{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:59:35Z","timestamp":1770274775358,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cca.2022.08.027","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T12:11:23Z","timestamp":1662725483000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Impact of Unconjugated estriol (uE3) assay interference on prenatal screening tests"],"prefix":"10.1016","volume":"536","author":[{"given":"Sara P.","family":"Wyness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor M.","family":"Snow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Kunzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Seiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Genzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cca.2022.08.027_b0005","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S1701-2163(16)32973-5","article-title":"Obstetrical complications associated with abnormal maternal serum markers analytes","volume":"30","author":"Gagnon","year":"2008","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"1","key":"10.1016\/j.cca.2022.08.027_b0010","first-page":"167","article-title":"Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions","volume":"102","author":"Schoen","year":"2003","journal-title":"Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.cca.2022.08.027_b0015","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/pd.2326","article-title":"Steroid sulfatase deficiency and contiguous gene deletion syndrome amongst pregnant patients with low serum unconjugated estriols","volume":"29","author":"Langlois","year":"2009","journal-title":"Prenat. Diagn."},{"issue":"4","key":"10.1016\/j.cca.2022.08.027_b0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.semperi.2005.05.011","article-title":"Second trimester serum markers","volume":"29","author":"Canick","year":"2005","journal-title":"Semin. Perinatol."},{"issue":"4","key":"10.1016\/j.cca.2022.08.027_b0025","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1097\/AOG.0000000000004084","article-title":"ACOG Practice Bulletin, Number 226","volume":"136","author":"Screening for Fetal Chromosomal Abnormalities","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.cca.2022.08.027_b0030","unstructured":"Beckman Coulter, Class 2 Device Recall Access Unconjugated Estriol. Ref: 33570. Brea, CA. 2020. https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfres\/res.cfm?id=183566 (accessed Aug 8, 2021)."},{"key":"10.1016\/j.cca.2022.08.027_b0035","unstructured":"Access Unconjugated Estriol, Instruction for Use, Ref 33570, Beckman Coulter, Brea, CA."},{"key":"10.1016\/j.cca.2022.08.027_b0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clinbiochem.2020.11.007","article-title":"Evaluation of sporadic bovine alkaline phosphatase interference in the Beckman Access unconjugated estriol (uE3) assay affecting maternal serum screening results","volume":"87","author":"Bornhorst","year":"2021","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2022.08.027_b0045","doi-asserted-by":"crossref","first-page":"e00131","DOI":"10.1016\/j.plabm.2019.e00131","article-title":"Detection and characterization of estradiol (E2) and unconjugated estriol (uE3) immunoassay interference due to anti-bovine alkaline phosphatase (ALP) antibodies","volume":"17","author":"Maharjan","year":"2019","journal-title":"Pract. Lab. Med."},{"issue":"1","key":"10.1016\/j.cca.2022.08.027_b0050","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1515\/tjb-2018-0189","article-title":"Alkaline phosphatase \u0131nterference in an unconjugated estriol assay causing a false positive Down syndrome screening result","volume":"44","author":"Yildiz","year":"2019","journal-title":"Turkish J. Biochem."},{"key":"10.1016\/j.cca.2022.08.027_b0055","unstructured":"College of American Pathologists (CAP), Maternal Serum Screening Risk Validation Tools, https:\/\/www.cap.org\/member-resources\/councils-committees\/biochemical-and-molecular-genetics-committee-topic-center\/maternal-serum-screening-risk-validation-tools, Accessed Jan 25th, 2022."},{"issue":"1","key":"10.1016\/j.cca.2022.08.027_b0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3343\/alm.2022.42.1.3","article-title":"Hormone Immunoassay Interference: a 2021 Update","volume":"42","author":"Ghazal","year":"2022","journal-title":"Ann. Lab. Med."},{"issue":"1\u20132","key":"10.1016\/j.cca.2022.08.027_b0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jns.2007.06.006","article-title":"Anti-alkaline phosphatase antibody positive myasthenia gravis","volume":"263","author":"Konishi","year":"2007","journal-title":"J. Neurol. Sci."},{"issue":"15","key":"10.1016\/j.cca.2022.08.027_b0070","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.clinbiochem.2016.06.006","article-title":"Endogenous alkaline phosphatase interference in cardiac troponin I and other sensitive chemiluminescence immunoassays that use alkaline phosphatase activity for signal amplification","volume":"49","author":"Herman","year":"2016","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.cca.2022.08.027_b0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1874192401812010055","article-title":"False Positive Troponin I Rendering Two Admissions for \u201cRecurrent Acute Myopericarditis\u201d","volume":"12","author":"Marinheiro","year":"2018","journal-title":"Open Cardiovasc Med J"},{"key":"10.1016\/j.cca.2022.08.027_b0080","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.clinbiochem.2018.04.024","article-title":"Spurious testosterone laboratory results in a patient taking synthetic alkaline phosphatase (asfotase alfa)","volume":"58","author":"Sofronescu","year":"2018","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.cca.2022.08.027_b0085","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2249.1994.tb06021.x","article-title":"Human intestinal alkaline phosphatase-binding IgG in patients with severe bacterial infections","volume":"95","author":"M\u00e4der","year":"1994","journal-title":"Clin. Exp. Immunol."},{"issue":"2\u20133","key":"10.1016\/j.cca.2022.08.027_b0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s004300050052","article-title":"Autoantibodies with a protective function: polyreactive antibodies against alkaline phosphatase in bacterial infections","volume":"186","author":"Ritter","year":"1997","journal-title":"Med. Microbiol. Immunol."},{"issue":"4","key":"10.1016\/j.cca.2022.08.027_b0095","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/jalm\/jfab022","article-title":"Validation of a commercial reagent for the depletion of biotin from serum\/plasma: a rapid and simple tool to detect biotin interference with immunoassay testing","volume":"6","author":"Katzman","year":"2021","journal-title":"J. Appl. Lab. Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122012852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122012852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:04:40Z","timestamp":1757862280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898122012852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":19,"alternative-id":["S0009898122012852"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2022.08.027","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Unconjugated estriol (uE3) assay interference on prenatal screening tests","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2022.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}