{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:54:23Z","timestamp":1791870863961,"version":"4.3.4"},"reference-count":246,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cca.2025.120569","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:01:59Z","timestamp":1756479719000},"page":"120569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Point-of-care testing for early detection of sepsis: a systematic literature review"],"prefix":"10.1016","volume":"578","author":[{"given":"Mahsa","family":"Kalantar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Hossein","family":"Rezayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Hajghassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Farazkish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza Askari","family":"Moghadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120569_b0005","doi-asserted-by":"crossref","unstructured":"G. Liu, C. Jiang, X. Lin, and Y. Yang, \u201cPoint-of-care detection of cytokines in cytokine storm management and beyond: Significance and challenges,\u201d Aug. 01, 2021, John Wiley and Sons Inc. doi: 10.1002\/VIW.20210003.","DOI":"10.1002\/VIW.20210003"},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0010","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1021\/acssensors.0c00979","article-title":"Biosensors for Managing the COVID-19 Cytokine storm: challenges Ahead","volume":"5","author":"Russell","year":"2020","journal-title":"ACS Sens"},{"key":"10.1016\/j.cca.2025.120569_b0015","article-title":"Current trends in biosensors for the detection of cattle diseases worldwide","volume":"14","author":"Nehra","year":"2023","journal-title":"Biosens. Bioelectron.: X"},{"key":"10.1016\/j.cca.2025.120569_b0020","doi-asserted-by":"crossref","unstructured":"M. Singer et al., \u201cThe third international consensus definitions for sepsis and septic shock (sepsis-3),\u201d Feb. 23, 2016, American Medical Association. doi: 10.1001\/jama.2016.0287.","DOI":"10.1001\/jama.2016.0287"},{"key":"10.1016\/j.cca.2025.120569_b0025","doi-asserted-by":"crossref","DOI":"10.1080\/14737159.2024.2392283","article-title":"Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens","volume":"24","author":"Adami","year":"2024","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.cca.2025.120569_b0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4274\/eajem.galenos.2022.21.2.1","article-title":"Can Acute Care Biomarkers Change Patient\u2019s Management in Sepsis?","volume":"21","author":"Somma","year":"2022","journal-title":"Eurasian Journal of Emergency Medicine"},{"key":"10.1016\/j.cca.2025.120569_b0035","article-title":"Biomarkers in Sepsis: a Current Review of New Technologies","volume":"39","author":"Cohen","year":"2023","journal-title":"J. Intensive Care Med."},{"key":"10.1016\/j.cca.2025.120569_b0040","doi-asserted-by":"crossref","unstructured":"A. Bonini et al., \u201cEmerging Biosensing Technologies towards Early Sepsis Diagnosis and Management,\u201d Oct. 01, 2022, MDPI. doi: 10.3390\/bios12100894.","DOI":"10.3390\/bios12100894"},{"key":"10.1016\/j.cca.2025.120569_b0045","article-title":"Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer","volume":"17","author":"Dmitriyeva","year":"2021","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.cca.2025.120569_b0050","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1701","article-title":"Point\u2010of\u2010critical\u2010care diagnostics for sepsis enabled by multiplexed micro and nanosensing technologies","volume":"13","author":"Ashley","year":"2021","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.cca.2025.120569_b0055","doi-asserted-by":"crossref","unstructured":"E. Gupta et al., \u201cFast Track Diagnostic Tools for Clinical Management of Sepsis: Paradigm Shift from Conventional to Advanced Methods,\u201d Jan. 01, 2023, Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390\/diagnostics13020277.","DOI":"10.3390\/diagnostics13020277"},{"key":"10.1016\/j.cca.2025.120569_b0060","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bios.2018.10.034","article-title":"Recent advances in biosensors for diagnosis and detection of sepsis: a comprehensive review","volume":"124\u2013125","author":"Kumar","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120569_b0065","first-page":"48","article-title":"Point-of-care testing in microbiology - the advantages and disadvantages of immunochromatographic test strips","volume":"106","author":"St\u00fcrenburg","year":"2009","journal-title":"Dtsch. Arztebl. Int."},{"issue":"9","key":"10.1016\/j.cca.2025.120569_b0070","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.chembiol.2016.07.016","article-title":"Synthetic Biology-based Point-of-Care Diagnostics for Infectious Disease","volume":"23","author":"Wei","year":"2016","journal-title":"Cell Chem. Biol."},{"issue":"12","key":"10.1016\/j.cca.2025.120569_b0075","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1097\/CCM.0000000000003342","article-title":"Epidemiology and costs of sepsis in the United States-an analysis based on timing of diagnosis and severity level","volume":"46","author":"Paoli","year":"2018","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cca.2025.120569_b0080","doi-asserted-by":"crossref","unstructured":"Y. Li, X. Yang, and W. Zhao, \u201cEmerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing,\u201d Dec. 01, 2017, SAGE Publications Inc. doi: 10.1177\/2472630317727519.","DOI":"10.1177\/2472630317727519"},{"key":"10.1016\/j.cca.2025.120569_b0085","doi-asserted-by":"crossref","DOI":"10.1007\/s10877-013-9446-5","article-title":"Potential of surface acoustic wave biosensors for early sepsis diagnosis","volume":"27","author":"Csete","year":"2013","journal-title":"J. Clin. Monit. Comput."},{"key":"10.1016\/j.cca.2025.120569_b0090","article-title":"Diagnosis of acute serious illness: the role of point-of-care technologies","volume":"11","author":"Damhorst","year":"2019","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"10.1016\/j.cca.2025.120569_b0095","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cobme.2019.08.011","article-title":"Point-of-care technologies in heart, lung, blood and sleep disorders from the Center for Advancing Point-of-Care Technologies","volume":"11","author":"Ding","year":"2019","journal-title":"Curr. Opin. Biomed. Eng."},{"issue":"47","key":"10.1016\/j.cca.2025.120569_b0100","doi-asserted-by":"crossref","first-page":"31390","DOI":"10.1021\/acsomega.1c04788","article-title":"Rapid Detection of Sepsis: recent advances in Biomarker Sensing Platforms","volume":"6","author":"Durkin","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.cca.2025.120569_b0105","doi-asserted-by":"crossref","unstructured":"A. Claxton, L. Papafilippou, M. Hadjidemetriou, K. Kostarelos, and P. Dark, \u201cThe challenge of recognising sepsis: Future nanotechnology solutions,\u201d Aug. 01, 2020, SAGE Publications Inc. doi: 10.1177\/1751143719896554.","DOI":"10.1177\/1751143719896554"},{"key":"10.1016\/j.cca.2025.120569_b0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cca.2021.06.021","article-title":"Neonatal sepsis at point of care","volume":"521","author":"Jyoti","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120569_b0115","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.3390\/s24103162","article-title":"The potential of Fecal Volatile Organic compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm infants: a Narrative Review","volume":"24","author":"Kroon","year":"2024","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2025.120569_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2021.124730","article-title":"Gold nanoparticles anchored onto covalent poly deep eutectic solvent functionalized graphene: an electrochemical aptasensor for the detection of C-reactive protein","volume":"269","author":"Mahyari","year":"2021","journal-title":"Mater. Chem. Phys."},{"issue":"8","key":"10.1016\/j.cca.2025.120569_b0125","doi-asserted-by":"crossref","first-page":"7341","DOI":"10.1021\/acsomega.1c07271","article-title":"Buried-Gate MWCNT FET-Based Nanobiosensing Device for Real-Time Detection of CRP","volume":"7","author":"Firoozbakhtian","year":"2022","journal-title":"ACS Omega"},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0130","doi-asserted-by":"crossref","DOI":"10.1149\/1945-7111\/acd1bc","article-title":"Detection of C-Reactive Protein using a Flexible Biosensor with improved Bending Life","volume":"170","author":"Takaloo","year":"2023","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.cca.2025.120569_b0135","doi-asserted-by":"crossref","unstructured":"M. R. Rabiei, A. H. Rezayan, M. Hosseini, and A. B. Pebdeni, \u201cElectrochemical Aptasensor for Selective and Sensitive Detection of Staphylococcus aureus Using Graphene oxide\/poly Deep Eutectic Solvent\/Nickel Oxide Nanocomposite Modified Electrode,\u201d ChemistrySelect, vol. 9, no. 3, Jan. 2024, doi: 10.1002\/slct.202302099.","DOI":"10.1002\/slct.202302099"},{"key":"10.1016\/j.cca.2025.120569_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.109744","article-title":"\u00b5PAD-based colorimetric nanogold aptasensor for CRP and IL-6 detection as sepsis biomarkers","volume":"197","author":"Malekmohamadi","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.cca.2025.120569_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127184","article-title":"Rapid and sensitive whole cell E. coli detection using deep eutectic solvents\/graphene oxide\/gold nanoparticles field-effect transistor","volume":"283","author":"Alvandi","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2025.120569_b0150","doi-asserted-by":"crossref","DOI":"10.2217\/pme.15.42","article-title":"Status and perspective of lab-on-a-chip systems for common diseases: a systematic review from 2003 to 2013","volume":"13","author":"Gebauer","year":"2016","journal-title":"Per Med"},{"key":"10.1016\/j.cca.2025.120569_b0155","first-page":"201","article-title":"Biomarkers for diagnosis of neonatal infections: a systematic analysis of their potential as a point-of-care diagnostics","volume":"1","author":"Meem","year":"2011","journal-title":"J. Glob. Health"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0160","doi-asserted-by":"crossref","first-page":"Dec","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"10.1016\/j.cca.2025.120569_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117615","article-title":"Analytical micro and nano technologies meet sepsis diagnosis","volume":"173","author":"Gord\u00f3n Pidal","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"issue":"19","key":"10.1016\/j.cca.2025.120569_b0170","doi-asserted-by":"crossref","first-page":"9056","DOI":"10.1021\/acs.nanolett.3c02828","article-title":"Dual Functional Ultrasensitive Point-of-Care Clinical Diagnosis using Metal\u2013Organic Frameworks-based Immunobeads","volume":"23","author":"Chai","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.cca.2025.120569_b0175","doi-asserted-by":"crossref","DOI":"10.1177\/21501327211000233","article-title":"A Point-of-Care Serum Lactate Level and Mortality in Adult Sepsis patients: a Community Hospital setting","volume":"12","author":"Charoentanyarak","year":"2021","journal-title":"J. Prim. Care Community Health"},{"key":"10.1016\/j.cca.2025.120569_b0180","doi-asserted-by":"crossref","unstructured":"D. Dayangac-Erden and M. Durusu-Tanriover, \u201cChapter 13 - Sepsis: A Challenging Disease With New Promises for Personalized Medicine and Biomarker Discovery,\u201d in Precision Medicine, H.-P. Deigner and M. Kohl, Eds., Academic Press, 2018, pp. 297\u2013314. doi: https:\/\/doi.org\/10.1016\/B978-0-12-805364-5.00013-5.","DOI":"10.1016\/B978-0-12-805364-5.00013-5"},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0185","doi-asserted-by":"crossref","first-page":"Sep","DOI":"10.1063\/5.0100589","article-title":"Integration of hydrogels into microfluidic devices with porous membranes as scaffolds enables their drying and reconstitution","volume":"16","author":"Shahriari","year":"2022","journal-title":"Biomicrofluidics"},{"issue":"11","key":"10.1016\/j.cca.2025.120569_b0190","first-page":"Nov","article-title":"Rapid Bacteria Detection from patients\u2019 Blood Bypassing Classical Bacterial Culturing","volume":"12","author":"Huber","year":"2022","journal-title":"Biosensors (basel)"},{"key":"10.1016\/j.cca.2025.120569_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132917","article-title":"A microfluidic platform combined with bacteriophage receptor binding proteins for multiplex detection of Escherichia coli and Pseudomonas aeruginosa in blood","volume":"376","author":"Costa","year":"2023","journal-title":"Sens Actuators B Chem"},{"key":"10.1016\/j.cca.2025.120569_b0200","doi-asserted-by":"crossref","unstructured":"F. S. H. Krismastuti, A. Cavallaro, B. Prieto-Simon, and N. H. Voelcker, \u201cToward multiplexing detection of wound healing biomarkers on porous silicon resonant microcavities,\u201d Advanced Science, vol. 3, no. 6, Jan. 2015, doi: 10.1002\/advs.201500383.","DOI":"10.1002\/advs.201500383"},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0205","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000536678","article-title":"Diagnostic Accuracy of Point-of-Care Testing of C-Reactive Protein, Interleukin-6, and Procalcitonin in Neonates with Clinically Suspected Sepsis: a prospective Observational Study","volume":"33","author":"Goyal","year":"2024","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.cca.2025.120569_b0210","doi-asserted-by":"crossref","unstructured":"A. Giannetti, C. Trono, G. Porro, C. Domenici, M. Puntoni, and F. Baldini, \u201cTowards an integrated system as point-of-care device for the optical detection of sepsis biomarkers,\u201d Chemosensors, vol. 8, no. 1, Mar. 2020, doi: 10.3390\/chemosensors8010012.","DOI":"10.3390\/chemosensors8010012"},{"key":"10.1016\/j.cca.2025.120569_b0215","doi-asserted-by":"crossref","unstructured":"P. Amornchai et al., \u201cSensitivity and specificity of DPP\u00ae Fever Panel II Asia in the diagnosis of malaria, dengue and melioidosis,\u201d J Med Microbiol, vol. 71, no. 8, 2022, doi: 10.1099\/jmm.0.001584.","DOI":"10.1099\/jmm.0.001584"},{"key":"10.1016\/j.cca.2025.120569_b0220","article-title":"Rapid screening for bacterial contamination of blood products","author":"Faure","year":"2006","journal-title":"May 01"},{"issue":"15","key":"10.1016\/j.cca.2025.120569_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/s20154182","article-title":"Development of solid-phase RPA on a lateral flow device for the detection of pathogens related to sepsis","volume":"20","author":"Heeroma","year":"2020","journal-title":"Sensors (switzerland)"},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0230","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1177\/2472630320978187","article-title":"Development of a Gold Nanoparticle-based Colorimetric Sensor for Water for Injection At-Line Impurity Testing","volume":"26","author":"Reichelt","year":"2021","journal-title":"SLAS Technol."},{"issue":"21","key":"10.1016\/j.cca.2025.120569_b0235","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1021\/acs.analchem.2c00316","article-title":"Progress toward a Simplified UTI Diagnostic: Pump-Free Magnetophoresis for E. coli Detection","volume":"94","author":"Call","year":"2022","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0240","doi-asserted-by":"crossref","DOI":"10.1149\/1945-7111\/abef85","article-title":"A Bacteriophage-based Electrochemical Biosensor for Detection of Methicillin-Resistant Staphylococcus aureus","volume":"168","author":"Patel","year":"2021","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.cca.2025.120569_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.129227","article-title":"Rapid detection of bacterial pathogens in blood through engineered phages-beads and integrated Real-Time PCR into MicroChip","volume":"329","author":"Rizzo","year":"2021","journal-title":"Sens Actuators B Chem"},{"issue":"21","key":"10.1016\/j.cca.2025.120569_b0250","doi-asserted-by":"crossref","first-page":"11007","DOI":"10.1021\/acs.analchem.5b02957","article-title":"Nanoparticle\u2013Drug Bioconjugate as dual Functional Affinity Ligand for Rapid Point-of-Care Detection of Endotoxin in Water and Serum","volume":"87","author":"Kalita","year":"2015","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0255","doi-asserted-by":"crossref","first-page":"Dec","DOI":"10.1038\/s41378-019-0063-4","article-title":"Isolation of intact bacteria from blood by selective cell lysis in a microfluidic porous silica monolith","volume":"5","author":"Han","year":"2019","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.cca.2025.120569_b0260","doi-asserted-by":"crossref","unstructured":"V. Garzarelli, M. S. Chiriac\u00f2, M. Cereda, G. Gigli, and F. Ferrara, \u201cUltrasensitive qPCR platform for rapid detection of bacterial contamination of raw biological samples at the point of care,\u201d Heliyon, vol. 9, no. 5, May 2023, doi: 10.1016\/j.heliyon.2023.e16229.","DOI":"10.1016\/j.heliyon.2023.e16229"},{"key":"10.1016\/j.cca.2025.120569_b0265","article-title":"Establishment and application of a rapid molecular diagnostic platform for the isothermal visual amplification of group B Streptococcus based on recombinase polymerase","volume":"14","author":"Liu","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b0270","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jhin.2020.09.033","article-title":"The SPaCE diagnostic: a pilot study to test the accuracy of a novel point of care sensor for point of care detection of burn wound infection","volume":"106","author":"Young","year":"2020","journal-title":"J. Hosp. Infect."},{"issue":"9","key":"10.1016\/j.cca.2025.120569_b0275","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1039\/D2LC00154C","article-title":"Exponential magnetophoretic gradient for the direct isolation of basophils from whole blood in a microfluidic system","volume":"22","author":"Casta\u00f1o","year":"2022","journal-title":"Lab Chip"},{"issue":"9","key":"10.1016\/j.cca.2025.120569_b0280","doi-asserted-by":"crossref","first-page":"Sep","DOI":"10.3390\/diagnostics12092150","article-title":"Critically Ill COVID-19 patients Show Reduced Point of Care-measured Butyrylcholinesterase Activity\u2014A prospective, Monocentric Observational Study","volume":"12","author":"Espeter","year":"2022","journal-title":"Diagnostics"},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0285","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/irv.12359","article-title":"Cost-effectiveness analysis of antiviral treatment in the management of seasonal influenza a: Point-of-care rapid test versus clinical judgment","volume":"10","author":"Nshimyumukiza","year":"2016","journal-title":"Influenza Other Respir. Viruses"},{"issue":"8","key":"10.1016\/j.cca.2025.120569_b0290","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/jmv.25659","article-title":"A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts","volume":"92","author":"Hayes","year":"2020","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b0295","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.1021\/acsomega.9b00499","article-title":"Microfluidic Chip for Detection of Fungal Infections","volume":"4","author":"Asghar","year":"2019","journal-title":"ACS Omega"},{"issue":"8","key":"10.1016\/j.cca.2025.120569_b0300","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/acssensors.0c01265","article-title":"SPaCE Swab: Point-of-Care Sensor for simple and Rapid Detection of Acute Wound Infection","volume":"5","author":"Thet","year":"2020","journal-title":"ACS Sens"},{"key":"10.1016\/j.cca.2025.120569_b0305","doi-asserted-by":"crossref","unstructured":"R. Gudisa, R. Harchand, and S. M. Rudramurthy, \u201cNucleic-Acid-Based Molecular Fungal Diagnostics: A Way to a Better Future,\u201d Diagnostics, vol. 14, no. 5, 2024, doi: 10.3390\/diagnostics14050520.","DOI":"10.3390\/diagnostics14050520"},{"key":"10.1016\/j.cca.2025.120569_b0310","doi-asserted-by":"crossref","unstructured":"B., D. D. , Z. A. , K. O. , B. E. , O. N. , & B. S. Aydin, \u201cComparison of a rapid bed-side test with a central laboratory analysis for C-reactive protein in newborn infants with suspicion of sepsis,\u201d Clin Lab, vol. 59, no. 9\u201310, pp. 1045\u20131051, 2013.","DOI":"10.7754\/Clin.Lab.2012.120923"},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0315","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/jvim.16550","article-title":"Serum amyloid a as a marker to detect sepsis and predict outcome in hospitalized neonatal foals","volume":"36","author":"Hoeberg","year":"2022","journal-title":"J. Vet. Intern. Med."},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0320","doi-asserted-by":"crossref","first-page":"712","DOI":"10.5005\/jp-journals-10071-24202","article-title":"Is there a Role of Presepsin as a Novel Biomarker in Pediatric Sepsis?","volume":"26","author":"Khera","year":"2022","journal-title":"Indian Journal of Critical Care Medicine"},{"issue":"17","key":"10.1016\/j.cca.2025.120569_b0325","doi-asserted-by":"crossref","first-page":"Sep","DOI":"10.3390\/jcm10173869","article-title":"Diagnostic performance of procalcitonin for the early identification of sepsis in patients with elevated qsofa score at emergency admission","volume":"10","author":"Bolanaki","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cca.2025.120569_b0330","doi-asserted-by":"crossref","unstructured":"J. M. Gord\u00f3n Pidal, L. Arruza, M. Moreno-Guzm\u00e1n, M. \u00c1. L\u00f3pez, and A. Escarpa, \u201cMicromotor-based dual aptassay for early cost-effective diagnosis of neonatal sepsis,\u201d Microchimica Acta, vol. 191, no. 2, Feb. 2024, doi: 10.1007\/s00604-023-06134-x.","DOI":"10.1007\/s00604-023-06134-x"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0335","doi-asserted-by":"crossref","first-page":"Dec","DOI":"10.1186\/s12887-022-03677-5","article-title":"Point-of-care C-reactive protein test results in acute infections in children in primary care: an observational study","volume":"22","author":"De Rop","year":"2022","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.cca.2025.120569_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2019.126437","article-title":"Copper and selenium status as biomarkers of neonatal infections","volume":"58","author":"Hackler","year":"2020","journal-title":"J. Trace Elem. Med Biol."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0345","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000336632","article-title":"Diagnostic value of an interleukin-6 bedside test in term and preterm neonates at the time of clinical suspicion of early- and late-onset bacterial infection","volume":"102","author":"Batfalsky","year":"2012","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0350","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.diagmicrobio.2018.07.011","article-title":"Rapid and visual detection of Group B streptococcus using recombinase polymerase amplification combined with lateral flow strips","volume":"93","author":"Hu","year":"2019","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0355","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1099\/jmm.0.000437","article-title":"Loop-mediated isothermal amplification assay for rapid detection of Streptococcus agalactiae (group B streptococcus) in vaginal swabs - a proof of concept study","volume":"66","author":"McKenna","year":"2017","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.cca.2025.120569_b0360","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1250358","article-title":"Efficacy of a paper-based interleukin-6 test strip combined with a spectrum-based optical reader for sequential monitoring and early recognition of respiratory failure in elderly pneumonia\u2014a pilot study","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.cca.2025.120569_b0365","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1021\/acsomega.2c07297","article-title":"Effect of Selenium Nanoparticle size on IL-6 Detection Sensitivity in a Lateral Flow Device","volume":"8","author":"Bradley","year":"2023","journal-title":"ACS Omega"},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0370","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cpem.2013.04.004","article-title":"A Biomarker-based Approach to Infectious Disease in the Pediatric Emergency Department","volume":"14","author":"Aranke","year":"2013","journal-title":"Clin Pediatr Emerg Med"},{"issue":"12","key":"10.1016\/j.cca.2025.120569_b0375","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1021\/acssensors.0c01618","article-title":"Rapid Detection of Pseudomonas aeruginosa Biofilms via Enzymatic Liquefaction of respiratory Samples","volume":"5","author":"Clemente","year":"2020","journal-title":"ACS Sens"},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0380","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5114\/ait.2021.104300","article-title":"Efficacy and safety of the point-of-care procalcitonin test for determining the antibiotic treatment duration in patients with ventilator-associated pneumonia in the intensive care unit: a randomised controlled trial","volume":"53","author":"Mazlan","year":"2021","journal-title":"Anaesthesiol Intensive Ther"},{"key":"10.1016\/j.cca.2025.120569_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.crbiot.2023.100130","article-title":"Importance of IP-10 as a biomarker of host immune response: critical perspective as a target for biosensing","volume":"5","author":"Madhurantakam","year":"2023","journal-title":"Curr. Res. Biotechnol."},{"key":"10.1016\/j.cca.2025.120569_b0390","doi-asserted-by":"crossref","unstructured":"C. Ruppert, L. Kaiser, L. J. Jacob, S. Laufer, M. Kohl, and H. P. Deigner, \u201cDuplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay,\u201d J Nanobiotechnology, vol. 18, no. 1, Sep. 2020, doi: 10.1186\/s12951-020-00688-1.","DOI":"10.1186\/s12951-020-00688-1"},{"issue":"8","key":"10.1016\/j.cca.2025.120569_b0395","doi-asserted-by":"crossref","first-page":"Aug","DOI":"10.3390\/pathogens10080996","article-title":"Direct detection of streptococcus suis from cerebrospinal fluid, positive hemoculture, and simultaneous differentiation of serotypes 1, 1\/2, 2, and 14 within single reaction","volume":"10","author":"Thu","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.cca.2025.120569_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113267","article-title":"Erythrocyte-camouflaged biosensor for \u03b1-hemolysin detection","volume":"185","author":"Kim","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0405","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s15010-018-1212-7","article-title":"Clinical benefits of introducing real-time multiplex PCR for cerebrospinal fluid as routine diagnostic at a tertiary care pediatric center","volume":"47","author":"Eichinger","year":"2019","journal-title":"Infection"},{"key":"10.1016\/j.cca.2025.120569_b0410","doi-asserted-by":"crossref","DOI":"10.1002\/adsr.202400051","article-title":"Point\u2010of\u2010Care Urinary Tract Infection (UTI) Diagnosis Enhanced by Nanostructured Biosensors: Review Paper","volume":"3","author":"Yang","year":"2024","journal-title":"Adv. Sensor Res."},{"issue":"12","key":"10.1016\/j.cca.2025.120569_b0415","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1177\/1098612X18812494","article-title":"A specific immunoassay for detection of feline kidney injury molecule 1","volume":"21","author":"Bland","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.cca.2025.120569_b0420","doi-asserted-by":"crossref","DOI":"10.1186\/s41100-017-0107-x","article-title":"Urinary excretion of liver-type fatty acid-binding protein reflects the severity of sepsis","volume":"3","author":"Sato","year":"2017","journal-title":"Ren Replace Ther"},{"key":"10.1016\/j.cca.2025.120569_b0425","doi-asserted-by":"crossref","unstructured":"S. Hayano, T. Hidaka, R. Tadakuma, and M. Kashima, \u201cDiagnostic Accuracy of Point-of-Care Gram Stains in Obstructive Pyelonephritis due to Ureteral Stones,\u201d Open Forum Infect Dis, vol. 11, no. 3, Mar. 2024, doi: 10.1093\/ofid\/ofae026.","DOI":"10.1093\/ofid\/ofae026"},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0430","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.kint.2020.01.044","article-title":"Measurement of innate immune response biomarkers in peritoneal dialysis effluent using arapid diagnostic point-of-care device asadiagnostic indicator of peritonitis","volume":"97","author":"Goodlad","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2025.120569_b0435","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbt.2021.08.003","article-title":"Point-of-care diagnosis of invasive non-typhoidal Salmonella enterica in bloodstream infections using immunomagnetic capture and loop-mediated isothermal amplification","volume":"66","author":"Vinayaka","year":"2022","journal-title":"N. Biotechnol."},{"issue":"105","key":"10.1016\/j.cca.2025.120569_b0440","doi-asserted-by":"crossref","first-page":"103463","DOI":"10.1039\/C6RA23816E","article-title":"Lanthanide chelate-encapsulated polystyrene nanoparticles for rapid and quantitative immunochromatographic assay of procalcitonin","volume":"6","author":"Liao","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.cca.2025.120569_b0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133598","article-title":"Wearable battery-free smart bandage with peptide functionalized biosensors based on MXene for bacterial wound infection detection","volume":"383","author":"Shi","year":"2023","journal-title":"Sens Actuators B Chem"},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0450","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1039\/D0AY01991G","article-title":"Vibrational spectroscopic analysis of blood for diagnosis of infections and sepsis: a review of requirements for a rapid diagnostic test","volume":"13","author":"Confield","year":"2021","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0455","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bios.2012.10.008","article-title":"Development of a colorimetric, superparamagnetic biosensor for the capture and detection of biomolecules","volume":"42","author":"Chan","year":"2013","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-016-0836-y","article-title":"Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group B streptococcus","volume":"16","author":"Clarke","year":"2016","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.cca.2025.120569_b0465","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-019-02256-7","article-title":"Microfluidics-based Organism Isolation from whole Blood: an Emerging Tool for Bloodstream Infection Diagnosis","volume":"47","author":"Burklund","year":"2019","journal-title":"Ann. Biomed. Eng."},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0470","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1039\/D4LC00117F","article-title":"Microfluidic systems for infectious disease diagnostics","volume":"24","author":"Lehnert","year":"2024","journal-title":"Lab Chip"},{"issue":"13","key":"10.1016\/j.cca.2025.120569_b0475","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1039\/C9AN00532C","article-title":"Smartphone-imaged microfluidic biochip for measuring CD64 expression from whole blood","volume":"144","author":"Ghonge","year":"2019","journal-title":"Analyst"},{"issue":"24","key":"10.1016\/j.cca.2025.120569_b0480","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1039\/D0AN01218A","article-title":"Mobile origami immunosensors for the rapid detection of urinary tract infections","volume":"145","author":"Adrover-Jaume","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2025.120569_b0485","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1179\/1465328111Y.0000000045","article-title":"Evaluating the QuikRead (R) C-reactive protein test as a point-of-care test","volume":"32","author":"Diar","year":"2012","journal-title":"Paediatr Int Child Health"},{"issue":"11","key":"10.1016\/j.cca.2025.120569_b0490","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.mpmed.2013.08.012","article-title":"Molecular-based diagnostics, including future trends","volume":"41","author":"Goldenberg","year":"2013","journal-title":"Medicine"},{"key":"10.1016\/j.cca.2025.120569_b0495","doi-asserted-by":"crossref","unstructured":"S. Emonet, J. Schrenzel, and B. Martinez De Tejada, \u201cMolecular-based screening for perinatal group B streptococcal infection: Implications for prevention and therapy,\u201d Dec. 2013. doi: 10.1007\/s40291-013-0047-2.","DOI":"10.1007\/s40291-013-0047-2"},{"key":"10.1016\/j.cca.2025.120569_b0500","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bios.2017.07.057","article-title":"A nanoparticle-based method for culture-free bacterial DNA enrichment from whole blood","volume":"99","author":"Hassan","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120569_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124325","article-title":"Quartz crystal microbalance biosensor for the detection of procalcitonin","volume":"257","author":"Pohanka","year":"2023","journal-title":"Talanta"},{"issue":"8","key":"10.1016\/j.cca.2025.120569_b0510","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1021\/acs.nanolett.3c04762","article-title":"Ultrasensitive and Rapid Detection of Procalcitonin via Waveguide-Enhanced Nanogold-Linked Immunosorbent Assay for Early Sepsis Diagnosis","volume":"24","author":"Barshilia","year":"2024","journal-title":"Nano Lett."},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0515","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1021\/acsmeasuresciau.1c00013","article-title":"Electrochemical Immunosensing of Interleukin-6 in Human Cerebrospinal Fluid and Human Serum as an Early Biomarker for Traumatic Brain Injury","volume":"1","author":"Oh","year":"2021","journal-title":"ACS Measurement Science Au"},{"key":"10.1016\/j.cca.2025.120569_b0520","article-title":"Electrochemical point-of-care devices for the diagnosis of sepsis","volume":"39","author":"Valera","year":"2023","journal-title":"Curr. Opin. Electrochem."},{"key":"10.1016\/j.cca.2025.120569_b0525","doi-asserted-by":"crossref","unstructured":"S. Akg\u00f6n\u00fcll\u00fc and A. Denizli, \u201cRecent advances in optical biosensing approaches for biomarkers detection,\u201d Dec. 01, 2022, Elsevier Ltd. doi: 10.1016\/j.biosx.2022.100269.","DOI":"10.1016\/j.biosx.2022.100269"},{"key":"10.1016\/j.cca.2025.120569_b0530","doi-asserted-by":"crossref","unstructured":"R. S\u00e1nchez-Salcedo, R. Miranda-Castro, N. de-los-Santos-\u00c1lvarez, M. J. Lobo-Casta\u00f1\u00f3n, and D. K. Corrigan, \u201cComparing nanobody and aptamer-based capacitive sensing for detection of interleukin-6 (IL-6) at physiologically relevant levels,\u201d Anal Bioanal Chem, vol. 415, no. 29\u201330, pp. 7035\u20137045, Dec. 2023, doi: 10.1007\/s00216-023-04973-4.","DOI":"10.1007\/s00216-023-04973-4"},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0535","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.3390\/s140610864","article-title":"A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma","volume":"14","author":"Canovi","year":"2014","journal-title":"Sensors (switzerland)"},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0540","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10544-020-00492-6","article-title":"Simultaneous electrical detection of IL-6 and PCT using a microfluidic biochip platform","volume":"22","author":"Berger","year":"2020","journal-title":"Biomed. Microdevices"},{"issue":"13","key":"10.1016\/j.cca.2025.120569_b0545","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1039\/D0LC00243G","article-title":"Rapid, multiplexed detection of biomolecules using electrically distinct hydrogel beads","volume":"20","author":"Cowell","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120569_b0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115181","article-title":"Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology","volume":"227","author":"Bradley","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"10.1016\/j.cca.2025.120569_b0555","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1039\/D0AN02374D","article-title":"Microfluidics for sepsis early diagnosis and prognosis: a review of recent methods","volume":"146","author":"Zhang","year":"2021","journal-title":"Analyst"},{"issue":"14","key":"10.1016\/j.cca.2025.120569_b0560","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1039\/D0AN00624F","article-title":"An on-chip microfluidic-based electrochemical magneto-immunoassay for the determination of procalcitonin in plasma obtained from sepsis diagnosed preterm neonates","volume":"145","author":"Molinero-Fern\u00e1ndez","year":"2020","journal-title":"Analyst"},{"issue":"23","key":"10.1016\/j.cca.2025.120569_b0565","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1039\/D1LC00840D","article-title":"A microfluidic chip with a serpentine channel enabling high-throughput cell separation using surface acoustic waves","volume":"21","author":"Ning","year":"2021","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120569_b0570","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.talanta.2015.07.051","article-title":"Paper-based ELISA to rapidly detect Escherichia coli","volume":"145","author":"Shih","year":"2015","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0575","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/acssensors.9b01937","article-title":"Nanoparticle Reservoirs for Paper-only Immunosensors","volume":"5","author":"Alba-Pati\u00f1o","year":"2020","journal-title":"ACS Sens"},{"key":"10.1016\/j.cca.2025.120569_b0580","doi-asserted-by":"crossref","unstructured":"A. G. Venkatesh et al., \u201cA Smartphone-Based Colorimetric Reader for Human C-Reactive Protein Immunoassay.,\u201d Methods in molecular biology, vol. 1571, pp. 343\u2013356, 2017, [Online]. Available: https:\/\/api.semanticscholar.org\/CorpusID:3564558.","DOI":"10.1007\/978-1-4939-6848-0_21"},{"issue":"10","key":"10.1016\/j.cca.2025.120569_b0585","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/acsaelm.2c00701","article-title":"Rapid Detection of Inflammation-Related Biomarkers using an Electrochemical Sensor Modified with a PBNC-AuNS-GO-Based Nanocomposite","volume":"4","author":"Schuck","year":"2022","journal-title":"ACS Appl. Electron. Mater."},{"key":"10.1016\/j.cca.2025.120569_b0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.129029","article-title":"A point-of-care testing sensor based on fluorescent nanoclusters for rapid detection of septicemia in children","volume":"328","author":"Sheini","year":"2021","journal-title":"Sens Actuators B Chem"},{"issue":"9","key":"10.1016\/j.cca.2025.120569_b0595","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/acssensors.8b00452","article-title":"A Robust and User-Friendly Alternative to Densitometry using Origami Biosensors and Digital Logic","volume":"3","author":"Russell","year":"2018","journal-title":"ACS Sens"},{"key":"10.1016\/j.cca.2025.120569_b0600","doi-asserted-by":"crossref","unstructured":"Y. Li et al., \u201cSimultaneous detection of inflammatory biomarkers by sers nanotag-based lateral flow assay with portable cloud raman spectrometer,\u201d Nanomaterials, vol. 11, no. 6, Jun. 2021, doi: 10.3390\/nano11061496.","DOI":"10.3390\/nano11061496"},{"issue":"41","key":"10.1016\/j.cca.2025.120569_b0605","article-title":"Chandra Mouli Pandey, and Aditya Sharma Ghrera, \u201cReduced Graphene Oxide-Gold Nanoparticle Nanohybrid Modified Cost-Effective Paper-based Biosensor for Procalcitonin Detection,\u201d","volume":"7","author":"Gupta","year":"2022","journal-title":"CHEMISTRY SELECT"},{"key":"10.1016\/j.cca.2025.120569_b0610","article-title":"Multiplexed host immune response biosensor for rapid sepsis stratification and endotyping at point-of-care","volume":"10","author":"Tanak","year":"2022","journal-title":"Biosens. Bioelectron.: X"},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0615","doi-asserted-by":"crossref","first-page":"Sep","DOI":"10.1002\/btm2.10310","article-title":"Simultaneous detection of sepsis host response biomarkers in whole blood using electrochemical biosensor","volume":"7","author":"Tanak","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.cca.2025.120569_b0620","doi-asserted-by":"crossref","DOI":"10.1097\/PCC.0000000000003565","article-title":"Pancreatic Stone Protein in the Diagnosis of Sepsis in Children Admitted to High-Dependency Care: a Single-Center prospective Cohort Study","author":"Bottari","year":"2024","journal-title":"Pediatr. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0625","first-page":"Dec","article-title":"\u201cAccuracy of Pancreatic Stone Protein for diagnosis of sepsis in children admitted to pediatric intensive care or high-dependency care: a pilot study,\u201d Ital","volume":"49","author":"Bottari","year":"2023","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cca.2025.120569_b0630","doi-asserted-by":"crossref","unstructured":"T. Clodi-Seitz et al., \u201cPoint-of-Care Method T2Bacteria\u00aePanel Enables a More Sensitive and Rapid Diagnosis of Bacterial Blood Stream Infections and a Shorter Time until Targeted Therapy than Blood Culture,\u201d Microorganisms, vol. 12, no. 5, May 2024, doi: 10.3390\/microorganisms12050967.","DOI":"10.3390\/microorganisms12050967"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0635","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1039\/D0AN01852J","article-title":"Portable, low cost and sensitive cavity enhanced absorption (CEA) detection","volume":"146","author":"Teggert","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2025.120569_b0640","article-title":"A diagnostic platform for rapid, simultaneous quantification of procalcitonin and C-reactive protein in human serum","volume":"76","author":"Elvis Cao","year":"2022","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b0645","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1039\/C0AN00699H","article-title":"Multi-parameter determination of TNF\u03b1, PCT and CRP for point-of-care testing","volume":"136","author":"Kr\u00e4mer","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2025.120569_b0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115772","article-title":"Simultaneous detection of C-reactive protein and lipopolysaccharide based on a dual-channel electrochemical biosensor for rapid Gram-typing of bacterial sepsis","volume":"243","author":"Lu","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120569_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117342","article-title":"CRISPR-based biosensors for human health: a novel strategy to detect emerging infectious diseases","volume":"168","author":"He","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.cca.2025.120569_b0660","doi-asserted-by":"crossref","unstructured":"S. Jirawannaporn et al., \u201cRapid and sensitive point-of-care detection of Leptospira by RPA-CRISPR\/Cas12a targeting lipL32,\u201d PLoS Negl Trop Dis, vol. 16, no. 1, Jan. 2022, doi: 10.1371\/JOURNAL.PNTD.0010112.","DOI":"10.1371\/journal.pntd.0010112"},{"key":"10.1016\/j.cca.2025.120569_b0665","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/MOL.0000000000000870","article-title":"Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review","volume":"34","author":"Barber","year":"2023","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.cca.2025.120569_b0670","doi-asserted-by":"crossref","unstructured":"E. P. Plata-Menchaca, J. C. Ruiz-Rodr\u00edguez, and R. Ferrer, \u201cEarly Diagnosis of Sepsis: The Role of Biomarkers and Rapid Microbiological Tests,\u201d Jul. 01, 2024, Thieme Medical Publishers, Inc. doi: 10.1055\/s-0044-1787270.","DOI":"10.1055\/s-0044-1787270"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0675","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccc.2019.08.007","article-title":"Biomarker Panels in critical Care","volume":"36","author":"Conway","year":"2020","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.cca.2025.120569_b0680","doi-asserted-by":"crossref","DOI":"10.1007\/s00253-021-11469-7","article-title":"Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives","volume":"105","author":"Kunze-Szikszay","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.cca.2025.120569_b0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124403","article-title":"Simultaneous determination of procalcitonin and interleukin-6 in human serum samples with a point-of-care biosensing device","volume":"258","author":"Tsounidi","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2025.120569_b0690","article-title":"Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager","volume":"16","author":"Belushkin","year":"2019","journal-title":"Small"},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b0695","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/acsnano.2c10371","article-title":"Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection","volume":"17","author":"Chin","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.cca.2025.120569_b0700","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aca.2019.02.039","article-title":"Detection of culture-negative sepsis in clinical blood samples using a microfluidic assay for combined CD64 and CD69 cell capture","volume":"1062","author":"Zhou","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120569_b0705","doi-asserted-by":"crossref","unstructured":"J. Chavez, S. Glaser, and Z. Krom, \u201cContinuous Lactate Measurement Devices and Implications for Critical Care: A Literature Review,\u201d Crit Care Nurs Q, vol. 43, no. 3, 2020, [Online]. Available: https:\/\/journals.lww.com\/ccnq\/fulltext\/2020\/07000\/continuous_lactate_measurement_devices_and.2.aspx.","DOI":"10.1097\/CNQ.0000000000000311"},{"key":"10.1016\/j.cca.2025.120569_b0710","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1586\/17476348.2015.1081063","article-title":"Management of patients with respiratory infections in primary care: procalcitonin, C-reactive protein or both?","volume":"9","author":"Meili","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.cca.2025.120569_b0715","article-title":"Emerging evidence for serum procalcitonin estimation at point-of-care and advancement in quantitative sensing strategies over the past decade","volume":"2","author":"Sahu","year":"2021","journal-title":"Sens. Int."},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0720","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1021\/acsabm.4c00061","article-title":"Structure-Switching Electrochemical Aptasensor for Rapid, Reagentless, and Single-step Nanomolar Detection of C-Reactive Protein","volume":"7","author":"Whitehouse","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0725","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1515\/labmed-2019-0008","article-title":"Clinical evaluation of point-of-care testing for wide-range C-reactive protein (wr-CRP) in neonates with suspected sepsis","volume":"43","author":"Billetop","year":"2019","journal-title":"Journal of Laboratory Medicine"},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0730","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jemermed.2010.05.073","article-title":"The Value of Procalcitonin, a Novel Inflammatory Marker, intheDiagnosis of Myocardial Infarction and Evaluation of Acute Coronary Syndrome patients","volume":"41","author":"Bektas","year":"2011","journal-title":"J. Emerg. Med."},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0735","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/jbcr\/iraa199","article-title":"PCT Kinetics in the first Week Postburn for Sepsis Diagnosis and Death Prognosis - an Accuracy Study","volume":"42","author":"Cabral","year":"2021","journal-title":"Journal of Burn Care and Research"},{"key":"10.1016\/j.cca.2025.120569_b0740","article-title":"Analytical performances of a novel point-of-care procalcitonin assay","volume":"18","author":"Dupuy","year":"2020","journal-title":"Pract. Lab. Med."},{"key":"10.1016\/j.cca.2025.120569_b0745","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/21691401.2023.2252016","article-title":"Advancement in biomarker based effective diagnosis of neonatal sepsis","volume":"51","author":"Gopal","year":"2023","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.cca.2025.120569_b0750","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.940030","article-title":"Comparison of Rapid Cytokine Immunoassays for Functional Immune Phenotyping","volume":"13","author":"Bonavia","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2025.120569_b0755","article-title":"Advancing electrochemical biosensors for interleukin-6 detection","volume":"13","author":"McCrae","year":"2023","journal-title":"Biosens. Bioelectron.: X"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0760","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jim.2012.02.002","article-title":"Critical role of the sample matrix in a point-of-care protein chip for sepsis","volume":"378","author":"Sauer","year":"2012","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cca.2025.120569_b0765","doi-asserted-by":"crossref","unstructured":"S. Rhedin, K. Elfving, and A. Berggren, \u201cNovel biomarkers differentiating viral from bacterial infection in febrile children: Future perspectives for management in clinical praxis,\u201d Nov. 01, 2021, MDPI. doi: 10.3390\/children8111070.","DOI":"10.3390\/children8111070"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0770","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/15513815.2013.842270","article-title":"Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement","volume":"33","author":"Berrington","year":"2014","journal-title":"Fetal Pediatr. Pathol."},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b0775","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/jleuko\/qiad163","article-title":"Point-of-care neutrophil and monocyte surface markers differentiate bacterial from viral infections at the emergency department within 30 min","volume":"115","author":"Jukema","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cca.2025.120569_b0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121475","article-title":"Development of a liposomal near-infrared fluorescence lactate assay for human blood","volume":"283","author":"Matoori","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.cca.2025.120569_b0785","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/s21030879","article-title":"Evaluating the Possibility of Translating Technological advances in Non-Invasive Continuous Lactate monitoring into critical Care","volume":"21","author":"Crapnell","year":"2021","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2025.120569_b0790","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bios.2017.02.053","article-title":"Smartphone\u2013based enzymatic biosensor for oral fluid L-lactate detection in one minute using confined multilayer paper reflectometry","volume":"94","author":"Calabria","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120569_b0795","first-page":"1","article-title":"Point-of-care lactate measurement for suspected sepsis in the prehospital environment: are we missing the point at the sharp end?","volume":"26","author":"Lightowler","year":"2020","journal-title":"Br. J. Healthc. Manag."},{"key":"10.1016\/j.cca.2025.120569_b0800","doi-asserted-by":"crossref","unstructured":"A. Malic, E. Ntrivalas, and J. DuBois, \u201cClinical Performance and Utility of Point-of-Care Lactate Technology in Patient Care Pathways,\u201d Point Care, vol. 18, no. 2, 2019, [Online]. Available: https:\/\/journals.lww.com\/poctjournal\/fulltext\/2019\/06000\/clinical_performance_and_utility_of_point_of_care.5.aspx.","DOI":"10.1097\/POC.0000000000000185"},{"issue":"9","key":"10.1016\/j.cca.2025.120569_b0805","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/14737159.2023.2242782","article-title":"One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers","volume":"23","author":"Essmann","year":"2023","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.cca.2025.120569_b0810","doi-asserted-by":"crossref","unstructured":"C. Michailides et al., \u201cDiagnostic and Prognostic Ability of Pancreatic Stone Protein: A Scoping Review,\u201d Jun. 01, 2024, Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390\/ijms25116046.","DOI":"10.3390\/ijms25116046"},{"issue":"10","key":"10.1016\/j.cca.2025.120569_b0815","doi-asserted-by":"crossref","first-page":"Oct","DOI":"10.3390\/microorganisms11102579","article-title":"The Role of the Pancreatic Stone Protein in predicting Intra-Abdominal Infection-Related Complications: a prospective Observational Single-Center Cohort Study","volume":"11","author":"Michailides","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0820","first-page":"Dec","article-title":"\u201cPancreatic stone protein point-of-care testing can reduce healthcare expenditure in sepsis,\u201d Health","volume":"12","author":"Schneider","year":"2022","journal-title":"Econ. Rev."},{"issue":"11","key":"10.1016\/j.cca.2025.120569_b0825","doi-asserted-by":"crossref","first-page":"Nov","DOI":"10.1371\/journal.pntd.0009840","article-title":"Evaluation of antigen-detecting and antibody-detecting diagnostic test combinations for diagnosing melioidosis","volume":"15","author":"Amornchai","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cca.2025.120569_b0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116202","article-title":"A point-of-care electrochemical biosensor for the rapid and sensitive detection of biomarkers in murine models with LPS-induced sepsis","volume":"254","author":"Ondevilla","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120569_b0835","doi-asserted-by":"crossref","DOI":"10.1515\/bmt-2013-4146","article-title":"Point-of-Care Chip for Diagnosis of Sepsis: joining Biomarker Quantification and Bacterial Class Identification","author":"Buchegger","year":"2013","journal-title":"Biomedical Engineering \/ Biomedizinische Technik"},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b0840","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ajic.2016.08.005","article-title":"The new frontier of diagnostics: Molecular assays and their role in infection prevention and control","volume":"45","author":"Das","year":"2017","journal-title":"Am. J. Infect. Control"},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0845","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1021\/acs.analchem.3c05459","article-title":"On-Site Fluorescent Detection of Sepsis-Inducing Bacteria using a Graphene-Oxide CRISPR-Cas12a (GO-CRISPR) system","volume":"96","author":"Kasputis","year":"2024","journal-title":"Anal. Chem."},{"issue":"22","key":"10.1016\/j.cca.2025.120569_b0850","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1007\/s00216-022-04210-4","article-title":"Designing electrochemical microfluidic multiplexed biosensors for on-site applications","volume":"414","author":"Glatz","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b0855","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2116\/analsci.18P357","article-title":"Dual Detection of Procalcitonin and C-reactive Protein with an Up-converting Nanoparticle based Lateral Flow Assay","volume":"35","author":"Zhan","year":"2019","journal-title":"Anal. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0860","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10544-016-0045-3","article-title":"A compact and integrated immunoassay with on-chip dispensing and magnetic particle handling","volume":"18","author":"Zirath","year":"2016","journal-title":"Biomed. Microdevices"},{"issue":"7","key":"10.1016\/j.cca.2025.120569_b0865","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1021\/acsami.9b19311","article-title":"Rapid Escherichia coli Trapping and Retrieval from Bodily Fluids via a Three-Dimensional Bead-Stacked Nanodevice","volume":"12","author":"Chen","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"25","key":"10.1016\/j.cca.2025.120569_b0870","doi-asserted-by":"crossref","first-page":"22164","DOI":"10.1021\/acsami.9b05666","article-title":"Biomimetic Octopus-like Particles for Ultraspecific Capture and Detection of Pathogens","volume":"11","author":"Lv","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.cca.2025.120569_b0875","doi-asserted-by":"crossref","unstructured":"S. Giorgi-Coll, M. J. Mar\u00edn, O. Sule, P. J. Hutchinson, and K. L. H. Carpenter, \u201cAptamer-modified gold nanoparticles for rapid aggregation-based detection of inflammation: an optical assay for interleukin-6,\u201d Microchimica Acta, vol. 187, no. 1, Jan. 2020, doi: 10.1007\/s00604-019-3975-7.","DOI":"10.1007\/s00604-019-3975-7"},{"key":"10.1016\/j.cca.2025.120569_b0880","doi-asserted-by":"crossref","unstructured":"A. S. Patterson, D. M. Heithoff, B. S. Ferguson, H. Tom Soh, M. J. Mahan, and K. W. Plaxco, \u201cMicrofluidic chip-based detection and intraspecies strain discrimination of Salmonella serovars derived from whole blood of septic mice,\u201d Appl Environ Microbiol, vol. 79, no. 7, pp. 2302\u20132311, Apr. 2013, doi: 10.1128\/AEM.03882-12.","DOI":"10.1128\/AEM.03882-12"},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b0885","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s00216-008-2547-1","article-title":"A new procalcitonin optical immunosensor for POCT applications","volume":"393","author":"Baldini","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cca.2025.120569_b0890","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clinbiochem.2018.03.006","article-title":"Lactate POCT in mobile intensive care units for septic patients? a comparison of capillary blood method versus venous blood and plasma-based reference methods","volume":"55","author":"L\u00e9guillier","year":"2018","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2025.120569_b0895","doi-asserted-by":"crossref","first-page":"Dec","DOI":"10.1149\/1945-7111\/ac0360","article-title":"Review\u2014Enzymatic and Non-Enzymatic Electrochemical Sensor for Lactate Detection in Human Biofluids","volume":"168","author":"Md Shakhih","year":"2021","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.cca.2025.120569_b0900","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.snb.2013.06.090","article-title":"An amperometric lactate biosensor using H2O2 reduction via a Prussian Blue impregnated poly(ethyleneimine) surface on screen printed carbon electrodes to detect anastomotic leak and sepsis","volume":"186","author":"Hirst","year":"2013","journal-title":"Sens Actuators B Chem"},{"key":"10.1016\/j.cca.2025.120569_b0905","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114429","article-title":"Tape integrated self-designed microfluidic chip for point-of-care immunoassays simultaneous detection of disease biomarkers with tunable detection range","volume":"212","author":"Yin","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"10","key":"10.1016\/j.cca.2025.120569_b0910","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1039\/C8LC00033F","article-title":"A microfluidic biochip platform for electrical quantification of proteins","volume":"18","author":"Valera","year":"2018","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b0915","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/acssensors.8b00789","article-title":"Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray based Interferometric Point-of-Care Device","volume":"4","author":"Dey","year":"2019","journal-title":"ACS Sens"},{"key":"10.1016\/j.cca.2025.120569_b0920","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jchromb.2011.12.001","article-title":"Rapid detection of sepsis in rats through volatile organic compounds in breath","volume":"881\u2013882","author":"Guam\u00e1n","year":"2012","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.cca.2025.120569_b0925","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bios.2014.03.052","article-title":"Total internal reflection (TIRF)-based quantification of procalcitonin for sepsis diagnosis \u2013 a point-of-care testing application","volume":"59","author":"Rascher","year":"2014","journal-title":"Biosens. Bioelectron."},{"issue":"18","key":"10.1016\/j.cca.2025.120569_b0930","doi-asserted-by":"crossref","first-page":"9997","DOI":"10.1021\/acs.analchem.7b02422","article-title":"Ultrasensitive Detection of Antiseptic Antibiotics in Aqueous Media and Human Urine using Deep UV Resonance Raman Spectroscopy","volume":"89","author":"Domes","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2025.120569_b0935","doi-asserted-by":"crossref","unstructured":"D. F. Gaieski, B. C. Drumheller, M. Goyal, B. D. Fuchs, F. S. Shofer, and K. Zogby, \u201cAccuracy of handheld point-of-care fingertip lactate measurement in the emergency department,\u201d Feb. 2013. doi: 10.5811\/westjem.2011.5.6706.","DOI":"10.5811\/westjem.2011.5.6706"},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b0940","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1021\/acsnano.7b01162","article-title":"Biotunable Nanoplasmonic Filter on Few-Layer MoS2 for Rapid and Highly Sensitive Cytokine Optoelectronic Immunosensing","volume":"11","author":"Park","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.cca.2025.120569_b0945","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202100862","article-title":"Compact Magneto\u2010Fluorescent Colloids by Hierarchical Assembly of Dual\u2010Components in Radial Channels for Sensitive Point\u2010of\u2010Care Immunoassay","volume":"17","author":"Huang","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.cca.2025.120569_b0950","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.snb.2013.10.003","article-title":"Biochip point-of-care device for sepsis diagnostics","volume":"192","author":"Kemmler","year":"2014","journal-title":"Sens Actuators B Chem"},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0955","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1021\/acssensors.9b02515","article-title":"Polymer-based Micromotor Fluorescence Immunoassay for On-the-move Sensitive Procalcitonin Determination in very Low Birth Weight infants\u2019 Plasma","volume":"5","author":"Molinero-Fern\u00e1ndez","year":"2020","journal-title":"ACS Sens"},{"issue":"12","key":"10.1016\/j.cca.2025.120569_b0960","doi-asserted-by":"crossref","first-page":"16864","DOI":"10.1021\/acsnano.0c05700","article-title":"Background-Free Chromatographic Detection of Sepsis Biomarker in Clinical Human Serum through Near-Infrared to Near-Infrared Upconversion Immunolabeling","volume":"14","author":"Ji","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.cca.2025.120569_b0965","doi-asserted-by":"crossref","unstructured":"Andryukov, Besednova, R. Romashko, T. A. Zaporozhets, and T. Efimov, \u201cLabel-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends,\u201d Biosensors (Basel), vol. 10, p. 11, Dec. 2020, doi: 10.3390\/bios10020011.","DOI":"10.3390\/bios10020011"},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b0970","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1039\/C8LC01102H","article-title":"Point of care technologies for sepsis diagnosis and treatment","volume":"19","author":"Oeschger","year":"2019","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120569_b0975","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2019.113468","article-title":"Rapid and sensitive detection of interleukin-6 in serum via time-resolved lateral flow immunoassay","volume":"588","author":"Huang","year":"2020","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cca.2025.120569_b0980","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112726","article-title":"Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping","volume":"171","author":"Tanak","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120569_b0985","doi-asserted-by":"crossref","unstructured":"M. Meisner, F. Brunkhorst, H. B. Reith, J. W. Schmidt, H. G. Lestin, and K. Reinhart, \u201cClinical Experiences with a New Semi-Quantitative Solid Phase Immunoassay for Rapid Measurement of Procalcitonin,\u201d in Clinical Chemistry and Laboratory Medicine, 2000. [Online]. Available: https:\/\/api.semanticscholar.org\/CorpusID:24777623.","DOI":"10.1515\/CCLM.2000.147"},{"key":"10.1016\/j.cca.2025.120569_b0990","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.aca.2019.05.038","article-title":"Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor","volume":"1077","author":"Fabri-Faja","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120569_b0995","article-title":"Graphene Enabled Low\u2010Noise Surface Chemistry for Multiplexed Sepsis Biomarker Detection in whole Blood","volume":"31","author":"Zupancic","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.cca.2025.120569_b1000","article-title":"Advances in Nanoporous Anodic Alumina-based Biosensors to Detect Biomarkers of Clinical significance: a Review","volume":"7","author":"Rajeev","year":"2017","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b1005","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1039\/C6AN02445A","article-title":"A critical insight into the development pipeline of microfluidic immunoassay devices for the sensitive quantitation of protein biomarkers at the point of care","volume":"142","author":"Barbosa","year":"2017","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2025.120569_b1010","doi-asserted-by":"crossref","DOI":"10.1002\/ange.201801815","article-title":"Controllable Assembly of Enzymes for Multiplexed Lab-on-a-Chip Bioassays with a Tunable Detection Range","volume":"130","author":"Xianyu","year":"2018","journal-title":"Angew. Chem."},{"issue":"10","key":"10.1016\/j.cca.2025.120569_b1015","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1021\/ac500277j","article-title":"Disposable Copper-based Electrochemical Sensor for Anodic Stripping Voltammetry","volume":"86","author":"Pei","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2025.120569_b1020","doi-asserted-by":"crossref","unstructured":"B. Reddy et al., \u201cPoint-of-care sensors for the management of sepsis,\u201d Sep. 01, 2018, Nature Publishing Group. doi: 10.1038\/s41551-018-0288-9.","DOI":"10.1038\/s41551-018-0288-9"},{"key":"10.1016\/j.cca.2025.120569_b1025","doi-asserted-by":"crossref","first-page":"15949","DOI":"10.1038\/ncomms15949","article-title":"A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification","volume":"8","author":"Hassan","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b1030","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1021\/acsnano.7b08965","article-title":"Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis","volume":"12","author":"Min","year":"2018","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b1035","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/ar500456w","article-title":"Integrated Electrochemical Microsystems for Genetic Detection of Pathogens at the Point of Care","volume":"48","author":"Hsieh","year":"2015","journal-title":"Acc. Chem. Res."},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b1040","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00216-008-2561-3","article-title":"Inflammation markers in point-of-care testing (POCT)","volume":"393","author":"Pf\u00e4fflin","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.cca.2025.120569_b1045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1039\/C9CS00621D","article-title":"Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review","volume":"51","author":"Hang","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"23","key":"10.1016\/j.cca.2025.120569_b1050","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.cca.2011.07.024","article-title":"Development of a point-of-care assay system for measurement of presepsin (sCD14-ST)","volume":"412","author":"Okamura","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120569_b1055","doi-asserted-by":"crossref","unstructured":"M. Singer, \u201cBiomarkers in sepsis,\u201d May 2013. doi: 10.1097\/MCP.0b013e32835f1b49.","DOI":"10.1097\/MCP.0b013e32835f1b49"},{"issue":"12","key":"10.1016\/j.cca.2025.120569_b1060","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1039\/D0LC00373E","article-title":"Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19","volume":"20","author":"McRae","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120569_b1065","doi-asserted-by":"crossref","unstructured":"J. A. Foushee, N. H. Hope, and E. Grace, \u201cApplying biomarkers to clinical practice: a guide for utilizing procalcitonin assays.,\u201d J Antimicrob Chemother, vol. 67 11, pp. 2560\u20139, 2012, [Online]. Available: https:\/\/api.semanticscholar.org\/CorpusID:9599624.","DOI":"10.1093\/jac\/dks265"},{"issue":"5","key":"10.1016\/j.cca.2025.120569_b1070","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jemermed.2007.11.099","article-title":"Point-of-Care Testing at Triage Decreases Time to Lactate Level in Septic patients","volume":"38","author":"Goyal","year":"2010","journal-title":"J. Emerg. Med."},{"key":"10.1016\/j.cca.2025.120569_b1075","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/s17030480","article-title":"Rapid and Sensitive Lateral Flow Immunoassay Method for Procalcitonin (PCT) based on Time-Resolved Immunochromatography","volume":"17","author":"Shao","year":"2017","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2025.120569_b1080","doi-asserted-by":"crossref","unstructured":"A. Teggert, H. Datta, and Z. Ali, \u201cBiomarkers for point-of-care diagnosis of sepsis,\u201d Mar. 01, 2020, MDPI AG. doi: 10.3390\/mi11030286.","DOI":"10.3390\/mi11030286"},{"key":"10.1016\/j.cca.2025.120569_b1085","doi-asserted-by":"crossref","unstructured":"T. Chan and F. Gu, \u201cEarly diagnosis of sepsis using serum biomarkers,\u201d Jun. 2011. doi: 10.1586\/erm.11.26.","DOI":"10.1586\/erm.11.26"},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b1090","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10156-005-0388-9","article-title":"Multicenter prospective study of procalcitonin as an indicator of sepsis","volume":"11","author":"Aikawa","year":"2005","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.cca.2025.120569_b1095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114268","article-title":"A label-free impedance biosensing assay based on CRISPR\/Cas12a collateral activity for bacterial DNA detection","volume":"204","author":"Bonini","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.cca.2025.120569_b1100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ebiom.2018.09.001","article-title":"Smartphone-based pathogen diagnosis in urinary sepsis patients","volume":"36","author":"Barnes","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cca.2025.120569_b1105","doi-asserted-by":"crossref","DOI":"10.2174\/1568026615666150413154233","article-title":"Aptamers: Molecular Tools for Medical Diagnosis","volume":"15","author":"Ozalp","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b1110","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1021\/acssensors.9b00063","article-title":"Ultrafast and Ultrasensitive Naked-Eye Detection of Urease-positive Bacteria with Plasmonic Nanosensors","volume":"4","author":"Santopolo","year":"2019","journal-title":"ACS Sens"},{"issue":"21","key":"10.1016\/j.cca.2025.120569_b1115","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1021\/ac5026623","article-title":"Agarose-based Microfluidic Device for Point-of-Care Concentration and Detection of Pathogen","volume":"86","author":"Li","year":"2014","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b1120","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/wrr.12414","article-title":"Electrochemical detection of Pseudomonas in wound exudate samples from patients with chronic wounds","volume":"24","author":"Sismaet","year":"2016","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.cca.2025.120569_b1125","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2013.213504","article-title":"Isothermal Recombinase Polymerase Amplification Assay Applied to the Detection of Group B Streptococci in Vaginal\/Anal Samples","volume":"60","author":"Daher","year":"2014","journal-title":"Clin. Chem."},{"issue":"26","key":"10.1016\/j.cca.2025.120569_b1130","doi-asserted-by":"crossref","first-page":"23093","DOI":"10.1021\/acsami.9b09279","article-title":"Bacteria-Instructed Click Chemistry between Functionalized Gold Nanoparticles for Point-of-Care Microbial Detection","volume":"11","author":"Mou","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b1135","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1021\/acssuschemeng.8b00112","article-title":"On\u2013Off\u2013On Gold Nanocluster-based Fluorescent Probe for Rapid Escherichia coli Differentiation, Detection and Bactericide Screening","volume":"6","author":"Yan","year":"2018","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.cca.2025.120569_b1140","doi-asserted-by":"crossref","unstructured":"S. Li, F. Ma, H. Bachman, C. E. Cameron, X. Zeng, and T. J. Huang, \u201cAcoustofluidic bacteria separation,\u201d Journal of Micromechanics and Microengineering, vol. 27, no. 1, Jan. 2017, doi: 10.1088\/1361-6439\/27\/1\/015031.","DOI":"10.1088\/1361-6439\/27\/1\/015031"},{"key":"10.1016\/j.cca.2025.120569_b1145","article-title":"Rapid, Electrical Impedance Detection of Bacterial Pathogens using Immobilized Antimicrobial Peptides","volume":"19","author":"Lillehoj","year":"2013","journal-title":"J. Lab. Autom."},{"issue":"6","key":"10.1016\/j.cca.2025.120569_b1150","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1039\/C7LC01180F","article-title":"Acoustic separation in plastic microfluidics for rapid detection of bacteria in blood using engineered bacteriophage","volume":"18","author":"Dow","year":"2018","journal-title":"Lab Chip"},{"issue":"7","key":"10.1016\/j.cca.2025.120569_b1155","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1021\/acs.bioconjchem.0c00297","article-title":"Nanoparticle-based Wound Dressing: recent Progress in the Detection and Therapy of Bacterial Infections","volume":"31","author":"Xu","year":"2020","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.cca.2025.120569_b1160","first-page":"2591","article-title":"Portable microfluidic chip for detection of Escherichia coli in produce and blood","volume":"7","author":"Wang","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"3","key":"10.1016\/j.cca.2025.120569_b1165","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1086\/600303","article-title":"Diagnostic accuracy of a rapid real-time polymerase chain reaction assay for universal intrapartum group b streptococcus screening","volume":"49","author":"El Helali","year":"2009","journal-title":"Clin. Infect. Dis."},{"issue":"7","key":"10.1016\/j.cca.2025.120569_b1170","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1128\/JCM.06504-11","article-title":"Recombinase polymerase amplification assay for rapid detection of Francisella tularensis","volume":"50","author":"Euler","year":"2012","journal-title":"J. Clin. Microbiol."},{"issue":"19","key":"10.1016\/j.cca.2025.120569_b1175","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1039\/b905065p","article-title":"Cell lysis and DNA extraction of gram-positive and gram-negative bacteria from whole blood in a disposable microfluidic chip","volume":"9","author":"Mahalanabis","year":"2009","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120569_b1180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112552","article-title":"Recent advances in developing biosensing based platforms for neonatal sepsis","volume":"169","author":"Balayan","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.cca.2025.120569_b1185","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3390\/s120201494","article-title":"Miniaturized protein microarray with internal calibration as point-of-care device for diagnosis of neonatal sepsis","volume":"12","author":"Buchegger","year":"2012","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2025.120569_b1190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112156","article-title":"On-the-fly rapid immunoassay for neonatal sepsis diagnosis: C-reactive protein accurate determination using magnetic graphene-based micromotors","volume":"158","author":"Molinero-Fern\u00e1ndez","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"10.1016\/j.cca.2025.120569_b1195","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1021\/acs.analchem.9b05384","article-title":"Electrochemical Microfluidic Micromotors-based Immunoassay for C-Reactive Protein Determination in Preterm Neonatal Samples with Sepsis Suspicion","volume":"92","author":"Molinero-Fern\u00e1ndez","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2025.120569_b1200","doi-asserted-by":"crossref","unstructured":"I. H. Celik, M. Hanna, F. E. Canpolat, and Mohan Pammi, \u201cDiagnosis of neonatal sepsis: the past, present and future,\u201d Jan. 01, 2022, Springer Nature. doi: 10.1038\/s41390-021-01696-z.","DOI":"10.1038\/s41390-021-01696-z"},{"issue":"16","key":"10.1016\/j.cca.2025.120569_b1205","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1039\/C9LC00517J","article-title":"Hierarchically structured microchip for point-of-care immunoassays with dynamic detection ranges","volume":"19","author":"Mou","year":"2019","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2025.120569_b1210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1586\/erm.11.98","article-title":"Development of chip-compatible sample preparation for diagnosis of infectious diseases","volume":"12","author":"Ritzi-Lehnert","year":"2012","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"4","key":"10.1016\/j.cca.2025.120569_b1215","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.biotechadv.2016.02.002","article-title":"Advances in microfluidics in combating infectious diseases","volume":"34","author":"Tay","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.cca.2025.120569_b1220","doi-asserted-by":"crossref","unstructured":"A. Afshari, J. Schrenzel, M. Ieven, and S. Harbarth, \u201cBench-to-bedside review: Rapid molecular diagnostics for bloodstream infection-a new frontier? R E V I E W,\u201d 2012. [Online]. Available: http:\/\/ccforum.com\/content\/16\/3\/222.","DOI":"10.1186\/cc11202"},{"key":"10.1016\/j.cca.2025.120569_b1225","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2110-5820-3-22","article-title":"Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections","volume":"3","author":"Dupuy","year":"2013","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.cca.2025.120569_b1230","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bios.2018.11.053","article-title":"Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real time","volume":"126","author":"Russell","year":"2019","journal-title":"Biosens. Bioelectron."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125004486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125004486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T13:05:02Z","timestamp":1763039102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125004486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":246,"alternative-id":["S0009898125004486"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120569","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Point-of-care testing for early detection of sepsis: a systematic literature review","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120569"}}