{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:32:25Z","timestamp":1793820745393,"version":"4.6.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.cca.2024.120086","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T16:57:33Z","timestamp":1733763453000},"page":"120086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Artificial intelligence aided serum protein electrophoresis analysis of Finnish patient samples: Retrospective validation"],"prefix":"10.1016","volume":"567","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-9754","authenticated-orcid":false,"given":"Tapio","family":"Lahtiharju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassi","family":"Paavolainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Suvisaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Nokelainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmi","family":"Rotgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Anttonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Itkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2024.120086_b0005","doi-asserted-by":"crossref","first-page":"e670","DOI":"10.1016\/S2352-3026(22)00165-X","article-title":"The epidemiological landscape of multiple myeloma: a global cancer registry estimate of disease burden, risk factors, and temporal trends","volume":"9","author":"Huang","year":"2022","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.cca.2024.120086_b0010","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group","volume":"121","author":"The International Myeloma Working Group","year":"2003","journal-title":"Br. J. Haematol."},{"issue":"Pt 5","key":"10.1016\/j.cca.2024.120086_b0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/000456329503200510","article-title":"Quantification of serum proteins using capillary electrophoresis","volume":"32","author":"Jenkins","year":"1995","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.cca.2024.120086_b0020","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/clinchem\/hvad055","article-title":"Machine Learning in Laboratory Medicine: Recommendations of the IFCC Working Group","volume":"69","author":"Master","year":"2023","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120086_b0025","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/jcp.45.7.612","article-title":"Neuronal network analysis of serum electrophoresis","volume":"45","author":"Kratzer","year":"1992","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.cca.2024.120086_b0030","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1515\/CCLM.2004.271","article-title":"Artificial neural network-based algorithm for the evaluation of serum protein capillary electrophoresis","volume":"42","author":"Ognibene","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2024.120086_b0035","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1515\/CCLM.2008.284","article-title":"An expert system for the classification of serum protein electrophoresis patterns","volume":"46","author":"Altinier","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2024.120086_b0040","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1515\/CCLM.2008.221","article-title":"Computer-assisted detection of monoclonal components: results from the multicenter study for the evaluation of CASPER (Computer Assisted Serum Protein Electrophoresis Recognizer) algorithm","volume":"46","author":"Ognibene","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2024.120086_b0045","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/clinchem\/hvab133","article-title":"Achieving Expert-Level Interpretation of Serum Protein Electrophoresis through Deep Learning Driven by Human Reasoning","volume":"67","author":"Chabrun","year":"2021","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120086_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpi.2022.100128","article-title":"Lightweight, open source, easy-use algorithm and web service for paraprotein screening using spatial frequency domain analysis of electrophoresis studies","volume":"13","author":"Chen","year":"2022","journal-title":"J. Pathol. Inform."},{"key":"10.1016\/j.cca.2024.120086_b0055","doi-asserted-by":"crossref","first-page":"e0273284","DOI":"10.1371\/journal.pone.0273284","article-title":"Development and validation of a deep learning-based protein electrophoresis classification algorithm","volume":"17","author":"Lee","year":"2022","journal-title":"PLOS ONE"},{"key":"10.1016\/j.cca.2024.120086_b0060","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/clinchem\/47.1.110","article-title":"Computer-supported Detection of M-Components and Evaluation of Immunoglobulins after Capillary Electrophoresis","volume":"47","author":"Jonsson","year":"2001","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120086_b0065","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1515\/CCLM.2008.146","article-title":"Reliability of M protein quantification: comparison of two peak integration methods on Capillarys 2","volume":"46","author":"Schild","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2024.120086_b0070","unstructured":"E. Turunen, HUS Acamedic. Virtual presentation., (2022). https:\/\/sway.office.com\/iiBUeFL0ZCF3ChY2 (accessed June 5, 2024)."},{"key":"10.1016\/j.cca.2024.120086_b0075","unstructured":"F. Chabrun, X. Dieu, M. Ferre, O. Gaillard, A. Mery, J.M. Chao de la Barca, A. Taisne, G. Urbanski, P. Reynier, D. Mirebeau-Prunier, SPECTR: Serum Protein Electrophoresis Computer-Assisted Recognition AI, (2024). https:\/\/github.com\/fchabrun\/SPECTR_AI (accessed June 5, 2024)."},{"key":"10.1016\/j.cca.2024.120086_b0080","doi-asserted-by":"crossref","first-page":"e012799","DOI":"10.1136\/bmjopen-2016-012799","article-title":"STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration","volume":"6","author":"Cohen","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.cca.2024.120086_b0085","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/clinchem\/hvac145","article-title":"In Reply to Performance of Deep Learning in the Interpretation of Serum Protein Electrophoresis","volume":"68","author":"Chabrun","year":"2022","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2024.120086_b0090","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/elps.1150181011","article-title":"Identification of monoclonal proteins in serum: a quantitative comparison of acetate, agarose gel, and capillary electrophoresis","volume":"18","author":"Katzmann","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.cca.2024.120086_b0095","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/cclm-2019-1105","article-title":"An international multi-center serum protein electrophoresis accuracy and M-protein isotyping study. Part II: limit of detection and follow-up of patients with small M-proteins","volume":"58","author":"Jacobs","year":"2020","journal-title":"Clin. Chem. Lab. Med. CCLM"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124023398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898124023398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T18:41:57Z","timestamp":1737830517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898124023398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":19,"alternative-id":["S0009898124023398"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2024.120086","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artificial intelligence aided serum protein electrophoresis analysis of Finnish patient samples: Retrospective validation","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2024.120086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120086"}}