{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T13:18:26Z","timestamp":1794057506222,"version":"4.8.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.cca.2023.117219","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T15:28:41Z","timestamp":1672846121000},"page":"117219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis"],"prefix":"10.1016","volume":"540","author":[{"given":"Troy D.","family":"Jaskowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille L.","family":"Novis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Tebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2023.117219_b0005","doi-asserted-by":"crossref","unstructured":"EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis, J. Hepatol. 67 (1) 2017) 145-172.","DOI":"10.1016\/j.jhep.2017.03.022"},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0010","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41395-018-0390-3","article-title":"Diagnosis and Management of Primary Biliary Cholangitis","volume":"114","author":"Younossi","year":"2019","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0015","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2023.117219_b0020","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3389\/fimmu.2015.00412","article-title":"Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014\u20132015","volume":"6","author":"Chan","year":"2015","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2023.117219_b0025","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/gut.2005.075002","article-title":"Clinical features and prognosis of primary biliary cirrhosis associated with systemic sclerosis","volume":"55","author":"Rigamonti","year":"2006","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.cca.2023.117219_b0030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1572-0241.2003.07257.x","article-title":"Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis","volume":"98","author":"Muratori","year":"2003","journal-title":"Am. J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.cca.2023.117219_b0035","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1440-1746.1995.tb01597.x","article-title":"High prevalence of antibodies to recombinant CENP-B in primary biliary cirrhosis: nuclear immunofluorescence patterns and ELISA reactivitie","volume":"10","author":"Parveen","year":"1995","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cld.2015.08.003","article-title":"Making Sense of Autoantibodies in Cholestatic Liver Diseases","volume":"20","author":"Marzorati","year":"2016","journal-title":"Clin. Liver. Dis."},{"issue":"3","key":"10.1016\/j.cca.2023.117219_b0045","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0168-8278(00)00040-4","article-title":"Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis","volume":"34","author":"Invernizzi","year":"2001","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hep.21472","article-title":"Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis","volume":"45","author":"Nakamura","year":"2007","journal-title":"Hepatology."},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/hep.28859","article-title":"C, Corpechot, French network of Immunology Laboratories, Large-scale characterization study of patients with antimitochondrial antibodies but nonestablished primary biliary cholangitis","volume":"65","author":"Dahlqvist","year":"2017","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.cca.2023.117219_b0060","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/2050640620919585","article-title":"Diagnosis and treatment of primary biliary cholangitis","volume":"8","author":"Laschtowitz","year":"2020","journal-title":"United. European. Gastroenterol. J."},{"issue":"10","key":"10.1016\/j.cca.2023.117219_b0065","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.14309\/ajg.0000000000000690","article-title":"Novel Anti-Hexokinase 1 Antibodies Are Associated With Poor Prognosis in Patients With Primary Biliary Cholangitis","volume":"115","author":"Reig","year":"2020","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2169\/internalmedicine.50.4462","article-title":"Risk factors and prediction of long-term outcome in primary biliary cirrhosis","volume":"50","author":"Ishibashi","year":"2011","journal-title":"Intern. Med."},{"issue":"9039","key":"10.1016\/j.cca.2023.117219_b0075","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0140-6736(96)04410-8","article-title":"Natural history of early primary biliary cirrhosis","volume":"348","author":"Metcalf","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2023.117219_b0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cca.2016.11.021","article-title":"Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis","volume":"464","author":"Han","year":"2017","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/cei.13512","article-title":"Autoantibodies associated with primary biliary cholangitis are common among patients with systemic lupus erythematosus even in the absence of elevated liver enzymes","volume":"203","author":"Ahmad","year":"2021","journal-title":"Clin. Exp. Immunol."},{"issue":"29","key":"10.1016\/j.cca.2023.117219_b0090","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.3748\/wjg.v27.i29.4890","article-title":"Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients: A single-center study","volume":"27","author":"Guatibonza-Garc\u00eda","year":"2021","journal-title":"World. J. Gastroenterol."},{"key":"10.1016\/j.cca.2023.117219_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.822996","article-title":"Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease","volume":"13","author":"Ceribelli","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2023.117219_b0100","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2019. https:\/\/www.R-project.org\/ (accessed 30 November 2022)."},{"issue":"4\u20135","key":"10.1016\/j.cca.2023.117219_b0105","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.autrev.2014.01.041","article-title":"The diagnosis of primary biliary cirrhosis","volume":"13","author":"Bowlus","year":"2014","journal-title":"Autoimmun. Rev."},{"issue":"11","key":"10.1016\/j.cca.2023.117219_b0110","doi-asserted-by":"crossref","first-page":"e0242164","DOI":"10.1371\/journal.pone.0242164","article-title":"Clinical significance of IgG antimitochondrial M2 antibody levels in primary biliary cholangitis: A single center study from China","volume":"5","author":"Feng","year":"2020","journal-title":"PLoS. One"},{"key":"10.1016\/j.cca.2023.117219_b0115","doi-asserted-by":"crossref","first-page":"8959103","DOI":"10.1155\/2019\/8959103","article-title":"Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis","volume":"2019","author":"Zhang","year":"2019","journal-title":"Gastroenterol. Res. Pract."},{"issue":"7","key":"10.1016\/j.cca.2023.117219_b0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/08916934.2013.801461","article-title":"Clinical significance of the fluctuation of primary biliary cirrhosis-related autoantibodies during the course of the disease","volume":"46","author":"Gatselis","year":"2013","journal-title":"Autoimmunity"},{"issue":"2","key":"10.1016\/j.cca.2023.117219_b0125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cld.2008.02.009","article-title":"Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value","volume":"12","author":"Muratori","year":"2008","journal-title":"Clin. Liver. Dis."},{"issue":"4","key":"10.1016\/j.cca.2023.117219_b0130","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jaut.2010.09.005","article-title":"PBC screen: an IgG\/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis","volume":"35","author":"Liu","year":"2010","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.cca.2023.117219_b0135","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ajg.2021.05.006","article-title":"Anti-gp210 and anti-Sp100 antibodies in primary biliary cholangitis","volume":"22","author":"Ben Lamine","year":"2021","journal-title":"Arab. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.cca.2023.117219_b0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5387\/fms.58.107","article-title":"Autoantibodies by line immunoassay in patients with primary biliary cirrhosis","volume":"58","author":"Saito","year":"2012","journal-title":"Fukushima. J. Med. Sci."},{"key":"10.1016\/j.cca.2023.117219_b0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cca.2014.08.024","article-title":"Study Group on Autoimmune Diseases of the Italian Society of Laboratory Medicine, Autoantibody profiling of patients with primary biliary cirrhosis using a multiplexed line-blot assay","volume":"438","author":"Villalta","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.cca.2023.117219_b0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1515\/cclm-2017-0249","article-title":"The diagnostic accuracy of biomarkers for diagnosis of primary biliary cholangitis (PBC) in anti-mitochondrial antibody (AMA)-negative PBC patients: a review of literature","volume":"56","author":"de Liso","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"issue":"4","key":"10.1016\/j.cca.2023.117219_b0155","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/15321819.2012.741088","article-title":"Detection of anti-SP100 antibodies in primary biliary cirrhosis. Comparison of ELISA and immunofluorescence","volume":"34","author":"Bauer","year":"2013","journal-title":"J. Immunoassay. Immunochem."},{"issue":"3","key":"10.1016\/j.cca.2023.117219_b0160","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12016-010-8234-y","article-title":"Overcoming a \u201cprobable\u201d diagnosis in antimitochondrial antibody negative primary biliary cirrhosis: study of 100 sera and review of the literature","volume":"42","author":"Bizzaro","year":"2012","journal-title":"Clin. Rev. Allergy. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2023.117219_b0165","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/diagnostics12030697","article-title":"On Behalf Of The Geai-Sei Workshop Participants, Working Algorithms and Detection Methods of Autoantibodies in Autoimmune Liver Disease: A Nationwide Study","volume":"12","author":"Mu\u00f1oz-S\u00e1nchez","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"9","key":"10.1016\/j.cca.2023.117219_b0170","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1515\/cclm-2020-0122","article-title":"Evaluation of a novel extended automated particle-based multi-analyte assay for the detection of autoantibodies in the diagnosis of primary biliary cholangitis","volume":"58","author":"Villalta","year":"2020","journal-title":"Clin. Chem. Lab. Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898123000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898123000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:08:08Z","timestamp":1757862488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898123000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":34,"alternative-id":["S0009898123000037"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2023.117219","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2023.117219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117219"}}