CD4+ CD28-T cells revisited: solved or still ongoing?","volume":"2015","author":"Maly","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.cca.2022.04.234_b0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.trim.2017.04.001","article-title":"CD28 biomarker quantification and expression level profiles in CD4 + T-lymphocytes in solid organ transplantation","volume":"42","author":"Boix","year":"2017","journal-title":"Transpl Immunol"},{"issue":"12","key":"10.1016\/j.cca.2022.04.234_b0225","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1177\/1933719113488444","article-title":"Effects of drospirenone-ethinylestradiol and\/or metformin on CD4(+)CD28(null) T lymphocytes frequency in women with hyperinsulinemia having polycystic ovary syndrome: a randomized clinical trial","volume":"20","author":"Moro","year":"2013","journal-title":"Reprod Sci"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0230","article-title":"Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome","volume":"9","author":"Li","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0235","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1210\/jc.2014-2401","article-title":"Reduced Tregs in peripheral blood of PCOS patients-a consequence of aberrant Il2 signaling","volume":"100","author":"Krishna","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2022.04.234_b0240","first-page":"1","article-title":"The Imbalance in Th17 and Treg Cells in Polycystic Ovarian Syndrome Patients with Autoimmune Thyroiditis","author":"Ma","year":"2021","journal-title":"Immunol Invest"},{"key":"10.1016\/j.cca.2022.04.234_b0245","first-page":"175","article-title":"T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome","volume":"15","author":"Nasri","year":"2018","journal-title":"Iran J Immunol"},{"key":"10.1016\/j.cca.2022.04.234_b0250","doi-asserted-by":"crossref","unstructured":"Wang H, Zhang Y, Fang X, Kwak-Kim J, Wu L. Insulin Resistance Adversely Affect IVF Outcomes in Lean Women Without PCOS. Front Endocrinol (Lausanne) 2021;12:734638.","DOI":"10.3389\/fendo.2021.734638"},{"issue":"11","key":"10.1016\/j.cca.2022.04.234_b0255","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1210\/jc.2015-2580","article-title":"Vitamin D Supplementation Decreases TGF-\u03b21 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial","volume":"100","author":"Irani","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.cca.2022.04.234_b0260","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/mrd.22076","article-title":"Regulation of the ovarian reserve by members of the transforming growth factor beta family","volume":"79","author":"Pangas","year":"2012","journal-title":"Mol Reprod Develop"},{"issue":"5","key":"10.1016\/j.cca.2022.04.234_b0265","doi-asserted-by":"crossref","first-page":"e0126532","DOI":"10.1371\/journal.pone.0126532","article-title":"TGF-\u03b21 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1\/2 Signaling Pathways","volume":"10","author":"Cheng","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.cca.2022.04.234_b0270","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1095\/biolreprod.102.013961","article-title":"Regulation of aromatase gene expression in purified germ cells of adult male rats: effects of transforming growth factor beta, tumor necrosis factor alpha, and cyclic adenosine 3',5'-monosphosphate","volume":"69","author":"Bourguiba","year":"2003","journal-title":"Biol Reprod"},{"key":"10.1016\/j.cca.2022.04.234_b0275","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1530\/REP-07-0316","article-title":"Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells","volume":"136","author":"Zheng","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.cca.2022.04.234_b0280","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.omtn.2020.11.005","article-title":"Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via up-regulating SERPINE1 expression in patients with PCOS","volume":"23","author":"Bai","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0285","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-021-01463-3","article-title":"Regulation of circulating CTRP-2\/CTRP-9 and GDF-8\/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training","volume":"20","author":"Jerobin","year":"2021","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.cca.2022.04.234_b0290","doi-asserted-by":"crossref","unstructured":"Fang L, Wang S, Li Y, Yu Y, Li Y, Yan Y, Cheng JC, Sun YP. High GDF-8 in follicular fluid is associated with a low pregnancy rate in IVF patients with PCOS. Reproduction 2020; 160:11\u201319.","DOI":"10.1530\/REP-20-0077"},{"key":"10.1016\/j.cca.2022.04.234_b0295","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.708089","article-title":"The Exploration of Poor Ovarian Response-Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient","volume":"12","author":"Bai","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cca.2022.04.234_b0300","doi-asserted-by":"crossref","unstructured":"Bukhari, Shazia Anwer, Yasmin Aysha. Secreted frizzled-related protein 4 and its implication in obesity and type-2 diabetes. IUBMB Life 2019; 2015: 1701\u20131710. 61.Almario RU, Karakas SE. Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation. Horm Metab Res 2015; 47:152\u20137.","DOI":"10.1055\/s-0034-1384521"},{"key":"10.1016\/j.cca.2022.04.234_b0305","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1210\/jc.2013-1923","article-title":"Mesenchymal stem\/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential","volume":"98","author":"Piltonen","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.cca.2022.04.234_b0310","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s40618-019-01108-4","article-title":"Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome","volume":"43","author":"Bicer","year":"2020","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"10.1016\/j.cca.2022.04.234_b0315","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3109\/07853890009011772","article-title":"Function of C-Reactive Protein","volume":"32","author":"Du Clos","year":"2000","journal-title":"Ann Med"},{"key":"10.1016\/j.cca.2022.04.234_b0320","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.720363","article-title":"Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections","volume":"12","author":"Luan","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0325","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/13813455.2018.1499120","article-title":"Insulin resistance and oxidative marker in women with PCOS","volume":"126","author":"Bannigida","year":"2020","journal-title":"Arch Physiol Biochem"},{"issue":"11","key":"10.1016\/j.cca.2022.04.234_b0330","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3109\/09513590.2013.824962","article-title":"The relationship of urotensin II with insulin resistance and hs-CRP in patients having PCOS","volume":"29","author":"Yilmaz","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.cca.2022.04.234_b0335","doi-asserted-by":"crossref","unstructured":"Ganie MA, Sahar T, Rashid A, Wani IA, Nisar S, Sathyapalan T, Vishnubhatla S, Ramakrishnan L, Parvez T, Geer I. Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet. Front Endocrinol (Lausanne)2019;10:699.","DOI":"10.3389\/fendo.2019.00699"},{"key":"10.1016\/j.cca.2022.04.234_b0340","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.667130","article-title":"\u03b2-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota","volume":"8","author":"Yu","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.cca.2022.04.234_b0345","doi-asserted-by":"crossref","first-page":"119076","DOI":"10.1016\/j.lfs.2021.119076","article-title":"Down-regulation of MALAT1 aggravates polycystic ovary syndrome by regulating MiR-302d-3p-mediated leukemia inhibitory factor activity","volume":"277","author":"Chen","year":"2021","journal-title":"Life Sci"},{"issue":"4","key":"10.1016\/j.cca.2022.04.234_b0350","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.fertnstert.2011.07.1092","article-title":"Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome","volume":"96","author":"Wallace","year":"2011","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.cca.2022.04.234_b0355","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.rbmo.2017.12.020","article-title":"Leukaemia inhibitory factor in serum and follicular fluid of women with polycystic ovary syndrome and its correlation with IVF outcome","volume":"36","author":"Li","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.cca.2022.04.234_b0360","first-page":"1","article-title":"Thyroid autoimmunity markers in women with polycystic ovary syndrome and controls","volume":"7","author":"Kim","year":"2020","journal-title":"Hum Fertil (Camb)"},{"issue":"6","key":"10.1016\/j.cca.2022.04.234_b0365","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/humrep\/det086","article-title":"Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence","volume":"28","author":"Zeng","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.cca.2022.04.234_b0370","doi-asserted-by":"crossref","unstructured":"Yang SH, Son WY, Yoon SH, Ko Y, Lim JH. Correlation between in vitro maturation and expression of LH receptor in cumulus cells of the oocytes collected from PCOS patients in HCG-primed IVM cycles. Hum Reprod 2005; 20:2097\u2013103.","DOI":"10.1093\/humrep\/dei045"},{"issue":"5","key":"10.1016\/j.cca.2022.04.234_b0375","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.21037\/apm-21-1003","article-title":"The expression of platelet-derived growth factor, epidermal growth factor, and insulin-like growth factor-II in patients with polycystic ovary syndrome and its correlation with pregnancy outcomes","volume":"10","author":"Gao","year":"2021","journal-title":"Ann Palliat Med"},{"issue":"9","key":"10.1016\/j.cca.2022.04.234_b0380","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1080\/09513590.2021.1942453","article-title":"sRAGE downregulates the VEGF expression in OHSS ovarian granulosa cells","volume":"37","author":"Wang","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.cca.2022.04.234_b0385","first-page":"367","article-title":"Epidermal growth factor and leukemia inhibitory factor levels in follicular fluid. Association with in vitro fertilization outcome","volume":"44","author":"Oz\u00f6rnek","year":"1999","journal-title":"J Reprod Med"},{"key":"10.1016\/j.cca.2022.04.234_b0390","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1095\/biolreprod66.2.297","article-title":"Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome","volume":"66","author":"Apparao","year":"2002","journal-title":"Biol Reprod"},{"issue":"14","key":"10.1016\/j.cca.2022.04.234_b0400","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.3390\/ijms21144853","article-title":"Metabolomic Insight into Polycystic Ovary Syndrome-An Overview","volume":"21","author":"Rajska","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cca.2022.04.234_b0405","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.lfs.2019.04.046","article-title":"Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)","volume":"228","author":"Li","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.cca.2022.04.234_b0410","doi-asserted-by":"crossref","unstructured":"Abdalla MA, Deshmukh H, Atkin S, Sathyapalan T. A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome. Ther Adv Endocrinol Metab 2020; 11:2042018820938305.","DOI":"10.1177\/2042018820938305"},{"key":"10.1016\/j.cca.2022.04.234_b0415","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fendo.2020.00440","article-title":"Ovarian Reserve and Serum Concentration of Thyroid Peroxidase Antibodies in Euthyroid Women With Different Polycystic Ovary Syndrome Phenotypes","volume":"11","author":"Adamska","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0420","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13224-016-0914-y","article-title":"Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome","volume":"67","author":"Menon","year":"2017","journal-title":"J Obstet Gynaecol India"},{"issue":"12","key":"10.1016\/j.cca.2022.04.234_b0425","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1369\/jhc.7A7259.2007","article-title":"Specific and sensitive immunoassays detect multiple anti-ovarian antibodies in women with infertility","volume":"55","author":"Pires","year":"2007","journal-title":"J Histochem Cytochem"},{"issue":"5","key":"10.1016\/j.cca.2022.04.234_b0430","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1071\/RD9910537","article-title":"Detection of anti-ovarian antibodies by indirect immunofluorescence in patients with premature ovarian failure","volume":"3","author":"Kirsop","year":"1991","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.cca.2022.04.234_b0435","first-page":"115","article-title":"Is endometriosis an autoimmune disease?","volume":"70","author":"Gleicher","year":"1987","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.cca.2022.04.234_b0440","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0140-6736(68)91053-2","article-title":"Immunological aspects of premature ovarian failure associated with Addison's disease","volume":"2","author":"Irvine","year":"1968","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0445","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1210\/jcem-70-1-69","article-title":"Ovarian antibodies detected by immobilized antigen immunoassay in patients with premature ovarian failure","volume":"70","author":"Luborsky","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0450","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-0897.2008.00678.x","article-title":"Anti-elastin antibodies and elastin turnover in normal pregnancy and recurrent pregnancy loss","volume":"61","author":"Konova","year":"2009","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"10.1016\/j.cca.2022.04.234_b0455","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3346\/jkms.1992.7.3.284","article-title":"Autoimmune oophoritis\u2013a case report","volume":"7","author":"Suh","year":"1992","journal-title":"J Korean Med Sci"},{"issue":"1","key":"10.1016\/j.cca.2022.04.234_b0460","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13224-013-0451-x","article-title":"Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome","volume":"64","author":"Samsami","year":"2014","journal-title":"J Obstet Gynaecol India"},{"key":"10.1016\/j.cca.2022.04.234_b0465","doi-asserted-by":"crossref","unstructured":"Kem DC, Li H, Yu X, Weedin E, Reynolds AC, Forsythe E, Beel M, Fischer H, Hines B, Guo Y, et al. The Role of GnRH Receptor Autoantibodies in Polycystic Ovary Syndrome. J Endocr Soc 2020; 4:bvaa078.","DOI":"10.1210\/jendso\/bvaa078"},{"key":"10.1016\/j.cca.2022.04.234_b0470","first-page":"35","article-title":"Antibodies Against Immunologically Sequestered Antigens in Patients with Polycystic Ovary Syndrome (PCOS)","volume":"55","author":"Lazarov","year":"2016","journal-title":"Akush Ginekol (Sofiia)"},{"issue":"3","key":"10.1016\/j.cca.2022.04.234_b0475","first-page":"299","article-title":"Elevated activity levels of activating autoantibodies to the GnRH receptor in patients with polycystic ovary syndrome","volume":"1","author":"Weedin","year":"2020","journal-title":"F S Rep"},{"issue":"4","key":"10.1016\/j.cca.2022.04.234_b0480","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1113\/EP089109","article-title":"Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model","volume":"106","author":"Li","year":"2021","journal-title":"Exp Physiol"},{"key":"10.1016\/j.cca.2022.04.234_b0485","first-page":"187","article-title":"Antinuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization","volume":"38","author":"Samsami Dehaghani","year":"2013","journal-title":"Iran J Med Sci"},{"issue":"11","key":"10.1016\/j.cca.2022.04.234_b0490","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1080\/09513590.2018.1469613","article-title":"Evaluation of serum antinuclear antibody among women with PCOS: a hospital based single center cross sectional study","volume":"34","author":"Rashid","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.cca.2022.04.234_b0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4071735","article-title":"Polycystic Ovary Syndrome May Be an Autoimmune Disorder","volume":"2016","author":"Mobeen","year":"2016","journal-title":"Scientifica (Cairo)"},{"issue":"2","key":"10.1016\/j.cca.2022.04.234_b0500","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0165-0378(01)00075-4","article-title":"Autoantibody studies of female patients with reproductive failure","volume":"51","author":"Reimand","year":"2001","journal-title":"J Reprod Immunol"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122003631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122003631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:06:11Z","timestamp":1757862371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898122003631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":97,"alternative-id":["S0009898122003631"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2022.04.234","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune regulation in polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2022.04.234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}