{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:27:58Z","timestamp":1792808878213,"version":"4.5.0"},"reference-count":135,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016286","name":"Urmia University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cca.2025.120623","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:46:30Z","timestamp":1758566790000},"page":"120623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Personalized biomarkers in male infertility"],"prefix":"10.1016","volume":"579","author":[{"given":"Ali","family":"Parvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Shadravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Sadeghpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mortaza","family":"Taheri-Anganeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojat","family":"Ghasemnejad-Berenji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120623_bb0005","series-title":"Examination and processing of human semen","first-page":"443","author":"Edition","year":"2010"},{"issue":"Suppl. 2","key":"10.1016\/j.cca.2025.120623_bb0010","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.21037\/tau.2019.10.20","article-title":"Future diagnostics in male infertility: Genomics, epigenetics, metabolomics and proteomics","volume":"9","author":"Krzastek","year":"2020","journal-title":"Translational Andrology and Urology"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0015","first-page":"19","article-title":"The office visit","volume":"41","author":"Smith","year":"2014","journal-title":"Urologic Clinics"},{"key":"10.1016\/j.cca.2025.120623_bb0020","series-title":"Andrological evaluation of male infertility","first-page":"113","author":"Agarwal","year":"2016"},{"issue":"19","key":"10.1016\/j.cca.2025.120623_bb0025","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa003005","article-title":"Sperm morphology, motility, and concentration in fertile and infertile men","volume":"345","author":"Guzick","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0030","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1590\/S1807-59322011000400026","article-title":"An update on the clinical assessment of the infertile male","volume":"66","author":"Esteves","year":"2011","journal-title":"Clinics"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.rbmo.2017.12.005","article-title":"A search for molecular mechanisms underlying male idiopathic infertility","volume":"36","author":"Bracke","year":"2018","journal-title":"Reproductive biomedicine online"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/01485019108987644","article-title":"Effects of varying the abstinence period in the same individuals on sperm quality","volume":"26","author":"Magnus","year":"1991","journal-title":"Archives of andrology"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2006.12.045","article-title":"High risk of temporary alteration of semen parameters after recent acute febrile illness","volume":"88","author":"Sergerie","year":"2007","journal-title":"Fertility and sterility"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/jog.12149","article-title":"Diabetes mellitus and abnormalities in semen analysis","volume":"40","author":"Bhattacharya","year":"2014","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.sxmr.2017.07.004","article-title":"Diet and men\u2019s sexual health","volume":"6","author":"La","year":"2018","journal-title":"Sexual medicine reviews"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.fertnstert.2016.11.004","article-title":"Associations between physical activity and semen quality in young healthy men","volume":"107","author":"J\u00f3\u017ak\u00f3w","year":"2017","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0065","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/andr.12198","article-title":"Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis","volume":"4","author":"Gabrielsen","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.cca.2025.120623_bb0070","article-title":"N. Bandara","author":"Wijesekara","year":"2015","journal-title":"Environmental and occupational exposures as a cause of male infertility"},{"key":"10.1016\/j.cca.2025.120623_bb0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cca.2015.01.033","article-title":"Antisperm antibodies in infertile men and their effect on semen parameters: a systematic review and meta-analysis","volume":"444","author":"Cui","year":"2015","journal-title":"Clinica Chimica Acta"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0080","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.fertnstert.2014.09.044","article-title":"Sperm functional tests","volume":"102","author":"Oehninger","year":"2014","journal-title":"Fertility and sterility"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0085","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/andr.12381","article-title":"DNA fragmentation in spermatozoa: a historical review","volume":"5","author":"Rex","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.cca.2025.120623_bb0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bpobgyn.2017.07.003","article-title":"diagnosis and impact of sperm DNA alterations in assisted reproduction","volume":"44","author":"Simon","year":"2017","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0095","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.fertnstert.2009.01.112","article-title":"Intrauterine insemination with or without mild ovarian stimulation in couples with male subfertility due to oligo\/astheno-and\/or teratozoospermia or antisperm antibodies: a prospective cross-over trial","volume":"92","author":"Francavilla","year":"2009","journal-title":"Fertility and sterility"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0100","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.fertnstert.2008.08.082","article-title":"Immunoglobulin G antisperm antibodies and prediction of spontaneous pregnancy","volume":"92","author":"Leushuis","year":"2009","journal-title":"Fertility and sterility"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0105","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/humrep\/der074","article-title":"Antisperm antibodies are not associated with pregnancy rates after IVF and ICSI: systematic review and meta-analysis","volume":"26","author":"Zini","year":"2011","journal-title":"Human reproduction"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0110","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.fertnstert.2022.04.028","article-title":"A systematic review identifying fertility biomarkers in semen: a clinical approach through omics to diagnose male infertility","volume":"118","author":"Llavanera","year":"2022","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0974-1208.138857","article-title":"OMICS: Current and future perspectives in reproductive medicine and technology","volume":"7","author":"Egea","year":"2014","journal-title":"Journal of Human Reproductive Sciences"},{"issue":"4657","key":"10.1016\/j.cca.2025.120623_bb0120","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/183302a0","article-title":"A case of human intersexuality having a possible XXY sex-determining mechanism","volume":"183","author":"Jacobs","year":"1959","journal-title":"Nature"},{"key":"10.1016\/j.cca.2025.120623_bb0125","series-title":"A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome)","author":"Ford","year":"1959"},{"key":"10.1016\/j.cca.2025.120623_bb0130","series-title":"The optimal evaluation of the infertile male: AUA best practice statement","author":"Jarow","year":"2010"},{"issue":"5079","key":"10.1016\/j.cca.2025.120623_bb0135","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.1359640","article-title":"The human Y chromosome: overlapping DNA clones spanning the euchromatic region","volume":"258","author":"Foote","year":"1992","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.cca.2025.120623_bb0140","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/00006254-199611000-00020","article-title":"Severe oligozoospermia resulting from deletions of azoospermia factor geneon Y chromosome","volume":"51","author":"Reijo","year":"1996","journal-title":"Obstetrical & gynecological survey"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0145","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ng0895-383","article-title":"Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA\u2013binding protein gene","volume":"10","author":"Reijo","year":"1995","journal-title":"Nature genetics"},{"issue":"8","key":"10.1016\/j.cca.2025.120623_bb0150","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/humrep\/deg348","article-title":"Detection of sperm in men with Y chromosome microdeletions of the AZFa","volume":"18","author":"Hopps","year":"2003","journal-title":"AZFb and AZFc regions, Human reproduction"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0155","first-page":"1","article-title":"Genetics of male infertility","volume":"41","author":"Hotaling","year":"2014","journal-title":"Urologic Clinics"},{"issue":"suppl_4","key":"10.1016\/j.cca.2025.120623_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/11.suppl_4.1","article-title":"Cytogenetics of infertile men","volume":"11","author":"Van Assche","year":"1996","journal-title":"Human reproduction"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0165","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.rbmo.2018.10.003","article-title":"Chromosomal translocations and semen quality: a study on 144 male translocation carriers","volume":"38","author":"Mayeur","year":"2019","journal-title":"Reproductive BioMedicine Online"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/and.12649","article-title":"Karyotype analysis in large sample cases from Shenyang Women's and Children's hospital: a study of 16,294 male infertility patients","volume":"49","author":"Gao","year":"2017","journal-title":"Andrologia"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0175","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1472-6483(10)62147-5","article-title":"Sperm aneuploidy and recurrent pregnancy loss","volume":"9","author":"Bernardini","year":"2004","journal-title":"Reproductive BioMedicine Online"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1756287210373758","article-title":"The use of fluorescent in situ hybridization in male infertility","volume":"2","author":"Hwang","year":"2010","journal-title":"Therapeutic advances in urology"},{"key":"10.1016\/j.cca.2025.120623_bb0185","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10815-005-6795-0","article-title":"MTHFR C677T polymorphism associates with unexplained infertile male factors","volume":"22","author":"Park","year":"2005","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"12","key":"10.1016\/j.cca.2025.120623_bb0190","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1093\/humrep\/del280","article-title":"Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility","volume":"21","author":"Lee","year":"2006","journal-title":"Human reproduction"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0195","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1745-7262.2008.00386.x","article-title":"Novel UBE2B-associated polymorphisms in an azoospermic\/oligozoospermic population","volume":"10","author":"Huang","year":"2008","journal-title":"Asian journal of andrology"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0200","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2164\/jandrol.109.007971","article-title":"Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia","volume":"30","author":"Aston","year":"2009","journal-title":"Journal of andrology"},{"key":"10.1016\/j.cca.2025.120623_bb0205","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.fertnstert.2004.06.027","article-title":"Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins","volume":"82","author":"Watanabe","year":"2004","journal-title":"Fertility and sterility"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0210","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.fertnstert.2006.12.041","article-title":"The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility","volume":"88","author":"Merisalu","year":"2007","journal-title":"Fertility and sterility"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0215","article-title":"Single nucleotide polymorphism C677T in the methylenete-trahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia","volume":"9","author":"Yang","year":"2007","journal-title":"Asian journal of andrology"},{"key":"10.1016\/j.cca.2025.120623_bb0220","first-page":"1","article-title":"Identification of high-risk non-synonymous SNPs (nsSNPs) in DNAH1 and DNAH17 genes associated with male infertility: a bioinformatics analysis","author":"Navapour","year":"2024","journal-title":"Journal of Applied Genetics"},{"key":"10.1016\/j.cca.2025.120623_bb0225","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s10815-018-1301-7","article-title":"Genetic evaluation of patients with non-syndromic male infertility","volume":"35","author":"Okutman","year":"2018","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.1016\/j.cca.2025.120623_bb0230","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00439-019-01974-1","article-title":"New insights into the genetics of spermatogenic failure: a review of the literature","volume":"138","author":"Cannarella","year":"2019","journal-title":"Human genetics"},{"issue":"8","key":"10.1016\/j.cca.2025.120623_bb0235","doi-asserted-by":"crossref","DOI":"10.1111\/and.13012","article-title":"Reactive oxygen species impact on sperm DNA and its role in male infertility","volume":"50","author":"Bui","year":"2018","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0240","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/19396368.2016.1274791","article-title":"Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications","volume":"63","author":"Jenkins","year":"2017","journal-title":"Systems biology in reproductive medicine"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0245","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.fertnstert.2018.04.004","article-title":"Inheritance of epigenetic dysregulation from male factor infertility has a direct impact on reproductive potential","volume":"110","author":"Denomme","year":"2018","journal-title":"Fertility and Sterility"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0250","doi-asserted-by":"crossref","first-page":"890","DOI":"10.2164\/jandrol.106.000703","article-title":"Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrity","volume":"27","author":"Aoki","year":"2006","journal-title":"Journal of andrology"},{"issue":"I","key":"10.1016\/j.cca.2025.120623_bb0255","first-page":"109","article-title":"Evaluation of protamines 1 and 2 transcript contents in spermatozoa from asthenozoospermic men","volume":"45","author":"Kempisty","year":"2007","journal-title":"Folia Histochemica et cytobiologica"},{"issue":"7","key":"10.1016\/j.cca.2025.120623_bb0260","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.fertnstert.2011.03.096","article-title":"Abnormal methylation of the promoter of CREM is broadly associated with male factor infertility and poor sperm quality but is improved in sperm selected by density gradient centrifugation","volume":"95","author":"Nanassy","year":"2011","journal-title":"Fertility and sterility"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0265","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/andr.12379","article-title":"Impairment of sperm DNA methylation in male infertility: a meta-analytic study","volume":"5","author":"Santi","year":"2017","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0270","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fertnstert.2015.09.013","article-title":"Decreased fecundity and sperm DNA methylation patterns","volume":"105","author":"Jenkins","year":"2016","journal-title":"Fertility and sterility"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0275","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.fertnstert.2009.07.1671","article-title":"The transcriptome of spermatozoa used in homologous intrauterine insemination varies considerably between samples that achieve pregnancy and those that do not","volume":"94","author":"Garc\u00eda-Herrero","year":"2010","journal-title":"Fertility and Sterility"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0280","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.fertnstert.2015.08.019","article-title":"Aberrant sperm DNA methylation predicts male fertility status and embryo quality","volume":"104","author":"Aston","year":"2015","journal-title":"Fertility and sterility"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0285","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mrrev.2011.04.002","article-title":"Epigenetics, spermatogenesis and male infertility","volume":"727","author":"Rajender","year":"2011","journal-title":"Mutation Research\/Reviews in Mutation Research"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0290","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/molehr\/gam093","article-title":"Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia","volume":"14","author":"Marques","year":"2008","journal-title":"MHR-Basic Science of Reproductive Medicine"},{"issue":"21","key":"10.1016\/j.cca.2025.120623_bb0295","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/hmg\/ddm187","article-title":"Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients","volume":"16","author":"Kobayashi","year":"2007","journal-title":"Human molecular genetics"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0300","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.fertnstert.2009.09.010","article-title":"Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility","volume":"94","author":"Hammoud","year":"2010","journal-title":"Fertility and sterility"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0305","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2605.2009.01000.x","article-title":"Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2\/H19 ICR1","volume":"33","author":"Poplinski","year":"2010","journal-title":"International journal of andrology"},{"key":"10.1016\/j.cca.2025.120623_bb0310","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10815-016-0682-8","article-title":"The role of epigenetics in idiopathic male infertility","volume":"33","author":"Gunes","year":"2016","journal-title":"Journal of assisted reproduction and genetics"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0315","doi-asserted-by":"crossref","first-page":"R209","DOI":"10.1530\/REP-18-0480","article-title":"The contribution of epididymosomes to the sperm small RNA profile","volume":"157","author":"Trigg","year":"2019","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0320","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/S0033583597003399","article-title":"Protein identification in the post-genome era: the rapid rise of proteomics","volume":"30","author":"James","year":"1997","journal-title":"Quarterly reviews of biophysics"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0325","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0167-7799(98)01245-1","article-title":"Proteomics: quantitative and physical mapping of cellular proteins","volume":"17","author":"Blackstock","year":"1999","journal-title":"Trends in biotechnology"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0330","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0021-9258(18)72490-3","article-title":"Proteins of human seminal plasma","volume":"144","author":"Ross","year":"1942","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0335","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1172\/JCI101382","article-title":"The electrophoretic analyses of the serum proteins in diseases of the liver","volume":"22","author":"Gray","year":"1943","journal-title":"The Journal of Clinical Investigation"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0340","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1210\/endo-113-5-1916","article-title":"Transferrin binds specifically to pachytene spermatocytes","volume":"113","author":"Holmes","year":"1983","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0345","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0015-0282(16)46641-0","article-title":"Transferrin and gonadal dysfunction in man","volume":"38","author":"Holmes","year":"1982","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0350","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/pros.20089","article-title":"A comprehensive characterization of the peptide and protein constituents of human seminal fluid","volume":"61","author":"Fung","year":"2004","journal-title":"The prostate"},{"key":"10.1016\/j.cca.2025.120623_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2006-7-5-r40","article-title":"Large-scale and high-confidence proteomic analysis of human seminal plasma","volume":"7","author":"Pilch","year":"2006","journal-title":"Genome biology"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0360","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1586\/14789450.2016.1151357","article-title":"Sperm proteomics: potential impact on male infertility treatment","volume":"13","author":"Agarwal","year":"2016","journal-title":"Expert Review of Proteomics"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0365","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/humrep\/den024","article-title":"Identification of proteomic differences in asthenozoospermic sperm samples","volume":"23","author":"Martinez-Heredia","year":"2008","journal-title":"Human reproduction"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0370","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/humrep\/dem030","article-title":"The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm","volume":"22","author":"Amaral","year":"2007","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0375","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/aja.2009.59","article-title":"Proteome analysis of round-headed and normal spermatozoa by 2-D fluorescence difference gel electrophoresis and mass spectrometry","volume":"11","author":"Liao","year":"2009","journal-title":"Asian journal of andrology"},{"issue":"17","key":"10.1016\/j.cca.2025.120623_bb0380","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1016\/j.jprot.2012.06.021","article-title":"Proteomic characteristics of spermatozoa in normozoospermic patients with infertility","volume":"75","author":"Xu","year":"2012","journal-title":"Journal of proteomics"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0385","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/19396368.2013.775396","article-title":"Evaluation of potential protein biomarkers in patients with high sperm DNA damage","volume":"59","author":"Behrouzi","year":"2013","journal-title":"Systems biology in reproductive medicine"},{"key":"10.1016\/j.cca.2025.120623_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-015-0007-2","article-title":"Major protein alterations in spermatozoa from infertile men with unilateral varicocele","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1016\/j.cca.2025.120623_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-11-48","article-title":"Proteomic analysis of human spermatozoa proteins with oxidative stress","volume":"11","author":"Sharma","year":"2013","journal-title":"Reproductive Biology and Endocrinology"},{"issue":"18","key":"10.1016\/j.cca.2025.120623_bb0400","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1016\/j.jprot.2012.07.003","article-title":"Sperm phosphoproteome profiling by ultra performance liquid chromatography followed by data independent analysis (LC\u2013MSE) reveals altered proteomic signatures in asthenozoospermia","volume":"75","author":"Parte","year":"2012","journal-title":"Journal of proteomics"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0405","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.juro.2018.11.001","article-title":"Are WHO recommendations to perform 2 consecutive semen analyses for reliable diagnosis of male infertility still valid?","volume":"201","author":"Blickenstorfer","year":"2019","journal-title":"The Journal of urology"},{"issue":"8","key":"10.1016\/j.cca.2025.120623_bb0410","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/prca.200700228","article-title":"Proteomics of semen and its constituents","volume":"1","author":"Duncan","year":"2007","journal-title":"PROTEOMICS\u2013Clinical Applications"},{"key":"10.1016\/j.cca.2025.120623_bb0415","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jprot.2016.08.018","article-title":"Semen proteomics and male infertility","volume":"162","author":"M. Jodar, A. Soler-Ventura, R. Oliva, M.B. of Reproduction, D.R. Group","year":"2017","journal-title":"Journal of proteomics"},{"key":"10.1016\/j.cca.2025.120623_bb0420","first-page":"88","article-title":"Proteomic analysis of testicular interstitial fluid in men with azoospermia, European Urology Open","volume":"54","author":"Huang","year":"2023","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0425","doi-asserted-by":"crossref","DOI":"10.1111\/and.12919","article-title":"Towards the identification of reliable sperm biomarkers for male infertility: A sperm proteomic approach","volume":"50","author":"Intasqui","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.cca.2025.120623_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12014-015-9094-5","article-title":"Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species","volume":"12","author":"Agarwal","year":"2015","journal-title":"Clinical proteomics"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0435","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.rbmo.2015.01.010","article-title":"Comparative analysis of the seminal plasma proteomes of oligoasthenozoospermic and normozoospermic men","volume":"30","author":"Giacomini","year":"2015","journal-title":"Reproductive biomedicine online"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0440","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1194\/jlr.R032326","article-title":"Sterols in spermatogenesis and sperm maturation","volume":"54","author":"Rozman","year":"2013","journal-title":"Journal of lipid research"},{"key":"10.1016\/j.cca.2025.120623_bb0445","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s10815-004-8761-7","article-title":"Relationship between standard semen parameters, calcium, cholesterol contents, and mitochondrial activity in ejaculated spermatozoa from fertile and infertile males","volume":"21","author":"Meseguer","year":"2004","journal-title":"Journal of assisted reproduction and genetics"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0450","doi-asserted-by":"crossref","DOI":"10.1111\/and.13158","article-title":"Difference in the seminal plasma protein expression in unexplained infertile men with successful and unsuccessful in vitro fertilisation outcome","volume":"51","author":"Kanannejad","year":"2019","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2021.100597","article-title":"Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status","volume":"22","author":"Nowicka-Bauer","year":"2022","journal-title":"Reproductive Biology"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0460","doi-asserted-by":"crossref","DOI":"10.1111\/and.14321","article-title":"Expressions of HSPA1L and HSPA9 are associated with poor sperm quality of low-motility spermatozoa in fertile men","volume":"54","author":"Liu","year":"2022","journal-title":"Andrologia"},{"issue":"12","key":"10.1016\/j.cca.2025.120623_bb0465","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1021\/pr501031x","article-title":"Investigation of male infertility using quantitative comparative proteomics","volume":"13","author":"L\u00e9gar\u00e9","year":"2014","journal-title":"Journal of proteome research"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0470","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1158\/1541-7786.MCR-16-0163","article-title":"Exosomal annexin II promotes angiogenesis and breast cancer metastasis","volume":"15","author":"Maji","year":"2017","journal-title":"Molecular Cancer Research"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0475","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1038\/s41598-020-64434-1","article-title":"Alterations in seminal plasma proteomic profile in men with primary and secondary infertility","volume":"10","author":"Martins","year":"2020","journal-title":"Scientific reports"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0480","doi-asserted-by":"crossref","first-page":"324","DOI":"10.5534\/wjmh.180108","article-title":"Protein fingerprinting of seminal plasma reveals dysregulation of exosome-associated proteins in infertile men with unilateral varicocele","volume":"39","author":"Selvam","year":"2019","journal-title":"The World Journal of Men's Health"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0485","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-5793(01)02613-8","article-title":"Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway","volume":"500","author":"ter Kuile","year":"2001","journal-title":"FEBS letters"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0490","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.fertnstert.2013.01.111","article-title":"The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility","volume":"99","author":"Kovac","year":"2013","journal-title":"Fertility and sterility"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0495","first-page":"109","article-title":"Metabolic fingerprinting of seminal plasma from non-obstructive azoospermia patients: Positive versus negative sperm retrieval","volume":"19","author":"Gilany","year":"2018","journal-title":"Journal of Reproduction & Infertility"},{"issue":"8","key":"10.1016\/j.cca.2025.120623_bb0500","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.3931","article-title":"Untargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men: A noninvasive detection of spermatogenesis","volume":"31","author":"Gilany","year":"2017","journal-title":"Biomedical Chromatography"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0505","first-page":"8327506","article-title":"Metabolomic profiling of human spermatozoa in idiopathic asthenozoospermia patients using gas chromatography-mass spectrometry","volume":"2018","author":"Zhao","year":"2018","journal-title":"BioMed Research International"},{"issue":"8","key":"10.1016\/j.cca.2025.120623_bb0510","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181115","article-title":"Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility","volume":"12","author":"Qiao","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0515","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1586\/14737159.7.4.351","article-title":"Role of metabolomic analysis of biomarkers in the management of male infertility","volume":"7","author":"Deepinder","year":"2007","journal-title":"Expert Review of Molecular Diagnostics"},{"key":"10.1016\/j.cca.2025.120623_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","journal-title":"Reproductive biology and endocrinology"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0525","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/and.12228","article-title":"Human catalase gene polymorphism (CAT C-262T) and risk of male infertility","volume":"47","author":"Sabouhi","year":"2015","journal-title":"Andrologia"},{"issue":"9","key":"10.1016\/j.cca.2025.120623_bb0530","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1210\/jc.2012-2400","article-title":"Approach to male infertility and induction of spermatogenesis","volume":"98","author":"Anawalt","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0535","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1038\/srep15654","article-title":"Increased male fertility using fertility-related biomarkers","volume":"5","author":"Kwon","year":"2015","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0540","first-page":"64","article-title":"Surgical management of male infertility: an update","volume":"3","author":"Velasquez","year":"2014","journal-title":"Transl Androl Urol"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0545","first-page":"202","article-title":"Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations, World J Mens","volume":"42","author":"Agarwal","year":"2024","journal-title":"Health"},{"issue":"18","key":"10.1016\/j.cca.2025.120623_bb0550","doi-asserted-by":"crossref","first-page":"10167","DOI":"10.3390\/ijms251810167","article-title":"Sperm DNA Fragmentation: Unraveling Its Imperative Impact on Male Infertility Based on Recent Evidence","volume":"25","author":"Stavros","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0555","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.fertnstert.2014.10.020","article-title":"Male infertility testing: reactive oxygen species and antioxidant capacity","volume":"102","author":"Ko","year":"2014","journal-title":"Fertil Steril"},{"issue":"17","key":"10.1016\/j.cca.2025.120623_bb0560","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710060","article-title":"Oxidative Stress Markers and Sperm DNA Fragmentation in Men Recovered from COVID-19","volume":"23","author":"Shcherbitskaia","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0565","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.rbmo.2022.05.010","article-title":"Predictive value of seminal oxidation-reduction potential analysis for reproductive outcomes of ICSI","volume":"45","author":"Henkel","year":"2022","journal-title":"Reproductive BioMedicine Online"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0570","article-title":"Current Updates on Involvement of Artificial Intelligence and Machine Learning in Semen Analysis","volume":"60","author":"Panner Selvam","year":"2024","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0575","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/uro4020003","article-title":"The Role of Artificial Intelligence in Male Infertility: Evaluation and Treatment: A Narrative Review","volume":"4","author":"Venishetty","year":"2024","journal-title":"Uro"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0580","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s43032-022-01071-1","article-title":"Combining Machine Learning with Metabolomic and Embryologic Data Improves Embryo Implantation Prediction","volume":"30","author":"Cheredath","year":"2023","journal-title":"Reprod Sci"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0585","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41746-024-01006-x","article-title":"The prospect of artificial intelligence to personalize assisted reproductive technology","volume":"7","author":"Hanassab","year":"2024","journal-title":"npj Digital Medicine"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0590","first-page":"117","article-title":"The relationship between reactive oxygen species","volume":"49","author":"Juanpanich","year":"2022","journal-title":"DNA fragmentation, and sperm parameters in human sperm using simplified sucrose vitrification with or without triple antioxidant supplementation, Clin Exp Reprod Med"},{"key":"10.1016\/j.cca.2025.120623_bb0595","first-page":"98","article-title":"Role of oxidative stress markers in predicting the outcomes of assisted reproductive technologies","volume":"5","author":"Ivancha","year":"2017","journal-title":"O&G"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0600","article-title":"Omics and Male Infertility: Highlighting the Application of Transcriptomic Data","volume":"12","author":"Omolaoye","year":"2022","journal-title":"Life (Basel)"},{"issue":"9","key":"10.1016\/j.cca.2025.120623_bb0605","doi-asserted-by":"crossref","DOI":"10.3390\/diseases12090209","article-title":"Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines","volume":"12","author":"Kaltsas","year":"2024","journal-title":"Diseases"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0610","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.fertnstert.2016.03.023","article-title":"Limitations and barriers in access to care for male factor infertility","volume":"105","author":"Mehta","year":"2016","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0615","first-page":"467","article-title":"What does the future hold?","volume":"113","author":"Brannigan","year":"2020","journal-title":"Emerging diagnostic and therapeutic strategies for male infertility, Fertil Steril"},{"key":"10.1016\/j.cca.2025.120623_bb0620","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.605237","article-title":"Male infertility diagnosis: improvement of genetic analysis performance by the introduction of pre-diagnostic genes in a next-generation sequencing custom-made panel","volume":"11","author":"Precone","year":"2021","journal-title":"Frontiers in Endocrinology"},{"issue":"11","key":"10.1016\/j.cca.2025.120623_bb0625","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/ncpuro1234","article-title":"Is gene therapy for the treatment of male infertility feasible?","volume":"5","author":"Boekelheide","year":"2008","journal-title":"Nature Clinical Practice Urology"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0630","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.21037\/tau.2020.03.43","article-title":"Defining new genetic etiologies of male infertility: progress and future prospects","volume":"10","author":"Salas-Huetos","year":"2020","journal-title":"Translational Andrology and Urology"},{"issue":"5","key":"10.1016\/j.cca.2025.120623_bb0635","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/os.12537","article-title":"Mixed Reality Combined with Three-Dimensional Printing Technology in Total Hip Arthroplasty: An Updated Review with a Preliminary Case Presentation","volume":"11","author":"Lei","year":"2019","journal-title":"Orthop Surg"},{"issue":"10","key":"10.1016\/j.cca.2025.120623_bb0640","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1172\/JCI72992","article-title":"Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9","volume":"124","author":"Gupta","year":"2014","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.cca.2025.120623_bb0645","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/biolre\/ioz103","article-title":"CRISPR\/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice\u2020","volume":"101","author":"Lu","year":"2019","journal-title":"Biol Reprod"},{"issue":"3","key":"10.1016\/j.cca.2025.120623_bb0650","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.21037\/tau.2020.03.43","article-title":"Defining new genetic etiologies of male infertility: progress and future prospects","volume":"10","author":"Salas-Huetos","year":"2021","journal-title":"Transl Androl Urol"},{"issue":"6","key":"10.1016\/j.cca.2025.120623_bb0655","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062910","article-title":"The Roles of MicroRNAs in Male Infertility","volume":"22","author":"Barbu","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"46","key":"10.1016\/j.cca.2025.120623_bb0660","doi-asserted-by":"crossref","first-page":"25974","DOI":"10.1039\/C8RA01897A","article-title":"Metabolic profiling putatively identifies plasma biomarkers of male infertility using UPLC-ESI-IT-TOFMS","volume":"8","author":"Zeng","year":"2018","journal-title":"RSC Adv"},{"issue":"4","key":"10.1016\/j.cca.2025.120623_bb0665","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/andr.13530","article-title":"A metabolomic perspective on the mechanisms by which environmental pollutants and lifestyle lead to male infertility","volume":"12","author":"Yang","year":"2024","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0670","doi-asserted-by":"crossref","first-page":"16786","DOI":"10.1038\/s41598-019-52903-1","article-title":"Sperm DNA Methylation Epimutation Biomarkers for Male Infertility and FSH Therapeutic Responsiveness","volume":"9","author":"Luj\u00e1n","year":"2019","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.cca.2025.120623_bb0675","first-page":"103","article-title":"Update on the proteomics of male infertility: A systematic review, Arab","volume":"16","author":"Panner Selvam","year":"2018","journal-title":"J Urol"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125005029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125005029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:25:19Z","timestamp":1766510719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125005029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":135,"alternative-id":["S0009898125005029"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120623","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Personalized biomarkers in male infertility","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120623"}}