{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:57:53Z","timestamp":1758052673453,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.cca.2022.11.022","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T14:09:38Z","timestamp":1669903778000},"page":"184-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Could the chylomicron marker apoB48 be of value in the diagnosis of chylous effusions?"],"prefix":"10.1016","volume":"539","author":[{"given":"Bertrand","family":"Lefr\u00e8re","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Sakka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Fourati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Levasseur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Curis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Cherfils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Gr\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zo\u00e9","family":"Guilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Lacorte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Chenevi\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa","family":"Bittar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bonnefont-Rousselot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2022.11.022_b0005","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/joa.12644","article-title":"Scholars and scientists in the history of the lymphatic system","volume":"231","author":"Natale","year":"2017","journal-title":"J. Anat."},{"key":"10.1016\/j.cca.2022.11.022_b0010","first-page":"1","article-title":"Serosal membranes (pleura, pericardium, peritoneum) Normal structure, development and experimental pathology","volume":"183","author":"Michailova","year":"2006","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"10.1016\/j.cca.2022.11.022_b0015","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.3389\/fphys.2019.01604","article-title":"Emerging Role of Lymphatics in the Regulation of Intestinal Lipid Mobilization","volume":"10","author":"Xiao","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cca.2022.11.022_b0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.14218\/JCTH.2017.00035","article-title":"Chylous Ascites: A Review of Pathogenesis, Diagnosis and Treatment","volume":"6","author":"Bhardwaj","year":"2018","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.cca.2022.11.022_b0025","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jtcvs.2008.03.033","article-title":"Chylopericardium in adults: a literature review over the past decade (1996\u20132006)","volume":"136","author":"Dib","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.cca.2022.11.022_b0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pcad.2016.12.009","article-title":"Pericardial Effusions: Causes, Diagnosis, and Management","volume":"59","author":"Vakamudi","year":"2017","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.cca.2022.11.022_b0035","first-page":"450","article-title":"Usefulness of the determination of lipids parameters in pleural effusions","volume":"92","author":"Romero Candeira","year":"1989","journal-title":"Med. Clin. (Barc.)"},{"key":"10.1016\/j.cca.2022.11.022_b0040","first-page":"700","article-title":"The lipoprotein profile of chylous and nonchylous pleural effusions","volume":"55","author":"Staats","year":"1980","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.cca.2022.11.022_b0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/0004563214530677","article-title":"Chylothorax diagnosis: can the clinical chemistry laboratory do more?","volume":"52","author":"Gibbons","year":"2015","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.cca.2022.11.022_b0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.clinbiochem.2016.10.008","article-title":"Establishment of triglyceride cut-off values to detect chylous ascites and pleural effusions","volume":"50","author":"Thaler","year":"2017","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2022.11.022_b0055","doi-asserted-by":"crossref","unstructured":"H. Wang H, J. Gao, R. Zhang, H. Xie, Z. Peng, Chyle test is not a valuable laboratory index in identifying chylothorax after pulmonary resection and lymph node dissection for primary non-small cell lung cancer. J. Cancer. Res. Ther. 15 (2019) 324-8. doi10.4103\/jcrt.JCRT_249_18.","DOI":"10.4103\/jcrt.JCRT_249_18"},{"key":"10.1016\/j.cca.2022.11.022_b0060","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1073\/pnas.77.5.2465","article-title":"Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons","volume":"77","author":"Kane","year":"1980","journal-title":"PNAS"},{"key":"10.1016\/j.cca.2022.11.022_b0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/B978-0-12-800263-6.00003-3","article-title":"Apolipoprotein B-48: a unique marker of chylomicron metabolism","volume":"64","author":"Nakajima","year":"2014","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.cca.2022.11.022_b0070","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1365-2362.2011.02635.x","article-title":"Exploring the value of apoB48 as a marker for atherosclerosis in clinical practice","volume":"42","author":"Alipour","year":"2012","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cca.2022.11.022_b0075","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1038\/s41598-019-40385-0","article-title":"Fasting apolipoprotein B48 is associated with large artery atherosclerotic stroke: a case-control study","volume":"9","author":"Tian","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2022.11.022_b0080","first-page":"249","article-title":"[L\u2019apoB48, un nouveau marqueur de l\u2019insuffisance intestinale chronique]","volume":"32","author":"Latour","year":"2018","journal-title":"Nut. Clin. Med."},{"key":"10.1016\/j.cca.2022.11.022_b0085","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fphys.2020.00004","article-title":"The role of interstitial matrix and the lymphatic system in gastrointestinal lipid and lipoprotein metabolism","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cca.2022.11.022_b0090","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0022-2275(20)37199-6","article-title":"A single copy of apolipoprotein B-48 is present on the human chylomicron remnant","volume":"38","author":"Phillips","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2022.11.022_b0095","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cca.2011.09.013","article-title":"Establishment of chemiluminescence enzyme immunoassay for apolipoprotein B-48 and its clinical applications for evaluation of impaired chylomicron remnant metabolism","volume":"18","author":"Hanada","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2022.11.022_b0100","first-page":"17","article-title":"Electrophoresis of serum lipoproteins (lipoproteinogram) with the Hydragel Lipo + Lp(a)\u00ae (Sebia) kit: evaluation of Fat Red 7B staining","volume":"78","author":"Bittar","year":"2020","journal-title":"Ann. Biol. Clin. (Paris)"},{"key":"10.1016\/j.cca.2022.11.022_b0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC. Bioinformartics"},{"key":"10.1016\/j.cca.2022.11.022_b0110","doi-asserted-by":"crossref","first-page":"507","DOI":"10.7326\/0003-4819-77-4-507","article-title":"Pleural effusions: the diagnostic separation of transudates and exudates","volume":"77","author":"Light","year":"1972","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cca.2022.11.022_b0115","doi-asserted-by":"crossref","first-page":"618","DOI":"10.5551\/jat.22558","article-title":"Reference interval for the apolipoprotein B-48 concentration in healthy Japanese individuals","volume":"21","author":"Masuda","year":"2014","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.cca.2022.11.022_b0120","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ijsu.2015.04.090","article-title":"Can early serum lipase measurement be routinely implemented to rule out clinically significant pancreatic fistula after pancreaticoduodenectomy?","volume":"21","author":"Dalla Valle","year":"2015","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cca.2022.11.022_b0125","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1515\/cclm-2019-0991","article-title":"Evaluating the need for free glycerol blanking for serum triglyceride measurements at Charlotte Maxeke Johannesburg Academic Hospital","volume":"58","author":"Van Heerden","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2022.11.022_b0130","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/joim.12877","article-title":"Investigation of human apoB48 metabolism using a new, integrated non-steady-state model of apoB48 and apoB100 kinetics","volume":"285","author":"Bj\u00f6rnson","year":"2019","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.cca.2022.11.022_b0135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cca.2018.12.010","article-title":"Hypothesis II: The majority of VLDL-apoB48 remnants in postprandial plasma are derived from the liver, not from the intestine","volume":"490","author":"Nakajima","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2022.11.022_b0140","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cca.2007.12.012","article-title":"Detection of apolipoproteins B-48 and B-100 carrying particles in lipoprotein fractions extracted from human aortic atherosclerotic plaques in sudden cardiac death cases","volume":"390","author":"Nakano","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2022.11.022_b0145","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.atherosclerosis.2012.02.001","article-title":"Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity","volume":"222","author":"Adiels","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cca.2022.11.022_b0150","doi-asserted-by":"crossref","first-page":"748","DOI":"10.14336\/AD.2017.1003","article-title":"Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects","volume":"9","author":"Vinagre","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.cca.2022.11.022_b0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-nutr-071714-034338","article-title":"New insights into the regulation of chylomicron production","volume":"35","author":"Dash","year":"2015","journal-title":"Annu. Rev. Nut."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122013894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898122013894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:09:17Z","timestamp":1757862557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898122013894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":31,"alternative-id":["S0009898122013894"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2022.11.022","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Could the chylomicron marker apoB48 be of value in the diagnosis of chylous effusions?","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2022.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}