{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:32:20Z","timestamp":1784046740641,"version":"3.55.0"},"reference-count":143,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900696"],"award-info":[{"award-number":["81900696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ5814"],"award-info":[{"award-number":["2020JJ5814"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.cca.2023.117756","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T03:50:46Z","timestamp":1705031446000},"page":"117756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The role of irisin in kidney diseases"],"prefix":"10.1016","volume":"554","author":[{"given":"Xiejia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"47","key":"10.1016\/j.cca.2023.117756_b0005","doi-asserted-by":"crossref","first-page":"33738","DOI":"10.1074\/jbc.M113.516641","article-title":"The structure of irisin reveals a novel intersubunit beta-sheet fibronectin type III (FNIII) dimer: implications for receptor activation","volume":"288","author":"Schumacher","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"7382","key":"10.1016\/j.cca.2023.117756_b0010","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060563","article-title":"FNDC5\/irisin is not only a myokine but also an adipokine","volume":"8","author":"Roca-Rivada","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0020","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrendo.2016.221","article-title":"Physiology and role of irisin in glucose homeostasis","volume":"13","author":"Perakakis","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0025","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ijo.2015.199","article-title":"Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway","volume":"40","author":"Xin","year":"2016","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0030","doi-asserted-by":"crossref","first-page":"E769","DOI":"10.1210\/jc.2012-2749","article-title":"Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance","volume":"98","author":"Moreno-Navarrete","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.cca.2023.117756_b0035","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1210\/jc.2013-2373","article-title":"Circulating irisin in relation to insulin resistance and the metabolic syndrome","volume":"98","author":"Park","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0040","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147480","article-title":"Effects and molecular mechanism of GST-irisin on lipolysis and autocrine function in 3T3-L1 adipocytes","volume":"11","author":"Gao","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12902-016-0123-9","article-title":"Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults","volume":"16","author":"Shi","year":"2016","journal-title":"BMC Endocr. Disord."},{"issue":"10","key":"10.1016\/j.cca.2023.117756_b0055","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1055\/s-0042-116155","article-title":"Association of circulating irisin with insulin resistance and oxidative stress in obese women","volume":"48","author":"Belviranli","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.cca.2023.117756_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145209","article-title":"Irisin improves insulin resistance by inhibiting autophagy through the PI3K\/Akt pathway in H9c2 cells","volume":"769","author":"Song","year":"2021","journal-title":"Gene"},{"issue":"12","key":"10.1016\/j.cca.2023.117756_b0065","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/ijo.2014.42","article-title":"Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans","volume":"38","author":"Huh","year":"2014","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.cca.2023.117756_b0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.peptides.2014.09.014","article-title":"A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues","volume":"61","author":"Aydin","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.cca.2023.117756_b0075","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.peptides.2013.11.024","article-title":"Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: cardiac muscle produces more irisin than skeletal muscle","volume":"52","author":"Aydin","year":"2014","journal-title":"Peptides"},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2023.117756_b0080","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.freeradbiomed.2014.10.592","article-title":"The effect of Irisin on antioxidant system in liver","volume":"75","author":"Batirel","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"418","key":"10.1016\/j.cca.2023.117756_b0085","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao6298","article-title":"Irisin protects mitochondria function during pulmonary ischemia\/reperfusion injury","volume":"9","author":"Chen","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0090","first-page":"243","article-title":"New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity","volume":"68","author":"Mazur-Bialy","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.cca.2023.117756_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.108788","article-title":"Lower levels of irisin in patients with type 2 diabetes mellitus: a meta-analysis","volume":"175","author":"Song","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"8","key":"10.1016\/j.cca.2023.117756_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082103","article-title":"Role of irisin in myocardial infarction, heart failure, and cardiac hypertrophy","volume":"10","author":"Ho","year":"2021","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.cca.2023.117756_b0105","first-page":"6003","article-title":"Irisin: linking metabolism with heart failure","volume":"12","author":"Li","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"39","key":"10.1016\/j.cca.2023.117756_b0110","doi-asserted-by":"crossref","first-page":"12157","DOI":"10.1073\/pnas.1516622112","article-title":"The myokine irisin increases cortical bone mass","volume":"112","author":"Colaianni","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.cca.2023.117756_b0115","article-title":"Irisin ameliorates age-associated sarcopenia and metabolic dysfunction","author":"Guo","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"13","key":"10.1016\/j.cca.2023.117756_b0120","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/jama.2019.14745","article-title":"Chronic kidney disease diagnosis and management: a review","volume":"322","author":"Chen","year":"2019","journal-title":"J. Am. Med. Assoc."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0125","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000516647","article-title":"Defining AKD: the spectrum of AKI, AKD, and CKD","volume":"146","author":"Levey","year":"2022","journal-title":"Nephron"},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0130","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1530\/EJE-13-1053","article-title":"Serum levels of the myokine irisin in relation to metabolic and renal function","volume":"170","author":"Ebert","year":"2014","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0135","first-page":"314","article-title":"Measurement of serum irisin in the different stages of chronic kidney disease","volume":"10","author":"Sadeghi Shad","year":"2019","journal-title":"Caspian J. Intern. Med."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0140","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s11255-021-03000-8","article-title":"Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis","volume":"54","author":"Gan","year":"2022","journal-title":"Int. Urol. Nephrol."},{"issue":"11","key":"10.1016\/j.cca.2023.117756_b0145","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.17219\/acem\/104551","article-title":"Adropin and irisin in arterial hypertension, diabetes mellitus and chronic kidney disease","volume":"28","author":"Maciorkowska","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176230","article-title":"Sarcopenia in patients with chronic kidney disease not yet on dialysis: analysis of the prevalence and associated factors","volume":"12","author":"Souza","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0155","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ajhb.22493","article-title":"Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women","volume":"26","author":"Crujeiras","year":"2014","journal-title":"Am. J. Hum. Biol."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0160","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3109\/0886022X.2016.1172918","article-title":"Circulating irisin levels reflect visceral adiposity in non-diabetic patients undergoing hemodialysis","volume":"38","author":"Yilmaz","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.cca.2023.117756_b0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.peptides.2012.11.014","article-title":"Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity\u2013correlation with body mass index","volume":"39","author":"Stengel","year":"2013","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0170","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/jcsm.12892","article-title":"Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice","volume":"13","author":"Kawao","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0175","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jdiacomp.2013.09.011","article-title":"Relationship between circulating irisin, renal function and body composition in type 2 diabetes","volume":"28","author":"Liu","year":"2014","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.cca.2023.117756_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s11255-022-03440-w","article-title":"Serum irisin level is higher in peritoneal dialysis than in hemodialysis","author":"Song","year":"2022","journal-title":"Int. Urol. Nephrol."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0185","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1046\/j.1523-1755.2003.00803.x","article-title":"Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients","volume":"63","author":"Kalantar-Zadeh","year":"2003","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0190","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1525-139X.2007.00335.x","article-title":"Reverse epidemiology in patients with chronic kidney disease who are not yet on dialysis","volume":"20","author":"Kovesdy","year":"2007","journal-title":"Semin. Dial."},{"issue":"7\u20138","key":"10.1016\/j.cca.2023.117756_b0195","first-page":"474","article-title":"Adropin and irisin levels in relation to nutrition, body composition, and insulin resistance in patients with end-stage renal disease on chronic hemodialysis and peritoneal dialysis","volume":"126","author":"Kaluzna","year":"2016","journal-title":"Pol. Arch. Med. Wewn."},{"issue":"12","key":"10.1016\/j.cca.2023.117756_b0200","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1055\/s-0033-1354402","article-title":"Resistance exercise training does not affect plasma irisin levels of hemodialysis patients","volume":"45","author":"Moraes","year":"2013","journal-title":"Horm. Metab. Res."},{"issue":"12","key":"10.1016\/j.cca.2023.117756_b0205","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.2215\/CJN.02660221","article-title":"Classification of uremic toxins and their role in kidney failure","volume":"16","author":"Rosner","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064025","article-title":"Decrease in irisin in patients with chronic kidney disease","volume":"8","author":"Wen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2023.117756_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153393","article-title":"Dojuksan ameliorates tubulointerstitial fibrosis through irisin-mediated muscle-kidney crosstalk","volume":"80","author":"Jiang","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0220","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12882-017-0530-9","article-title":"Plasma Urotensin II levels in children and adolescents with chronic kidney disease: a single-centre study","volume":"18","author":"Garoufi","year":"2017","journal-title":"BMC Nephrol."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0225","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/ndt\/gfq416","article-title":"Renal impairment, hypertension and plasma urotensin II","volume":"26","author":"Mosenkis","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0230","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0272-6386(04)01130-8","article-title":"Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy","volume":"44","author":"Langham","year":"2004","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0235","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1113\/EP087366","article-title":"Urotensin II in the development and progression of chronic kidney disease following (5\/6) nephrectomy in the rat","volume":"104","author":"Eyre","year":"2019","journal-title":"Exp. Physiol."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0240","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1159\/000499880","article-title":"Urotensin II induces mice skeletal muscle atrophy associated with enhanced autophagy and inhibited irisin precursor (fibronectin type III domain containing 5) expression in chronic renal failure","volume":"44","author":"Pan","year":"2019","journal-title":"Kidney Blood Press. Res."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176137","article-title":"Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients","volume":"12","author":"Tan","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0250","first-page":"496","article-title":"Serum levels of the adipomyokine irisin in patients with chronic kidney disease","volume":"36","author":"Rodriguez-Carmona","year":"2016","journal-title":"Nefrologia"},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0255","doi-asserted-by":"crossref","first-page":"347","DOI":"10.17219\/acem\/81538","article-title":"Adropin and irisin: New biomarkers of cardiac status in patients with end-stage renal disease? A preliminary study","volume":"28","author":"Kaluzna","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0260","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s11914-020-00602-6","article-title":"Bone-muscle mutual interactions","volume":"18","author":"Lara-Castillo","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100218","article-title":"Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates","volume":"9","author":"Singhal","year":"2014","journal-title":"PLoS One"},{"issue":"4 suppl. 1","key":"10.1016\/j.cca.2023.117756_b0270","first-page":"21","article-title":"Irisin levels correlate with bone mineral density in soccer players","volume":"31","author":"Colaianni","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0275","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00198-014-2673-x","article-title":"Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months","volume":"25","author":"Anastasilakis","year":"2014","journal-title":"Osteoporos Int."},{"issue":"8","key":"10.1016\/j.cca.2023.117756_b0280","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1210\/jc.2018-02216","article-title":"A novel interplay between irisin and PTH: from basic studies to clinical evidence in hyperparathyroidism","volume":"104","author":"Palermo","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0285","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000487689","article-title":"Lower serum irisin levels are associated with increased vascular calcification in hemodialysis patients","volume":"43","author":"He","year":"2018","journal-title":"Kidney Blood Press. Res."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0290","doi-asserted-by":"crossref","first-page":"587","DOI":"10.33594\/000000578","article-title":"Skeletal muscle and kidney crosstalk in chronic kidney disease","volume":"56","author":"Jenkin","year":"2022","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cca.2023.117756_b0295","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12882-015-0009-5","article-title":"Association of serum irisin and body composition with chronic kidney disease in obese Chinese adults: a cross-sectional study","volume":"16","author":"Yang","year":"2015","journal-title":"BMC Nephrol."},{"issue":"10212","key":"10.1016\/j.cca.2023.117756_b0300","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0305","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/path.5198","article-title":"UCP2-dependent improvement of mitochondrial dynamics protects against acute kidney injury","volume":"247","author":"Qin","year":"2019","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0310","doi-asserted-by":"crossref","first-page":"F926","DOI":"10.1152\/ajprenal.00118.2017","article-title":"UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury","volume":"313","author":"Zhou","year":"2017","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cca.2023.117756_b0315","article-title":"Irisin pretreatment protects kidneys against acute kidney injury induced by ischemia\/reperfusion via upregulating the expression of uncoupling protein 2","volume":"2020","author":"Zhang","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0320","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2015121376","article-title":"Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI","volume":"28","author":"Martin-Sanchez","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0325","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcp.29903","article-title":"Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.cca.2023.117756_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165792","article-title":"Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53","volume":"1866","author":"Liu","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0335","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2215\/CJN.02730313","article-title":"Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals","volume":"9","author":"Zeng","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0340","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000330244","article-title":"Septic acute kidney injury: the culprit is inflammatory apoptosis rather than ischemic necrosis","volume":"32","author":"Jacobs","year":"2011","journal-title":"Blood Purif."},{"issue":"11","key":"10.1016\/j.cca.2023.117756_b0345","first-page":"6470","article-title":"Irisin alleviates renal injury caused by sepsis via the NF-kappaB signaling pathway","volume":"24","author":"Jin","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0350","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/s41467-017-01646-6","article-title":"Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys","volume":"8","author":"Peng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cca.2023.117756_b0355","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2020.06.038","article-title":"Aerobic exercise alleviates oxidative stress-induced apoptosis in kidneys of myocardial infarction mice by inhibiting ALCAT1 and activating FNDC5\/Irisin signaling pathway","volume":"158","author":"Wu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.cca.2023.117756_b0360","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1055\/s-0042-108730","article-title":"Lower circulating irisin level in patients with diabetes mellitus: a systematic review and meta-analysis","volume":"48","author":"Du","year":"2016","journal-title":"Horm. Metab. Res."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0365","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2174\/1573399813666170829163442","article-title":"Study of irisin hormone level in type 2 diabetic patients and patients with diabetic nephropathy","volume":"14","author":"Shelbaya","year":"2018","journal-title":"Curr. Diabetes Rev."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0370","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/a-1475-4444","article-title":"Association between serum irisin and diabetic nephropathy in patients with type 2 diabetes mellitus: a meta-analysis","volume":"53","author":"Wang","year":"2021","journal-title":"Horm. Metab. Res."},{"issue":"11","key":"10.1016\/j.cca.2023.117756_b0375","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1055\/a-0748-6170","article-title":"Plasma Irisin levels in subjects with type 1 diabetes: comparison with healthy controls","volume":"50","author":"Tentolouris","year":"2018","journal-title":"Horm. Metab. Res."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0380","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-13054-y","article-title":"Renal protection induced by physical exercise may be mediated by the irisin\/AMPK axis in diabetic nephropathy","volume":"12","author":"Formigari","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0385","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.pop.2014.08.008","article-title":"Obesity-related kidney disease","volume":"41","author":"Snyder","year":"2014","journal-title":"Prim. Care"},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0390","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s11255-013-0404-4","article-title":"Sonographic evaluation of para- and perirenal fat thickness is an independent predictor of early kidney damage in obese patients","volume":"45","author":"Sun","year":"2013","journal-title":"Int. Urol. Nephrol."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0395","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4239\/wjd.v11.i4.115","article-title":"Novel insight into perirenal adipose tissue: a neglected adipose depot linking cardiovascular and chronic kidney disease","volume":"11","author":"Huang","year":"2020","journal-title":"World J. Diabetes"},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0400","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10061291","article-title":"Perirenal adipose tissue-current knowledge and future opportunities","volume":"10","author":"Grigoras","year":"2021","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0405","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s11255-013-0428-9","article-title":"High FFA levels related to microalbuminuria and uncoupling of VEGF-NO axis in obese rats","volume":"45","author":"Sun","year":"2013","journal-title":"Int. Urol. Nephrol."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0410","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11255-014-0656-7","article-title":"Perirenal fat associated with microalbuminuria in obese rats","volume":"46","author":"Hou","year":"2014","journal-title":"Int. Urol. Nephrol."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0415","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12944-022-01727-6","article-title":"Irisin protects against obesity-related chronic kidney disease by regulating perirenal adipose tissue function in obese mice","volume":"21","author":"Han","year":"2022","journal-title":"Lipids Health Dis."},{"issue":"11","key":"10.1016\/j.cca.2023.117756_b0420","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003433","article-title":"Irisin lowers blood pressure by improvement of endothelial dysfunction via AMPK-Akt-eNOS-NO pathway in the spontaneously hypertensive rat","volume":"5","author":"Fu","year":"2016","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0425","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.atherosclerosis.2015.08.002","article-title":"Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients","volume":"242","author":"Lee","year":"2015","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0430","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1038\/s41598-017-02557-8","article-title":"Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice","volume":"7","author":"Colaianni","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0435","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jcb.25040","article-title":"Interactions between muscle tissues and bone metabolism","volume":"116","author":"Kawao","year":"2015","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0440","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11914-016-0313-4","article-title":"Crosstalk between muscle and bone via the muscle-myokine irisin","volume":"14","author":"Colaianni","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0445","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00774-019-01043-7","article-title":"Role of irisin in androgen-deficient muscle wasting and osteopenia in mice","volume":"38","author":"Iemura","year":"2020","journal-title":"J. Bone Miner. Metab."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0450","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00223-018-0387-3","article-title":"Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice","volume":"103","author":"Kawao","year":"2018","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0455","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.kint.2017.07.021","article-title":"Fractures in patients with CKD-diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation","volume":"92","author":"Pimentel","year":"2017","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.cca.2023.117756_b0460","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"Nickolas","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0465","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1159\/000517529","article-title":"Cardiometabolic effects of irisin in patients with end-stage renal disease on regular hemo- or peritoneal dialysis","volume":"51","author":"Csiky","year":"2022","journal-title":"Blood Purif."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0470","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s11033-020-06086-y","article-title":"An update on vascular calcification and potential therapeutics","volume":"48","author":"Singh","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.cca.2023.117756_b0475","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cca.2014.08.034","article-title":"Vascular calcification: from pathophysiology to biomarkers","volume":"438","author":"Evrard","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2023.117756_b0480","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijcard.2018.05.075","article-title":"Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: a prospective, population-based study","volume":"267","author":"Hisamatsu","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0485","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000512514","article-title":"Lower serum irisin levels are associated with increased abdominal aortic calcification in peritoneal dialysis patients","volume":"7","author":"Zhou","year":"2021","journal-title":"Kidney Dis. (Basel)"},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0490","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41419-022-04735-7","article-title":"Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease","volume":"13","author":"Pang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"13","key":"10.1016\/j.cca.2023.117756_b0495","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2023.117756_b0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2017.05.002","volume":"73","author":"Anastasilakis","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.cca.2023.117756_b0505","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.peptides.2014.02.008","article-title":"Irisin: a potentially candidate marker for myocardial infarction","volume":"55","author":"Kuloglu","year":"2014","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0510","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jcsm.12006","article-title":"Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines","volume":"6","author":"Matsuo","year":"2015","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"9","key":"10.1016\/j.cca.2023.117756_b0515","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/s41401-020-00557-5","article-title":"Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target","volume":"42","author":"Zhang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.cca.2023.117756_b0520","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.33963\/KP.14989","article-title":"Leptin, adiponectin, tumor necrosis factor alpha, and irisin concentrations as factors linking obesity with the risk of atrial fibrillation among inpatients with cardiovascular diseases","volume":"77","author":"Anaszewicz","year":"2019","journal-title":"Kardiol. Pol."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0525","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210320","article-title":"Circulating irisin levels in heart failure with preserved or reduced ejection fraction: a pilot study","volume":"14","author":"Silvestrini","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2023.117756_b0530","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.12659\/MSM.897376","article-title":"Association of serum irisin concentrations with presence and severity of coronary artery disease","volume":"22","author":"Deng","year":"2016","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0535","doi-asserted-by":"crossref","first-page":"61","DOI":"10.23736\/S0391-1977.17.02663-3","article-title":"Lower irisin levels in coronary artery disease: a meta-analysis","volume":"45","author":"Guo","year":"2020","journal-title":"Minerva Endocrinol."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0540","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.dsx.2018.04.025","article-title":"Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus","volume":"12","author":"El-Lebedy","year":"2018","journal-title":"Diabetes Metab. Syndr."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0545","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.jrn.2021.05.007","article-title":"Serum irisin may predict cardiovascular events in elderly patients with chronic kidney disease stage 3\u20135","volume":"32","author":"Arcidiacono","year":"2022","journal-title":"J. Ren. Nutr."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0550","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.21037\/apm-21-406","article-title":"Lower serum irisin levels are associated with the increasing mortality of cardiovascular and cerebrovascular diseases in hemodialysis patients","volume":"10","author":"Dong","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.cca.2023.117756_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114953","article-title":"Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats","volume":"394","author":"Huo","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"10","key":"10.1016\/j.cca.2023.117756_b0560","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s41401-019-0230-z","article-title":"Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis","volume":"40","author":"Liao","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0565","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/FJC.0000000000000608","article-title":"Irisin protects heart against ischemia-reperfusion injury through a SOD2-dependent mitochondria mechanism","volume":"72","author":"Wang","year":"2018","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"8","key":"10.1016\/j.cca.2023.117756_b0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136816","article-title":"Irisin controls growth, intracellular Ca2+ signals, and mitochondrial thermogenesis in cardiomyoblasts","volume":"10","author":"Xie","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0575","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/jcp.27037","article-title":"Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart","volume":"234","author":"Zhao","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0580","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/CS20190016","article-title":"FNDC5\/Irisin inhibits pathological cardiac hypertrophy","volume":"133","author":"Yu","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0585","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41420-021-00434-y","article-title":"NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin","volume":"7","author":"Yue","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.cca.2023.117756_b0590","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1949415","article-title":"Serum irisin levels, endothelial dysfunction, and inflammation in pediatric patients with type 2 diabetes mellitus and metabolic syndrome","volume":"2020","author":"Huerta-Delgado","year":"2020","journal-title":"J. Diabetes Res."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0595","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.numecd.2019.09.025","article-title":"Irisin as a mediator between obesity and vascular inflammation in Chinese children and adolescents","volume":"30","author":"Yin","year":"2020","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0600","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1136\/jim-2015-000044","article-title":"Novel myokine: irisin may be an independent predictor for subclinic atherosclerosis in Behcet's disease","volume":"64","author":"Icli","year":"2016","journal-title":"J. Invest. Med."},{"issue":"10","key":"10.1016\/j.cca.2023.117756_b0605","doi-asserted-by":"crossref","first-page":"18951","DOI":"10.1002\/jcp.28535","article-title":"Irisin attenuates oxidized low-density lipoprotein impaired angiogenesis through AKT\/mTOR\/S6K1\/Nrf2 pathway","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.cca.2023.117756_b0610","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.atherosclerosis.2015.10.020","article-title":"Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice","volume":"243","author":"Lu","year":"2015","journal-title":"Atherosclerosis"},{"issue":"9","key":"10.1016\/j.cca.2023.117756_b0615","first-page":"H1501","article-title":"Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway","volume":"309","author":"Han","year":"2015","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"10","key":"10.1016\/j.cca.2023.117756_b0620","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110273","article-title":"Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis","volume":"9","author":"Song","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0625","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158038","article-title":"Protective effect of irisin on atherosclerosis via suppressing oxidized low density lipoprotein induced vascular inflammation and endothelial dysfunction","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.cca.2023.117756_b0630","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.numecd.2018.04.009","article-title":"High irisin levels in overweight\/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells","volume":"28","author":"De Meneck","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.cca.2023.117756_b0635","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3669","article-title":"Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study","volume":"5","author":"Huang","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.cca.2023.117756_b0640","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.yjmcc.2016.09.005","article-title":"Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1\/adiponectin axis in diet-induced obese mice","volume":"99","author":"Hou","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0645","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00592-014-0576-0","article-title":"High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects","volume":"51","author":"Sesti","year":"2014","journal-title":"Acta Diabetol."},{"issue":"3","key":"10.1016\/j.cca.2023.117756_b0650","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/1570161120666220510120220","article-title":"Current insights on the role of irisin in endothelial dysfunction","volume":"20","author":"Luna-Ceron","year":"2022","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"7552","key":"10.1016\/j.cca.2023.117756_b0655","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/521274a","article-title":"Reproducibility crisis: blame it on the antibodies","volume":"521","author":"Baker","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cca.2023.117756_b0660","doi-asserted-by":"crossref","DOI":"10.1038\/srep08889","article-title":"Irisin - a myth rather than an exercise-inducible myokine","volume":"5","author":"Albrecht","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cca.2023.117756_b0665","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1530\/EJE-17-0572","article-title":"5 years later: irisin detection still an issue","volume":"177","author":"Cooke","year":"2017","journal-title":"Eur. J. Endocrinol."},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0670","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001","article-title":"Detection and quantitation of circulating human irisin by tandem mass spectrometry","volume":"22","author":"Jedrychowski","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cca.2023.117756_b0675","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.peptides.2018.03.013","article-title":"Detection and quantitation of irisin in human cerebrospinal fluid by tandem mass spectrometry","volume":"103","author":"Ruan","year":"2018","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0680","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1210\/endrev\/bnab003","article-title":"Progress and challenges in the biology of FNDC5 and irisin","volume":"42","author":"Maak","year":"2021","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.cca.2023.117756_b0685","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","article-title":"Irisin mediates effects on bone and fat via alphaV integrin receptors","volume":"175","author":"Kim","year":"2018","journal-title":"Cell"},{"issue":"7413","key":"10.1016\/j.cca.2023.117756_b0690","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1038\/nature11364","article-title":"Is irisin a human exercise gene?","volume":"488","author":"Timmons","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cca.2023.117756_b0695","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18052476","article-title":"Effect of chronic resistance training on circulating irisin: systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Cosio","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.cca.2023.117756_b0700","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.ajkd.2011.10.008","article-title":"Exercise in individuals with CKD","volume":"59","author":"Johansen","year":"2012","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cca.2023.117756_b0705","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118954","article-title":"The \u201cirisin system\u201d: From biological roles to pharmacological and nutraceutical perspectives","volume":"267","author":"Flori","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.cca.2023.117756_b0710","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mehy.2016.08.003","article-title":"Hypothesis: Irisin is a metabolic trigger for the activation of the neurohormonal axis governing puberty onset","volume":"95","author":"Wahab","year":"2016","journal-title":"Med. Hypotheses"},{"issue":"4","key":"10.1016\/j.cca.2023.117756_b0715","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.bbrc.2018.07.005","article-title":"Excessive irisin increases oxidative stress and apoptosis in murine heart","volume":"503","author":"Ho","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898123005582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898123005582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T13:09:37Z","timestamp":1728652177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898123005582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":143,"alternative-id":["S0009898123005582"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2023.117756","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of irisin in kidney diseases","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2023.117756","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117756"}}