{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:01:04Z","timestamp":1793239264645,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cca.2025.120451","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T11:01:34Z","timestamp":1751367694000},"page":"120451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Parathyroid hormone reference intervals revisited: a data-driven approach for age-related reference intervals in adults"],"prefix":"10.1016","volume":"577","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-8135","authenticated-orcid":false,"given":"Esra","family":"Payda\u015f Hataysal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruh Kemal","family":"\u0130\u015fman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120451_b0005","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5496710","article-title":"Parathyroid hormone measurement in chronic kidney disease: from basics to clinical implications","volume":"2019","author":"Kritmetapak","year":"2019","journal-title":"Int J Nephrol."},{"issue":"5","key":"10.1016\/j.cca.2025.120451_b0010","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1530\/EJE-07-0849","article-title":"Elevated serum parathyroid hormone predicts impaired survival prognosis in a general aged population","volume":"158","author":"Bj\u00f6rkman","year":"2008","journal-title":"Eur. J. Endocrinol."},{"issue":"7","key":"10.1016\/j.cca.2025.120451_b0015","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/a-1856-4900","article-title":"The Diagnosis of Normocalcaemic Hyperparathyroidism is Strikingly Dissimilar using Different Commercial Laboratory Assays","volume":"54","author":"Kalaria","year":"2022","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.cca.2025.120451_b0020","article-title":"Age-specific Reference Intervals of Abbott Intact PTH-Potential Impacts on Clinical Care","volume":"8(3):bvae004","author":"Kalaria","year":"2024","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.cca.2025.120451_b0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cca.2020.05.030","article-title":"Use of data mining in the establishment of age-adjusted reference intervals for parathyroid hormone","volume":"508","author":"Delgado","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.cca.2025.120451_b0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/cen.13486","article-title":"Parathyroid hormone: Data mining for age-related reference intervals in adults","volume":"88","author":"Farrell","year":"2018","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.cca.2025.120451_b0035","doi-asserted-by":"crossref","unstructured":"Cavalcante L, Brand\u00e3o C, Chiamolera MI, Biscolla RPM, Junior JVL, de S\u00e1 Tavares Russo P, et al. Big data-based parathyroid hormone (PTH) values emphasize need for age correction. J Endocrinol Invest. 2023;46(12):2525-33.","DOI":"10.1007\/s40618-023-02107-2"},{"issue":"5","key":"10.1016\/j.cca.2025.120451_b0040","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1210\/jc.2014-4370","article-title":"Brief Report: does PTH increase with Age, Independent of 25-Hydroxyvitamin D, Phosphate, Renal Function, and Ionized Calcium?","volume":"100","author":"Carrivick","year":"2015","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"2","key":"10.1016\/j.cca.2025.120451_b0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/clinchem\/36.2.265","article-title":"On dividing reference data into subgroups to produce separate reference ranges","volume":"36","author":"Harris","year":"1990","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2025.120451_b0050","doi-asserted-by":"crossref","first-page":"11224","DOI":"10.3389\/bjbs.2023.11224","article-title":"UK Reference Intervals for Parathyroid Hormone using Abbott Methods","volume":"80","author":"Mirzazadeh","year":"2023","journal-title":"Br. J. Biomed. Sci."},{"issue":"10","key":"10.1016\/j.cca.2025.120451_b0055","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s40618-023-02057-9","article-title":"Threshold of 25(OH)D and consequently adjusted parathyroid hormone reference intervals: data mining for relationship between vitamin D and parathyroid hormone","volume":"46","author":"Gong","year":"2023","journal-title":"J. Endocrinol. Invest."},{"issue":"8","key":"10.1016\/j.cca.2025.120451_b0060","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ki.2008.4","article-title":"Prevalence and severity of disordered mineral metabolism in Blacks with chronic kidney disease","volume":"73","author":"Guti\u00e9rrez","year":"2008","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.cca.2025.120451_b0065","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1093\/ndt\/gfq316","article-title":"Racial differences in postprandial mineral ion handling in health and in chronic kidney disease","volume":"25","author":"Guti\u00e9rrez","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"issue":"5","key":"10.1016\/j.cca.2025.120451_b0070","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1080\/09637486.2018.1551335","article-title":"The effect of multiple nutrients on plasma parathyroid hormone level in healthy individuals","volume":"70","author":"Popovi\u0107","year":"2019","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.cca.2025.120451_b0075","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/732636","article-title":"Associations of Sun Exposure with 25-Hydroxyvitamin D and Parathyroid Hormone Levels in a Cohort of Hypertensive patients: the Graz Endocrine Causes of Hypertension (GECOH) study","volume":"2012","author":"Pilz","year":"2012","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.cca.2025.120451_b0080","doi-asserted-by":"crossref","unstructured":"Anderson JL, Vanwoerkom RC, Horne BD, Bair TL, May HT, Lapp\u00e9 DL, et al. Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors? Am Heart J. 2011;162(2):331-9.e2.","DOI":"10.1016\/j.ahj.2011.05.005"},{"issue":"1","key":"10.1016\/j.cca.2025.120451_b0085","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.eprac.2021.09.005","article-title":"Association of Serum Parathyroid Hormone Levels with All-Cause and Cause-Specific Mortality among U.S","volume":"28","author":"Kato","year":"2022","journal-title":"Adults. Endocr Pract."},{"issue":"11","key":"10.1016\/j.cca.2025.120451_b0090","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1210\/jc.2012-1551","article-title":"25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study","volume":"97","author":"Kritchevsky","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.cca.2025.120451_b0095","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/jbmr.2795","article-title":"Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling older adults: a Population-based prospective Cohort Study in Brazil. the S\u00e3o Paulo Ageing & Health (SPAH) study","volume":"31","author":"Domiciano","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.cca.2025.120451_b0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.arr.2012.06.001","article-title":"Age-related changes in the response of intestinal cells to 1\u03b1,25(OH)2-vitamin D3","volume":"12","author":"Gonzalez Pardo","year":"2013","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"10.1016\/j.cca.2025.120451_b0105","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ajcn\/80.4.998","article-title":"Effect of age on calcium absorption in postmenopausal women","volume":"80","author":"Nordin","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"issue":"7","key":"10.1016\/j.cca.2025.120451_b0110","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1056\/NEJM198108133050704","article-title":"Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients","volume":"305","author":"Slovik","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2025.120451_b0115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cca.2020.03.020","article-title":"Oxidation of parathyroid hormone","volume":"506","author":"Ursem","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.cca.2025.120451_b0120","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.bbrc.2016.11.150","article-title":"Oxidation inhibits PTH receptor signaling and trafficking","volume":"482","author":"Ardura","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.cca.2025.120451_b0125","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s40618-019-01075-w","article-title":"Parathyroid hormone reference ranges in healthy individuals classified by vitamin D status","volume":"42","author":"Yalla","year":"2019","journal-title":"J. Endocrinol. Invest."},{"issue":"4","key":"10.1016\/j.cca.2025.120451_b0130","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1210\/jc.2013-3349","article-title":"Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values","volume":"99","author":"Touvier","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.cca.2025.120451_b0135","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2265.2000.00912.x","article-title":"The effects of age and gender on parathyroid hormone dynamics","volume":"52","author":"Haden","year":"2000","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"5","key":"10.1016\/j.cca.2025.120451_b0140","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1590\/S0004-27302011000500003","article-title":"Normocalcemic primary hyperparathyroidism in clinical practice: an indolent condition or a silent threat?","volume":"55","author":"Marques","year":"2011","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"issue":"4","key":"10.1016\/j.cca.2025.120451_b0145","doi-asserted-by":"crossref","first-page":"e1171","DOI":"10.1210\/clinem\/dgaa084","article-title":"Normocalcemic Hyperparathyroidism: Study of its Prevalence and Natural history","volume":"105","author":"Schini","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.cca.2025.120451_b0150","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/imj.15502","article-title":"Normocalcaemic primary hyperparathyroidism: is nephrolithiasis more common than osteoporosis?","volume":"53","author":"Wu","year":"2023","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.cca.2025.120451_b0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cca.2016.10.016","article-title":"Perspective and priorities for improvement of parathyroid hormone (PTH) measurement - a view from the IFCC Working Group for PTH","volume":"467","author":"Sturgeon","year":"2017","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.cca.2025.120451_b0160","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.ki.5001606","article-title":"Inter-method variability in PTH measurement: Implication for the care of CKD patients","volume":"70","author":"Souberbielle","year":"2006","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.cca.2025.120451_b0165","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1515\/cclm-2018-0300","article-title":"Moving from the second to the third generation Roche PTH assays: what are the consequences for clinical practice?","volume":"57","author":"Dupuy","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"issue":"9","key":"10.1016\/j.cca.2025.120451_b0170","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.clinbiochem.2013.01.016","article-title":"Comparison of the Elecsys PTH(1-84) assay with four contemporary second generation intact PTH assays and association with other biomarkers in chronic kidney disease patients","volume":"46","author":"Tan","year":"2013","journal-title":"Clin. Biochem."},{"issue":"10","key":"10.1016\/j.cca.2025.120451_b0175","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.metabol.2013.05.007","article-title":"Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients","volume":"62","author":"Gannag\u00e9-Yared","year":"2013","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.cca.2025.120451_b0180","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.ajkd.2008.01.017","article-title":"Variation in serum and plasma PTH levels in second-generation assays in hemodialysis patients: a cross-sectional study","volume":"51","author":"Joly","year":"2008","journal-title":"Am. J. Kidney Dis."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125003304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125003304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T21:45:12Z","timestamp":1753134312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125003304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":36,"alternative-id":["S0009898125003304"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120451","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid hormone reference intervals revisited: a data-driven approach for age-related reference intervals in adults","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120451"}}