{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:49:55Z","timestamp":1792673395467,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cca.2024.120022","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T09:57:52Z","timestamp":1730195872000},"page":"120022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["UPLC-Q-TOF\/MS-based urine metabolomics for the diagnosis and staging of bladder cancer"],"prefix":"10.1016","volume":"565","author":[{"given":"Xingyu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10364","key":"10.1016\/j.cca.2024.120022_b0005","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/S0140-6736(22)01188-6","article-title":"Current best practice for bladder cancer: a narrative review of diagnostics and treatments","volume":"400","author":"Comp\u00e9rat","year":"2022","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.cca.2024.120022_b0010","article-title":"State-of-the-art advances of nanomedicine for diagnosis and treatment of bladder cancer","volume":"12","author":"Kong","year":"2022","journal-title":"Biosensors (Basel)"},{"issue":"19","key":"10.1016\/j.cca.2024.120022_b0015","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder cancer: a review","volume":"324","author":"Lenis","year":"2020","journal-title":"Jama"},{"issue":"2","key":"10.1016\/j.cca.2024.120022_b0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/14737159.2020.1699791","article-title":"Current and emerging bladder cancer biomarkers with an emphasis on urine biomarkers","volume":"20","author":"Lopez-Beltran","year":"2020","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.cca.2024.120022_b0025","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/acs.jproteome.9b00574","article-title":"Serum metabolomics reveals personalized metabolic patterns for macular neovascular disease patient stratification","volume":"19","author":"Liu","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cca.2024.120022_b0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.semcdb.2019.05.018","article-title":"Metabolic pathways regulating colorectal cancer initiation and progression","volume":"98","author":"La Vecchia","year":"2020","journal-title":"Semin Cell Dev Biol."},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s13668-019-0257-2","article-title":"The role of the microbiome in cancer initiation and progression: how microbes and cancer cells utilize excess energy and promote one another\u2019s growth","volume":"8","author":"Whisner","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"10.1016\/j.cca.2024.120022_b0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cca.2018.10.039","article-title":"Tissue and serum metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma","volume":"488","author":"Han","year":"2019","journal-title":"Clin. Chim. Acta."},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0045","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.1038\/s41598-022-12590-x","article-title":"Gas chromatography-mass spectrometry-based untargeted metabolomics reveals metabolic perturbations in medullary thyroid carcinoma","volume":"12","author":"Jajin","year":"2022","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cca.2024.120022_b0050","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2217\/bmm-2018-0229","article-title":"Discovering biomarkers in bladder cancer by metabolomics","volume":"12","author":"Zhang","year":"2018","journal-title":"Biomark. Med."},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0055","article-title":"Urinary metabolomics for discovering metabolic biomarkers of bladder cancer by UPLC-MS","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.cca.2024.120022_b0060","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.18632\/oncotarget.1744","article-title":"Diagnosis of bladder cancer and prediction of survival by urinary metabolomics","volume":"5","author":"Jin","year":"2014","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0065","article-title":"Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer","volume":"7","author":"Tan","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.cca.2024.120022_b0070","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s00345-022-04136-7","article-title":"LC-MS metabolomics of urine reveals distinct profiles for non-muscle-invasive and muscle-invasive bladder cancer","volume":"40","author":"Oto","year":"2022","journal-title":"World J. Urol."},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0075","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.1038\/s41598-023-36874-y","article-title":"Untargeted urinary metabolomics for bladder cancer biomarker screening with ultrahigh-resolution mass spectrometry","volume":"13","author":"Niziol","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0080","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1021\/acs.jproteome.1c00777","article-title":"UPLC\u2013q-TOF\/MS-based plasma and urine metabolomics contribute to the diagnosis of sepsis","volume":"21","author":"Guan","year":"2022","journal-title":"J. Proteome Res."},{"issue":"4","key":"10.1016\/j.cca.2024.120022_b0085","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/acs.jproteome.2c00816","article-title":"Metabolomics identifies a panel of diagnostic biomarkers for early human embryonic development arrest","volume":"22","author":"Liu","year":"2023","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.cca.2024.120022_b0090","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00535-016-1261-6","article-title":"Serum metabolomics analysis for early detection of colorectal cancer","volume":"52","author":"Uchiyama","year":"2017","journal-title":"J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.cca.2024.120022_b0095","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1021\/acs.jproteome.2c00348","article-title":"Integrated metabolomics and lipidomics approach for the study of metabolic network and early diagnosis in cerebral infarction","volume":"21","author":"Ye","year":"2022","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0100","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1038\/s41598-018-27538-3","article-title":"Bladder cancer recurrence surveillance by urine metabolomics analysis","volume":"8","author":"Loras","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cca.2024.120022_b0105","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1021\/pr901173v","article-title":"Noninvasive urinary metabonomic diagnosis of human bladder cancer","volume":"9","author":"Pasikanti","year":"2010","journal-title":"J. Proteome Res."},{"issue":"9","key":"10.1016\/j.cca.2024.120022_b0110","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1021\/pr4000448","article-title":"Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry","volume":"12","author":"Pasikanti","year":"2013","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.cca.2024.120022_b0115","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/14789450.2021.1962301","article-title":"Kidney stone proteomics: an update and perspectives","volume":"18","author":"Peerapen","year":"2021","journal-title":"Expert Rev. Proteomics"},{"issue":"6","key":"10.1016\/j.cca.2024.120022_b0120","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.3390\/app11062835","article-title":"A serum metabolomic signature for the detection and grading of bladder cancer","volume":"11","author":"Troisi","year":"2021","journal-title":"Appl. Sci."},{"issue":"2","key":"10.1016\/j.cca.2024.120022_b0125","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ijc.30016","article-title":"Biomarkers in bladder cancer: a metabolomic approach using in vitro and ex vivo model systems","volume":"139","author":"Rodrigues","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.cca.2024.120022_b0130","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/ijc.31323","article-title":"Investigation of the urinary metabolic variations and the application in bladder cancer biomarker discovery","volume":"143","author":"Liu","year":"2018","journal-title":"Int. J. Cancer."},{"issue":"10","key":"10.1016\/j.cca.2024.120022_b0135","doi-asserted-by":"crossref","first-page":"M111","DOI":"10.1074\/mcp.M111.007922","article-title":"Bladder cancer determination via two urinary metabolites: a biomarker pattern approach","volume":"10","author":"Huang","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"issue":"12","key":"10.1016\/j.cca.2024.120022_b0140","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1158\/1078-0432.CCR-18-1515","article-title":"Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1b effect on fatty acid metabolism in bladder cancer","volume":"25","author":"Vantaku","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cca.2024.120022_b0150","doi-asserted-by":"crossref","unstructured":"A. S. Breathnach, Azelaic acid: potential as a general antitumoural agent, Med Hypotheses. 52(3) (1999) 221\u2013226, https:\/\/doi.org\/10.1054\/mehy.1997.0647.","DOI":"10.1054\/mehy.1997.0647"},{"key":"10.1016\/j.cca.2024.120022_b0155","doi-asserted-by":"crossref","unstructured":"L. Yue, P. Zeng, Y. Li, Y. Chai, C. Wu, B. Gao, Nontargeted and targeted metabolomics approaches reveal the key amino acid alterations involved in multiple myeloma, PeerJ 10 (2022) e12918, https:\/\/doi.org\/10.7717\/peerj.12918.","DOI":"10.7717\/peerj.12918"},{"issue":"4","key":"10.1016\/j.cca.2024.120022_b0160","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/bju.15205","article-title":"Tryptophan\u2013kynurenine ratio as a biomarker of bladder cancer","volume":"127","author":"Lee","year":"2021","journal-title":"BJU Int."},{"issue":"12","key":"10.1016\/j.cca.2024.120022_b0165","doi-asserted-by":"crossref","first-page":"e115870","DOI":"10.1371\/journal.pone.0115870","article-title":"Bladder cancer biomarker discovery using global metabolomic profiling of urine","volume":"9","author":"Wittmann","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2024.120022_b0170","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.chroma.2013.10.002","article-title":"Searching for urine biomarkers of bladder cancer recurrence using a liquid chromatography\u2013mass spectrometry and capillary electrophoresis\u2013mass spectrometry metabolomics approach","volume":"1318","author":"Alberice","year":"2013","journal-title":"J. Chromatogr. A."},{"issue":"2","key":"10.1016\/j.cca.2024.120022_b0175","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11306-010-0199-6","article-title":"Metabolomic screening and star pattern recognition by urinary amino acid profile analysis from bladder cancer patients","volume":"6","author":"Kim","year":"2010","journal-title":"Metabolomics"},{"key":"10.1016\/j.cca.2024.120022_b0180","doi-asserted-by":"crossref","unstructured":"S. Park, J. Nam, Kynurenine pathway enzyme KMO in cancer progression: a tip of the iceberg, EBioMedicine 55 (2020) 102762, https:\/\/doi.org\/10.1016\/j.ebiom.2020.102762.","DOI":"10.1016\/j.ebiom.2020.102762"},{"key":"10.1016\/j.cca.2024.120022_b0185","doi-asserted-by":"crossref","unstructured":"F. Scaglia, New insights in nutritional management and amino acid supplementation in urea cycle disorders, Mol. Genet. Metab. 100 (Suppl. 1) (2010) S72\u2013S76, https:\/\/doi.org\/10.1016\/j.ymgme.2010.02.019.","DOI":"10.1016\/j.ymgme.2010.02.019"},{"key":"10.1016\/j.cca.2024.120022_b0190","doi-asserted-by":"crossref","unstructured":"J. Li, B. Cheng, H. Xie, C. Zhan, S. Li, P. Bai, Bladder cancer biomarker screening based on non-targeted urine metabolomics, Int. Urol. Nephrol. 54(1) (2022) 23-29, https:\/\/doi.org\/10.1007\/s11255-021-03080-6.","DOI":"10.1007\/s11255-021-03080-6"},{"key":"10.1016\/j.cca.2024.120022_b0195","doi-asserted-by":"crossref","unstructured":"S. Srivastava, R. Roy, S. Singh, P. Kumar, D. Dalela, S. N. Sankhwar, et al., Taurine - a possible fingerprint biomarker in non-muscle invasive bladder cancer: a pilot study by 1h NMR spectroscopy, Cancer Biomarkers: Section a of Disease Markers. 6(1) (2010) 11\u201320, https:\/\/doi.org\/10.3233\/CBM-2009-0115.","DOI":"10.3233\/CBM-2009-0115"},{"key":"10.1016\/j.cca.2024.120022_b0200","doi-asserted-by":"crossref","unstructured":"M. Wyss, R. Kaddurah-Daouk, Creatine and creatinine metabolism, Physiol Rev. 80(3) (2000) 1107\u20131213, https:\/\/doi.org\/10.1152\/physrev.2000.80.3.1107.","DOI":"10.1152\/physrev.2000.80.3.1107"},{"key":"10.1016\/j.cca.2024.120022_b0205","doi-asserted-by":"crossref","unstructured":"H. N. Kwon, H. Lee, J. W. Park, Y. Kim, S. Park, J. J. Kim., Screening for early gastric cancer using a noninvasive urine metabolomics approach, Cancers (Basel). 12(10) (2020) 2904, https:\/\/doi.org\/10.3390\/cancers12102904.","DOI":"10.3390\/cancers12102904"},{"key":"10.1016\/j.cca.2024.120022_b0210","doi-asserted-by":"crossref","unstructured":"J. B. Thacker, C. He, S. Pennathur., Quantitative analysis of gamma-glutamylisoleucine, gamma-glutamylthreonine, and gamma-glutamylvaline in HeLa cells using UHPLC-MS\/MS, J. Sep Sci. 44(15) (2021) 2898-2907, https:\/\/doi.org\/10.1002\/jssc.202001266.","DOI":"10.1002\/jssc.202001266"},{"issue":"1","key":"10.1016\/j.cca.2024.120022_b0215","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ptr.6829","article-title":"Oridonin induces ferroptosis by inhibiting gamma-glutamyl cycle inTE1 cells","volume":"35","author":"Zhang","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.cca.2024.120022_b0220","doi-asserted-by":"crossref","unstructured":"A. Bansal, M. C. Simon., Glutathione metabolism in cancer progression and treatment resistance, J. Cell Biol. 217(7) (2018) 2291-2298, https:\/\/doi.org\/10.1083\/jcb.201804161.","DOI":"10.1083\/jcb.201804161"},{"key":"10.1016\/j.cca.2024.120022_b0225","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2017.09.194","article-title":"Occurrence of bisphenol s in the environment and implications for human exposure: a short review","volume":"615","author":"Wu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cca.2024.120022_b0230","doi-asserted-by":"crossref","unstructured":"\u00c8. Pellerin, F. Pellerin, S. Chabaud, F. Pouliot, S. Bolduc, M. Pelletier, Bisphenols a and s alter the bioenergetics and behaviours of normal urothelial and bladder cancer cells, Cancers (Basel). 14(16) (2022) 4011, https:\/\/doi.org\/10.3390\/cancers14164011.","DOI":"10.3390\/cancers14164011"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124022757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124022757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:04:49Z","timestamp":1741064689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898124022757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0009898124022757"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.120022","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UPLC-Q-TOF\/MS-based urine metabolomics for the diagnosis and staging of bladder cancer","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.120022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120022"}}