{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:15:24Z","timestamp":1782836124823,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.cca.2025.120350","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:29:36Z","timestamp":1747204176000},"page":"120350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk"],"prefix":"10.1016","volume":"575","author":[{"given":"Kaleem","family":"Maqsood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaaf","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Roohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120350_b0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cca.2025.120350_b0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/eurheartj\/ehac031","article-title":"Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus","volume":"43","author":"Raman","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cca.2025.120350_b0015","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/jama.2020.14103","article-title":"Recovery from severe COVID-19: leveraging the lessons of survival from sepsis","volume":"324","author":"Prescott","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.cca.2025.120350_b0020","article-title":"Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study","volume":"6","author":"Augustin","year":"2021","journal-title":"Lancet Regional Health\u2013Eur."},{"key":"10.1016\/j.cca.2025.120350_b0025","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: a cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2025.120350_b0030","first-page":"392","article-title":"Post-COVID-19 syndrome: the persistent symptoms at the post-viral stage of the disease. A systematic review of the current data","author":"Salamanna","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.cca.2025.120350_b0035","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.28568","article-title":"Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review","volume":"4","author":"Groff","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.cca.2025.120350_b0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11883-021-00935-2","article-title":"COVID and cardiovascular disease: what we know in 2021","volume":"23","author":"Chilazi","year":"2021","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.cca.2025.120350_b0045","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41591-021-01292-y","article-title":"Attributes and predictors of long COVID","volume":"27","author":"Sudre","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cca.2025.120350_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101019","article-title":"Characterizing long COVID in an international cohort: 7 months of symptoms and their impact","volume":"38","author":"Davis","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.cca.2025.120350_b0055","doi-asserted-by":"crossref","unstructured":"N. Ziauddeen, D. Gurdasani, M.E. O\u2019Hara, C. Hastie, P. Roderick, G. Yao, N.A. Alwan, Characteristics of Long Covid: findings from a social media survey, MedRxiv, (2021), 2021.2003. 2021.21253968.","DOI":"10.1101\/2021.03.21.21253968"},{"key":"10.1016\/j.cca.2025.120350_b0060","article-title":"Acute phase reactants as novel predictors of cardiovascular disease","volume":"2012","author":"Ahmed","year":"2012","journal-title":"Int. Scholarly Res. Notices"},{"key":"10.1016\/j.cca.2025.120350_b0065","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3324\/haematol.2019.236901","article-title":"Fibrin (ogen) in human disease: both friend and foe","volume":"105","author":"Vilar","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.cca.2025.120350_b0070","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1089\/vim.2020.0062","article-title":"Correlation between relative nasopharyngeal virus RNA load and lymphocyte count disease severity in patients with COVID-19","volume":"34","author":"Liu","year":"2021","journal-title":"Viral Immunol."},{"key":"10.1016\/j.cca.2025.120350_b0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cca.2025.120350_b0080","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1080\/17474086.2020.1831383","article-title":"D-dimer level in COVID-19 infection: a systematic review","volume":"13","author":"Rostami","year":"2020","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.cca.2025.120350_b0085","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1172\/JCI93025","article-title":"CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis","volume":"128","author":"Guo","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cca.2025.120350_b0090","unstructured":"G. De Simone, A. di Masi, P. Ascenzi, Pseudo-Enzymatic Properties of Haptoglobin: Hemoglobin Complexes."},{"key":"10.1016\/j.cca.2025.120350_b0095","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/ajh.23623","article-title":"Haptoglobin testing in hemolysis: measurement and interpretation","volume":"89","author":"Shih","year":"2014","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.cca.2025.120350_b0100","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.7150\/ijbs.48400","article-title":"Immune response and COVID-19: a mirror image of sepsis","volume":"16","author":"Lopez-Collazo","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cca.2025.120350_b0105","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cca.2025.120350_b0110","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1073\/pnas.74.12.5421","article-title":"High resolution two-dimensional electrophoresis of human plasma proteins","volume":"74","author":"Anderson","year":"1977","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cca.2025.120350_b0115","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1002\/rcm.3752","article-title":"A comparative study of the accuracy of several de novo sequencing software packages for datasets derived by matrix\u2010assisted laser desorption\/ionisation and electrospray","volume":"22","author":"Bringans","year":"2008","journal-title":"Rapid Communications Mass Spectrometry: Inte. J. Devoted Rapid Dissemination Up\u2010to\u2010the\u2010Minute Res. Mass Spectrometry"},{"key":"10.1016\/j.cca.2025.120350_b0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/rth2.12191","article-title":"Fibrinogen and fibrin: an illustrated review","volume":"3","author":"Pieters","year":"2019","journal-title":"Res. Practice Thrombosis Haemostasis"},{"key":"10.1016\/j.cca.2025.120350_b0125","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/jth.15016","article-title":"Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis","volume":"18","author":"Nougier","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cca.2025.120350_b0130","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.2020006520","article-title":"COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection","volume":"136","author":"Al-Samkari","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.cca.2025.120350_b0135","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12185-022-03437-2","article-title":"Plasma biomarkers associated with survival and thrombosis in hospitalized COVID-19 patients","volume":"116","author":"Cabrera-Garcia","year":"2022","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.cca.2025.120350_b0140","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1097\/TA.0000000000002963","article-title":"Hypercoagulable viscoelastic blood clot characteristics in critically ill coronavirus disease, 2019 patients and associations with thrombotic complications","volume":"90","author":"Roh","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.cca.2025.120350_b0145","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S2213-2600(20)30243-5","article-title":"Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans","volume":"8","author":"Fox","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cca.2025.120350_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.734005","article-title":"Elevated plasma fibrinogen is associated with excessive inflammation and disease severity in COVID-19 patients","volume":"11","author":"Sui","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cca.2025.120350_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bvth.2025.100048","article-title":"Association of high \u03b3\u2032 fibrinogen levels with adverse events in patients with COVID-19","volume":"2","author":"Revollido","year":"2025","journal-title":"Blood Vessels, Thrombosis Hemostasis"},{"key":"10.1016\/j.cca.2025.120350_b0160","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.2147\/JIR.S483001","article-title":"High fibrinogen levels with diabetes mellitus are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease and acute coronary syndrome","author":"Xie","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cca.2025.120350_b0165","article-title":"Plasma haptoglobin concentrations are elevated in patients with coronary artery disease","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2025.120350_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242306","article-title":"Performance of serum apolipoprotein-A1 as a sentinel of Covid-19","volume":"15","author":"Poynard","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2025.120350_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-022-02272-7","article-title":"Plasma markers of COVID-19 severity: a pilot study","volume":"23","author":"Beimdiek","year":"2022","journal-title":"Respir. Res."},{"key":"10.1016\/j.cca.2025.120350_b0180","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00011-021-01445-2","article-title":"Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection","volume":"70","author":"Bahari","year":"2021","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.cca.2025.120350_b0185","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/biomedicines10030699","article-title":"Clinical interest of serum alpha-2 macroglobulin, apolipoprotein A1, and haptoglobin in patients with non-alcoholic fatty liver disease, with and without type 2 diabetes, before or during COVID-19","volume":"10","author":"Deckmyn","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.cca.2025.120350_b0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200305","article-title":"Pregestational overweight and obesity are associated with differences in gut microbiota composition and systemic inflammation in the third trimester","volume":"13","author":"Zacar\u00edas","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2025.120350_b0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12940-022-00851-1","article-title":"Air pollution and biomarkers of cardiovascular disease and inflammation in the Malm\u00f6 Diet and Cancer cohort","volume":"21","author":"Azzouz","year":"2022","journal-title":"Environ. Health"},{"key":"10.1016\/j.cca.2025.120350_b0200","first-page":"176","article-title":"Biomarcadores: antecedentes, clasificaci\u00f3n y gu\u00eda para su aplicaci\u00f3n en epidemiolog\u00eda nutricional","volume":"21","author":"Corella","year":"2015","journal-title":"Revista Espa\u00f1ola De Nutrici\u00f3n Comunitaria"},{"key":"10.1016\/j.cca.2025.120350_b0205","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10557-020-07084-9","article-title":"Thrombotic complications in patients with COVID-19: pathophysiological mechanisms, diagnosis, and treatment","volume":"35","author":"G\u0105secka","year":"2021","journal-title":"Cardiovasc. Drugs Ther."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125002293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125002293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:16:46Z","timestamp":1748477806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125002293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"alternative-id":["S0009898125002293"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120350","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120350"}}