{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:23:32Z","timestamp":1785270212236,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cca.2024.120015","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T18:08:40Z","timestamp":1729620520000},"page":"120015","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Urine organic acid metabolomic profiling by gas chromatography mass spectrometry: Assessment of solvent extract evaporation parameters on the recovery of key diagnostic metabolites"],"prefix":"10.1016","volume":"565","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-3088","authenticated-orcid":false,"given":"Rachel S.","family":"Carling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Witek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C","family":"Emmett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Moat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2024.120015_b0005","doi-asserted-by":"crossref","first-page":"17591","DOI":"10.1038\/s41598-023-44690-7","article-title":"Optimising a urinary extraction method for non-targeted GC\u2013MS metabolomics","volume":"13","author":"Olivier","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2024.120015_b0010","doi-asserted-by":"crossref","unstructured":"O. Fiehn. Metabolomics by Gas Chromatography\u2013Mass Spectrometry: Combined Targeted and Untargeted Profiling. Curr. Protocols Mol. Biol. 114 (2016) 30.34.31-30.34.32, Doi: 10.1002\/0471142727.mb3004s114.","DOI":"10.1002\/0471142727.mb3004s114"},{"key":"10.1016\/j.cca.2024.120015_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11306-020-01687-x","article-title":"A review of strategies for untargeted urinary metabolomic analysis using gas chromatography-mass spectrometry","volume":"16","author":"Khodadadi","year":"2020","journal-title":"Metabolomics"},{"key":"10.1016\/j.cca.2024.120015_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462590","article-title":"Analysis of urinary organic acids by gas chromatography tandem mass spectrometry method for metabolic profiling applications","volume":"1658","author":"Mouskeftara","year":"2021","journal-title":"J. Chrom. A"},{"key":"10.1016\/j.cca.2024.120015_b0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-61737-985-7_4","article-title":"Analysis of organic acids and acylglycines for the diagnosis of related inborn errors of metabolism by GC- and HPLC-MS","volume":"708","author":"la Marca","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cca.2024.120015_b0030","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/clinchem\/26.13.1847","article-title":"Gas-chromatographic method of analysis for urinary organic acids. II. Description of the procedure, and its application to diagnosis of patients with organic acidurias","volume":"26","author":"Tanaka","year":"1980","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120015_b0035","unstructured":"G.F. Hoffman, P. Fehy, Organic Acid Analysis, in: N. Blau, M. Duran, M.E. Blaskovics, K.M. Gibson (Eds) Physician\u2019s Guide to the Laboratory Diagnosis of Metabolic Diseases. Springer, Berlin, Heidelberg, 2003, pp 27-44."},{"key":"10.1016\/j.cca.2024.120015_b0040","doi-asserted-by":"crossref","unstructured":"R.C. Gallagher, L. Pollard, A.I. Scott, S. Huguenin, S. Goodman, Q. Sun & ACMG Biochemical Genetics Subcommittee of the Laboratory Quality Assurance Committee. Laboratory analysis of organic acids, 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet. Med. 20 (2018) 683\u2013691, Doi: 10.1038\/gim.2018.45.","DOI":"10.1038\/gim.2018.45"},{"key":"10.1016\/j.cca.2024.120015_b0045","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/clinchem\/42.10.1609","article-title":"GC-MS profiling of urinary organic acids evaluated as a quantitative method","volume":"42","author":"Duez","year":"1996","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120015_b0050","doi-asserted-by":"crossref","unstructured":"P.M. Jones, M.J. Bennett, Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas-chromatography-Mass Spectrometry, in: U. Garg, C. A. Hammett-Stabler (Eds) Clinical Applications of Mass Spectrometry. Methods in Molecular Biology, vol 603. Humana Press, 2010, pp 423-443.","DOI":"10.1007\/978-1-60761-459-3_41"},{"key":"10.1016\/j.cca.2024.120015_b0055","unstructured":"R.S. Carling, R. Barski, S.L. Hogg, K. Witek, S.J. Moat. U.K. Metabolic Biochemistry Network Recommendations for the Analysis of Urinary Organic Acids by Gas Chromatography Mass Spectrometry 2018, MetBioNet best practice guidelines for analysis of organic acids by Gas Chromatography Mass Spectrometry (accessed 05 August 2024)."},{"key":"10.1016\/j.cca.2024.120015_b0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-4347(91)80571-S","article-title":"Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease","volume":"562","author":"Shoemaker","year":"1991","journal-title":"J. Chrom."},{"key":"10.1016\/j.cca.2024.120015_b0065","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/clinchem\/35.4.587","article-title":"Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis","volume":"35","author":"Hoffmann","year":"1989","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120015_b0070","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/clinchem\/26.13.1839","article-title":"Gas-Chromatographic method of analysis for urinary organic acids. I. Retention indices of 155 metabolically important compounds","volume":"26","author":"Tanaka","year":"1980","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120015_b0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.trac.2009.12.007","article-title":"Experiment-originated variations and multi-peak and multi-origination phenomena in derivatisation-based GC-MS metabolomics","volume":"29","author":"Xu","year":"2010","journal-title":"Trends Analyt. Chem"},{"key":"10.1016\/j.cca.2024.120015_b0080","doi-asserted-by":"crossref","unstructured":"C. Christou, H.G. Gika, N. Raikos, G. Theodoridis. GC-MS analysis of organic acids in human urine in clinical settings: A study of derivatization and other analytical parameters. J. Chrom. B. Analytical technologies in the biomedical and life sciences. 964 (2014) 195\u2013201, Doi: 10.1016\/j.jchromb.2013.12.038.","DOI":"10.1016\/j.jchromb.2013.12.038"},{"key":"10.1016\/j.cca.2024.120015_b0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-4347(00)00105-5","article-title":"Gas chromatography-mass spectrometry with tert-butyldimethylsilyl derivation: use of the simplified sample preparations and the automated data system to screen for organic acidemias","volume":"746","author":"Ohie","year":"2000","journal-title":"J. Chrom. B. Biomed. Sci. Appl."},{"key":"10.1016\/j.cca.2024.120015_b0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4155\/bio-2016-0224","article-title":"Investigation of the derivatization conditions for GC-MS metabolomics of biological samples","volume":"9","author":"Moros","year":"2017","journal-title":"Bioanalysis"},{"key":"10.1016\/j.cca.2024.120015_b0095","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1023\/A:1005527315019","article-title":"Adsorption of small hydroxy acids on glass: A pitfall in quantitative urinary organic acid analysis by GC-MS","volume":"22","author":"van Landeghem","year":"1999","journal-title":"J. Inherit. Metab Dis."},{"key":"10.1016\/j.cca.2024.120015_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(99)00267-8","article-title":"Artifacts in trimethylsilyl derivatization reactions and ways to avoid them","volume":"844","author":"Little","year":"1999","journal-title":"J. Chrom. A"},{"key":"10.1016\/j.cca.2024.120015_b0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0009-8981(00)00324-7","article-title":"Artefacts in organic acid analysis: occurrence and origin of partially trimethylsilylated 3-hydroxy-3-methyl carboxylic acids","volume":"300","author":"Jones","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2024.120015_b0110","article-title":"ERNDIM - Quantitative schemes organic acids (urine)","author":"Roux-Petronelli","year":"2021","journal-title":"Annu. Rep."},{"key":"10.1016\/j.cca.2024.120015_b0115","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/clinchem\/45.8.1297","article-title":"Gas chromatography\u2013mass spectrometry analysis of organic acids: Altered quantitative response for aqueous calibrators and dilute urine specimens","volume":"45","author":"Kumps","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120015_b0120","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1373\/clinchem.2009.135517","article-title":"Automated mass spectral deconvolution and identification system for GC-MS screening for drugs, poisons, and metabolites in urine","volume":"56","author":"Meyer","year":"2010","journal-title":"Clin. Chem."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812402268X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812402268X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:04:07Z","timestamp":1741064647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989812402268X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"alternative-id":["S000989812402268X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.120015","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urine organic acid metabolomic profiling by gas chromatography mass spectrometry: Assessment of solvent extract evaporation parameters on the recovery of key diagnostic metabolites","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.120015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120015"}}