{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:00:16Z","timestamp":1792598416270,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cca.2024.119968","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T20:54:31Z","timestamp":1726174471000},"page":"119968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Untargeted metabolomics analysis of the urinary metabolic signature of acute and chronic gout"],"prefix":"10.1016","volume":"565","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-5479","authenticated-orcid":false,"given":"Qiangqiang","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2024.119968_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar3898","article-title":"Enhanced interleukin-1\u03b2 production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals","volume":"14","author":"Mylona","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cca.2024.119968_b0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41584-018-0004-x","article-title":"An update on the genetics of hyperuricaemia and gout","volume":"14","author":"Major","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cca.2024.119968_b0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"Kuo","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cca.2024.119968_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar3199","article-title":"Gout. Epidemiology of gout","volume":"12","author":"Roddy","year":"2010","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.cca.2024.119968_b0025","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cca.2024.119968_b0030","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/annrheumdis-2016-210588","article-title":"The unclosing premature mortality gap in gout: a general population-based study","volume":"76","author":"Fisher","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2024.119968_b0035","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s40266-021-00866-2","article-title":"Gout flare burden, diagnosis, and management: navigating care in older patients with comorbidity","volume":"38","author":"Kumar","year":"2021","journal-title":"Drugs Aging"},{"key":"10.1016\/j.cca.2024.119968_b0040","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar3806","article-title":"Risk of end-stage renal disease associated with gout: a nationwide population study","volume":"14","author":"Yu","year":"2012","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.cca.2024.119968_b0045","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.107.703389","article-title":"Independent impact of gout on mortality and risk for coronary heart disease","volume":"116","author":"Choi","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2024.119968_b0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12891-019-2519-y","article-title":"The anatomical pathology of gout: a systematic literature review","volume":"20","author":"Towiwat","year":"2019","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.cca.2024.119968_b0055","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study","volume":"372","author":"Dehghan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2024.119968_b0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/ard.2007.082222","article-title":"Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process","volume":"68","author":"Giamarellos-Bourboulis","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2024.119968_b0065","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/art.27667","article-title":"Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1\u03b2 production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis","volume":"62","author":"Joosten","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cca.2024.119968_b0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrrheum.2016.1","article-title":"Metabolomics in rheumatic diseases: desperately seeking biomarkers","volume":"12","author":"Guma","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cca.2024.119968_b0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13075-018-1600-5","article-title":"Metabolomics approach by (1)H NMR spectroscopy of serum reveals progression axes for asymptomatic hyperuricemia and gout","volume":"20","author":"Zhang","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cca.2024.119968_b0080","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/jssc.201900170","article-title":"Simultaneous quantification of urinary purines and creatinine by ultra high performance liquid chromatography with ultraviolet spectroscopy and quadrupole time-of-flight mass spectrometry: method development, validation, and application to gout study","volume":"42","author":"Yuan","year":"2019","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.cca.2024.119968_b0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ab.2019.05.013","article-title":"Quantitative analysis of free fatty acids in gout by disposable paper-array plate based MALDI MS","volume":"579","author":"Ren","year":"2019","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cca.2024.119968_b0090","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.talanta.2005.06.035","article-title":"Advantages of application of UPLC in pharmaceutical analysis","volume":"68","author":"Nov\u00e1kov\u00e1","year":"2006","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2024.119968_b0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cca.2020.12.028","article-title":"Serum metabolic profiling analysis of gout patients based on UPLC-Q-TOF\/MS","volume":"515","author":"Zhong","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2024.119968_b0100","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1039\/c2mb25227a","article-title":"Metabolite target analysis of human urine combined with pattern recognition techniques for the study of symptomatic gout","volume":"8","author":"Liu","year":"2012","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.cca.2024.119968_b0105","first-page":"3461572","article-title":"Urinary metabolomics study of patients with gout using gas chromatography-mass spectrometry","volume":"6","author":"Li","year":"2018","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.cca.2024.119968_b0110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.talanta.2016.01.014","article-title":"Hypercrosslinked strong cation-exchange polymers for selective extraction of serum purine metabolites associated with gout","volume":"151","author":"Xu","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2024.119968_b0115","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cjoc.201600810","article-title":"Therapeutic effects of Selaginella tamariscina on the model of acute gout with hyperuricemia in rats based on metabolomics analysis","volume":"35","author":"Chen","year":"2017","journal-title":"Chin. J. Chem ."},{"key":"10.1016\/j.cca.2024.119968_b0120","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/rheumatology\/key284","article-title":"Metabolic profiling of human plasma reveals the activation of 5-lipoxygenase in the acute attack of gouty arthritis","volume":"58","author":"Luo","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cca.2024.119968_b0125","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1104\/pp.109.150045","article-title":"Glycolysis and the tricarboxylic acid cycle are linked by alanine aminotransferase during hypoxia induced by waterlogging of Lotus japonicus","volume":"152","author":"Rocha","year":"2010","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cca.2024.119968_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj1860001","article-title":"Inhibition of urea-cycle activity by high concentrations of alanine","volume":"186","author":"Hensgens","year":"1980","journal-title":"Biochem. J"},{"key":"10.1016\/j.cca.2024.119968_b0135","first-page":"1715","article-title":"Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)","volume":"2013","author":"Dankers","year":"1832","journal-title":"BBA"},{"key":"10.1016\/j.cca.2024.119968_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113153","article-title":"In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum","volume":"151","author":"Okokon","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cca.2024.119968_b0145","first-page":"1408","article-title":"Ultra high performance liquid chromatography coupled with Q exactive hybrid quadrupole-orbitrap mass spectrometry for serumal metabonomics study of drug-induced liver injury in patients","volume":"43","author":"An","year":"2015","journal-title":"Chin. J. Chem ."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124022216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124022216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:01:04Z","timestamp":1741064464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898124022216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"alternative-id":["S0009898124022216"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.119968","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Untargeted metabolomics analysis of the urinary metabolic signature of acute and chronic gout","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.119968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119968"}}