{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:40:12Z","timestamp":1766050812759,"version":"3.38.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001407","name":"India Ministry of Science &amp; Technology Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cca.2025.120168","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T07:49:38Z","timestamp":1738136978000},"page":"120168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["\u201cWhole genome bisulfite sequencing of serum extracellular vesicle DNA identifies alterations in mitochondrial DNA methylation in early onset preeclampsia\u201d"],"prefix":"10.1016","volume":"569","author":[{"given":"Uma","family":"Shinde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kushaan","family":"Khambata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanketa","family":"Raut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishwarya","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niranjan","family":"Mayadeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanjit Kumar","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taruna","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinoth Prasanna","family":"Gunasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafisa Huseni","family":"Balasinor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120168_b0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.preghy.2018.10.011","article-title":"Preeclampsia: disease biology and burden, its management strategies with reference to India","volume":"15","author":"Malik","year":"2019","journal-title":"Pregnancy Hypertension"},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0010","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"ACOG Practice Bulletin, Number 222","volume":"135","author":"Gestational Hypertension and Preeclampsia","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"20","key":"10.1016\/j.cca.2025.120168_b0015","doi-asserted-by":"crossref","first-page":"11202","DOI":"10.3390\/ijms222011202","article-title":"Defective uteroplacental vascular remodeling in preeclampsia: key molecular factors leading to long term cardiovascular disease","volume":"22","author":"Hong","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cca.2025.120168_b0020","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.cca.2025.120168_b0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13148-018-0463-6","article-title":"Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia","volume":"10","author":"Leavey","year":"2018","journal-title":"Clin. Epigenet."},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0030","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3892\/mmr.2012.763","article-title":"DNA methylation in the human placenta and fetal growth (review)","volume":"5","author":"Koukoura","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cca.2025.120168_b0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.placenta.2020.09.004","article-title":"Global DNA methylation in placental tissues from pregnant with preeclampsia: a systematic review and pathway analysis","volume":"101","author":"Cruz","year":"2020","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.cca.2025.120168_b0040","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/molehr\/gat044","article-title":"Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia","volume":"19","author":"Blair","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.cca.2025.120168_b0045","doi-asserted-by":"crossref","unstructured":"Ashraf, U. M., Hall, D. L., Rawls, A. Z., & Alexander, B. T. (2021). Epigenetic processes during preeclampsia and effects on fetal development and chronic health. Clinical science (London, England : 1979), 135(19), 2307\u20132327. https:\/\/doi.org\/10.1042\/CS20190070.","DOI":"10.1042\/CS20190070"},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100148","article-title":"Differential methylation of genes associated with cell adhesion in preeclamptic placentas","volume":"9","author":"Anton","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cca.2025.120168_b0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.imlet.2006.09.005","article-title":"Exosomes: from biogenesis and secretion to biological function","volume":"107","author":"Keller","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cca.2025.120168_b0060","doi-asserted-by":"crossref","unstructured":"Redman, C. W., & Sargent, I. L. (2008). Circulating microparticles in normal pregnancy and pre-eclampsia. Placenta, 29 Suppl A, S73\u2013S77. https:\/\/doi.org\/10.1016\/j.placenta.2007.11.016.","DOI":"10.1016\/j.placenta.2007.11.016"},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0065","first-page":"108","article-title":"Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies","volume":"1841","author":"Record","year":"2014","journal-title":"BBA"},{"key":"10.1016\/j.cca.2025.120168_b0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jri.2016.08.008","article-title":"Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia","volume":"119","author":"Tannetta","year":"2017","journal-title":"J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0075","doi-asserted-by":"crossref","first-page":"828","DOI":"10.5858\/arpa.2013-0134-OA","article-title":"Study of circulating microRNA-125b levels in serum exosomes in advanced melanoma","volume":"138","author":"Alegre","year":"2014","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"6478","key":"10.1016\/j.cca.2025.120168_b0080","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Sci. (New York, N.Y.)"},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0085","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3390\/cancers13040822","article-title":"Exosomes and cell communication: from tumour-derived exosomes and their role in tumour progression to the use of exosomal cargo for cancer treatment","volume":"13","author":"Nicolini","year":"2021","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/j.cca.2025.120168_b0090","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1074\/jbc.C113.532267","article-title":"Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer","volume":"289","author":"Kahlert","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12206","article-title":"Analysis of extracellular vesicle DNA at the single-vesicle level by nano-flow cytometry","volume":"11","author":"Liu","year":"2022","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.cca.2025.120168_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1370449","article-title":"A recognition of exosomes as regulators of epigenetic mechanisms in central nervous system diseases","volume":"17","author":"Hu","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.cca.2025.120168_b0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.placenta.2024.10.019","article-title":"Methylation and expression of imprinted genes in circulating extracellular vesicles from women experiencing early onset preeclampsia","volume":"158","author":"Shinde","year":"2024","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0110","doi-asserted-by":"crossref","DOI":"10.1530\/REP-23-0215","article-title":"Isolation of serum-derived placental\/amnio-chorionic extracellular vesicles across pregnancy by immunoaffinity using PLAP and HLA-G","volume":"167","author":"Shinde","year":"2024","journal-title":"Reprod. (Cambridge, England)"},{"issue":"3","key":"10.1016\/j.cca.2025.120168_b0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nmeth.3152","article-title":"Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing","volume":"12","author":"Ziller","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cca.2025.120168_b0120","doi-asserted-by":"crossref","first-page":"W193","DOI":"10.1093\/nar\/gkm226","article-title":"g:Profiler\u2013a web-based toolset for functional profiling of gene lists from large-scale experiments","volume":"35(Web Server issue)","author":"Reimand","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cca.2025.120168_b0125","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/s41419-018-1190-9","article-title":"Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery","volume":"9","author":"Holland","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0130","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/s12916-023-03178-x","article-title":"Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study","volume":"21","author":"Lekva","year":"2023","journal-title":"BMC Med."},{"issue":"36","key":"10.1016\/j.cca.2025.120168_b0135","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13293-020-00313-8","article-title":"Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization","volume":"11","author":"Cirkovic","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.cca.2025.120168_b0145","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41419-020-02803-4","article-title":"Bioactive DNA from extracellular vesicles and particles","volume":"11","author":"Malkin","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cca.2025.120168_b0150","unstructured":"Ram\u00edrez-Clavijo S, Montoya-Ort\u00edz G. Gene expression and regulation. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 1. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459456\/."},{"key":"10.1016\/j.cca.2025.120168_b0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-61779-612-8_5","article-title":"DNA methylation in promoter region as biomarkers in prostate cancer.","volume":"863","author":"Yang","year":"2012","journal-title":"Methods in molecular biology (CliftonN.J.)"},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0160","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3748\/wjg.v20.i4.943","article-title":"Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer","volume":"20","author":"Copped\u00e8","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0165","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3349\/ymj.2008.49.4.592","article-title":"The inhibition of insulin-stimulated proliferation of vascular smooth muscle cells by rosiglitazone is mediated by the Akt-mTOR-P70S6K pathway","volume":"49","author":"Park","year":"2008","journal-title":"Yonsei Med. J."},{"issue":"3","key":"10.1016\/j.cca.2025.120168_b0170","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1210\/en.2007-1282","article-title":"Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling","volume":"149","author":"Prast","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2025.120168_b0175","first-page":"988","article-title":"An integrative biomedical informatics approach to elucidate the similarities between pre-eclampsia and hypertension","volume":"264","author":"Lopez-Campos","year":"2019","journal-title":"Stud. Health Technol. Inform."},{"issue":"23","key":"10.1016\/j.cca.2025.120168_b0180","doi-asserted-by":"crossref","first-page":"16882","DOI":"10.3390\/ijms242316882","article-title":"The role of TGF-\u03b2 during pregnancy and pregnancy complications","volume":"24","author":"Wen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2025.120168_b0185","doi-asserted-by":"crossref","unstructured":"Spaans, F., de Vos, P., Bakker, W. W., van Goor, H., & Faas, M. M. (2014). Danger signals from ATP and adenosine in pregnancy and preeclampsia. Hypertension (Dallas, Tex. : 1979), 63(6), 1154\u20131160. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03240.","DOI":"10.1161\/HYPERTENSIONAHA.114.03240"},{"issue":"21","key":"10.1016\/j.cca.2025.120168_b0190","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.3390\/jcm10215063","article-title":"Characterization of mitochondrial bioenergetics in preeclampsia","volume":"10","author":"Vaka","year":"2021","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0195","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11906-022-01184-7","article-title":"Mitochondrial dysfunction in the pathogenesis of preeclampsia","volume":"24","author":"Hu","year":"2022","journal-title":"Curr. Hypertens. Rep."},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2020.100275","article-title":"Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: a role for angiotension II type 1 autoantibodies","volume":"3","author":"Deer","year":"2021","journal-title":"Am. J. Obstetrics Gynecology MFM"},{"issue":"12","key":"10.1016\/j.cca.2025.120168_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165961","article-title":"Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia. Biochimica et biophysica acta","volume":"1866","author":"Mar\u00edn","year":"2020","journal-title":"Molecular Basis of Disease"},{"issue":"9","key":"10.1016\/j.cca.2025.120168_b0210","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.3390\/ijms22094594","article-title":"Mitochondrial DNA methylation and human diseases","volume":"22","author":"Stoccoro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0215","doi-asserted-by":"crossref","first-page":"E981","DOI":"10.1152\/ajpendo.00354.2020","article-title":"Mitochondrial transformations in the aging human placenta","volume":"319","author":"Bartho","year":"2020","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0220","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12967-016-1113-4","article-title":"Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight","volume":"15","author":"Janssen","year":"2017","journal-title":"J. Transl. Med."},{"issue":"8","key":"10.1016\/j.cca.2025.120168_b0225","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.3390\/ijms24087005","article-title":"The potential use of mitochondrial extracellular vesicles as biomarkers or therapeutical tools","volume":"24","author":"Sanz-Ros","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cca.2025.120168_b0230","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1152\/physiolgenomics.00005.2023","article-title":"Maternal and fetal mitochondrial gene dysregulation in hypertensive disorders of pregnancy","volume":"55","author":"Ricci","year":"2023","journal-title":"Physiol. Genomics"},{"issue":"7","key":"10.1016\/j.cca.2025.120168_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28808","article-title":"Mitochondrial complex I subunit MT-ND1 mutations affect disease progression","volume":"10","author":"Lin","year":"2024","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.cca.2025.120168_b0240","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3390\/ijms19051496","article-title":"Oxidative stress in preeclampsia and placental diseases","volume":"19","author":"Aouache","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2025.120168_b0245","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fphys.2014.00516","article-title":"Oxidative stress in preeclampsia and the role of free fetal hemoglobin","volume":"5","author":"Hansson","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cca.2025.120168_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2020.10.002","article-title":"Mitochondrial DNA copy number variation - a potential biomarker for early onset preeclampsia","volume":"23","author":"Pandey","year":"2021","journal-title":"Pregnancy Hypertension"},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0255","first-page":"851","article-title":"Understanding mitochondrial complex I assembly in health and disease","volume":"1817","author":"Mimaki","year":"2012","journal-title":"BBA"},{"issue":"12","key":"10.1016\/j.cca.2025.120168_b0260","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1177\/1933719112450337","article-title":"Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia","volume":"19","author":"Ding","year":"2012","journal-title":"Reprod. Sci. (Thousand Oaks, Calif.)"},{"key":"10.1016\/j.cca.2025.120168_b0265","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.mito.2021.06.006","article-title":"Placental mitochondrial DNA mutational load and perinatal outcomes: findings from a multi-ethnic pregnancy cohort","volume":"59","author":"Cowell","year":"2021","journal-title":"Mitochondrion"},{"issue":"4","key":"10.1016\/j.cca.2025.120168_b0270","doi-asserted-by":"crossref","first-page":"E404","DOI":"10.1152\/ajpendo.00426.2013","article-title":"Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia","volume":"306","author":"Mand\u00f2","year":"2014","journal-title":"Am. J. phys. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055194","article-title":"Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition","volume":"8","author":"Colleoni","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0280","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3892\/ijmm.2020.4799","article-title":"Mitochondrial gene COX2 methylation and downregulation is a biomarker of aging in heart mesenchymal stem cells","volume":"47","author":"Sun","year":"2021","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.cca.2025.120168_b0285","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s11064-020-03192-y","article-title":"Hypermethylation of mitochondrial cytochrome b and cytochrome c oxidase II genes with decreased mitochondrial DNA copy numbers in the APP\/PS1 transgenic mouse model of alzheimer's disease","volume":"46","author":"Xu","year":"2021","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.cca.2025.120168_b0290","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13148-015-0078-0","article-title":"Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease","volume":"7","author":"Baccarelli","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.cca.2025.120168_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2021.12.021","article-title":"Placental mtDNA copy number and methylation in association with macrosomia in healthy pregnancy","volume":"118","author":"Lin","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.cca.2025.120168_b0300","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.placenta.2017.05.008","article-title":"Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency","volume":"55","author":"Novielli","year":"2017","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.cca.2025.120168_b0305","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.placenta.2014.06.371","article-title":"Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta","volume":"35","author":"Janssen","year":"2014","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.cca.2025.120168_b0310","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/15592294.2015.1048412","article-title":"Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: an ENVIRONAGE birth cohort study","volume":"10","author":"Janssen","year":"2015","journal-title":"Epigenetics"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:26:17Z","timestamp":1740479177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":62,"alternative-id":["S0009898125000476"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120168","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201cWhole genome bisulfite sequencing of serum extracellular vesicle DNA identifies alterations in mitochondrial DNA methylation in early onset preeclampsia\u201d","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120168"}}