{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:56:29Z","timestamp":1786985789839,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.cca.2024.117773","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T20:09:45Z","timestamp":1704744585000},"page":"117773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Exosomal miRNAs from neutrophils act as accurate biomarkers for gastric cancer diagnosis"],"prefix":"10.1016","volume":"554","author":[{"given":"Dan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runbi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2024.117773_b0005","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2024.117773_b0010","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology function and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cca.2024.117773_b0015","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.7150\/thno.46568","article-title":"Nanozyme-assisted sensitive profiling of exosomal proteins for rapid cancer diagnosis","volume":"10","author":"Di","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.cca.2024.117773_b0020","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1038\/s41467-020-18311-0","article-title":"Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cca.2024.117773_b0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature14581","article-title":"Glypican-1 identifies cancer exosomes and detects early pancreatic cancer","volume":"523","author":"Melo","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cca.2024.117773_b0030","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1136\/gutjnl-2021-325137","article-title":"Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT","volume":"71","author":"Tian","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.cca.2024.117773_b0035","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1136\/gutjnl-2021-325272","article-title":"Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6\/AXL signalling axis","volume":"71","author":"Bellomo","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.cca.2024.117773_b0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-020-2394-6","article-title":"DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25","volume":"583","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cca.2024.117773_b0045","doi-asserted-by":"crossref","first-page":"eabb5817","DOI":"10.1126\/scitranslmed.abb5817","article-title":"Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils","volume":"12","author":"Perego","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cca.2024.117773_b0050","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cca.2024.117773_b0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-021-00571-6","article-title":"Neutrophils in cancer: heterogeneous and multifaceted","volume":"22","author":"Hedrick","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cca.2024.117773_b0060","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1158\/1078-0432.CCR-16-0617","article-title":"Interleukin-17-producing neutrophils link inflammatory stimuli to disease progression by promoting angiogenesis in gastric cancer","volume":"23","author":"Li","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cca.2024.117773_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107589","article-title":"A risk signature with inflammatory and immune cells infiltration predicts survival and efficiency of chemotherapy in gastric cancer","volume":"96","author":"Li","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cca.2024.117773_b0070","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/hmg\/ddab283","article-title":"Exosomal transfer of activated neutrophil-derived lncRNA CRNDE promotes proliferation and migration of airway smooth muscle cells in asthma","volume":"31","author":"Zhang","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cca.2024.117773_b0075","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1038\/s41388-022-02322-w","article-title":"Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis","volume":"41","author":"Tyagi","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.cca.2024.117773_b0080","doi-asserted-by":"crossref","first-page":"e588","DOI":"10.1002\/ctm2.588","article-title":"Therapeutic targeting of SPIB\/SPI1-facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression","volume":"11","author":"Wang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cca.2024.117773_b0085","doi-asserted-by":"crossref","first-page":"1692401","DOI":"10.1080\/20013078.2019.1692401","article-title":"Purity and yield of melanoma exosomes are dependent on isolation method","volume":"9","author":"Shu","year":"2020","journal-title":"J. Extracell. Vesicles."},{"key":"10.1016\/j.cca.2024.117773_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113753","article-title":"Microfluidic device for one-step detection of breast cancer-derived exosomal mRNA in blood using signal-amplifiable 3D nanostructure","volume":"197","author":"Lim","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117773_b0095","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1002\/anie.201916039","article-title":"Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction","volume":"59","author":"Huang","year":"2020","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.cca.2024.117773_b0100","doi-asserted-by":"crossref","first-page":"e12204","DOI":"10.1002\/jev2.12204","article-title":"A new strategy to count and sort neutrophil-derived extracellular vesicles: Validation in infectious disorders","volume":"11","author":"Bonifay","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.cca.2024.117773_b0105","doi-asserted-by":"crossref","first-page":"14207","DOI":"10.1021\/acs.analchem.8b03031","article-title":"Isolation and visible detection of tumor-derived exosomes from plasma","volume":"90","author":"Chen","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2024.117773_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.111749","article-title":"Simultaneous multiplexed detection of exosomal microRNAs and surface proteins for prostate cancer diagnosis","volume":"146","author":"Cho","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117773_b0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1158\/0008-5472.CAN-18-0014","article-title":"M2 macrophage-derived exosomes promote cell migration and invasion in colon cancer","volume":"79","author":"Lan","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.cca.2024.117773_b0120","doi-asserted-by":"crossref","first-page":"e76319","DOI":"10.7554\/eLife.76319","article-title":"Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses","volume":"11","author":"Dosil","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.cca.2024.117773_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.129511","article-title":"A herringbone mixer based microfluidic device HBEXO-chip for purifying tumor-derived exosomes and establishing miRNA signature in pancreatic cancer","volume":"332","author":"Zhang","year":"2021","journal-title":"Sensor. Actuat. B Chem."},{"key":"10.1016\/j.cca.2024.117773_b0130","doi-asserted-by":"crossref","first-page":"14280","DOI":"10.1039\/C8NR02871K","article-title":"Immuno-modified superparamagnetic nanoparticles via host-guest interactions for high-purity capture and mild release of exosomes","volume":"10","author":"Cai","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.cca.2024.117773_b0135","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1039\/D1LC00663K","article-title":"Isolation and quantification of extracellular vesicle-encapsulated microRNA on an integrated microfluidic platform","volume":"21","author":"Sung","year":"2021","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2024.117773_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113879","article-title":"Integrated microfluidic system for isolating exosome and analyzing protein marker PD-L1","volume":"204","author":"Lu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117773_b0145","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.canlet.2019.02.051","article-title":"miRNA-223 at the crossroads of inflammation and cancer","volume":"451","author":"Jeffries","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cca.2024.117773_b0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-019-1095-1","article-title":"Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype","volume":"38","author":"Zhu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cca.2024.117773_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113615","article-title":"Multiplexed analysis of small extracellular vesicle-derived mRNAs by droplet digital PCR and machine learning improves breast cancer diagnosis","volume":"194","author":"Liu","year":"2021","journal-title":"Biosens. Bioelectron."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124000147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124000147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T09:09:34Z","timestamp":1728637774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898124000147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":31,"alternative-id":["S0009898124000147"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.117773","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomal miRNAs from neutrophils act as accurate biomarkers for gastric cancer diagnosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.117773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117773"}}