{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:11:55Z","timestamp":1768032715645,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.cca.2025.120323","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T06:05:31Z","timestamp":1746165931000},"page":"120323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Soluble thrombomodulin in preeclampsia: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"574","author":[{"given":"Jesiel Francisco","family":"de Jesus Fernandes Martins Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00edse Emilia","family":"Moreira da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"dos Santos Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Antonio","family":"Ferreira Freire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Barros-Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-2645","authenticated-orcid":false,"given":"Patr\u00edcia Nessralla","family":"Alpoim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cca.2025.120323_b0005","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1055\/s-0039-1687859","article-title":"Pre-eclampsia\/Eclampsia","volume":"41","author":"Pera\u00e7oli","year":"2019","journal-title":"Rev. Bras. Ginecol. Obstet."},{"issue":"11","key":"10.1016\/j.cca.2025.120323_b0010","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1055\/s-0037-1604103","article-title":"Preterm preeclampsia and timing of delivery: a systematic literature review","volume":"39","author":"Guida","year":"2017","journal-title":"Rev. BrasGinecol Obstet"},{"issue":"7","key":"10.1016\/j.cca.2025.120323_b0015","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/s-0042-1742680","article-title":"Prevalence of preeclampsia in Brazil: an integrative review","volume":"44","author":"Guida","year":"2022","journal-title":"Rev. BrasGinecol Obstet"},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1182\/blood.V75.2.329.329","article-title":"Structure and function of thrombomodulin: a natural anticoagulant","volume":"75","author":"Dittman","year":"1990","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1083\/jcb.101.2.363","article-title":"Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta","volume":"101","author":"Maruyama","year":"1985","journal-title":"J. Cell Biol."},{"issue":"10","key":"10.1016\/j.cca.2025.120323_b0030","article-title":"Roles of oxidative stress and inflammation in vascular endothelial dysfunction-related disease","volume":"11","author":"Higashi","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"9","key":"10.1016\/j.cca.2025.120323_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098237","article-title":"Endotheliopathy in Acute COVID-19 and Long COVID","volume":"24","author":"Vassiliou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.cca.2025.120323_b0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cca.2007.08.015","article-title":"Increased circulating thrombomodulin levels in pre-eclampsia","volume":"387","author":"Dusse","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120323_b0045","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cca.2018.04.039","article-title":"Oxidative stress markers and thrombomodulin plasma levels in women with early and late severe preeclampsia","volume":"483","author":"Alpoim","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0030-1270343","article-title":"Sources of thrombomodulin in pre-eclampsia: renal dysfunction or endothelial damage?","volume":"37","author":"Dusse","year":"2011","journal-title":"Semin. Thromb. Hemost."},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejogrb.2009.06.001","article-title":"Elevated circulating soluble thrombomodulin activity, tissue factor activity and circulating procoagulant phospholipids: new and useful markers for pre-eclampsia?","volume":"146","author":"Rousseau","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"4","key":"10.1016\/j.cca.2025.120323_b0060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000292631","article-title":"Increased levels of plasma thrombomodulin in preeclampsia","volume":"36","author":"Minakami","year":"1993","journal-title":"Gynecol. Obstet. Invest."},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0065","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9378(93)90151-8","article-title":"Elevated circulating thrombomodulin in severe preeclampsia","volume":"169","author":"Hsu","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0028-2243(95)02093-8","article-title":"Maternal plasma level of thrombomodulin is increased in mild preeclampsia","volume":"60","author":"Bontis","year":"1995","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.47391\/JPMA.7537","article-title":"Comparison of thrombomodulin, vWF, and ADAMTS13 levels between preeclampsia and normal pregnancy","volume":"74","author":"Ahmad","year":"2024","journal-title":"J. Pak. Med. Assoc."},{"key":"10.1016\/j.cca.2025.120323_b0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.placenta.2024.01.016","article-title":"Altered release of thrombomodulin and HMGB1 in the placenta complicated with preeclampsia","volume":"148","author":"Oda","year":"2024","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0085","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"issue":"9","key":"10.1016\/j.cca.2025.120323_b0090","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.cca.2025.120323_b0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d549","article-title":"Interpretation of random effects meta-analyses","volume":"342","author":"Riley","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.cca.2025.120323_b0100","unstructured":"Higgins, J., et al., Handbook for Systematic Reviews of Interventions, Cochrane, Editor. 2024."},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/ijh.ijh_46_22","article-title":"Increased thrombomodulin level in hypertensive disorders of pregnancy","volume":"11","author":"Hashim","year":"2022","journal-title":"Iraqi J. Hematology"},{"issue":"3","key":"10.1016\/j.cca.2025.120323_b0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1155\/2009\/658943","article-title":"Emerging role of endothelial and inflammatory markers in preeclampsia","volume":"26","author":"Swellam","year":"2009","journal-title":"Dis. Markers"},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0120","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/10641950802601195","article-title":"In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study","volume":"28","author":"Pottecher","year":"2009","journal-title":"Hypertens. Pregnancy"},{"issue":"3","key":"10.1016\/j.cca.2025.120323_b0125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/1076029607299986","article-title":"Hemostatic abnormalities in patients with severe preeclampsia","volume":"13","author":"Heilmann","year":"2007","journal-title":"Clin. Appl. Thromb. Hemost."},{"issue":"6","key":"10.1016\/j.cca.2025.120323_b0130","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1055\/s-0037-1615021","article-title":"Predictive value of plasma thrombomodulin in preeclampsia and gestational hypertension","volume":"79","author":"Boffa","year":"1998","journal-title":"Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.cca.2025.120323_b0135","doi-asserted-by":"crossref","first-page":"e6192","DOI":"10.1371\/journal.pone.0006192","article-title":"Search for an association between V249I and T280M CX3CR1 genetic polymorphisms, endothelial injury and preeclampsia: the ECLAXIR study","volume":"4","author":"Stepanian","year":"2009","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cca.2025.120323_b0140","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/cyto.b.20537","article-title":"Levels of circulating endothelial cells in normotensive and severe preeclamptic pregnancies","volume":"78","author":"Strijbos","year":"2010","journal-title":"Cytometry B Clin. Cytom."},{"issue":"4","key":"10.1016\/j.cca.2025.120323_b0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/labmed\/lmac128","article-title":"A retrospective case-control study on the diagnostic values of hemostatic markers in hypertensive disorder of pregnancy","volume":"54","author":"Sun","year":"2023","journal-title":"Lab. Med."},{"issue":"5","key":"10.1016\/j.cca.2025.120323_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23740","article-title":"Predictive values of various serum biomarkers in women with suspected preeclampsia: a prospective study","volume":"35","author":"Wang","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.cca.2025.120323_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1022770","article-title":"Circulating concentrations of glycocalyx degradation products in preeclampsia","volume":"13","author":"Carlberg","year":"2022","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0002-9378(86)90129-8","article-title":"Conservative management of preeclampsia","volume":"155","author":"Horvath","year":"1986","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2025.120323_b0165","unstructured":"Practice, A.C.o.O., ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet, 2002. 77(1): p. 67-75."},{"key":"10.1016\/j.cca.2025.120323_b0170","doi-asserted-by":"crossref","unstructured":"Bulletins\u2014Obstetrics, A.C.o.O.a.G.C.o.P., ACOG Practice Bulletin No. 203: Chronic Hypertension in Pregnancy. Obstet Gynecol, 2019. 133(1): p. e26-e50.","DOI":"10.1097\/AOG.0000000000003020"},{"key":"10.1016\/j.cca.2025.120323_b0175","doi-asserted-by":"crossref","unstructured":"Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol, 2020. 135(6): p. e237-e260.","DOI":"10.1097\/AOG.0000000000003891"},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0180","doi-asserted-by":"crossref","first-page":"IX","DOI":"10.3109\/10641950109152635","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.cca.2025.120323_b0190","doi-asserted-by":"crossref","unstructured":"Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol, 2000. 183(1): p. S1-S22.","DOI":"10.1067\/mob.2000.107928"},{"key":"10.1016\/j.cca.2025.120323_b0195","unstructured":"Shaarawy, M. and H.E. Didy, Trombomodulina, inibidor do ativador do plasminog\u00eanio tipo 1 (PAI-1) e fibronectina como biomarcadores de dano endotelial na pr\u00e9-ecl\u00e2mpsia e ecl\u00e2mpsia. 1 996: E gypt."},{"issue":"3","key":"10.1016\/j.cca.2025.120323_b0200","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/107155769700400304","article-title":"Antepartum and postpartum thrombomodulin levels in preeclamptic and normotensive pregnancies","volume":"4","author":"Hsu","year":"1997","journal-title":"J. Soc. Gynecol. Investig."},{"issue":"3","key":"10.1016\/j.cca.2025.120323_b0205","first-page":"425","article-title":"Thrombomodulin release from umbilical endothelial cells initiated by preeclampsia plasma-induced neutrophil activation","volume":"92","author":"Kobayashi","year":"1998","journal-title":"Obstet. Gynecol."},{"issue":"5\u20136","key":"10.1016\/j.cca.2025.120323_b0210","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1034\/j.1600-0609.2002.02691.x","article-title":"Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia","volume":"69","author":"Hayashi","year":"2002","journal-title":"Eur. J. Haematol."},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0215","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/1076029608325543","article-title":"Correlation between maternal plasma thrombomodulin and infant birth weight in hypertensive disorders of pregnancy","volume":"15","author":"Varol","year":"2009","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.cca.2025.120323_b0220","first-page":"009","article-title":"Evaluation of Serum level of thrombomodulin in cases with preeclampsia","author":"Mohammed","year":"2022","journal-title":"GinPolMedProject."},{"issue":"6","key":"10.1016\/j.cca.2025.120323_b0225","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0029-7844(95)00326-M","article-title":"Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension","volume":"86","author":"Hsu","year":"1995","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.cca.2025.120323_b0230","unstructured":"Shaarawy, M. and H.E. Didy, Trombomodulina, inibidor do ativador do plasminog\u00eanio tipo 1 (PAI-1) e fibronectina como biomarcadores de dano endotelial na pr\u00e9-ecl\u00e2mpsia e ecl\u00e2mpsia. 1996: E gypt."},{"issue":"2","key":"10.1016\/j.cca.2025.120323_b0235","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1182\/blood-2017-12-768994","article-title":"Exploring traditional and nontraditional roles for thrombomodulin","volume":"132","author":"Loghmani","year":"2018","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cca.2025.120323_b0240","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/cvr\/cvaa070","article-title":"The effects of sepsis on endothelium and clinical implications","volume":"117","author":"Dolmatova","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"1\u20132","key":"10.1016\/j.cca.2025.120323_b0245","first-page":"39","article-title":"Markers of endothelial activation in preeclampsia","volume":"61","author":"Prochazka","year":"2015","journal-title":"Clin. Lab."},{"key":"10.1016\/j.cca.2025.120323_b0250","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.placenta.2022.12.009","article-title":"Evaluation of oxidative stress markers in subtypes of preeclampsia: a systematic review and meta-analysis","volume":"132","author":"Freire","year":"2023","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.cca.2025.120323_b0255","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1055\/a-1801-2055","article-title":"Circulating thrombomodulin: release mechanisms, measurements, and levels in diseases and medical procedures","volume":"6","author":"Boron","year":"2022","journal-title":"TH Open"},{"key":"10.1016\/j.cca.2025.120323_b0260","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.575890","article-title":"Thrombomodulin as a physiological modulator of intravascular injury","volume":"11","author":"Watanabe-Kusunoki","year":"2020","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.cca.2025.120323_b0265","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00068-023-02369-8","article-title":"Assessment of soluble thrombomodulin and soluble endoglin as endothelial dysfunction biomarkers in seriously ill surgical septic patients: correlation with organ dysfunction and disease severity","volume":"50","author":"Khan","year":"2024","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"10.1016\/j.cca.2025.120323_b0270","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.cca.2025.120323_b0275","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1055\/s-0040-1713916","article-title":"Evaluation of angiogenic factors (PlGF and sFlt-1) in pre-eclampsia diagnosis","volume":"42","author":"S\u00e1","year":"2020","journal-title":"Rev. BrasGinecol. Obstet"},{"issue":"Suppl A","key":"10.1016\/j.cca.2025.120323_b0280","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1053\/plac.1999.0522","article-title":"Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia","volume":"21","author":"Caniggia","year":"2000","journal-title":"Placenta"}],"updated-by":[{"DOI":"10.1016\/j.cca.2025.120589","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000}},{"DOI":"10.1016\/j.cca.2025.120589","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000}}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125002025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125002025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T07:51:26Z","timestamp":1748073086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125002025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":56,"alternative-id":["S0009898125002025"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120323","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soluble thrombomodulin in preeclampsia: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120323","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120323"}}