{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:33:03Z","timestamp":1790353983824,"version":"4.1.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomeranian Medical University in Szczecin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cca.2025.120515","type":"journal-article","created":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T14:05:08Z","timestamp":1753625108000},"page":"120515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The role of lipidomics in psoriasis"],"prefix":"10.1016","volume":"578","author":[{"given":"Dominika","family":"Boboryko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra Wiktoria","family":"Bratborska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patryk","family":"Sk\u00f3rka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-1208","authenticated-orcid":false,"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.cca.2025.120515_b0005","doi-asserted-by":"crossref","first-page":"12793","DOI":"10.3390\/ijms222312793","article-title":"The Cytokine Mediated Molecular Pathophysiology of Psoriasis and its Clinical Implications","volume":"22","author":"Singh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","article-title":"Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies","volume":"80","author":"Alinaghi","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12291-011-0132-4","article-title":"C-Reactive Protein and Uric Acid Levels in patients with Psoriasis. Indian","volume":"26","author":"Isha","year":"2011","journal-title":"J Clin Biochem."},{"key":"10.1016\/j.cca.2025.120515_b0020","doi-asserted-by":"crossref","unstructured":"Grechin C, Solov\u0103stru L, V\u00e2\u021b\u0103 D, P\u0103tra\u0219cu A, Gr\u0103jdeanu A, Porumb\u2011Andrese E. Inflammatory marker alteration in response to systemic therapies in psoriasis. Exp Ther Med [Internet]. 2020 Feb 18 [cited 2025 Jul 6]; Available from: http:\/\/www.spandidos-publications.com\/10.3892\/etm.2020.8535.","DOI":"10.3892\/etm.2020.8535"},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4274\/turkderm.05025","article-title":"Effect of psoriasis severity on inflammation parameters: Controlled study","volume":"52","author":"G\u00f6kalp","year":"2018","journal-title":"TURKDERM"},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13075-020-2111-8","article-title":"A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations","volume":"22","author":"Sokolova","year":"2020","journal-title":"Arthritis Res. Ther."},{"issue":"10","key":"10.1016\/j.cca.2025.120515_b0035","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s10067-020-05065-9","article-title":"Elevated CRP even at the first visit to a rheumatologist is associated with long-term poor outcomes in patients with psoriatic arthritis","volume":"39","author":"Haroon","year":"2020","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.cca.2025.120515_b0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4081\/reumatismo.2012.88","article-title":"Biomarkers and prognostic stratification in psoriatic arthritis","volume":"64","author":"Bogliolo","year":"2012","journal-title":"Reumatismo"},{"key":"10.1016\/j.cca.2025.120515_b0045","doi-asserted-by":"crossref","unstructured":"Yang X, Pan Y, Zhang Y, Meng Y, Tong T, Zhao M. Association of systemic immune-inflammation index (SII) with risk of psoriasis: a cross-sectional analysis of National Health and Nutrition Examination Survey 2011\u20132014. Eur J Med Res [Internet]. 2025 Jan 29 [cited 2025 Jul 11];30(1). Available from: https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-02304-0.","DOI":"10.1186\/s40001-025-02304-0"},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/acr.22926","article-title":"Risk of Cardiovascular Morbidity in patients with Psoriatic Arthritis: a Meta\u2010Analysis of Observational Studies","volume":"69","author":"Polachek","year":"2017","journal-title":"Arthritis Care Res."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/ijms19010058","article-title":"Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis","volume":"19","author":"Puig","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0060","article-title":"Psoriasis increased the risk of adverse Cardiovascular Outcomes: a New Systematic Review and Meta-Analysis of Cohort Study","volume":"25","author":"Liu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cca.2025.120515_b0065","doi-asserted-by":"crossref","DOI":"10.1155\/dth\/5568546","article-title":"Noncoding RNAs in Atopic Dermatitis: Insight into Inflammation and Immune Regulation","author":"Zhu","year":"2025","journal-title":"Yao z, Editor. Dermatol Ther [internet]."},{"key":"10.1016\/j.cca.2025.120515_b0070","doi-asserted-by":"crossref","unstructured":"Zhou X, Li H, Xie Z. METTL3-modified exosomes from adipose-derived stem cells enhance the proliferation and migration of dermal fibroblasts by mediating m6A modification of CCNB1 mRNA. Arch Dermatol Res [Internet]. 2025 Feb 15 [cited 2025 Jul 11];317(1). Available from: https:\/\/link.springer.com\/10.1007\/s00403-025-03896-7.","DOI":"10.1007\/s00403-025-03896-7"},{"key":"10.1016\/j.cca.2025.120515_b0075","doi-asserted-by":"crossref","unstructured":"Elgueta E, Prieto CP, Hartmann D, Carrillo D, Edwards N, Mart\u00ednez C, et al. Novel sponge formulation of mesenchymal stem cell secretome and hyaluronic acid: a safe and effective topical therapy for Psoriasis vulgaris. Stem Cell Res Ther [Internet]. 2025 Jul 6 [cited 2025 Jul 11];16(1). Available from: https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04415-1.","DOI":"10.1186\/s13287-025-04415-1"},{"issue":"10","key":"10.1016\/j.cca.2025.120515_b0080","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2174\/1566524022666211217102105","article-title":"Metabolomics Work Flow and Analytics in Systems Biology","volume":"22","author":"Chacko","year":"2022","journal-title":"Curr. Mol. Med."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0085","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/mas.21562","article-title":"Challenges and emergent solutions for LC\u2010MS\/MS based untargeted metabolomics in diseases","volume":"37","author":"Cui","year":"2018","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.cca.2025.120515_b0090","doi-asserted-by":"crossref","unstructured":"Spathies J, Ratley G, D\u2019Souza BN, Sun AA, Gough P, Chaudhary PP, et al. Skin imaging mass spectrometry of controls versus atopic dermatitis patients with and without STAT3 mutations. iScience. 2025 Jun;28(6):112644.","DOI":"10.1016\/j.isci.2025.112644"},{"key":"10.1016\/j.cca.2025.120515_b0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01399-3","article-title":"Small molecule metabolites: discovery of biomarkers and therapeutic targets","author":"Qiu","year":"2023","journal-title":"Signal Transduct Target Ther [internet]."},{"issue":"7","key":"10.1016\/j.cca.2025.120515_b0100","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.cca.2025.120515_b0105","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.ajhg.2022.08.007","article-title":"Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk","volume":"109","author":"Yin","year":"2022","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0110","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1038\/s41467-023-42682-9","article-title":"Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis","volume":"14","author":"\u00c5kesson","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-023-01229-9","article-title":"Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0120","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1194\/jlr.M071738","article-title":"Sweat lipid mediator profiling: a noninvasive approach for cutaneous research","volume":"58","author":"Agrawal","year":"2017","journal-title":"J. Lipid Res."},{"issue":"5","key":"10.1016\/j.cca.2025.120515_b0125","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jid.2024.09.003","article-title":"Current Insights on Lipidomics in Dermatology: a Systematic Review","volume":"145","author":"Sanabria-de La Torre","year":"2025","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cca.2025.120515_b0130","doi-asserted-by":"crossref","unstructured":"Zhou Y, Ding Y, Cui M, Zhang Y, Wang M, Zhou F, et al. Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe Psoriasis. Med Sci Monit [Internet]. 2024 Mar 12 [cited 2025 Jul 11];30. Available from: https:\/\/www.medscimonit.com\/abstract\/index\/idArt\/943360.","DOI":"10.12659\/MSM.943360"},{"key":"10.1016\/j.cca.2025.120515_b0135","doi-asserted-by":"crossref","unstructured":"Zeng C, Wen B, Hou G, Lei L, Mei Z, Jia X, et al. Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis. GigaScience [Internet]. 2017 Oct 1 [cited 2025 Jul 11];6(10). Available from: https:\/\/academic.oup.com\/gigascience\/article\/doi\/10.1093\/gigascience\/gix087\/4103626.","DOI":"10.1093\/gigascience\/gix087"},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0140","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12944-023-01999-6","article-title":"Serum lipidomic study of long-chain fatty acids in psoriasis patients prior to and after anti-IL-17A monoclonal antibody treatment by quantitative GC-MS analysis with in situ extraction","volume":"23","author":"Guo","year":"2024","journal-title":"Lipids Health Dis."},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0145","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/ics.12942","article-title":"Lipidomic analysis of facial skin surface lipids in acne in young women","volume":"46","author":"Su","year":"2024","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.cca.2025.120515_b0150","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-021-01802-6","article-title":"Interpreting the lipidome: bioinformatic approaches to embrace the complexity","author":"Kyle","year":"2021","journal-title":"Metabolomics [internet]."},{"issue":"8","key":"10.1016\/j.cca.2025.120515_b0155","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrm2934","article-title":"Lipidomics: coming to grips with lipid diversity","volume":"11","author":"Shevchenko","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0160","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/biom8040174","article-title":"Quantification of Lipids: Model, reality, and Compromise","volume":"8","author":"Khoury","year":"2018","journal-title":"Biomolecules"},{"issue":"16","key":"10.1016\/j.cca.2025.120515_b0165","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159762","article-title":"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes","volume":"7","author":"Merleev","year":"2022","journal-title":"JCI Insight"},{"issue":"11","key":"10.1016\/j.cca.2025.120515_b0170","article-title":"The Skin Epilipidome in stress, Aging, and Inflammation","volume":"21","author":"Gruber","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.cca.2025.120515_b0175","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00403-024-03294-5","article-title":"The impact of lipidome on five inflammatory skin diseases: a Mendelian randomization study","volume":"316","author":"Zhu","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.cca.2025.120515_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108681","article-title":"Bioactive lipids in the skin barrier mediate its functionality in health and disease","volume":"260","author":"Nicolaou","year":"2024","journal-title":"Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.cca.2025.120515_b0185","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s00403-024-03217-4","article-title":"Assessing the genetic associations between plasma lipidomic profiles and psoriasis vulgaris","volume":"316","author":"Zhang","year":"2024","journal-title":"Arch. Dermatol. Res."},{"issue":"12","key":"10.1016\/j.cca.2025.120515_b0190","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.jid.2022.06.015","article-title":"Serum Lipids and risk of Incident Psoriasis: a prospective Cohort Study from the UK Biobank Study and Mendelian Randomization Analysis","volume":"142","author":"Xiao","year":"2022","journal-title":"J. Invest. Dermatol."},{"issue":"14","key":"10.1016\/j.cca.2025.120515_b0195","article-title":"The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysis","volume":"22","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.cca.2025.120515_b0200","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/bjd\/ljae089","article-title":"Elevated plasma triglycerides increase the risk of psoriasis: a cohort and Mendelian randomization study","volume":"191","author":"Greve","year":"2024","journal-title":"Br. J. Dermatol."},{"issue":"7","key":"10.1016\/j.cca.2025.120515_b0205","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00403-017-1760-1","article-title":"The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease","volume":"309","author":"Ottas","year":"2017","journal-title":"Arch. Dermatol. Res."},{"issue":"13","key":"10.1016\/j.cca.2025.120515_b0210","article-title":"Integrative lipidomic features identify plasma lipid signatures in chronic urticaria","volume":"28","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.cca.2025.120515_b0215","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.3390\/ijms21186592","article-title":"Cannabidiol-Mediated changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic patients","volume":"21","author":"\u0141uczaj","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0220","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jaad.2014.01.891","article-title":"The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products","volume":"71","author":"Meckfessel","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0225","first-page":"422","article-title":"Ceramide synthesis in the epidermis","volume":"1841","author":"Rabionet","year":"2014","journal-title":"Biochim Biophys Acta BBA - Mol Cell Biol Lipids."},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0230","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/ics.12972","article-title":"The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications","volume":"46","author":"Schild","year":"2024","journal-title":"Int. J. Cosmet. Sci."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0235","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.biochi.2009.04.001","article-title":"Ceramide biosynthesis in keratinocyte and its role in skin function","volume":"91","author":"Mizutani","year":"2009","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0240","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s40257-021-00619-2","article-title":"Ceramides in Skin Health and Disease: an Update","volume":"22","author":"Uchida","year":"2021","journal-title":"Am. J. Clin. Dermatol."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0245","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jdermsci.2019.12.002","article-title":"The role of ceramides in skin homeostasis and inflammatory skin diseases","volume":"97","author":"Li","year":"2020","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0250","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3346\/jkms.2006.21.1.95","article-title":"Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-\u03b1, and JNK","volume":"21","author":"Lew","year":"2006","journal-title":"J. Korean Med. Sci."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0255","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.0022-202X.2004.23469.x","article-title":"Alterations of Glucosylceramide-\u03b2-Glucosidase Levels in the Skin of patients with Psoriasis Vulgaris","volume":"123","author":"Alessandrini","year":"2004","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0260","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/jid.2013.440","article-title":"The adverse effect of IFN Gamma on Stratum Corneum Structure and Function in Psoriasis and Atopic Dermatitis","volume":"134","author":"Feingold","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12895-020-00102-1","article-title":"The ceramide [NP]\/[NS] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation","volume":"20","author":"Yokose","year":"2020","journal-title":"BMC Dermatol."},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0270","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/molecules25030630","article-title":"Lipidomic Analysis reveals specific differences between Fibroblast and Keratinocyte Ceramide Profile of patients with Psoriasis Vulgaris","volume":"25","author":"\u0141uczaj","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.cca.2025.120515_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100094","article-title":"Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions","volume":"62","author":"Tyrrell","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2025.120515_b0280","article-title":"Lipidomic profiling reveals metabolic signatures in psoriatic skin lesions","volume":"246","author":"Liu","year":"2023","journal-title":"Clin Immunol Orlando Fla."},{"issue":"8","key":"10.1016\/j.cca.2025.120515_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100591","article-title":"Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial","volume":"65","author":"Rousel","year":"2024","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0290","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/annrheumdis-2019-216374","article-title":"Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis","volume":"79","author":"Souto-Carneiro","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0295","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3390\/biom14091114","article-title":"Novel Fatty Acid Biomarkers in Psoriasis and the Role of Modifiable Factors: results from the METHAP Clinical Study","volume":"14","author":"Sarandi","year":"2024","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.cca.2025.120515_b0300","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.jid.2021.02.755","article-title":"Investigation of Omega-3 Polyunsaturated Fatty Acid Biological activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells","volume":"141","author":"Simard","year":"2021","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0305","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3390\/cells11091513","article-title":"Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model","volume":"11","author":"Morin","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cca.2025.120515_b0310","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.actbio.2021.11.021","article-title":"\u03b1-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model","volume":"140","author":"Simard","year":"2022","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0315","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3390\/biom13091413","article-title":"Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells","volume":"13","author":"Morin","year":"2023","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.cca.2025.120515_b0320","article-title":"Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway","volume":"1866","author":"Morin","year":"2021","journal-title":"Biochim Biophys Acta BBA - Mol Cell Biol Lipids."},{"issue":"10","key":"10.1016\/j.cca.2025.120515_b0325","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1002\/fsn3.3543","article-title":"The effects of unsaturated fatty acids on psoriasis: a two\u2010sample Mendelian randomization study","volume":"11","author":"Lei","year":"2023","journal-title":"Food Sci. Nutr."},{"issue":"7","key":"10.1016\/j.cca.2025.120515_b0330","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13840","article-title":"Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis","volume":"30","author":"Wang","year":"2024","journal-title":"Skin Res. Technol."},{"key":"10.1016\/j.cca.2025.120515_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109348","article-title":"Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction","volume":"117","author":"Sorokin","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cca.2025.120515_b0340","doi-asserted-by":"crossref","unstructured":"Sarandi E, Thanasoula M, Anamaterou C, Papakonstantinou E, Geraci F, Papamichael MM, et al. Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases. In: Advances in Clinical Chemistry [Internet]. Elsevier; 2021 [cited 2024 Dec 18]. p. 169\u2013229. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065242320300755.","DOI":"10.1016\/bs.acc.2020.06.003"},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0345","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fmolb.2019.00120","article-title":"Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases","volume":"1","author":"Tsoukalas","year":"2019","journal-title":"Front. Mol. Biosci."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0350","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/jid.2015.41","article-title":"Distribution of Bioactive Lipid Mediators in Human Skin","volume":"135","author":"Kendall","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.cca.2025.120515_b0355","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1515\/hsz-2017-0146","article-title":"Immune-regulation and -functions of eicosanoid lipid mediators","volume":"398","author":"Esser-von","year":"2017","journal-title":"Biol. Chem."},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0360","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jacl.2018.03.091","article-title":"Identification of proresolving and inflammatory lipid mediators in human psoriasis","volume":"12","author":"Sorokin","year":"2018","journal-title":"J. Clin. Lipidol."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0365","first-page":"766","article-title":"Phospholipase A2 catalysis and lipid mediator lipidomics","volume":"1864","author":"Mouchlis","year":"2019","journal-title":"Biochim Biophys Acta BBA - Mol Cell Biol Lipids."},{"key":"10.1016\/j.cca.2025.120515_b0370","doi-asserted-by":"crossref","unstructured":"Tsirvouli E, Ashcroft F, Johansen B, Kuiper M. Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes. iScience. 2021 Dec;24(12):103451.","DOI":"10.1016\/j.isci.2021.103451"},{"key":"10.1016\/j.cca.2025.120515_b0375","doi-asserted-by":"crossref","DOI":"10.3390\/ph15091039","article-title":"Leukotrienes vs. Montelukast\u2014Activity, Metabolism, and Toxicity Hints for Repurposing","author":"Marques","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0380","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jaad.2004.04.026","article-title":"Expression of cysteinyl leukotriene receptor-1 in skin","volume":"51","author":"Hussain","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0385","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.7150\/ijbs.92514","article-title":"CYSLTR1 antagonist inhibits Th17 cell differentiation by regulating the NF-\u03baB signaling for the treatment of psoriasis","volume":"20","author":"Zhao","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0390","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.4049\/jimmunol.1302959","article-title":"Interplay between CXCR2 and BLT1 Facilitates Neutrophil Infiltration and Resultant Keratinocyte Activation in a Murine Model of Imiquimod-Induced Psoriasis","volume":"192","author":"Sumida","year":"2014","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0395","doi-asserted-by":"crossref","first-page":"11873","DOI":"10.1038\/s41598-018-30373-1","article-title":"Resolvin E1 attenuates murine psoriatic dermatitis","volume":"8","author":"Sawada","year":"2018","journal-title":"Sci. Rep."},{"issue":"193","key":"10.1016\/j.cca.2025.120515_b0400","first-page":"1","article-title":"derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice","volume":"20","author":"Malabaricone","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0405","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000246631","article-title":"Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis","volume":"190","author":"Kawana","year":"1995","journal-title":"Dermatol Basel Switz."},{"issue":"2","key":"10.1016\/j.cca.2025.120515_b0410","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jaci.2018.01.054","article-title":"Thromboxane A2 facilitates IL-17A production from V\u03b34+ \u03b3\u03b4 T cells and promotes psoriatic dermatitis in mice","volume":"142","author":"Ueharaguchi","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.cca.2025.120515_b0415","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jaci.2018.05.036","article-title":"T cell\u2013intrinsic prostaglandin E2-EP2\/EP4 signaling is critical in pathogenic TH17 cell\u2013driven inflammation","volume":"143","author":"Lee","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0420","doi-asserted-by":"crossref","first-page":"16591","DOI":"10.1038\/s41598-021-96043-x","article-title":"Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin","volume":"11","author":"Okoro","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.cca.2025.120515_b0425","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3390\/biomedicines10051078","article-title":"Remodeling of the Dermal Extracellular Matrix in a Tissue-Engineered Psoriatic Skin Model by n-3 Polyunsaturated Fatty Acids","volume":"10","author":"Simard","year":"2022","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0430","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11306-019-1527-0","article-title":"Pro- and anti-inflammatory eicosanoids in psoriatic arthritis","volume":"15","author":"Coras","year":"2019","journal-title":"Metabolomics"},{"issue":"13","key":"10.1016\/j.cca.2025.120515_b0435","article-title":"Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis","volume":"4","author":"Kong","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2025.120515_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110305","article-title":"Metabolomic and lipidomic fingerprints in inflammatory skin diseases \u2013 Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasis","volume":"265","author":"Rischke","year":"2024","journal-title":"Clin. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0445","doi-asserted-by":"crossref","first-page":"118","DOI":"10.31083\/j.fbl2806118","article-title":"The Role of Oxidative stress in the Induction and Development of Psoriasis","volume":"28","author":"Blagov","year":"2023","journal-title":"Front Biosci-Landmark."},{"key":"10.1016\/j.cca.2025.120515_b0450","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101958R","article-title":"Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti\u2010inflammatory lipid N \u2010acylethanolamine","author":"Liang","year":"2022","journal-title":"FASEB J [internet]."},{"key":"10.1016\/j.cca.2025.120515_b0455","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biochi.2023.09.027","article-title":"Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2","volume":"215","author":"Hakoi","year":"2023","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0460","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000529253","article-title":"Evaluation of a Novel Skin Emollient Cream on Skin Lipidome and Lipid Organization","volume":"36","author":"Jacques","year":"2023","journal-title":"Skin Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0465","doi-asserted-by":"crossref","first-page":"7207","DOI":"10.1038\/s41598-023-34073-3","article-title":"Ultraviolet exposure regulates skin metabolome based on the microbiome","volume":"13","author":"Patra","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0470","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.bbamem.2017.03.016","article-title":"Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model","volume":"1859","author":"Kendall","year":"2017","journal-title":"Biochim Biophys Acta BBA - Biomembr."},{"issue":"3","key":"10.1016\/j.cca.2025.120515_b0475","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2340\/00015555-3384","article-title":"Psoriasis and Genetics","volume":"100","author":"Dand","year":"2020","journal-title":"Acta Derm. Venereol."},{"issue":"9","key":"10.1016\/j.cca.2025.120515_b0480","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/toxins16090401","article-title":"Astaxanthin Alleviates Hepatic Lipid Metabolic Dysregulation Induced by Microcystin-LR","volume":"16","author":"Tan","year":"2024","journal-title":"Toxins"},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0485","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/toxins15040293","article-title":"Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: a Cross-Sectional Study in Hunan Province, China","volume":"15","author":"Feng","year":"2023","journal-title":"Toxins"},{"issue":"12","key":"10.1016\/j.cca.2025.120515_b0490","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.3390\/foods14122103","article-title":"Production Methods, Biological activity and potential Application prospects of Astaxanthin","volume":"14","author":"Ren","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.cca.2025.120515_b0495","doi-asserted-by":"crossref","DOI":"10.1111\/bph.70084","article-title":"Mangiferin modulates lipid metabolism via AKR1B1 in response to advanced glycation end products","author":"Sharda","year":"2025","journal-title":"Br J Pharmacol [internet]."},{"key":"10.1016\/j.cca.2025.120515_b0500","doi-asserted-by":"crossref","unstructured":"Wang S, Qin Y, Liu Y, Jiao R, Lin R, Yuan Z, et al. Lipid\u2010lowering effect of mangiferin through the inhibition of pancreatic lipase activity. J Sci Food Agric [Internet]. 2025 Apr 23; Available from: https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.14301.","DOI":"10.1002\/jsfa.14301"},{"key":"10.1016\/j.cca.2025.120515_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176724","article-title":"Mangiferin alleviated poststroke cognitive impairment by modulating lipid metabolism in cerebral ischemia\/reperfusion rats","volume":"977","author":"Zhang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cca.2025.120515_b0510","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15011","article-title":"The impacts of biologic treatment on metabolic profiling in psoriasis","volume":"33","author":"Deng","year":"2024","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.cca.2025.120515_b0515","doi-asserted-by":"crossref","unstructured":"Zhao S, Sun W, Sun J, Peng L, Wang C. Clinical features, treatment, and outcomes of nivolumab induced psoriasis. Invest New Drugs [Internet]. 2024 Dec 26; Available from: https:\/\/link.springer.com\/10.1007\/s10637-024-01494-4.","DOI":"10.1007\/s10637-024-01494-4"},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0520","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/dth.12259","article-title":"Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial: Linoleic acid-ceramide therapy in psoriasis","volume":"28","author":"Liu","year":"2015","journal-title":"Dermatol. Ther."},{"issue":"6","key":"10.1016\/j.cca.2025.120515_b0525","article-title":"Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild\u2010to\u2010moderate psoriasis vulgaris: a multicenter randomized controlled trial","volume":"33","author":"Li","year":"2020","journal-title":"Dermatol Ther [internet]."},{"key":"10.1016\/j.cca.2025.120515_b0530","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205061","article-title":"Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents","author":"Takeda","year":"2018","journal-title":"Kim SH, Editor. PLOS ONE."},{"issue":"4","key":"10.1016\/j.cca.2025.120515_b0535","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/exd.12658","article-title":"Keratinocyte differentiation and upregulation of ceramide synthesis induced by an oat lipid extract via the activation of PPAR pathways","volume":"24","author":"Chon","year":"2015","journal-title":"Exp. Dermatol."},{"issue":"8","key":"10.1016\/j.cca.2025.120515_b0540","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.3390\/molecules25081832","article-title":"Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-like Keratinocytes","volume":"25","author":"Gendrisch","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.cca.2025.120515_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118164","article-title":"Mechanisms and therapeutic potential of pharmacological agents targeting inflammasomes","volume":"189","author":"Li","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.cca.2025.120515_b0550","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s12012-020-09576-4","article-title":"Involvement of ROS\/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity","volume":"20","author":"Wei","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.cca.2025.120515_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177738","article-title":"The potential effects of ticagrelor and\/or sodium butyrate on imiquimod-induced psoriasis in mice model: the role of NLRP3 inflammasome signaling pathway","volume":"1000","author":"Elkhouly","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cca.2025.120515_b0560","article-title":"Broad-spectrum anti-inflammatory and antioxidant therapy of inflammatory-storm actuated diseases via programmable self-derived cryo-dead neutrophils","volume":"507","author":"Li","year":"2025","journal-title":"Chem. Eng. J."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125003948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125003948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T13:07:54Z","timestamp":1763039274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125003948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":112,"alternative-id":["S0009898125003948"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120515","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of lipidomics in psoriasis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120515"}}