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Zhong, Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting complement activation and upregulation of miR-499., Exp. Ther. 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Surg. 14 (2019) 14, doi:10.1186\/s13019-019-0834-x.","DOI":"10.1186\/s13019-019-0834-x"},{"key":"10.1016\/j.cca.2023.117374_b0370","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(19)32039-2","article-title":"Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): a single-blind randomised controlled trial","volume":"394","author":"Hausenloy","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2023.117374_b0375","first-page":"82","article-title":"Remote ischaemic conditioning for myocardial infarction or elective PCI: systematic review and meta-analyses of randomised trials","volume":"9","author":"Haller","year":"2020","journal-title":"Eur. Heart J. Acute Cardiovasc. 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Brizzi, Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury., Pharmacol Res. 170 (2021) 105715, doi:10.1016\/j.phrs.2021.105715.","DOI":"10.1016\/j.phrs.2021.105715"},{"key":"10.1016\/j.cca.2023.117374_b0390","doi-asserted-by":"crossref","first-page":"H1365","DOI":"10.1152\/ajpheart.00580.2022","article-title":"Remote ischemic conditioning in Ossabaw minipigs induces the release of humoral cardioprotective triggers, but the myocardium does not respond with reduced infarct size","volume":"323","author":"Lieder","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cca.2023.117374_b0395","doi-asserted-by":"crossref","unstructured":"F. Abel, F. Murke, M. Gaida, N. Garnier, C. Ochsenfarth, C. Theiss, M. Thielmann, P. Kleinbongard, B. Giebel, J. Peters, U.H. 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