{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:03:38Z","timestamp":1789157018071,"version":"build-2803163510"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.cca.2024.117841","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T04:15:42Z","timestamp":1708575342000},"page":"117841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Microfluidics as diagnostic tools"],"prefix":"10.1016","volume":"556","author":[{"given":"Avanthika Satish","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Venkatesalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmugapriya","family":"Dilliyappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay Prakash","family":"Pasupulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Prathap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirunavukkarasu","family":"Palaniyandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gomathy","family":"Baskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddaly","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abimanyu","family":"Sugumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cca.2024.117841_b0005","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.3390\/ijms22042011","article-title":"Fabrication and applications of microfluidic devices: a review","volume":"22","author":"Niculescu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2024.117841_b0010","article-title":"Rheumatoid arthritis: etiology, treatment and animal models","volume":"10","author":"Archana","year":"2020","journal-title":"J. Drug Deliv. Therapeutics"},{"key":"10.1016\/j.cca.2024.117841_b0015","doi-asserted-by":"crossref","unstructured":"R. Golfinopoulou, S. Kintzios, Biosensing for Autoimmune Chronic Disease: A Review. (2023). Doi: 10.20944\/preprints202305.2085.v1\\.","DOI":"10.20944\/preprints202305.2085.v1"},{"key":"10.1016\/j.cca.2024.117841_b0020","series-title":"Cardiovascular Disease, in StatPearls","author":"Lopez","year":"2022"},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41378-021-00245-2","article-title":"Microfluidics in cardiovascular disease research: state of the art and future outlook","volume":"7","author":"Ma","year":"2021","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.cca.2024.117841_b0030","article-title":"Microfluidic and organ-on-a-chip approaches to investigate cellular and microenvironmental contributions to cardiovascular function and pathology","volume":"9","author":"Doherty","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cca.2024.117841_b0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bios.2018.05.050","article-title":"Point-of-care microfluidic devices for pathogen detection","volume":"117","author":"Nasseri","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"4\u20135","key":"10.1016\/j.cca.2024.117841_b0040","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.addr.2009.11.016","article-title":"Nano\/Microfluidics for diagnosis of infectious diseases in developing countries","volume":"62","author":"Lee","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2015","key":"10.1016\/j.cca.2024.117841_b0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chroma.2014.12.041","article-title":"Microfluidic platform towards point-of-care diagnostics in infectious diseases","volume":"1377","author":"Su","year":"2015","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.cca.2024.117841_b0050","doi-asserted-by":"crossref","first-page":"1700489","DOI":"10.1002\/adhm.201700489","article-title":"In vitro microfluidic models for neurodegenerative disorders","volume":"7","author":"Osaki","year":"2018","journal-title":"Adv. Healthc. Mater."},{"issue":"5","key":"10.1016\/j.cca.2024.117841_b0055","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.3390\/jcm12051709","article-title":"Advances in neurodegenerative diseases","volume":"12","author":"Van Schependom","year":"2023","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.cca.2024.117841_b0060","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.3390\/molecules27113516","article-title":"A prospective viewpoint on neurological diseases and their biomarkers","volume":"27","author":"Zehravi","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cca.2024.117841_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10404-021-02502-2","article-title":"Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives","volume":"25","author":"Pattanayak","year":"2021","journal-title":"Microfluid. Nanofluid."},{"key":"10.1016\/j.cca.2024.117841_b0070","article-title":"Microfluidic platforms in diagnostic of ovarian cancer","volume":"117084","author":"Moghaddam","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.cca.2024.117841_b0075","doi-asserted-by":"crossref","unstructured":"S.C. Terry, J.H. Jerman, J.B. Angell, A gas chromatographic air analyzer fabricated on a silicon wafer, IEEE transactions on electron devices. 26(12) (1979) 1880-1886. Doi: 10.1109\/T-ED.1979.19791.","DOI":"10.1109\/T-ED.1979.19791"},{"issue":"3","key":"10.1016\/j.cca.2024.117841_b0080","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/bp0300568","article-title":"Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes","volume":"20","author":"Leclerc","year":"2004","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.cca.2024.117841_b0085","unstructured":"E. Team, Introduction to lab-on-a-chip 2023: review, history and future, Elveflow. (2023)."},{"issue":"4","key":"10.1016\/j.cca.2024.117841_b0090","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1039\/C4IB00292J","article-title":"Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics\/pharmacodynamics modeling","volume":"7","author":"Abaci","year":"2015","journal-title":"Integr. Biol."},{"key":"10.1016\/j.cca.2024.117841_b0095","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s12541-019-00103-2","article-title":"Microchannel fabrication on glass materials for microfluidic devices","volume":"20","author":"Hwang","year":"2019","journal-title":"Int. J. Precis. Eng. Manuf."},{"key":"10.1016\/j.cca.2024.117841_b0100","article-title":"Prospectives and retrospectives of microfluidics devices and lab-on-A-chip emphasis on cancer","volume":"117646","author":"Venkatesalu","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"9","key":"10.1016\/j.cca.2024.117841_b0105","doi-asserted-by":"crossref","first-page":"1905318","DOI":"10.1002\/smll.201905318","article-title":"Inner surface design of functional microchannels for microscale flow control","volume":"16","author":"Wang","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.cca.2024.117841_b0110","doi-asserted-by":"crossref","unstructured":"A. Shahidian, M. Ghassemi, J. Mohammadi, M. Hashemi, Application of microfluidics in cancer treatment || Bio-Engineering Approaches to Cancer Diagnosis and Treatment, Academic Press. (2020) 219-250. Doi: 10.1016\/B978-0-12-817809-6.00009-1.","DOI":"10.1016\/B978-0-12-817809-6.00009-1"},{"issue":"3","key":"10.1016\/j.cca.2024.117841_b0115","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/mi12030319","article-title":"Fabrication methods for microfluidic devices: an overview","volume":"12","author":"Scott","year":"2021","journal-title":"Micromachines"},{"key":"#cr-split#-10.1016\/j.cca.2024.117841_b0120.1","doi-asserted-by":"crossref","unstructured":"J.R. Mejia-Salazar, K. Rodrigues Cruz, E.M. Materon Vasques, 2020. Microfluidic point-of-care devices: New trends and future prospects for ehealth diagnostics, Sensors. 20","DOI":"10.3390\/s20071951"},{"key":"#cr-split#-10.1016\/j.cca.2024.117841_b0120.2","doi-asserted-by":"crossref","unstructured":"(7) (2020) 1951. Doi: 10.3390\/s20071951.","DOI":"10.3390\/s20071951"},{"issue":"24","key":"10.1016\/j.cca.2024.117841_b0125","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.3390\/molecules25246013","article-title":"Biosensors-on-chip: an up-to-date review","volume":"25","author":"Chircov","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.cca.2024.117841_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114189","article-title":"Next generation point-of-care test for therapeutic drug monitoring of adalimumab in patients diagnosed with autoimmune diseases","volume":"208","author":"Ordutowski","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117841_b0135","doi-asserted-by":"crossref","unstructured":"N.R. Rose, Autoimmune diseases. In International Encyclopedia of Public Health, Elsevier Inc.. (2008) 267-271. Doi: 10.1016\/B978-0-12-803678-5.00029-1.","DOI":"10.1016\/B978-012373960-5.00408-1"},{"issue":"6","key":"10.1016\/j.cca.2024.117841_b0140","first-page":"2","article-title":"IMMUNE DB: a large internet framework for collecting and analysing biological immune results","volume":"10","author":"Paritala","year":"2021","journal-title":"J. Appl. Bioinforma Comput. Biol."},{"key":"10.1016\/j.cca.2024.117841_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40744-020-00252-1","article-title":"A review of the prevalence and unmet needs in the management of rheumatoid arthritis in Africa and the Middle East","volume":"8","author":"Almoallim","year":"2021","journal-title":"Rheumatol. Therapy"},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/imr.12379","article-title":"Mechanisms involved in triggering rheumatoid arthritis","volume":"269","author":"Catrina","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cca.2024.117841_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122886","article-title":"Peptide-based electrochemical sensor with nanogold enhancement for detecting rheumatoid arthritis","volume":"236","author":"Lin","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2024.117841_b0160","series-title":"MEMS and Microfluidics in Healthcare: Devices and Applications Perspectives (157\u2013181)","article-title":"Lab-on-chip electrochemical biosensor for rheumatoid arthritis","author":"Ram","year":"2023"},{"key":"10.1016\/j.cca.2024.117841_b0165","unstructured":"B. Aterini, Development of a microfluidic platform to evaluate migration and recruitment of different immune cell types involved in rheumatoid arthritis. (2023)."},{"key":"10.1016\/j.cca.2024.117841_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133587","article-title":"A microfluidic platform for detection and quantification of two biomarkers for rheumatoid arthritis","volume":"383","author":"Wu","year":"2023","journal-title":"Sens. Actuators B"},{"issue":"3","key":"10.1016\/j.cca.2024.117841_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2023.105556","article-title":"Predicting the onset of rheumatoid arthritis","volume":"90","author":"Gilbert","year":"2023","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.cca.2024.117841_b0180","article-title":"Developments of microfluidics for orthopedic applications: a review","author":"Sun","year":"2022","journal-title":"Smart Mater. Med."},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3390\/mi14010151","article-title":"Type 1 diabetes mellitus: a review on advances and challenges in creating insulin producing devices","volume":"14","author":"Rodrigues Oliveira","year":"2023","journal-title":"Micromachines"},{"key":"10.1016\/j.cca.2024.117841_b0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biomaterials.2018.07.002","article-title":"Engineered microenvironments and microdevices for modeling the pathophysiology of type 1 diabetes","volume":"198","author":"Becker","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.cca.2024.117841_b0195","unstructured":"F. Vicinanza, Design and development of a flow focusing microfluidic device for the conformal coating of pancreatic islets in a PEG-based hydrogel. (2023)."},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0200","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s44164-021-00005-6","article-title":"Islet-on-a-chip for the study of pancreatic \u03b2-cell function","volume":"1","author":"Rodr\u00edguez-Comas","year":"2022","journal-title":"In Vitro Models."},{"key":"10.1016\/j.cca.2024.117841_b0205","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.addr.2018.10.010","article-title":"Stem-cell based organ-on-a-chip models for diabetes research","volume":"140","author":"Rogal","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cca.2024.117841_b0210","unstructured":"S. Vaqar, K. Shackelford, Pernicious anemia. In StatPearls [Internet], StatPearls Publishing. (2023)."},{"issue":"8","key":"10.1016\/j.cca.2024.117841_b0215","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3390\/nu14081672","article-title":"Pernicious anemia: the hematological presentation of a multifaceted disorder caused by cobalamin deficiency","volume":"14","author":"Esposito","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.cca.2024.117841_b0220","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.3390\/s22041620","article-title":"Microfluidic point-of-care (POC) devices in early diagnosis: a review of opportunities and challenges","volume":"22","author":"Yang","year":"2022","journal-title":"Sensors"},{"issue":"10","key":"10.1016\/j.cca.2024.117841_b0225","doi-asserted-by":"crossref","DOI":"10.1063\/1.4997185","article-title":"A microfluidic approach for hemoglobin detection in whole blood","volume":"7","author":"Taparia","year":"2017","journal-title":"AIP Adv."},{"key":"10.1016\/j.cca.2024.117841_b0230","series-title":"Investigations on Novel Analytical Approaches for Some Drugs and Pharmaceuticals","author":"Sathe","year":"2020"},{"key":"10.1016\/j.cca.2024.117841_b0235","doi-asserted-by":"crossref","unstructured":"B. Sj\u00f6gren, C. Bigert, P. Gustavsson, Cardiovascular disease || Handbook on the toxicology of metals, Academic press. (2015) 459-483. Doi: 10.1016\/B978-0-444-59453-2.00016-0.","DOI":"10.1016\/B978-0-12-823292-7.00012-7"},{"key":"10.1016\/j.cca.2024.117841_b0240","unstructured":"World Heart Federation, World Heart Report. https:\/\/world-heart-federation.org\/wp-content\/uploads\/World-Heart-Report-2023.pdf."},{"issue":"10","key":"10.1016\/j.cca.2024.117841_b0245","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/S2214-109X(19)30318-3","article-title":"World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions","volume":"7","author":"Kaptoge","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.cca.2024.117841_b0250","unstructured":"A. Mandal, Cardiovascular disease diagnosis. (2019)."},{"issue":"2","key":"10.1016\/j.cca.2024.117841_b0255","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/children10020218","article-title":"The use of stress cardiovascular imaging in pediatric population","volume":"10","author":"Moscatelli","year":"2023","journal-title":"Children"},{"issue":"24","key":"10.1016\/j.cca.2024.117841_b0260","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2009.02.050","article-title":"Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management","volume":"53","author":"Yeh","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"issue":"39","key":"10.1016\/j.cca.2024.117841_b0265","doi-asserted-by":"crossref","first-page":"33576","DOI":"10.1021\/acsami.7b07590","article-title":"Microporous nanocomposite enabled microfluidic biochip for cardiac biomarker detection","volume":"9","author":"Singh","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.cca.2024.117841_b0270","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bios.2019.01.001","article-title":"An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples","volume":"129","author":"Sinha","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117841_b0275","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bios.2019.02.010","article-title":"Electrochemical cardiovascular platforms: current state of the art and beyond","volume":"131","author":"Szunerits","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117841_b0280","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.aca.2013.11.047","article-title":"Graphene-gated biochip for the detection of cardiac marker troponin I","volume":"809","author":"Tuteja","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2024.117841_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339375","article-title":"Dry-reagent microfluidic biosensor for simple detection of NT-proBNP via ag nanoparticles","volume":"1191","author":"Beck","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"20","key":"10.1016\/j.cca.2024.117841_b0290","doi-asserted-by":"crossref","first-page":"10019","DOI":"10.1021\/acs.analchem.6b02028","article-title":"Aptamer-based microfluidic electrochemical biosensor for monitoring cell-secreted trace cardiac biomarkers","volume":"88","author":"Shin","year":"2016","journal-title":"Anal. Chem."},{"issue":"11","key":"10.1016\/j.cca.2024.117841_b0295","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1016\/j.bios.2011.05.019","article-title":"Functionalized SnO2 nanobelt field-effect transistor sensors for label-free detection of cardiac troponin","volume":"26","author":"Cheng","year":"2011","journal-title":"Biosens. Bioelectron."},{"issue":"9\u201310","key":"10.1016\/j.cca.2024.117841_b0300","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/j.bios.2006.11.011","article-title":"Amplification of fluorescence with packed beads to enhance the sensitivity of miniaturized detection in microfluidic chip","volume":"22","author":"Shin","year":"2007","journal-title":"Biosens. Bioelectron."},{"issue":"14","key":"10.1016\/j.cca.2024.117841_b0305","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1021\/ac070452v","article-title":"Detection of cardiac biomarkers using micellar electrokinetic chromatography and a cleavable tag immunoassay","volume":"79","author":"Caulum","year":"2007","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0310","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00216-021-03553-8","article-title":"Advances in multiplex electrical and optical detection of biomarkers using microfluidic devices","volume":"414","author":"Mitchell","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.cca.2024.117841_b0315","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.aca.2008.11.019","article-title":"Chemiluminometric enzyme-linked immunosorbent assays (ELISA)-on-a-chip biosensor based on cross-flow chromatography","volume":"632","author":"Cho","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2024.117841_b0320","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.741058","article-title":"Point-of-care testing for multiple cardiac markers based on a snail-shaped microfluidic chip","volume":"9","author":"Yin","year":"2021","journal-title":"Front. Chem."},{"issue":"3","key":"10.1016\/j.cca.2024.117841_b0325","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1039\/C9AN01748H","article-title":"Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced raman scattering","volume":"145","author":"Mabbott","year":"2020","journal-title":"Analyst"},{"issue":"3","key":"10.1016\/j.cca.2024.117841_b0330","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1109\/JSEN.2008.917489","article-title":"Quantum dot-based biosensor for detection of human cardiac troponin I using a liquid-core waveguide","volume":"8","author":"Stringer","year":"2008","journal-title":"IEEE Sens. J."},{"issue":"15","key":"10.1016\/j.cca.2024.117841_b0335","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1021\/ac060480y","article-title":"On-chip enzyme immunoassay of a cardiac marker using a microfluidic device combined with a portable surface plasmon resonance system","volume":"78","author":"Kurita","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2024.117841_b0340","article-title":"Acoustic wave based microfluidic and lab-on-chip (515\u2013556)","author":"Luo","year":"2013","journal-title":"In Tech."},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2011.05.016","article-title":"Detection of multiple cardiac markers with an integrated acoustic platform for cardiovascular risk assessment","volume":"699","author":"Mitsakakis","year":"2011","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.cca.2024.117841_b0350","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/chemosensors9050106","article-title":"A surface acoustic wave sensor with a Microfluidic Channel for detecting C-reactive protein","volume":"9","author":"Jeng","year":"2021","journal-title":"Chemosensors."},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0355","first-page":"1","article-title":"Microfluidics-based strategies for molecular diagnostics of infectious diseases","volume":"9","author":"Wang","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"9","key":"10.1016\/j.cca.2024.117841_b0360","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3390\/microorganisms11092277","article-title":"Tackling drug-resistant tuberculosis: new challenges from the old pathogen mycobacterium tuberculosis","volume":"11","author":"Mancuso","year":"2023","journal-title":"Microorganisms."},{"key":"10.1016\/j.cca.2024.117841_b0365","unstructured":"World Health Organization. https:\/\/www.who.int\/."},{"key":"10.1016\/j.cca.2024.117841_b0370","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.3390\/microorganisms9112330","article-title":"Microfluidics as a novel technique for tuberculosis: from diagnostics to drug discovery","volume":"9","author":"Molloy","year":"2021","journal-title":"Microorganism."},{"key":"10.1016\/j.cca.2024.117841_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131968","article-title":"Rapid molecular diagnosis of live mycobacterium tuberculosis on an integrated microfluidic system","volume":"365","author":"Wang","year":"2022","journal-title":"Sens. Actuators B"},{"issue":"3","key":"10.1016\/j.cca.2024.117841_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.cca.2024.117841_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108144","article-title":"Rapid diagnosis of COVID-19 in the first year of the pandemic: a systematic review","volume":"101","author":"Borges","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cca.2024.117841_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2021.114337","article-title":"SARS-CoV-2 microfluidic antigen point-of-care testing in emergency room patients during COVID-19 pandemic","volume":"299","author":"Burdino","year":"2022","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.cca.2024.117841_b0395","doi-asserted-by":"crossref","unstructured":"Q. Fernandes, V.P. Inchakalody, M. Merhi, S. Mestiri, N. Taib, D. Moustafa Abo El-Ella, T. Bedhiafi, A. Raza, L. Al-Zaidan, M.O. Mohsen, M.A. Yousuf Al-Nesf, Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines, Ann. Med., 54(1) (2022) 524-540. Doi: 10.1080\/07853890.2022.2031274.","DOI":"10.1080\/07853890.2022.2031274"},{"issue":"15","key":"10.1016\/j.cca.2024.117841_b0400","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1021\/acs.analchem.0c02060","article-title":"Molecular diagnosis of COVID-19: challenges and research needs","volume":"92","author":"Feng","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2024.117841_b0405","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bios.2017.04.044","article-title":"A fully integrated distance readout ELISA-Chip for point-of-care testing with sample-in-answer-out capability","volume":"96","author":"Liu","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"20","key":"10.1016\/j.cca.2024.117841_b0410","doi-asserted-by":"crossref","first-page":"14139","DOI":"10.1021\/acs.analchem.0c03202","article-title":"Development of a lateral flow strip membrane assay for rapid and sensitive detection of the SARS-CoV-2","volume":"92","author":"Yu","year":"2020","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.cca.2024.117841_b0415","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jiac.2022.02.004","article-title":"Evaluation of the QIAstat-dx respiratory SARS-CoV-2 panel, a rapid multiplex PCR method for the diagnosis of COVID-19","volume":"28","author":"Ishikane","year":"2022","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.cca.2024.117841_b0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133331","article-title":"Development of nucleocapsid-specific monoclonal antibodies for SARS-CoV-2 and their ELISA diagnostics on an automatic microfluidic device","volume":"380","author":"Yang","year":"2023","journal-title":"Sens. Actuators B"},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0425","first-page":"2","article-title":"A narrative review of influenza: a seasonal and pandemic disease","volume":"42","author":"Moghadami","year":"2017","journal-title":"Iranian J. Med. Sci."},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0430","first-page":"1","article-title":"Evaluation of a new, rapid, simple test for the detection of influenza virus","volume":"15","author":"Hurtado","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cca.2024.117841_b0435","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bios.2016.03.073","article-title":"Integrated microfluidic system for rapid detection of influenza H1N1 virus using a sandwich-based aptamer assay","volume":"82","author":"Tseng","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117841_b0440","first-page":"e50325","article-title":"Microfluidic chip fabrication and method to detect influenza","volume":"73","author":"Cao","year":"2013","journal-title":"JoVE (J. Visualized Exp.)"},{"key":"10.1016\/j.cca.2024.117841_b0445","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/B978-0-12-813855-7.00013-1","article-title":"Biosensors based on microfluidic devices lab-on-a-chip and microfluidic technology","author":"Nikoleli","year":"2018","journal-title":"Nanotechnol. Biosensors"},{"key":"10.1016\/j.cca.2024.117841_b0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.115812","article-title":"Automated, flexible and versatile manipulation of nanoliter-to-picoliter droplets based on sequential operation droplet array technique","volume":"124","author":"Dong","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.cca.2024.117841_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340698","article-title":"An automated, fully-integrated nucleic acid analyzer based on microfluidic liquid handling robot technique","volume":"1239","author":"Lin","year":"2023","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-022-00301-5","article-title":"A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin","volume":"11","author":"Younas","year":"2022","journal-title":"Translat. Neurodegenerat."},{"key":"10.1016\/j.cca.2024.117841_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116693","article-title":"Overview on microfluidics devices for monitoring brain disorder biomarkers","volume":"155","author":"Nix","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"issue":"10","key":"10.1016\/j.cca.2024.117841_b0470","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3390\/life11101022","article-title":"Microfluidic platforms to unravel mysteries of alzheimer\u2019s disease: how far have we come?","volume":"11","author":"Prasanna","year":"2021","journal-title":"Life."},{"key":"10.1016\/j.cca.2024.117841_b0475","first-page":"371","article-title":"Diagnosis of early alzheimer\u2019s disease: clinical practice in 2021","volume":"8","author":"Porsteinsson","year":"2021","journal-title":"J. Prev Alzheimers Dis."},{"issue":"9","key":"10.1016\/j.cca.2024.117841_b0480","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/mi11090787","article-title":"Microfluidics-based systems in diagnosis of alzheimer\u2019s disease and biomimetic modeling","volume":"11","author":"Li","year":"2020","journal-title":"Micromachines"},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0485","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/tcr.202000103","article-title":"Recent electrokinetic and microfluidic strategies for detection of amyloid beta peptide biomarkers: towards molecular diagnosis of alzheimer's disease","volume":"21","author":"Van Thanh Nguyen","year":"2021","journal-title":"Chem. Rec."},{"key":"10.1016\/j.cca.2024.117841_b0490","article-title":"Plasma and cerebrospinal fluid amyloid beta for the diagnosis of alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)","volume":"6","author":"Ritchie","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.cca.2024.117841_b0495","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cca.2016.05.014","article-title":"CSF A\u03b21\u201342\u2013an excellent but complicated alzheimer's biomarker\u2013a route to standardisation","volume":"467","author":"Kuhlmann","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2024.117841_b0500","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bios.2013.03.077","article-title":"Development of a high-sensitivity immunoassay for amyloid-beta 1\u201342 using a silicon microarray platform","volume":"47","author":"Gagni","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2024.117841_b0505","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.snb.2017.09.003","article-title":"Single-step immunoassays and microfluidic droplet operation: towards a versatile approach for detection of amyloid-\u03b2 peptide-based biomarkers of alzheimer\u2019s disease","volume":"255","author":"Mai","year":"2018","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.cca.2024.117841_b0510","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.aca.2019.02.006","article-title":"In-capillary immuno-preconcentration with circulating bio-functionalized magnetic beads for capillary electrophoresis","volume":"1062","author":"Mai","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"10.1016\/j.cca.2024.117841_b0515","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/pharmaceutics12060542","article-title":"Recent developments in microfluidic technologies for central nervous system targeted studies","volume":"12","author":"Teixeira","year":"2020","journal-title":"Pharmaceutics."},{"issue":"13","key":"10.1016\/j.cca.2024.117841_b0520","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.3390\/jcm12134274","article-title":"Cellular and molecular evidence of multiple sclerosis diagnosis and treatment challenges","volume":"12","author":"Khan","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cca.2024.117841_b0525","series-title":"Microfluidic devices for accessible medical diagnostics","author":"Maltezos","year":"2007"},{"key":"10.1016\/j.cca.2024.117841_b0530","article-title":"Biochemical biomarkers for multiple sclerosis","volume":"117471","author":"Maroto-Garc\u00eda","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"10","key":"10.1016\/j.cca.2024.117841_b0535","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.3390\/ijms23105330","article-title":"Sphingolipid players in multiple sclerosis: their influence on the initiation and course of the disease","volume":"23","author":"Podbielska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2024.117841_b0540","doi-asserted-by":"crossref","unstructured":"E. Koutsouraki, E. Hatzifilippou, T. Kalatha, E. Antoniadou, S. Baloyannis, Antibodies against gangliosides in the serum of patients suffering from multiple sclerosis compared with healthy individuals. (2013) (P03. 243). Doi: 10.4172\/2168-9784.1000136.","DOI":"10.1212\/WNL.80.7_supplement.P03.243"},{"key":"10.1016\/j.cca.2024.117841_b0545","series-title":"Electrochemical Sensors, Biosensors and Their Biomedical Applications","year":"2011"},{"issue":"11","key":"10.1016\/j.cca.2024.117841_b0550","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1021\/acssensors.0c01935","article-title":"Detection of multiple sclerosis biomarkers in serum by ganglioside microarrays and surface plasmon resonance imaging","volume":"5","author":"Malinick","year":"2020","journal-title":"ACS Sensors"},{"issue":"4","key":"10.1016\/j.cca.2024.117841_b0555","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/epi.14683","article-title":"Diagnostic implications of genetic copy number variation in epilepsy plus","volume":"60","author":"Coppola","year":"2019","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.cca.2024.117841_b0560","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/s41598-017-01947-2","article-title":"\u201cTORNADO\u201d\u2013THERANOSTIC one-step RNA detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid","volume":"7","author":"McArdle","year":"2017","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.cca.2024.117841_b0565","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.3390\/s20205903","article-title":"A microfluidic system for stable and continuous EEG monitoring from multiple larval zebrafish","volume":"20","author":"Lee","year":"2020","journal-title":"Sensors"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124000822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124000822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T02:55:50Z","timestamp":1716087350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898124000822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":114,"alternative-id":["S0009898124000822"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.117841","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microfluidics as diagnostic tools","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.117841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117841"}}