{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:56:35Z","timestamp":1786985795527,"version":"build-2736575974"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cca.2025.120582","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T21:42:10Z","timestamp":1756676530000},"page":"120582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Amyloid beta biosensors in neurodegenerative disease"],"prefix":"10.1016","volume":"578","author":[{"given":"Mohsen Jabbari","family":"Jooshin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Koohkansaadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Hassanzadeh-Khanmiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Fazilat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmadalipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-3688","authenticated-orcid":false,"given":"Ahmad","family":"Mobed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Charsouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120582_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2024.114778","article-title":"Gut microbiota dysbiosis in Alzheimer's disease (AD): Insights from human clinical studies and the mouse AD models","volume":"290","author":"Manfredi","year":"2025","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.cca.2025.120582_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102642","article-title":"Biomarkers of synaptic degeneration in Alzheimer\u2019s disease","volume":"104","author":"Cheng","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cca.2025.120582_b0015","first-page":"1","article-title":"Resveratrol mitigates activated astrocytes and microglia preventing Alzheimer\u2019s Disease (AD) progression and facilitates neuronal communication in amyloid-\u03b225\u201335 induced rat model for AD: a special emphasis on non-neuronal involvement in AD pathophysiology","author":"Surya","year":"2025","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0020","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.jval.2025.04.407","article-title":"EE115 Markov simulation for estimating the Impact of Lecanemab Treatment on Health Outcomes in Early Alzheimer's Disease from a Japanese Societal Perspective","volume":"28","author":"Igarashi","year":"2025","journal-title":"Value Health"},{"key":"10.1016\/j.cca.2025.120582_b0025","first-page":"1","article-title":"Kumar, Crosstalk between copper, Alzheimer\u2019s disease, and melatonin","author":"Deepika","year":"2025","journal-title":"Biometals"},{"key":"10.1016\/j.cca.2025.120582_b0030","article-title":"MRI-to-PET cross-modality translation using globally & locally aware GAN (GLA-GAN) for multi-modal diagnosis of Alzheimer\u2019s disease","author":"Sikka","year":"2025","journal-title":"The Journal of Precision Medicine: Health and Disease"},{"key":"10.1016\/j.cca.2025.120582_b0035","article-title":"Hybrid PET\/MRI Imaging of Alzheimer's Disease based on 18F-AV-1451","volume":"JoVE) (218","author":"Zhan","year":"2025","journal-title":"J. Vis. Exp."},{"issue":"3","key":"10.1016\/j.cca.2025.120582_b0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.14715\/cmb\/2025.71.3.14","article-title":"Effect of regular exercise on ocular inflammation and mitochondrial biogenesis in experimental Alzheimer\u2019s disease model","volume":"71","author":"Okudan","year":"2025","journal-title":"Cell. Mol. Biol."},{"issue":"2","key":"10.1016\/j.cca.2025.120582_b0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.54817\/IC.v66n2a06","article-title":"The p300-NF-\u03baB pathway induces the activation of the NLRP3 inflammasome and the pyroptosis of neurons in an in vitro model of Alzheimer\u2019s disease","volume":"66","author":"Sun","year":"2025","journal-title":"Investigaci\u00f3n Cl\u00ednica"},{"key":"10.1016\/j.cca.2025.120582_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2025.05.007","article-title":"Amyloid precursor protein carboxy-terminal fragments as catalyzers of endolysosomal dysfunction in Alzheimer\u2019s disease","author":"Vrancx","year":"2025","journal-title":"Trends Neurosci."},{"issue":"4","key":"10.1016\/j.cca.2025.120582_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjpad.2025.100082","article-title":"Biofluid biomarker changes following treatment with sabirnetug (ACU193) in INTERCEPT-AD, a phase 1 trial in early Alzheimer's disease","volume":"12","author":"Cline","year":"2025","journal-title":"J. Prev Alzheimers Dis."},{"issue":"21","key":"10.1016\/j.cca.2025.120582_b0060","doi-asserted-by":"crossref","first-page":"12924","DOI":"10.3390\/ijms232112924","article-title":"Amyloid beta in aging and Alzheimer\u2019s disease","volume":"23","author":"Sehar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cca.2025.120582_b0065","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/alz.12321","article-title":"Visualization of neurofibrillary tangle maturity in Alzheimer's disease: a clinicopathologic perspective for biomarker research","volume":"17","author":"Moloney","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cca.2025.120582_b0070","doi-asserted-by":"crossref","unstructured":"M. Otero-Garcia, S.U. Mahajani, D. Wakhloo, W. Tang, Y.-Q. Xue, S. Morabito, J. Pan, J. Oberhauser, A.E. Madira, T. Shakouri, Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer\u2019s disease, Neuron 110(18) (2022) 2929-2948. e8.","DOI":"10.1016\/j.neuron.2022.06.021"},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/alz.13387","article-title":"Distinct transcriptomic responses to A\u03b2 plaques, neurofibrillary tangles, and APOE in Alzheimer's disease","volume":"20","author":"Das","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0080","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s40520-019-01341-0","article-title":"Familial Alzheimer\u2019s disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability","volume":"33","author":"Pendin","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"issue":"19","key":"10.1016\/j.cca.2025.120582_b0085","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.3390\/jcm10194582","article-title":"The clinical and neuropathological features of sporadic (Late-onset) and genetic forms of alzheimer\u2019s disease","volume":"10","author":"Rujeedawa","year":"2021","journal-title":"J. Clin. Med."},{"issue":"23","key":"10.1016\/j.cca.2025.120582_b0090","doi-asserted-by":"crossref","first-page":"27789","DOI":"10.1021\/acsami.3c06460","article-title":"Biophysical properties of the fibril structure of the toxic conformer of amyloid-\u03b242: Characterization by atomic force microscopy in liquid and molecular docking","volume":"15","author":"Biyani","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.cca.2025.120582_b0095","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/biom12020166","article-title":"Recent advances in our molecular and mechanistic understanding of misfolded cellular proteins in Alzheimer\u2019s disease (AD) and prion disease (PrD)","volume":"12","author":"Lukiw","year":"2022","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0100","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2174\/1389203720666190125160937","article-title":"New mechanism of amyloid fibril formation","volume":"20","author":"Galzitskaya","year":"2019","journal-title":"Curr. Protein Pept. Sci."},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0105","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/jcb.30141","article-title":"Distinct types of amyloid\u2010\u03b2 oligomers displaying diverse neurotoxicity mechanisms in Alzheimer's disease","volume":"122","author":"Madhu","year":"2021","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cca.2025.120582_b0110","unstructured":"B.S.F. Mira, MOLECULAR MECHANISMS OF PRESYNAPTIC APP FUNCTION IN THE CONTEXT OF ALZHEIMER\u2019S DISEASE, 2024."},{"key":"10.1016\/j.cca.2025.120582_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1271203","article-title":"GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions","volume":"14","author":"Meera","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-201027","article-title":"Selective secretase targeting for Alzheimer\u2019s disease therapy","volume":"81","author":"Miranda","year":"2021","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"8","key":"10.1016\/j.cca.2025.120582_b0125","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/toxins15080500","article-title":"A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the \u03b1-Cleavage Site","volume":"15","author":"Futai","year":"2023","journal-title":"Toxins"},{"issue":"7","key":"10.1016\/j.cca.2025.120582_b0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.15698\/cst2018.07.143","article-title":"Alzheimer\u2019s disease: Amyloid-based pathogenesis and potential therapies","volume":"2","author":"Zhou","year":"2018","journal-title":"Cell Stress"},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0135","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.3390\/ijms22115991","article-title":"An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?","volume":"22","author":"Sciaccaluga","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cca.2025.120582_b0140","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2174\/1871527322666230627123426","article-title":"Role of alpha-7-nicotinic acetylcholine receptor in Alzheimer's disease","volume":"23","author":"Singh","year":"2024","journal-title":"CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders)"},{"issue":"7","key":"10.1016\/j.cca.2025.120582_b0145","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.3390\/ijms25073733","article-title":"Targeting n-methyl-d-aspartate receptors in neurodegenerative diseases","volume":"25","author":"Carles","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s10571-024-01529-7","article-title":"AMPA receptors in synaptic plasticity, memory function, and brain diseases","volume":"45","author":"de Le\u00f3n-L\u00f3pez","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.cca.2025.120582_b0155","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cca.2025.120582_b0160","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbi.2023.07.006","article-title":"LPS priming before plaque deposition impedes microglial activation and restrains A\u03b2 pathology in the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"113","author":"Yang","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cca.2025.120582_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2023.120866","article-title":"Exploring cerebral amyloid angiopathy: insights into pathogenesis, diagnosis, and treatment","volume":"454","author":"Cozza","year":"2023","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5853\/jos.2015.17.1.17","article-title":"Cerebral amyloid angiopathy: emerging concepts","volume":"17","author":"Yamada","year":"2015","journal-title":"Journal of Stroke"},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0175","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/jnnp-2021-327788","article-title":"Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer\u2019s disease, frontotemporal dementia and progressive supranuclear palsy","volume":"93","author":"Chouliaras","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0180","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41398-023-02692-z","article-title":"Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-\u03b2-associated pathology in APP\/PS1 mouse model of Alzheimer\u2019s disease","volume":"13","author":"Chen","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"19","key":"10.1016\/j.cca.2025.120582_b0185","doi-asserted-by":"crossref","first-page":"14794","DOI":"10.3390\/ijms241914794","article-title":"Amyloid precursor protein and Alzheimer\u2019s disease","volume":"24","author":"Orobets","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2025.120582_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.969547","article-title":"Amyloid precursor protein (APP) and amyloid \u03b2 (A\u03b2) interact with cell adhesion molecules: Implications in Alzheimer\u2019s disease and normal physiology","volume":"10","author":"Pfundstein","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"21","key":"10.1016\/j.cca.2025.120582_b0195","doi-asserted-by":"crossref","first-page":"12209","DOI":"10.18632\/aging.205174","article-title":"Effects of amyloid \u03b2 (A\u03b2) 42 and Gasdermin D on the progression of Alzheimer\u2019s disease in vitro and in vivo through the regulation of astrocyte pyroptosis","volume":"15","author":"Hong","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0200","first-page":"17","article-title":"Time dependent expression profiling of PTK2B and its relationship with A\u03b2, Tau and LRP-1 in hippocampus and blood of APPswe\/PS1dE9 double-transgenic mouse, Zhongguo Ying Yong Sheng li xue za zhi= Zhongguo Yingyong Shenglixue Zazhi= chinese","volume":"38","author":"Hao","year":"2022","journal-title":"J. Appl. Physiol."},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0205","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jamaneurol.2019.2214","article-title":"Staging \u03b2-amyloid pathology with amyloid positron emission tomography","volume":"76","author":"Mattsson","year":"2019","journal-title":"JAMA Neurol."},{"issue":"9","key":"10.1016\/j.cca.2025.120582_b0210","doi-asserted-by":"crossref","first-page":"100610074","DOI":"10.21037\/apm-21-825","article-title":"A literature review of MRI techniques used to detect amyloid-beta plaques in Alzheimer\u2019s disease patients","volume":"10","author":"Yu","year":"2021","journal-title":"Ann. Palliative Med."},{"issue":"4","key":"10.1016\/j.cca.2025.120582_b0215","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3233\/JAD-2010-091681","article-title":"Immunohistochemical visualization of amyloid-\u03b2 protein precursor and amyloid-\u03b2 in extra-and intracellular compartments in the human brain","volume":"20","author":"Aho","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"3","key":"10.1016\/j.cca.2025.120582_b0220","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/13506129.2013.797389","article-title":"Immunohistochemical characterization of novel monoclonal antibodies against the N-terminus of amyloid \u03b2-peptide","volume":"20","author":"Verwey","year":"2013","journal-title":"Amyloid"},{"issue":"4","key":"10.1016\/j.cca.2025.120582_b0225","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s13361-018-1896-z","article-title":"Detection of amyloid beta (A\u03b2) oligomeric composition using matrix-assisted laser desorption ionization mass spectrometry (MALDI MS)","volume":"29","author":"Wang","year":"2018","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"4","key":"10.1016\/j.cca.2025.120582_b0230","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/mas.21814","article-title":"Using mass spectrometry\u2010based methods to understand amyloid formation and inhibition of alpha\u2010synuclein and amyloid beta","volume":"43","author":"Wagner","year":"2024","journal-title":"Mass Spectrom. Rev."},{"issue":"10","key":"10.1016\/j.cca.2025.120582_b0235","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70111","article-title":"Comparative Diagnostic Performance of Amyloid\u2010\u03b2 Positron Emission Tomography and magnetic Resonance Imaging in Alzheimer's Disease: a Head\u2010to\u2010Head Meta\u2010Analysis","volume":"14","author":"Li","year":"2024","journal-title":"Brain Behav."},{"issue":"1\u20132","key":"10.1016\/j.cca.2025.120582_b0240","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000439257","article-title":"A.S.D.N. Initiative, discriminative power of arterial spin labeling magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography changes for amyloid-\u03b2-positive subjects in the Alzheimer's disease continuum","volume":"16","author":"Tosun","year":"2016","journal-title":"Neurodegener. Dis."},{"issue":"17","key":"10.1016\/j.cca.2025.120582_b0245","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/acschemneuro.4c00097","article-title":"Fluorescence-based monitoring of Early-Stage Aggregation of Amyloid-\u03b2, Amylin Peptide, Tau, and \u03b1-Synuclein Proteins","volume":"15","author":"Li","year":"2024","journal-title":"ACS Chem. Nerosci."},{"issue":"5","key":"10.1016\/j.cca.2025.120582_b0250","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00249-021-01505-9","article-title":"Fluorescence-based techniques for the detection of the oligomeric status of proteins: implication in amyloidogenic diseases","volume":"50","author":"Mirdha","year":"2021","journal-title":"Eur. Biophys. J."},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0255","doi-asserted-by":"crossref","DOI":"10.1002\/mds3.10129","article-title":"Recent advances of medical biosensors for clinical applications","volume":"4","author":"Saylan","year":"2021","journal-title":"Med. Devices Sens."},{"issue":"3","key":"10.1016\/j.cca.2025.120582_b0260","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/bab.1621","article-title":"Biosensors: Classifications, medical applications, and future prospective","volume":"65","author":"Alhadrami","year":"2018","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"2","key":"10.1016\/j.cca.2025.120582_b0265","article-title":"Bioreceptors as the key components for electrochemical biosensing in medicine","volume":"5","author":"Wang","year":"2024","journal-title":"Cell Rep. Phys. Sci."},{"key":"10.1016\/j.cca.2025.120582_b0270","series-title":"Next Generation Smart Nano-Bio-Devices","first-page":"29","article-title":"Overview of Biosensors and its Application in Health Care","author":"Bag","year":"2023"},{"key":"10.1016\/j.cca.2025.120582_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120414","article-title":"Nanosensing for tramadol detection: innovative opioid analysis","volume":"576","author":"Zeinaly","year":"2025","journal-title":"Clin. Chim. Acta"},{"issue":"22","key":"10.1016\/j.cca.2025.120582_b0280","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1007\/s00216-021-03301-y","article-title":"Integrating high-performing electrochemical transducers in lateral flow assay","volume":"413","author":"Perju","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cca.2025.120582_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123425","article-title":"Textile-based electrochemical sensors and their applications","volume":"244","author":"Sinha","year":"2022","journal-title":"Talanta"},{"issue":"12","key":"10.1016\/j.cca.2025.120582_b0290","doi-asserted-by":"crossref","DOI":"10.20964\/2021.12.15","article-title":"Quartz Crystal Microbalance (QCM) Sensing Materials in Biosensors Development","volume":"16","author":"Pohanka","year":"2021","journal-title":"Int. J. Electrochem. Sci."},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0295","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/10408363.2024.2321202","article-title":"DNA\/RNA-based electrochemical nanobiosensors for early detection of cancers","volume":"61","author":"Mikaeeli Kangarshahi","year":"2024","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"issue":"15","key":"10.1016\/j.cca.2025.120582_b0300","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.3390\/s21155114","article-title":"A Review on the Development of Gold and Silver Nanoparticles-based Biosensor as a Detection strategy of Emerging and Pathogenic RNA Virus","volume":"21","author":"Ibrahim","year":"2021","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2025.120582_b0305","series-title":"Biomaterials-Based Sensors: Recent Advances and Applications","first-page":"101","article-title":"Transducers in Biosensors","author":"Yadav","year":"2023"},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0310","doi-asserted-by":"crossref","DOI":"10.1149\/1945-7111\/ac2fc6","article-title":"Review\u2014MXene based Transducer for Biosensor applications","volume":"168","author":"Thenmozhi","year":"2021","journal-title":"J. Electrochem. Soc."},{"issue":"12","key":"10.1016\/j.cca.2025.120582_b0315","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.3390\/s22124555","article-title":"A Low-Power Analog Processor-in-Memory-based Convolutional Neural Network for Biosensor applications","volume":"22","author":"Byun","year":"2022","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2025.120582_b0320","series-title":"Fundamentals of Biosensors in Healthcare","first-page":"71","article-title":"Chapter 3 - Biosensor-signal transducers","author":"Lal Srivastava","year":"2025"},{"key":"10.1016\/j.cca.2025.120582_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117683","article-title":"Recent advances in protein biomarkers based enzymatic biosensors for non-communicable diseases","volume":"174","author":"Kaur","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.cca.2025.120582_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.sna.2024.115499","article-title":"Enzymatic electrochemical biosensors for urea detection: a review","volume":"374","author":"Mashhadban-K","year":"2024","journal-title":"Sens. Actuators, A"},{"issue":"5","key":"10.1016\/j.cca.2025.120582_b0335","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1007\/s10311-024-01745-z","article-title":"Immunosensors in food, health, environment, and agriculture: a review","volume":"22","author":"Kumar","year":"2024","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.cca.2025.120582_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.talo.2025.100495","article-title":"Recent advancements in microcystin detection: a comprehensive review of immunosensors and nucleic acid-based biosensors for efficient monitoring in drinking water and human samples","volume":"12","author":"Antonyraj","year":"2025","journal-title":"Talanta Open"},{"key":"10.1016\/j.cca.2025.120582_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117511","article-title":"Paper-based nucleic acid biosensors","volume":"171","author":"Eksin","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.cca.2025.120582_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.215745","article-title":"Nanotechnology-leveraged nucleic acid amplification for foodborne pathogen detection","volume":"506","author":"Deng","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cca.2025.120582_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126897","article-title":"Advancements in electrochemical glucose sensors","volume":"281","author":"Huang","year":"2025","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.cca.2025.120582_b0360","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41565-024-01821-z","article-title":"Advanced characterization of confined electrochemical interfaces in electrochemical capacitors","volume":"20","author":"Ge","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.cca.2025.120582_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120293","article-title":"Alpha-Fetoprotein (AFP) biosensors","volume":"573","author":"Niaki","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2025.120582_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120222","article-title":"Aspirin nanosensors","volume":"571","author":"Koohkansaadi","year":"2025","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.cca.2025.120582_b0375","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1039\/D3TB02648E","article-title":"A review of nanomaterials for biosensing applications","volume":"12","author":"Li","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.cca.2025.120582_b0380","article-title":"Next-generation nanomaterials-based biosensors: Real-time biosensing devices for detecting emerging environmental pollutants","volume":"29","author":"Sharma","year":"2025","journal-title":"Mater. Today Sustainability"},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0385","article-title":"A review on the types of nanomaterials and methodologies used for the development of biosensors, advances in Natural Sciences","volume":"15","author":"Ghosh","year":"2024","journal-title":"Nanosci. Nanotechnol."},{"key":"10.1016\/j.cca.2025.120582_b0390","article-title":"Toxicity of gold nanoparticles (AuNPs): a review","volume":"26","author":"Sani","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.cca.2025.120582_b0395","first-page":"18","article-title":"Synthesis paradigm and applications of silver nanoparticles (AgNPs), a review","volume":"13","author":"Beyene","year":"2017","journal-title":"Sustain. Mater. Technol."},{"issue":"9","key":"10.1016\/j.cca.2025.120582_b0400","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/nano14090756","article-title":"The effectiveness mechanisms of carbon nanotubes (CNTs) as reinforcements for magnesium-based composites for biomedical applications: a review","volume":"14","author":"Saberi","year":"2024","journal-title":"Nanomaterials"},{"key":"10.1016\/j.cca.2025.120582_b0405","doi-asserted-by":"crossref","unstructured":"A. Petushkov, N. Ndiege, A.K. Salem, S.C. Larsen, Chapter 7 - Toxicity of Silica Nanomaterials: Zeolites, Mesoporous Silica, and Amorphous Silica Nanoparticles, in: J.C. Fishbein (Ed.), Advances in Molecular Toxicology, Elsevier2010, pp. 223-266.","DOI":"10.1016\/S1872-0854(10)04007-5"},{"key":"10.1016\/j.cca.2025.120582_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127802","article-title":"Recent advances in fluorescence nanoparticles \u201cquantum dots\u201d as gene delivery system: a review","volume":"254","author":"Zahed","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.cca.2025.120582_b0415","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.3390\/nano11123432","article-title":"A Comprehensive Updated Review on magnetic Nanoparticles in Diagnostics","volume":"11","author":"Farinha","year":"2021","journal-title":"Nanomaterials"},{"issue":"18","key":"10.1016\/j.cca.2025.120582_b0420","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/cancers13184570","article-title":"Recent advances in zinc oxide nanoparticles (ZnO NPs) for cancer diagnosis, target drug delivery, and treatment","volume":"13","author":"Anjum","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0425","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jbiosc.2021.03.016","article-title":"Development of liquid crystal biosensor for the detection of amyloid beta-42 levels associated with Alzheimer's disease","volume":"132","author":"Kemiklioglu","year":"2021","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.cca.2025.120582_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114365","article-title":"Ultrasensitive probeless capacitive biosensor for amyloid beta (A\u03b21-42) detection in human plasma using interdigitated electrodes","volume":"212","author":"Sharma","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120582_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2023.108501","article-title":"A new ITO-based A\u03b242 biosensor for early detection of Alzheimer's disease","volume":"153","author":"Altay","year":"2023","journal-title":"Bioelectrochemistry"},{"issue":"10","key":"10.1016\/j.cca.2025.120582_b0440","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1021\/acssensors.4c00945","article-title":"Chemically Self-Assembled Monolayer Semiconducting Single-Walled Carbon Nanotube-based Biosensor Platform for Amyloid-\u03b2 Detection","volume":"9","author":"Kim","year":"2024","journal-title":"ACS Sensors"},{"issue":"46","key":"10.1016\/j.cca.2025.120582_b0445","doi-asserted-by":"crossref","first-page":"24463","DOI":"10.1021\/acs.langmuir.4c03042","article-title":"SERS-based microfluidic bioscreening platform for selective detection of \u03b2-amyloid peptides","volume":"40","author":"Jaiswal","year":"2024","journal-title":"Langmuir"},{"key":"10.1016\/j.cca.2025.120582_b0450","article-title":"Detection of amyloid-\u03b2(1\u201342) aggregation with a nanostructured electrochemical sandwich immunoassay biosensor","volume":"10\u20132022","author":"Wang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cca.2025.120582_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131727","article-title":"Quantitative analysis of PACAP-38 and amyloid beta composition using a dual reaction in reduced graphene oxide biosensor to verify the neuroprotective role of PACAP-38","volume":"361","author":"Lee","year":"2022","journal-title":"Sens. Actuators B"},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0460","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/bios12111059","article-title":"Electrochemical immunosensor for early detection of \u03b2-Amyloid Alzheimer\u2019s disease biomarker based on aligned carbon nanotubes gold nanocomposites","volume":"12","author":"Ranjan","year":"2022","journal-title":"Biosensors"},{"issue":"2","key":"10.1016\/j.cca.2025.120582_b0465","first-page":"215","article-title":"A \u03b2-Amyloid((1-42)) Biosensor based on molecularly imprinted poly-pyrrole for early diagnosis of Alzheimer's disease","volume":"11","author":"Dehdari Vais","year":"2021","journal-title":"J Biomed Phys Eng"},{"key":"10.1016\/j.cca.2025.120582_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.112997","article-title":"A cathodic photoelectrochemical dual aptamer-based biosensor for detection of \u03b2-amyloid peptide","volume":"210","author":"Zhang","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.cca.2025.120582_b0475","doi-asserted-by":"crossref","unstructured":"C.d.A. Razzino, L.F. Sgobbi, J. Cancino-Bernardi, A.M.M. Zapata, C.C. Costa, V. Zucolotto, L. Vieira, A.O. Lobo, A microbead-enhanced electrochemical platform for \u03b2-amyloid peptide (1\u201342) detection, Frontiers in Sensors Volume 5 - 2024 (2024).","DOI":"10.3389\/fsens.2024.1508810"},{"issue":"4","key":"10.1016\/j.cca.2025.120582_b0480","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1021\/acsabm.3c01201","article-title":"Ultrasensitive aptasensing platform for the detection of \u03b2-Amyloid-42 Peptide based on MOF containing bimetallic porphyrin graphene oxide and gold nanoparticles","volume":"7","author":"Vajedi","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.cca.2025.120582_b0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.114105","article-title":"Peptide-based electrochemical sensor for sensitive detection of amyloid-\u03b2 oligomer with laccase-mimicking nanozyme assemblies as a signal amplifier","volume":"214","author":"Li","year":"2025","journal-title":"Microchem. J."},{"issue":"8","key":"10.1016\/j.cca.2025.120582_b0490","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1039\/D0NA00801J","article-title":"Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides A\u03b2 (1\u201342)","volume":"3","author":"Abbasi","year":"2021","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.cca.2025.120582_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125134","article-title":"Ultrasensitive electrochemical detection of amyloid-beta oligomers using double amplification strategy by MXene substrate and covalent organic framework-based probe","volume":"266","author":"Lv","year":"2024","journal-title":"Talanta"},{"issue":"4","key":"10.1016\/j.cca.2025.120582_b0500","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/bios15040228","article-title":"Stamp-imprinted Polymer EIS biosensor for amyloid-beta detection: a novel approach towards Alzheimer\u2019s screening","volume":"15","author":"Davidson","year":"2025","journal-title":"Biosensors"},{"key":"10.1016\/j.cca.2025.120582_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111680","article-title":"An electrochemiluminescent\/colorimetric dual-mode biosensor for ultrasensitive detection of amyloid \u03b2 based on Cu2+-g-C3N4 nanomaterials","volume":"207","author":"Tang","year":"2024","journal-title":"Microchem. J."},{"issue":"9","key":"10.1016\/j.cca.2025.120582_b0510","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1021\/acs.langmuir.4c04261","article-title":"Utilizing functionalized dual-microbead interfaces for measurements of amyloid-beta (1\u201342) with Femtomolar Sensitivity","volume":"41","author":"Pollock","year":"2025","journal-title":"Langmuir"},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0515","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1039\/D5AN00048C","article-title":"An innovative electrochemiluminescent immunosensor using dual amplified signals from AuNPs@CoSn(OH)6 for the detection of the AD biomarker: amyloid beta 1\u201340","volume":"150","author":"Sun","year":"2025","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2025.120582_b0520","first-page":"1","article-title":"Construction of an \u201captamer-target-peptide\u201d sandwich electrochemical biosensor for ultrasensitive assay of amyloid-beta oligomers based on bimetallic covalent organic framework","author":"Lv","year":"2025","journal-title":"J. Anal. Test."},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0525","doi-asserted-by":"crossref","DOI":"10.3390\/chemosensors13060220","article-title":"Advanced biosensing technologies: leading innovations in Alzheimer's disease diagnosis","volume":"13","author":"Benjamin","year":"2025","journal-title":"Chemosensors"},{"key":"10.1016\/j.cca.2025.120582_b0530","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bios.2016.01.065","article-title":"Nano-biosensors to detect beta-amyloid for Alzheimer's disease management","volume":"80","author":"Kaushik","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2025.120582_b0535","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.snb.2016.07.181","article-title":"Alzheimer\u2019s disease: development of a sensitive label-free electrochemical immunosensor for detection of amyloid beta peptide","volume":"239","author":"Carneiro","year":"2017","journal-title":"Sens. Actuators B"},{"issue":"6","key":"10.1016\/j.cca.2025.120582_b0540","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/00032719.2014.968925","article-title":"Biosensors for the determination of amyloid-beta peptides and their aggregates with application to Alzheimer's disease","volume":"48","author":"Xing","year":"2015","journal-title":"Anal. Lett."},{"issue":"8","key":"10.1016\/j.cca.2025.120582_b0545","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3390\/biomedicines12081836","article-title":"P-tau217 as a reliable blood-based marker of Alzheimer\u2019s disease","volume":"12","author":"Lai","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0550","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s43856-025-00768-z","article-title":"Alzheimer\u2019s disease biological PET staging using plasma p217+ tau","volume":"5","author":"Feizpour","year":"2025","journal-title":"Commun. Med."},{"issue":"1","key":"10.1016\/j.cca.2025.120582_b0555","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13195-025-01712-y","article-title":"Evaluating the diagnostic performance of six plasma biomarkers for Alzheimer\u2019s disease and other neurodegenerative dementias in a large chinese cohort","volume":"17","author":"Jiao","year":"2025","journal-title":"Alzheimers Res. Ther."},{"issue":"11","key":"10.1016\/j.cca.2025.120582_b0560","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1136\/jnnp-2021-327370","article-title":"Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer\u2019s disease: a focused review on recent advances","volume":"92","author":"Chong","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125004619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125004619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:59:41Z","timestamp":1763038781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125004619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":112,"alternative-id":["S0009898125004619"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120582","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid beta biosensors in neurodegenerative disease","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120582"}}