{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:08:23Z","timestamp":1790874503384,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.cca.2024.119691","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T11:01:45Z","timestamp":1714215705000},"page":"119691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Importance of AIM2 as a serum marker for reflecting severity and predicting a poor outcome of human severe traumatic brain injury: A prospective longitudinal cohort study"],"prefix":"10.1016","volume":"559","author":[{"given":"Si-Hua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Lin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Song","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.mcna.2019.11.001","article-title":"Traumatic brain injury: An overview of epidemiology, pathophysiology, and medical management","volume":"104","author":"Capizzi","year":"2020","journal-title":"Med Clin North Am."},{"issue":"8","key":"10.1016\/j.cca.2024.119691_b0010","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2174\/1570159X15666170613083606","article-title":"Recent advances in pathophysiology of traumatic brain injury","volume":"16","author":"Kaur","year":"2018","journal-title":"Curr Neuropharmacol."},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pmr.2016.12.001","article-title":"Pathophysiology of traumatic brain injury","volume":"28","author":"Dixon","year":"2017","journal-title":"Phys Med Rehabil Clin N Am."},{"issue":"23","key":"10.1016\/j.cca.2024.119691_b0020","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1089\/neu.2021.0199","article-title":"Diagnosing level of consciousness: the limits of the glasgow coma scale total score","volume":"38","author":"Bodien","year":"2021","journal-title":"J Neurotrauma."},{"issue":"3","key":"10.1016\/j.cca.2024.119691_b0025","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.4081\/ejtm.2018.7542","article-title":"Marshall and rotterdam computed tomography scores in predicting early deaths after brain trauma","volume":"28","author":"Mohammadifard","year":"2018","journal-title":"Eur J Transl Myol."},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/14737159.2018.1428089","article-title":"An update on diagnostic and prognostic biomarkers for traumatic brain injury","volume":"18","author":"Wang","year":"2018","journal-title":"Expert Rev Mol Diagn."},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0035","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/brainsci10020110","article-title":"Traumatic brain injury patients mortality and serum total antioxidant capacity","volume":"10","author":"Lorente","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.cca.2024.119691_b0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cca.2021.01.014","article-title":"Serum apelin-13 and risk of death following severe traumatic brain injury","volume":"516","author":"Zhuang","year":"2021","journal-title":"Clin Chim Acta."},{"key":"10.1016\/j.cca.2024.119691_b0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/NDT.S348682","article-title":"Elevated serum complement C1q levels after traumatic brain injury and its association with poor prognosis","volume":"18","author":"Yan","year":"2022","journal-title":"Neuropsychiatr Dis Treat."},{"issue":"7","key":"10.1016\/j.cca.2024.119691_b0050","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"10.1016\/j.cca.2024.119691_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104969","article-title":"Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: a comprehensive overview","volume":"144","author":"Kattan","year":"2023","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.cca.2024.119691_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105122","article-title":"The emerging roles of absent in melanoma 2 (AIM2) inflammasome in central nervous system disorders","volume":"149","author":"Li","year":"2021","journal-title":"Neurochem Int."},{"key":"10.1016\/j.cca.2024.119691_b0065","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bbi.2020.03.011","article-title":"AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice","volume":"87","author":"Kim","year":"2020","journal-title":"Brain Behav Immun."},{"issue":"13","key":"10.1016\/j.cca.2024.119691_b0070","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1073\/pnas.1419090112","article-title":"AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3","volume":"112","author":"Denes","year":"2015","journal-title":"Proc Natl Acad Sci U S a."},{"key":"10.1016\/j.cca.2024.119691_b0075","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2018.06.008","article-title":"The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury","volume":"1697","author":"Ge","year":"2018","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.cca.2024.119691_b0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41419-020-2248-z","article-title":"Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.cca.2024.119691_b0085","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/cns.13699","article-title":"AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke","volume":"27","author":"Xu","year":"2021","journal-title":"CNS Neurosci Ther."},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0090","first-page":"149","article-title":"Significance of expression of AIM2, IL-1\u03b2, and IL-18 in plasma of patients with acute cerebral infarction","volume":"46","author":"Wang","year":"2021","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0095","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3109\/02688697.2016.1139047","article-title":"Predicting outcomes of decompressive craniectomy: use of rotterdam computed tomography classification and marshall classification","volume":"30","author":"Waqas","year":"2016","journal-title":"Br J Neurosurg."},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0100","article-title":"Traumatic brain injury: association between the glasgow coma scale score and intensive care unit mortality","volume":"38","author":"Mkubwa","year":"2022","journal-title":"South Afr J Crit Care."},{"issue":"1","key":"10.1016\/j.cca.2024.119691_b0105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13054-023-04573-9","article-title":"Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months","volume":"27","author":"Banoei","year":"2023","journal-title":"Crit Care."},{"key":"10.1016\/j.cca.2024.119691_b0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-444-52892-6.00004-0","article-title":"The neuropathology of traumatic brain injury","volume":"127","author":"Mckee","year":"2015","journal-title":"Handb Clin Neurol."},{"issue":"3","key":"10.1016\/j.cca.2024.119691_b0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jamaneurol.2014.3558","article-title":"Inflammation and neuroprotection in traumatic brain injury","volume":"72","author":"Corps","year":"2015","journal-title":"JAMA Neurol."},{"issue":"4","key":"10.1016\/j.cca.2024.119691_b0120","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10787-022-01017-8","article-title":"Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs","volume":"30","author":"Kalra","year":"2022","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.cca.2024.119691_b0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/imr.12618","article-title":"The AIM2 inflammasome: sensor of pathogens and cellular perturbations","volume":"281","author":"Lugrin","year":"2018","journal-title":"Immunol Rev."},{"issue":"2","key":"10.1016\/j.cca.2024.119691_b0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/eji.201545839","article-title":"AIM2 inflammasome in infection, cancer, and autoimmunity: role in DNA sensing, inflammation, and innate immunity","volume":"46","author":"Man","year":"2016","journal-title":"Eur J Immunol."},{"issue":"10","key":"10.1016\/j.cca.2024.119691_b0135","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.2741\/3489","article-title":"Systemic inflammatory response following acute traumatic brain injury","volume":"14","author":"Lu","year":"2009","journal-title":"Front Biosci (landmark Ed)."},{"issue":"4","key":"10.1016\/j.cca.2024.119691_b0140","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/jnr.24100","article-title":"Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury","volume":"96","author":"Chaikittisilpa","year":"2018","journal-title":"J Neurosci Res."},{"issue":"1","key":"10.1016\/j.cca.2024.119691_b0145","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12028-017-0410-y","article-title":"Systemic inflammatory response syndrome (SIRS) score independently predicts poor outcome in isolated traumatic brain injury","volume":"28","author":"Jacome","year":"2018","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.cca.2024.119691_b0150","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fimmu.2019.00943","article-title":"Evolution of C-reactive protein","volume":"10","author":"Pathak","year":"2019","journal-title":"Front Immunol."},{"issue":"7","key":"10.1016\/j.cca.2024.119691_b0155","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1089\/neu.2020.7177","article-title":"High-sensitivity C-reactive protein is a prognostic biomarker of six-month disability after traumatic brain injury: results from the TRACK-TBI study","volume":"38","author":"Xu","year":"2021","journal-title":"J Neurotrauma."},{"issue":"3","key":"10.1016\/j.cca.2024.119691_b0160","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4103\/1673-5374.245481","article-title":"Expression and localization of absent in melanoma 2 in the injured spinal cord","volume":"14","author":"Wang","year":"2019","journal-title":"Neural Regen Res."},{"issue":"5","key":"10.1016\/j.cca.2024.119691_b0165","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.humimm.2013.01.022","article-title":"Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B","volume":"74","author":"Wu","year":"2013","journal-title":"Hum Immunol."},{"issue":"1","key":"10.1016\/j.cca.2024.119691_b0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/TA.0000000000002706","article-title":"Blood-based biomarkers for prediction of intracranial hemorrhage and outcome in patients with moderate or severe traumatic brain injury","volume":"89","author":"Anderson","year":"2020","journal-title":"J Trauma Acute Care Surg."},{"issue":"5","key":"10.1016\/j.cca.2024.119691_b0175","doi-asserted-by":"crossref","first-page":"599","DOI":"10.23736\/S0390-5616.18.04509-5","article-title":"Long-term outcome following severe traumatic brain injury: ethical considerations","volume":"62","author":"Honeybul","year":"2018","journal-title":"J Neurosurg Sci."},{"issue":"8","key":"10.1016\/j.cca.2024.119691_b0180","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1371\/journal.pmed.0050165","article-title":"Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics","volume":"5","author":"Steyerberg","year":"2008","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.cca.2024.119691_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.2019.6401","article-title":"Prognosis in moderate and severe traumatic brain injury: a systematic review of contemporary models and validation studies","volume":"37","author":"Dijkland","year":"2020","journal-title":"J Neurotrauma."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124019326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124019326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:48:04Z","timestamp":1790873284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898124019326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":37,"alternative-id":["S0009898124019326"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.119691","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importance of AIM2 as a serum marker for reflecting severity and predicting a poor outcome of human severe traumatic brain injury: A prospective longitudinal cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.119691","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119691"}}