{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:10:09Z","timestamp":1762114209894,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-Z22212","LBH-Z23277"],"award-info":[{"award-number":["LBH-Z22212","LBH-Z23277"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["YQ2022H007","LH2024G005"],"award-info":[{"award-number":["YQ2022H007","LH2024G005"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["PYMS2023-4"],"award-info":[{"award-number":["PYMS2023-4"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200304","82000381"],"award-info":[{"award-number":["82200304","82000381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M710985"],"award-info":[{"award-number":["2022M710985"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Project On Basic Research Business Fee of Heilongjiang Provincial Higher Education Institutions","award":["2022-KYYWF-0260"],"award-info":[{"award-number":["2022-KYYWF-0260"]}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cultivation Fund of the Second Affiliated Hospital of Harbin Medical University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cca.2025.120382","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T11:58:10Z","timestamp":1748001490000},"page":"120382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The impact of urinary metal exposure on cardiac injury measured by four high-sensitivity troponin assays in US adults: A nationwide cross-sectional study"],"prefix":"10.1016","volume":"576","author":[{"given":"Yilan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingsi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongpeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120382_b0005","first-page":"133","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Exp. Suppl."},{"key":"10.1016\/j.cca.2025.120382_b0010","doi-asserted-by":"crossref","unstructured":"G.A. Lamas, A. Bhatnagar, M.R. Jones, K.K. Mann, K. Nasir, M. Tellez-Plaza, F. Ujueta, A. Navas-Acien, E. American Heart Association Council on, Prevention, C. Council on, N. Stroke, L. Council on, H. Cardiometabolic, D. Council on Peripheral Vascular, D. Council on the Kidney in Cardiovascular, Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association, J. Am. Heart Assoc. 12(13) (2023) e029852.","DOI":"10.1161\/JAHA.123.029852"},{"key":"10.1016\/j.cca.2025.120382_b0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","author":"Jarup","year":"2003","journal-title":"Br. Med. Bull."},{"issue":"1","key":"10.1016\/j.cca.2025.120382_b0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/ATVBAHA.121.316358","article-title":"Toxic metals and subclinical atherosclerosis in carotid, femoral, and coronary vascular territories: the aragon workers health study","volume":"42","author":"Grau-Perez","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.cca.2025.120382_b0025","first-page":"371","article-title":"The carcinogenicity of metals in humans","volume":"8","author":"Hayes","year":"1997","journal-title":"Cancer Causes Control"},{"issue":"4","key":"10.1016\/j.cca.2025.120382_b0030","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s40572-016-0117-9","article-title":"Environmental metals and cardiovascular disease in adults: a systematic review beyond lead and cadmium","volume":"3","author":"Nigra","year":"2016","journal-title":"Curr. Environ. Health Rep."},{"issue":"10","key":"10.1016\/j.cca.2025.120382_b0035","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1289\/ehp.6751","article-title":"Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke","volume":"112","author":"Satarug","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.cca.2025.120382_b0040","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/EDE.0b013e31828b0631","article-title":"Cadmium exposure and incident cardiovascular disease","volume":"24","author":"Tellez-Plaza","year":"2013","journal-title":"Epidemiology"},{"issue":"7","key":"10.1016\/j.cca.2025.120382_b0045","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1289\/ehp.1104352","article-title":"Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population","volume":"120","author":"Tellez-Plaza","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cca.2025.120382_b0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-1-60327-492-0_6","article-title":"Lung cancer and exposure to metals: the epidemiological evidence","volume":"472","author":"Wild","year":"2009","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.cca.2025.120382_b0055","first-page":"H479","article-title":"Cardiovascular pathophysiology of environmental pollutants","volume":"286","author":"Bhatnagar","year":"2004","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"1","key":"10.1016\/j.cca.2025.120382_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15563650.2018.1497172","article-title":"Mechanisms of toxic cardiomyopathy","volume":"57","author":"Hantson","year":"2019","journal-title":"Clin. Toxicol. (Phila.)"},{"issue":"Pt 3","key":"10.1016\/j.cca.2025.120382_b0065","article-title":"Combined exposure to multiple metals on cardiovascular disease in NHANES under five statistical models","volume":"215","author":"Guo","year":"2022","journal-title":"Environ. Res."},{"issue":"Pt A","key":"10.1016\/j.cca.2025.120382_b0070","article-title":"Levels of a mixture of heavy metals in blood and urine and all-cause, cardiovascular disease and cancer mortality: a population-based cohort study","volume":"263","author":"Duan","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cca.2025.120382_b0075","article-title":"Environmental metals and cardiovascular disease","volume":"362","author":"Tellez-Plaza","year":"2018","journal-title":"BMJ"},{"issue":"22","key":"10.1016\/j.cca.2025.120382_b0080","first-page":"e368","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: executive summary: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"144","author":"Gulati","year":"2021","journal-title":"Circulation"},{"issue":"28","key":"10.1016\/j.cca.2025.120382_b0085","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1093\/eurheartj\/ehad328","article-title":"High-sensitivity troponins and mortality in the general population","volume":"44","author":"McEvoy","year":"2023","journal-title":"Eur. Heart J."},{"issue":"10","key":"10.1016\/j.cca.2025.120382_b0090","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/CIRCULATIONAHA.124.069414","article-title":"Association of urinary metals with cardiovascular disease incidence and all-cause mortality in the multi-ethnic study of atherosclerosis (MESA)","volume":"150","author":"Martinez-Morata","year":"2024","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.cca.2025.120382_b0095","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2015","journal-title":"J. Agric. Biol. Environ. Stat."},{"issue":"4","key":"10.1016\/j.cca.2025.120382_b0100","doi-asserted-by":"crossref","first-page":"47004","DOI":"10.1289\/EHP5838","article-title":"A Quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cca.2025.120382_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119356","article-title":"A review of practical statistical methods used in epidemiological studies to estimate the health effects of multi-pollutant mixture","volume":"306","author":"Yu","year":"2022","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.cca.2025.120382_b0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12933-023-01986-2","article-title":"Association of cardio-renal biomarkers and mortality in the U.S.: a prospective cohort study","volume":"22","author":"Yang","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"issue":"11","key":"10.1016\/j.cca.2025.120382_b0115","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1210\/clinem\/dgac504","article-title":"Low serum bicarbonate levels increase the risk of all-cause, cardiovascular disease, and cancer mortality in type 2 diabetes","volume":"107","author":"Li","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2025.120382_b0120","unstructured":"C.f.D.C.a. Prevention, National Health and Nutrition Examination Survey: 1999-2004 Data Documentation, Codebook, and Frequencies. https:\/\/wwwn.cdc.gov\/Nchs\/Nhanes\/1999-2000\/SSTROP_A.htm, (2022)."},{"key":"10.1016\/j.cca.2025.120382_b0125","unstructured":"IFCC, Contemporary cardiac troponin I and T assay analytical characteristics designated by manufacturer IFCC committee on clinical applications of cardiac bio-markers. https:\/\/ifcc.web.insd.dk\/media\/479434\/contemporary-cardiac-troponin-i-and-t-assay-analytical-characteristics-designatedby-manufacturer-v052022.pdf., (2023)."},{"issue":"1","key":"10.1016\/j.cca.2025.120382_b0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12933-023-02003-2","article-title":"Association between high sensitivity cardiac troponin and mortality risk in the non-diabetic population: findings from the national health and nutrition examination survey","volume":"22","author":"Liu","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cca.2025.120382_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106798","article-title":"Prenatal and postnatal exposures to four metals mixture and IQ in 6-year-old children: a prospective cohort study in South Korea","volume":"157","author":"Lee","year":"2021","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.cca.2025.120382_b0140","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","article-title":"Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures","volume":"16","author":"Bobb","year":"2015","journal-title":"Biostatistics"},{"issue":"6","key":"10.1016\/j.cca.2025.120382_b0145","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.cell.2021.01.043","article-title":"Hallmarks of environmental insults","volume":"184","author":"Peters","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cca.2025.120382_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104282","article-title":"Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: a prospective study in the UK Biobank","volume":"84","author":"Luo","year":"2022","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.cca.2025.120382_b0155","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1289\/ehp.1104020","article-title":"Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates","volume":"120","author":"Tellez-Plaza","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.cca.2025.120382_b0160","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1289\/ehp.0800317","article-title":"Population toxicokinetic modeling of cadmium for health risk assessment","volume":"117","author":"Amzal","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"22","key":"10.1016\/j.cca.2025.120382_b0165","doi-asserted-by":"crossref","first-page":"61659","DOI":"10.1007\/s11356-023-26451-1","article-title":"Associations of urinary and blood cadmium concentrations with all-cause mortality in US adults with chronic kidney disease: a prospective cohort study","volume":"30","author":"Zhang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"6","key":"10.1016\/j.cca.2025.120382_b0170","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/ije\/dyz061","article-title":"The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study","volume":"48","author":"Domingo-Relloso","year":"2019","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.cca.2025.120382_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/biostatistics\/kxac038","article-title":"Multiple exposure distributed lag models with variable selection","volume":"25","author":"Antonelli","year":"2023","journal-title":"Biostatistics"},{"key":"10.1016\/j.cca.2025.120382_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111433","article-title":"HDL cholesterol: a potential mediator of the association between urinary cadmium concentration and cardiovascular disease risk","volume":"208","author":"Xu","year":"2021","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812500261X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812500261X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:07:05Z","timestamp":1762114025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989812500261X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":36,"alternative-id":["S000989812500261X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120382","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of urinary metal exposure on cardiac injury measured by four high-sensitivity troponin assays in US adults: A nationwide cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120382"}}