{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:42:37Z","timestamp":1784202157264,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100025246","name":"Departament de Recerca i Universitats, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021 SGR 00881"],"award-info":[{"award-number":["2021 SGR 00881"]}],"id":[{"id":"10.13039\/501100025246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022-138243OB-I00"],"award-info":[{"award-number":["PID2022-138243OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["MICIU\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MICIU\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cca.2025.120155","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T16:33:13Z","timestamp":1738254793000},"page":"120155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Redefining vitamin D status: Establishing population-based indirect reference intervals through big data analysis"],"prefix":"10.1016","volume":"569","author":[{"given":"Aleix B.","family":"Fabregat-Bolufer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Escol\u00e0-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Bedini-Chesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregori","family":"Casals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Morales-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Filella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120155_b0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2015","journal-title":"Physiol Rev."},{"key":"10.1016\/j.cca.2025.120155_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2025.120155_b0015","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Medical progress: Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2025.120155_b0020","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S2213-8587(23)00060-8","article-title":"Vitamin D-852.: 100 years of discoveries, yet controversy continues","volume":"11","author":"Gallagher","year":"2023","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.cca.2025.120155_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105917","article-title":"Vitamin D Standardization Program (VDSP) intralaboratory study for the assessment of 25-hydroxyvitamin D assay variability and bias","volume":"212","author":"Wise","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cca.2025.120155_b0030","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2025.120155_b0035","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1210\/clinem\/dgae290","article-title":"Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline","volume":"109","author":"Demay","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2025.120155_b0040","first-page":"4547","article-title":"Dietary reference values for vitamin D","volume":"14","author":"Bresson","year":"2016","journal-title":"EFSA J."},{"key":"10.1016\/j.cca.2025.120155_b0045","first-page":"67","article-title":"Vitamin D \u2013 a scoping review for Nordic nutrition recommendations 2023","volume":"13","author":"Brustad","year":"2023","journal-title":"FoodNutr. Res."},{"key":"10.1016\/j.cca.2025.120155_b0050","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: an update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2025.120155_b0055","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/MPG.0b013e31828f3c05","article-title":"Vitamin d in the healthy European paediatric population","volume":"56","author":"Braegger","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.cca.2025.120155_b0060","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.115.120873","article-title":"Vitamin D deficiency in Europe: Pandemic?","volume":"103","author":"Cashman","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2025.120155_b0065","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3945\/jn.115.227728","article-title":"National estimates of serum total 25-hydroxyvitamin D and metabolite concentrations measured by liquid chromatography-tandem mass spectrometry in the US population during 2007-2010","volume":"146","author":"Schleicher","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.cca.2025.120155_b0070","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3945\/ajcn.114.103689","article-title":"Standardizing 25-hydroxyVitamin D values from the Canadian Health Measures Survey","volume":"102","author":"Sarafin","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2025.120155_b0075","series-title":"Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2013"},{"key":"10.1016\/j.cca.2025.120155_b0080","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1515\/cclm-2018-0059","article-title":"Verification of reference intervals in routine clinical laboratories: Practical challenges and recommendations","volume":"57","author":"Ozarda","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2025.120155_b0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/clinchem\/hvac142","article-title":"RIbench: A Proposed Benchmark for the Standardized Evaluation of Indirect Methods for Reference Interval Estimation","volume":"68","author":"Ammer","year":"2022","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2025.120155_b0090","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1515\/cclm-2018-0073","article-title":"Indirect methods for reference interval determination - Review and recommendations","volume":"57","author":"Jones","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2025.120155_b0095","doi-asserted-by":"crossref","first-page":"16023","DOI":"10.1038\/s41598-021-95301-2","article-title":"refineR: A Novel Algorithm for Reference Interval Estimation from Real-World Data","volume":"11","author":"Ammer","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120155_b0100","unstructured":"Centers for Disease Control and Prevention (CDC), Certified Total 25-hydroxyvitamin D Assays. https:\/\/www.cdc.gov\/clinical-standardization-programs\/media\/pdfs\/2024\/04\/CDC-Certified-Vitamin-D-Assays-508.pdf, 2024 (Accessed 13 July 2024)."},{"key":"10.1016\/j.cca.2025.120155_b0105","first-page":"1129","article-title":"Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. EPIDOS Study Group","volume":"81","author":"Chapuy","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2025.120155_b0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.cca.2025.120155_b0115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4065\/81.3.353","article-title":"High prevalence of vitamin D inadequacy and implications for health","volume":"81","author":"Holick","year":"2006","journal-title":"Mayo. Clin. Proc."},{"key":"10.1016\/j.cca.2025.120155_b0120","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ecl.2017.07.002","article-title":"Global Overview of Vitamin D Status","volume":"46","author":"Van Schoor","year":"2017","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"key":"10.1016\/j.cca.2025.120155_b0125","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-028355","article-title":"Trends in the incidence of testing for Vitamin D deficiency in primary care in the UK: A retrospective analysis of the Health Improvement Network (THIN), 2005-2015","volume":"9","author":"Crowe","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.cca.2025.120155_b0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5858\/arpa.2013-0149-OA","article-title":"Trends in laboratory test volumes for medicare part b reimbursements, 2000-2010","volume":"138","author":"Shahangian","year":"2014","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.cca.2025.120155_b0135","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/kem240","article-title":"Effect of annual intramuscular vitamin D on fracture risk in elderly men and women - A population-based, randomized, double-blind, placebo-controlled trial","volume":"46","author":"Smith","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.cca.2025.120155_b0140","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.cca.2025.120155_b0145","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0140-6736(05)63013-9","article-title":"Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium or vitamin D, RECORD): A randomised placebo-controlled trial","volume":"365","author":"Grant","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2025.120155_b0150","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1001\/jama.2020.16909","article-title":"Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial","volume":"324","author":"Bischoff-Ferrari","year":"2020","journal-title":"JAMA \u2013 J. Am. Med. Assoc."},{"key":"10.1016\/j.cca.2025.120155_b0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2202106","article-title":"Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults","volume":"387","author":"LeBoff","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2025.120155_b0160","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1001\/jama.2017.19344","article-title":"Association between calcium or Vitamin D supplementation and fracture incidence in community-dwelling older adults a systematic review and meta-analysis","volume":"318","author":"Zhao","year":"2017","journal-title":"JAMA \u2013 J. Am. Med. Assoc."},{"key":"10.1016\/j.cca.2025.120155_b0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/jalm\/jfac101","article-title":"Estimation of Reference Intervals from Routine Data Using the refineR Algorithm - A Practical Guide","volume":"8","author":"Ammer","year":"2023","journal-title":"J. Appl. Lab. Med."},{"key":"10.1016\/j.cca.2025.120155_b0170","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1046\/j.1523-1755.63.s85.11.x","article-title":"Vitamin D status and secondary hyperparathyroidism: the importance of 25-hydroxyvitamin D cut-off levels","volume":"85","author":"G\u00f3mez-Alonso","year":"2003","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.cca.2025.120155_b0175","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s00394-017-1564-2","article-title":"A systematic review of vitamin D status in southern European countries","volume":"57","author":"Manios","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.cca.2025.120155_b0180","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1210\/jcem-67-2-373","article-title":"Influence of Season and Latitude on the Cutaneous Synthesis of Vitamin D3: Exposure to Winter Sunlight in Boston and Edmonton Will Not Promote Vitamin D3 Synthesis in Human Skin","volume":"67","author":"Webb","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2025.120155_b0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00223-019-00559-4","article-title":"Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing","volume":"106","author":"Cashman","year":"2020","journal-title":"Calcif. Tissue Int."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:42:29Z","timestamp":1778636549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":37,"alternative-id":["S0009898125000348"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120155","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redefining vitamin D status: Establishing population-based indirect reference intervals through big data analysis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120155"}}