{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:51:16Z","timestamp":1787698276065,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["60(0118)\/19\/EMR-II"],"award-info":[{"award-number":["60(0118)\/19\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.cca.2025.120335","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:05:34Z","timestamp":1745838334000},"page":"120335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Clinical correlations of plasma sphingosine-1-phosphate and sphingolipid key enzymes in severe dengue using laboratory and machine learning approach"],"prefix":"10.1016","volume":"574","author":[{"given":"Aashika Raagavi","family":"Jean Pierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Kasirajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva Ranganathan","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Sivaprakasam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithanya Syam","family":"Sahaya Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhansi Venkata Nagamani","family":"Josyula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa Rao","family":"Mutheneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veni","family":"Subramanyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-2977","authenticated-orcid":false,"given":"Agieshkumar Balakrishna","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120335_b0005","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1194\/jlr.R800073-JLR200","article-title":"Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease","volume":"50","author":"Merrill","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2025.120335_b0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cca.2025.120335_b0015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.matbio.2018.01.006","article-title":"Sphingolipid signaling in renal fibrosis","volume":"68\u201369","author":"Huwiler","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cca.2025.120335_b0020","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2875","article-title":"Sphingosine 1-phosphate and cancer","volume":"10","author":"Pyne","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cca.2025.120335_b0025","doi-asserted-by":"crossref","first-page":"25847","DOI":"10.1074\/jbc.R200008200","article-title":"The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind *","volume":"277","author":"Hannun","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cca.2025.120335_b0030","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1038\/s41467-022-31097-7","article-title":"A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants","volume":"13","author":"Farley","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cca.2025.120335_b0035","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3390\/v14061226","article-title":"Mosquito-borne flaviviruses and current therapeutic advances","volume":"14","author":"Qian","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.cca.2025.120335_b0040","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1515\/hsz-2014-0273","article-title":"Sphingolipids in viral infection","volume":"396","author":"Schneider-Schaulies","year":"2015","journal-title":"Biol. Chem."},{"key":"10.1016\/j.cca.2025.120335_b0045","doi-asserted-by":"crossref","first-page":"11761","DOI":"10.1128\/JVI.00638-10","article-title":"Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner","volume":"84","author":"Weng","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.cca.2025.120335_b0050","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/biom13020274","article-title":"Acid ceramidase deficiency: bridging gaps between clinical presentation mouse models, and future therapeutic interventions","volume":"13","author":"Kleynerman","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.cca.2025.120335_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178820","article-title":"Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro","volume":"12","author":"Tramontini Gomes de Sousa Cardozo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2025.120335_b0060","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.trsl.2021.02.001","article-title":"Expression dynamics of vascular endothelial markers: endoglin and syndecan-1 in predicting dengue disease outcome","volume":"232","author":"Mariappan","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.cca.2025.120335_b0065","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/1354750X.2024.2430997","article-title":"Severity prediction markers in dengue: a prospective cohort study using machine learning approach","volume":"29","author":"Jean Pierre","year":"2024","journal-title":"Biomarkers"},{"key":"10.1016\/j.cca.2025.120335_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113394","article-title":"Sphingosine 1-phosphate in acute dengue infection","volume":"9","author":"Gomes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2025.120335_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255358","article-title":"Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis","volume":"16","author":"Talukdar","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2025.120335_b0080","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jinf.2015.06.014","article-title":"Decreased plasma levels of the endothelial protective sphingosine-1-phosphate are associated with dengue-induced plasma leakage","volume":"71","author":"Michels","year":"2015","journal-title":"J. Infect."},{"key":"10.1016\/j.cca.2025.120335_b0085","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/1995-7645.377741","article-title":"Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China","volume":"16","author":"Wang","year":"2023","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.cca.2025.120335_b0090","doi-asserted-by":"crossref","first-page":"44645","DOI":"10.1074\/jbc.M112.423426","article-title":"Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (hdl)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1*","volume":"287","author":"Wilkerson","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cca.2025.120335_b0095","article-title":"Association between leucopenia, transaminitis, nonstructural protein one antigen (Ns1Ag) level, and thrombocytopenia in adult dengue patients in a tertiary care hospital: a cross-sectional study","volume":"16","author":"Ramalingam","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.cca.2025.120335_b0100","doi-asserted-by":"crossref","DOI":"10.11604\/pamj.2021.40.261.29795","article-title":"Liver function in dengue and its correlation with disease severity: a retrospective cross-sectional observational study in a tertiary care center in Coastal India","volume":"40","author":"Swamy","year":"2021","journal-title":"Pan Afr. Med. J."},{"key":"10.1016\/j.cca.2025.120335_b0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ejlt.200700024","article-title":"The functional role of sphingomyelin in cell membranes","volume":"109","author":"Slotte","year":"2007","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.cca.2025.120335_b0110","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/sj.bjc.6603400","article-title":"Targeting sphingosine-1-phosphate for cancer therapy","volume":"95","author":"Sabbadini","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2025.120335_b0115","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcb.2011.09.003","article-title":"Sphingosine-1-phosphate signaling and its role in diseasE","volume":"22","author":"Maceyka","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cca.2025.120335_b0120","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3390\/ijms23158082","article-title":"Ceramide\/Sphingosine 1-phosphate axis as a key target for diagnosis and treatment in alzheimer\u2019s disease and other neurodegenerative diseases","volume":"23","author":"Custodia","year":"2022","journal-title":"Int. J. Mol Sci"},{"key":"10.1016\/j.cca.2025.120335_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1392055","article-title":"Editorial: Sphingolipids in infections, diseases, and disorders","volume":"15","author":"Naz","year":"2024","journal-title":"Front Immunol."},{"key":"10.1016\/j.cca.2025.120335_b0130","doi-asserted-by":"crossref","first-page":"e2415","DOI":"10.1002\/rmv.2415","article-title":"Sphingosine-1-phosphate related signalling pathways manipulating virus replication","volume":"33","author":"Zhang","year":"2023","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.cca.2025.120335_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2023.101251","article-title":"Sphingosine 1-phosphate signaling during infection and immunity","volume":"92","author":"Mohammed","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cca.2025.120335_b0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-7091-1368-4_8","article-title":"The role of ceramide-1-phosphate in biological functions","author":"Hoeferlin","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.cca.2025.120335_b0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-511X-9-15","article-title":"Ceramide and ceramide 1-phosphate in health and disease","volume":"9","author":"Arana","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.cca.2025.120335_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108267","article-title":"Sphingomyelin synthase 1 supports two steps of rubella virus life cycle","volume":"26","author":"Yagi","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.cca.2025.120335_b0155","doi-asserted-by":"crossref","first-page":"37829","DOI":"10.1038\/srep37829","article-title":"Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus","volume":"6","author":"Taniguchi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120335_b0160","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1073\/pnas.1219909110","article-title":"Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins","volume":"110","author":"Tafesse","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125002141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125002141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:40:23Z","timestamp":1778708423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125002141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"alternative-id":["S0009898125002141"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120335","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical correlations of plasma sphingosine-1-phosphate and sphingolipid key enzymes in severe dengue using laboratory and machine learning approach","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120335"}}