{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:01:04Z","timestamp":1780776064041,"version":"3.54.1"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.cca.2025.120221","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T11:57:43Z","timestamp":1740743863000},"page":"120221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Electrochemical biosensors for enhanced detection of diabetes mellitus"],"prefix":"10.1016","volume":"571","author":[{"given":"Yong","family":"Zhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120221_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"5","key":"10.1016\/j.cca.2025.120221_b0010","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s44222-023-00032-w","article-title":"Device integration of electrochemical biosensors","volume":"1","author":"Wu","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"issue":"21","key":"10.1016\/j.cca.2025.120221_b0015","doi-asserted-by":"crossref","first-page":"7671","DOI":"10.1039\/D0CS00304B","article-title":"Electrochemical glucose sensors in diabetes management: An updated review (2010-2020)","volume":"49","author":"Teymourian","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.cca.2025.120221_b0020","article-title":"Early detection of type 2 diabetes risk: Limitations of current diagnostic criteria","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Endocrinol (lausanne)."},{"issue":"8","key":"10.1016\/j.cca.2025.120221_b0025","article-title":"Advances in the management of diabetes mellitus: A focus on personalized medicine","volume":"15","author":"Sugandh","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.cca.2025.120221_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1446355","article-title":"Recent advances in gold nanostructure-based biosensors in detecting diabetes biomarkers","volume":"12","author":"Jamshidnejad-Tosaramandani","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0035","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5599\/admet.2361","article-title":"Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus","volume":"12","author":"Zuliska","year":"2024","journal-title":"ADMET DMPK."},{"issue":"5","key":"10.1016\/j.cca.2025.120221_b0040","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/nano13050867","article-title":"A nanotechnology-based approach to biosensor application in current diabetes management practices","volume":"13","author":"Shoaib","year":"2023","journal-title":"Nanomaterials"},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0045","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0050","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2337\/diabetes.53.2.426","article-title":"Insulin secretion in type 1 diabetes","volume":"53","author":"Steele","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2025.120221_b0055","article-title":"Type 1 diabetes","author":"Lucier","year":"2023","journal-title":"StatPearls [internet]: Statpearls Publishing"},{"key":"10.1016\/j.cca.2025.120221_b0060","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvab131","article-title":"The epidemiology and genetic analysis of children with idiopathic type 1 diabetes in the state of Qatar","author":"Abdel-Karim","year":"2021","journal-title":"J. Endocr. Soc."},{"issue":"Suppl 1","key":"10.1016\/j.cca.2025.120221_b0065","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.2337\/dc09-S080","article-title":"Diabetes and employment","volume":"32","author":"Association","year":"2009","journal-title":"Diab. Care."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0070","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ncpendmet0351","article-title":"Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners","volume":"3","author":"Hanafusa","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0075","article-title":"Fulminant type 1 diabetes mellitus in a GDM pregnancy: Early recognition is vital for maternal and fetal outcomes","volume":"2022","author":"Choy","year":"2022","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"10.1016\/j.cca.2025.120221_b0080","doi-asserted-by":"crossref","DOI":"10.2337\/diabetes.50.2007.S169","article-title":"Decreased insulin secretion in type 2 diabetes: A problem of cellular mass or function?","volume":"50","author":"Clark","year":"2001","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1566524053766004","article-title":"Type 2 diabetes, insulin secretion and beta-cell mass","volume":"5","author":"Ahren","year":"2005","journal-title":"Curr. Mol. Med."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0090","first-page":"151","article-title":"Gestational diabetes mellitus: Why screen and how to diagnose","volume":"14","author":"Karagiannis","year":"2010","journal-title":"Hippokratia"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/14767058.2012.734874","article-title":"The proposed GDM diagnostic criteria: A difference, to be a difference, must make a difference","volume":"26","author":"Langer","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"8","key":"10.1016\/j.cca.2025.120221_b0100","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1046\/j.1525-1497.2000.08024.x","article-title":"Revisiting the oral glucose tolerance test criterion for the diagnosis of diabetes","volume":"15","author":"Davidson","year":"2000","journal-title":"J. Gen. Intern. Med."},{"issue":"11","key":"10.1016\/j.cca.2025.120221_b0105","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41591-023-02610-2","article-title":"Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c","volume":"29","author":"Collaboration","year":"2023","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171315","article-title":"Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis","volume":"12","author":"Cavagnolli","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0115","doi-asserted-by":"crossref","first-page":"12419","DOI":"10.1038\/s41598-018-29998-z","article-title":"Screening for diabetes with HbA1c: Test performance of HbA1c compared to fasting plasma glucose among Chinese, Malay and Indian community residents in Singapore","volume":"8","author":"Lim","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120221_b0120","article-title":"Prediabetes: the variation between HbA1c and fasting plasma glucose","author":"White","year":"2015","journal-title":"Int. J. Diabetol. Vas. Disease Res."},{"issue":"1148","key":"10.1016\/j.cca.2025.120221_b0125","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/postgradmedj-2020-138756","article-title":"Is HbA1c an ideal biomarker of well-controlled diabetes?","volume":"97","author":"Kaiafa","year":"2021","journal-title":"Postgrad. Med. J."},{"issue":"6","key":"10.1016\/j.cca.2025.120221_b0130","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1172\/JCI108436","article-title":"The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo","volume":"57","author":"Bunn","year":"1976","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cca.2025.120221_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.950225","article-title":"Fasting plasma glucose and HbA1c levels predict the risk of type 2 diabetes and diabetic retinopathy in a Thai high-risk population with prediabetes","volume":"13","author":"Washirasaksiri","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0140","doi-asserted-by":"crossref","first-page":"13721","DOI":"10.1038\/s41598-017-14172-8","article-title":"Impact of analytical and biological variations on classification of diabetes using fasting plasma glucose, oral glucose tolerance test and HbA1c","volume":"7","author":"Chai","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cca.2025.120221_b0145","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3343\/alm.2013.33.6.393","article-title":"HbA1c: A review of analytical and clinical aspects","volume":"33","author":"Weykamp","year":"2013","journal-title":"Ann. Lab. Med."},{"issue":"22","key":"10.1016\/j.cca.2025.120221_b0150","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.3390\/diagnostics13223449","article-title":"A Comparative evaluation of HbA1c measurement methods and their implications for diabetes management","volume":"13","author":"Yun","year":"2023","journal-title":"Diagnostics."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0155","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1590\/2359-3997000000272","article-title":"Glycated albumin: A potential biomarker in diabetes","volume":"61","author":"Freitas","year":"2017","journal-title":"Arch Endocrinol Metab."},{"issue":"4","key":"10.1016\/j.cca.2025.120221_b0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.115.015415","article-title":"Fructosamine and glycated albumin and the risk of cardiovascular outcomes and death","volume":"132","author":"Selvin","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0165","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/1932296814567227","article-title":"Advantages and pitfalls of fructosamine and glycated albumin in the diagnosis and treatment of diabetes","volume":"9","author":"Danese","year":"2015","journal-title":"J. Diabetes Sci. Technol."},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0170","first-page":"262","article-title":"Estimated average blood glucose level based on fructosamine level.","volume":"67","author":"de Oliveira Andrade","year":"2023","journal-title":"Arch. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.cca.2025.120221_b0175","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/s41390-024-03146-y","article-title":"HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia","volume":"96","author":"Mahmoud","year":"2024","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cca.2025.120221_b0180","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902020000419078","article-title":"Evaluation of 1, 5-anhydroglucitol as a biomarker for type 2 diabetes mellitus in patients without overt nephropathy","volume":"57","author":"Gobor","year":"2021","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.cca.2025.120221_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1471577","article-title":"The clinical potential of 1, 5-anhydroglucitol as biomarker in diabetes mellitus","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"Suppl","key":"10.1016\/j.cca.2025.120221_b0190","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1016\/0168-8227(94)90259-3","article-title":"Serum 1,5-anhydroglucitol (1,5 AG): New clinical marker for glycemic control","volume":"24","author":"Yamanouchi","year":"1994","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"8","key":"10.1016\/j.cca.2025.120221_b0195","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1038\/nutd.2014.27","article-title":"Circulating adiponectin levels and risk of type 2 diabetes in the Japanese","volume":"4","author":"Yamamoto","year":"2014","journal-title":"Nutr. Diabetes"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/jmcb\/mjw014","article-title":"Adiponectin signaling and function in insulin target tissues","volume":"8","author":"Ruan","year":"2016","journal-title":"J. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0205","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/1806-9282.61.01.072","article-title":"Portal VL. Relationship between adiponectin, obesity and insulin resistance","volume":"61","author":"Balsan","year":"2015","journal-title":"Revista Da Associa\u00e7\u00e3o M\u00e9dica Brasileira."},{"issue":"10","key":"10.1016\/j.cca.2025.120221_b0210","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.2337\/db08-0538","article-title":"Plasma fetuin-A levels and the risk of type 2 diabetes","volume":"57","author":"Stefan","year":"2008","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0215","doi-asserted-by":"crossref","first-page":"21469","DOI":"10.1038\/s41598-023-48600-9","article-title":"Fetuin-A and its genetic association with cardiometabolic disease","volume":"13","author":"Al Ali","year":"2023","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cca.2025.120221_b0220","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4093\/dmj.2018.0171","article-title":"Plasma fetuin-A levels and risk of type 2 diabetes mellitus in A Chinese population: A nested case-control study","volume":"43","author":"Wang","year":"2019","journal-title":"Diabetes Metab. J."},{"issue":"8","key":"10.1016\/j.cca.2025.120221_b0225","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm.2851","article-title":"Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance","volume":"18","author":"Pal","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.cca.2025.120221_b0230","doi-asserted-by":"crossref","DOI":"10.4137\/BMI.S38440","article-title":"Significance of HbA1c test in diagnosis and prognosis of diabetic patients","volume":"11","author":"Sherwani","year":"2016","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.cca.2025.120221_b0235","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/DMSO.S100074","article-title":"Novel biomarkers for prediabetes, diabetes, and associated complications","volume":"10","author":"Dorcely","year":"2017","journal-title":"Diabetes Metab Syndr Obes."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0240","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1038\/s41598-021-81803-6","article-title":"Fructosamine is a valuable marker for glycemic control and predicting adverse outcomes following total hip arthroplasty: A prospective multi-institutional investigation","volume":"11","author":"Shohat","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.cca.2025.120221_b0245","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-007689","article-title":"Fructosamine measurement for diabetes mellitus diagnosis and monitoring: A systematic review and meta-analysis protocol","volume":"5","author":"Nansseu","year":"2015","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.cca.2025.120221_b0250","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S2213-8587(13)70199-2","article-title":"Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: A prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study","volume":"2","author":"Selvin","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"8","key":"10.1016\/j.cca.2025.120221_b0255","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/aje\/kwx167","article-title":"Serum levels of 1,5-anhydroglucitol and risk of incident end-stage renal disease","volume":"186","author":"Rebholz","year":"2017","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.cca.2025.120221_b0260","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/nu13041180","article-title":"Adiponectin: Structure, physiological functions, role in diseases, and effects of nutrition","volume":"13","author":"Khoramipour","year":"2021","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0265","first-page":"134","article-title":"Adiponectin synthesis, secretion and extravasation from circulation to interstitial space","volume":"36","author":"da Silva Rosa","year":"2021","journal-title":"Physiology (Bethesda)"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0270","doi-asserted-by":"crossref","first-page":"72","DOI":"10.21608\/mjmr.2023.187092.1300","article-title":"Serum fetuin-A in diabetic and nondiabetic hemodialysis patients","volume":"34","author":"Akad","year":"2023","journal-title":"Minia J. Med. Res.."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0275","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1038\/s41598-019-43431-z","article-title":"Serum amino acid profiles and risk of type 2 diabetes among Japanese adults in the Hitachi Health Study","volume":"9","author":"Chen","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cca.2025.120221_b0280","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2337\/db12-0876","article-title":"Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes","volume":"62","author":"Xie","year":"2013","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0285","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41467-019-08936-1","article-title":"Assessing the causal association of glycine with risk of cardio-metabolic diseases","volume":"10","author":"Wittemans","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.cca.2025.120221_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010883","article-title":"\u03b1-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population","volume":"5","author":"Gall","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0295","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2014-000038","article-title":"Serum alpha-hydroxybutyrate (alpha-HB) predicts elevated 1 h glucose levels and early-phase beta-cell dysfunction during OGTT","volume":"2","author":"Varvel","year":"2014","journal-title":"BMJ Open Diabetes Res. Care"},{"issue":"11","key":"10.1016\/j.cca.2025.120221_b0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166682","article-title":"Targeting mitochondrial dysfunction with L-Alpha glycerylphosphorylcholine","volume":"11","author":"Strifler","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0305","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41541-018-0062-8","article-title":"Long-term reduction in hyperglycemia in advanced type 1 diabetes: The value of induced aerobic glycolysis with BCG vaccinations","volume":"3","author":"Kuhtreiber","year":"2018","journal-title":"npj Vaccines"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0310","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00394-014-0691-2","article-title":"Protective effects of L-alpha-glycerylphosphorylcholine on ischaemia-reperfusion-induced inflammatory reactions","volume":"54","author":"Tokes","year":"2015","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0315","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12902-021-00788-5","article-title":"Impact of triglycerides and waist circumference on insulin resistance and beta-cell function in non-diabetic first-degree relatives of type 2 diabetes","volume":"21","author":"Ahmed","year":"2021","journal-title":"BMC Endocr. Disord."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0320","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1586\/erc.11.182","article-title":"HDL dysfunction in diabetes: Causes and possible treatments","volume":"10","author":"Farbstein","year":"2012","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.cca.2025.120221_b0325","article-title":"Ceramide on the road to insulin resistance and immunometabolic disorders in transition dairy cows: Driver or passenger?","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2025.120221_b0330","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.958837","article-title":"Ceramide metabolism associated with chronic dietary nutrient surplus and diminished insulin sensitivity in the liver, muscle, and adipose tissue of cattle","volume":"13","author":"Kenez","year":"2022","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0335","doi-asserted-by":"crossref","first-page":"41231","DOI":"10.1038\/srep41231","article-title":"Mechanistic interplay between ceramide and insulin resistance","volume":"7","author":"Reali","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120221_b0340","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1143919","article-title":"Association between systemic iron status and \u03b2-cell function and insulin sensitivity in patients with newly diagnosed type 2 diabetes","volume":"14","author":"Qin","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0345","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s40200-023-01268-4","article-title":"Association between iron profile status and insulin resistance in patients with type 2 diabetes mellitus","volume":"22","author":"Sam","year":"2023","journal-title":"J. Diabetes Metab. Disord."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0350","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10654-017-0236-0","article-title":"Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: The Rotterdam Study","volume":"32","author":"Brahimaj","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0355","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2337\/diabetes.53.3.693","article-title":"Inflammatory markers and risk of developing type 2 diabetes in women","volume":"53","author":"Hu","year":"2004","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0360","article-title":"Analysis of inflammatory mediators in prediabetes and newly diagnosed type 2 diabetes patients","volume":"2016","author":"Wang","year":"2016","journal-title":"J. Diabetes Res."},{"issue":"12","key":"10.1016\/j.cca.2025.120221_b0365","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3390\/cells8121533","article-title":"MicroRNA signatures as future biomarkers for diagnosis of diabetes states","volume":"8","author":"Vasu","year":"2019","journal-title":"Cells."},{"issue":"21","key":"10.1016\/j.cca.2025.120221_b0370","doi-asserted-by":"crossref","first-page":"15673","DOI":"10.3390\/ijms242115673","article-title":"identification of MicroRNAs associated with prediabetic status in obese women","volume":"24","author":"Kovac","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0375","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1038\/s41598-019-43793-4","article-title":"Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes","volume":"9","author":"Mononen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120221_b0380","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15566","article-title":"Electrochemical biosensors in healthcare services: bibliometric analysis and recent developments","volume":"11","author":"Yunus","year":"2023","journal-title":"PeerJ"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0385","first-page":"36","article-title":"Review on biosensor technologies","volume":"6","author":"Bhardwaj","year":"2015","journal-title":"Int. J. Adv. Res. Eng. Technol."},{"issue":"4","key":"10.1016\/j.cca.2025.120221_b0390","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4093\/dmj.2019.0121","article-title":"Continuous glucose monitoring sensors for diabetes management: A review of technologies and applications","volume":"43","author":"Cappon","year":"2019","journal-title":"Diabetes Metab. J."},{"issue":"41","key":"10.1016\/j.cca.2025.120221_b0395","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1039\/D3AY01414B","article-title":"Biomarkers and optical based biosensors in cardiac disease detection: Early and accurate diagnosis","volume":"15","author":"Nejati-Koshki","year":"2023","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0400","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1038\/s41598-022-26951-z","article-title":"Reshaping healthcare with wearable biosensors","volume":"13","author":"Smith","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120221_b0405","article-title":"Approaches of wearable and implantable biosensor towards of developing in precision medicine","volume":"11","author":"Ghazizadeh","year":"2024","journal-title":"Front Med (lausanne)."},{"issue":"11","key":"10.1016\/j.cca.2025.120221_b0410","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3390\/bios14110560","article-title":"Advances in wearable biosensors for healthcare: Current trends, applications, and future perspectives","volume":"14","author":"Vo","year":"2024","journal-title":"Biosensors (basel)"},{"key":"10.1016\/j.cca.2025.120221_b0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.117878","article-title":"Electrochemical biosensors for early diagnosis of glioblastoma","volume":"557","author":"Vatankhahan","year":"2024","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0420","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/bab.2354","article-title":"Review of electrochemical and optical biosensors for testosterone measurement","volume":"70","author":"Nikkhah","year":"2023","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0425","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/s8031366","article-title":"Assembling Amperometric Biosensors for Clinical Diagnostics","volume":"8","author":"Belluzo","year":"2008","journal-title":"Sensors (basel)."},{"issue":"7","key":"10.1016\/j.cca.2025.120221_b0430","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3390\/bios12070494","article-title":"Application and progress of chemometrics in voltammetric biosensing","volume":"12","author":"Liu","year":"2022","journal-title":"Biosensors (basel)"},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0435","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.3390\/s120303449","article-title":"New trends in impedimetric biosensors for the detection of foodborne pathogenic bacteria","volume":"12","author":"Wang","year":"2012","journal-title":"Sensors (basel)"},{"key":"10.1016\/j.cca.2025.120221_b0440","doi-asserted-by":"crossref","unstructured":"W. Ji, J. Zhu, W. Wu, N. Wang, J. Wang, J. Wu, et al. Wearable Sweat Biosensors Refresh Personalized Health\/Medical Diagnostics. Research (Wash D C). 2021;2021:9757126.10.34133\/2021\/9757126.","DOI":"10.34133\/2021\/9757126"},{"issue":"8","key":"10.1016\/j.cca.2025.120221_b0445","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/bios11080245","article-title":"Wearable biosensors for non-invasive sweat diagnostics","volume":"11","author":"Xu","year":"2021","journal-title":"Biosensors (basel)"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0450","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13534-021-00191-y","article-title":"A review of wearable biosensors for sweat analysis","volume":"11","author":"Jo","year":"2021","journal-title":"Biomed. Eng. Lett."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0455","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrd4477","article-title":"Managing diabetes with nanomedicine: Challenges and opportunities","volume":"14","author":"Veiseh","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cca.2025.120221_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342828","article-title":"An origami microfluidic paper device based on core-shell Cu@Cu(2)S@N-doped carbon hollow nanocubes","volume":"1316","author":"Li","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120221_b0465","article-title":"Simultaneous electrochemical detection of glycated and human serum albumin for diabetes management","volume":"246","author":"Dastidar","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120221_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126807","article-title":"Regeneratable bioinspired nanochannels for highly sensitive electrochemical detection of glycated albumin","volume":"281","author":"Wang","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2025.120221_b0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2023.108601","article-title":"Clinical validation of electrochemical biosensor for the detection of methylglyoxal in subjects with type-2 diabetes mellitus","volume":"155","author":"Kumar","year":"2024","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.cca.2025.120221_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.124137","article-title":"Electrochemical sensor based on molecularly imprinted polymer cryogel and multiwalled carbon nanotubes for direct insulin detection","volume":"254","author":"Wardani","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2025.120221_b0485","doi-asserted-by":"crossref","unstructured":"H.H. Hung, H. Lee, J. Yea, K-I. Jang. Wearable electrochemical sensors for real-time monitoring in diabetes mellitus and associated complications. 2024.","DOI":"10.20517\/ss.2024.02"},{"issue":"2","key":"10.1016\/j.cca.2025.120221_b0490","article-title":"Wearable electrochemical biosensors for advanced healthcare monitoring","volume":"12","author":"Duan","year":"2025","journal-title":"Adv Sci (weinh)."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0495","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1021\/ac5039863","article-title":"Electrochemical sensors and biosensors based on nanomaterials and nanostructures","volume":"87","author":"Zhu","year":"2015","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0500","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1039\/D2SD00226D","article-title":"Carbon-based electrochemical biosensors as diagnostic platforms for connected decentralized healthcare","volume":"2","author":"Khan","year":"2023","journal-title":"Sens. Diagnos."},{"issue":"15","key":"10.1016\/j.cca.2025.120221_b0505","doi-asserted-by":"crossref","first-page":"6420","DOI":"10.1039\/C5NR00585J","article-title":"Carbon nanomaterial-based electrochemical biosensors: An overview","volume":"7","author":"Wang","year":"2015","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0510","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1021\/acsnano.5b05690","article-title":"Engineered carbon-nanomaterial-based electrochemical sensors for biomolecules","volume":"10","author":"Tiwari","year":"2016","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.cca.2025.120221_b0515","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.3390\/nano14231890","article-title":"Innovative carbonaceous materials and metal\/metal oxide nanoparticles for electrochemical biosensor applications","volume":"14","author":"Puttaningaiah","year":"2024","journal-title":"Nanomaterials (basel)"},{"issue":"19","key":"10.1016\/j.cca.2025.120221_b0520","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.3390\/s22197539","article-title":"Advances in electrochemical nano-biosensors for biomedical and environmental applications: From current work to future perspectives","volume":"22","author":"Hassan","year":"2022","journal-title":"Sensors (basel)."},{"key":"10.1016\/j.cca.2025.120221_b0525","doi-asserted-by":"crossref","unstructured":"U. Zupan\u010di\u010d, J. Rainbow, C. Flynn, J. Aidoo-Brown, P. Estrela, D. Moschou. Strategies for multiplexed electrochemical sensor development. Modern techniques in biosensors: Detection methods and commercial aspects. (2021) 63\u201393.","DOI":"10.1007\/978-981-15-9612-4_3"},{"key":"10.1016\/j.cca.2025.120221_b0530","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4939-6730-8_3","article-title":"Multiplex biomarker approaches in type 2 diabetes mellitus research","volume":"1546","author":"Ozanne","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0535","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/s22010161","article-title":"Advances in design strategies of multiplex electrochemical aptasensors","volume":"22","author":"Grabowska","year":"2021","journal-title":"Sensors (basel)"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0540","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1021\/acssensors.7b00840","article-title":"Beyond simple cartoons: Challenges in characterizing electrochemical biosensor interfaces","volume":"3","author":"Bizzotto","year":"2018","journal-title":"ACS Sens."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0545","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12933-024-02125-1","article-title":"Multiplexed MRM-based proteomics for identification of circulating proteins as biomarkers of cardiovascular damage progression associated with diabetes mellitus","volume":"23","author":"Piarulli","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"12","key":"10.1016\/j.cca.2025.120221_b0550","doi-asserted-by":"crossref","first-page":"30011","DOI":"10.3390\/s151229783","article-title":"Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications","volume":"15","author":"Luka","year":"2015","journal-title":"Sensors (basel)"},{"issue":"19","key":"10.1016\/j.cca.2025.120221_b0555","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.3390\/su141912844","article-title":"Microfluidic devices and microfluidics-integrated electrochemical and optical (Bio) Sensors for pollution analysis: a review","volume":"14","author":"Alhalaili","year":"2022","journal-title":"Sustainability"},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0560","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1038\/s41598-017-06144-9","article-title":"Single microfluidic electrochemical sensor system for simultaneous multi-pulmonary hypertension biomarker analyses","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120221_b0565","article-title":"Microfluidic integration for electrochemical biosensor applications","volume":"29","author":"Schmidt-Speicher","year":"2021","journal-title":"Curr. Opin. Electrochem."},{"issue":"19","key":"10.1016\/j.cca.2025.120221_b0570","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1039\/c3lc50437a","article-title":"Lab-on-CMOS integration of microfluidics and electrochemical sensors","volume":"13","author":"Huang","year":"2013","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120221_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2023.102978","article-title":"Sensor integration into microfluidic systems: trends and challenges","volume":"83","author":"Buttkewitz","year":"2023","journal-title":"Curr. Opin. Biotechnol."},{"issue":"3","key":"10.1016\/j.cca.2025.120221_b0580","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/bios11030085","article-title":"Immobilization-free electrochemical sensor coupled with a graphene-oxide-based aptasensor for glycated albumin detection","volume":"11","author":"Waiwinya","year":"2021","journal-title":"Biosensors (basel)"},{"issue":"13","key":"10.1016\/j.cca.2025.120221_b0585","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1039\/D1AN00556A","article-title":"Dual sensitive and rapid detection of glycated human serum albumin using a versatile lead\/graphene nanocomposite probe as a fluorescence\u2013electrochemical aptasensor","volume":"146","author":"Putnin","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2025.120221_b0590","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.2147\/IJN.S321480","article-title":"Neutral nonenzymatic glucose biosensors based on electrochemically deposited Pt\/Au nanoalloy electrodes","volume":"16","author":"Lin","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.cca.2025.120221_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2020.107645","article-title":"Platinum and zinc oxide modified carbon nitride electrode as non-enzymatic highly selective and reusable electrochemical diabetic sensor in human blood","volume":"137","author":"Imran","year":"2021","journal-title":"Bioelectrochemistry"},{"issue":"14","key":"10.1016\/j.cca.2025.120221_b0600","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1039\/D1NA00194A","article-title":"Determination of sitagliptin in human plasma using a smart electrochemical sensor based on electroactive molecularly imprinted nanoparticles","volume":"3","author":"Haq","year":"2021","journal-title":"Nanoscale Adv."},{"issue":"22","key":"10.1016\/j.cca.2025.120221_b0605","doi-asserted-by":"crossref","first-page":"13699","DOI":"10.3390\/ijms232213699","article-title":"Polydopamine nanoparticles functionalized electrochemical DNA aptasensor for serum glycated albumin detection","volume":"23","author":"Maraming","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2025.120221_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116358","article-title":"All-printed wearable biosensor based on MWCNT-iron oxide nanocomposite ink for physiological level detection of glucose in human sweat","volume":"258","author":"Shamili","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120221_b0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2023.115209","article-title":"MiR-29b detection in serum using an electrochemical biosensor for the early diagnosis of gestational diabetes","volume":"674","author":"Yan","year":"2023","journal-title":"Anal. Biochem."},{"issue":"7","key":"10.1016\/j.cca.2025.120221_b0620","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.3390\/ma16072786","article-title":"An efficient electrochemical biosensor to determine 1,5-anhydroglucitol with persimmon-tannin-reduced graphene oxide-PtPd nanocomposites","volume":"16","author":"Li","year":"2023","journal-title":"Materials (basel)"},{"key":"10.1016\/j.cca.2025.120221_b0625","article-title":"Grand challenges in nanomaterial-based electrochemical sensors","author":"Ferrag","year":"2020","journal-title":"Frontiers Media SA"},{"issue":"11","key":"10.1016\/j.cca.2025.120221_b0630","doi-asserted-by":"crossref","first-page":"986","DOI":"10.2174\/0115680266304711240327072348","article-title":"Nanomaterial-based electrochemical sensors for multiplex medicinal applications","volume":"24","author":"Traipop","year":"2024","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.cca.2025.120221_b0635","doi-asserted-by":"crossref","DOI":"10.1039\/D4SD00086B","article-title":"Advances in electrochemical sensors for real-time glucose monitoring","author":"Harun-Or-Rashid","year":"2024","journal-title":"Sens. Diagnost."},{"issue":"1","key":"10.1016\/j.cca.2025.120221_b0640","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jcla.20500","article-title":"Application of electrochemical biosensors in clinical diagnosis","volume":"26","author":"Monosik","year":"2012","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.cca.2025.120221_b0645","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.130349","article-title":"New challenges in point of care electrochemical detection of clinical biomarkers","volume":"345","author":"Campuzano","year":"2021","journal-title":"Sens. Actuators B"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125001007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125001007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:07:10Z","timestamp":1762114030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125001007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":129,"alternative-id":["S0009898125001007"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120221","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrochemical biosensors for enhanced detection of diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120221"}}