{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:19:27Z","timestamp":1778635167389,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cca.2025.120636","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:18:22Z","timestamp":1759763902000},"page":"120636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Detection of monoclonal alpha heavy chains in the absence of other monoclonal proteins in a patient with a history of IgG-\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" altimg=\"si5.svg\" display=\"inline\" id=\"d1e68\">\n                      <mml:mi>\u03ba<\/mml:mi>\n                    <\/mml:math>\n                    MGUS"],"prefix":"10.1016","volume":"579","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6623-9522","authenticated-orcid":false,"given":"Morgan W.","family":"Mann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla S.W.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben Y.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara L.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.B.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah J.","family":"Lusk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cca.2025.120636_b1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.beha.2005.01.029","article-title":"Heavy chain diseases","volume":"18","author":"Wahner-Roedler","year":"2005","journal-title":"Best Pr. Res. Clin. Haematol."},{"issue":"6","key":"10.1016\/j.cca.2025.120636_b2","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1182\/blood-2004-07-2755","article-title":"Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms","volume":"105","author":"Al-Saleem","year":"2005","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cca.2025.120636_b3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1056\/NEJMoa031887","article-title":"Immunoproliferative small intestinal disease associated with campylobacter jejuni","volume":"350","author":"Lecuit","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.cca.2025.120636_b4","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/jalm\/jfab067","article-title":"Immunotyping provides equivalent results to immunofixation in a population with a high prevalence of monoclonal gammopathies","volume":"6","author":"Thoren","year":"2021","journal-title":"J. Appl. Lab. Med."},{"issue":"8","key":"10.1016\/j.cca.2025.120636_b5","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/clinchem\/46.8.1230","article-title":"Understanding and identifying monoclonal gammopathies","volume":"46","author":"Attaelmannan","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2025.120636_b6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clinbiochem.2017.08.013","article-title":"Recognition and management of common, rare, and novel serum protein electrophoresis and immunofixation interferences","volume":"51","author":"McCudden","year":"2018","journal-title":"Clin. Biochem."},{"issue":"2","key":"10.1016\/j.cca.2025.120636_b7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1373\/clinchem.2016.269050","article-title":"Restricted igg-kappa and free alpha-heavy-chain bands in an asymptomatic 62-year-old man","volume":"64","author":"Yu","year":"2018","journal-title":"Clin. Chem."},{"issue":"40","key":"10.1016\/j.cca.2025.120636_b8","doi-asserted-by":"crossref","first-page":"14686","DOI":"10.3748\/wjg.v20.i40.14686","article-title":"Gastrointestinal dysfunction in liver cirrhosis","volume":"20","author":"Kalaitzakis","year":"2014","journal-title":"World J. Gastroenterol. : WJG"},{"key":"10.1016\/j.cca.2025.120636_b9","series-title":"Clinical Methods: The History, Physical, and Laboratory Examinations","article-title":"BUN and creatinine","author":"Hosten","year":"1990"},{"issue":"1","key":"10.1016\/j.cca.2025.120636_b10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/hematology.2022000408","article-title":"Thrombocytopenia and liver disease: pathophysiology and periprocedural management","volume":"2022","author":"Lim","year":"2022","journal-title":"Hematol.: Am. Soc. Hematol. Educ. Program"},{"issue":"4","key":"10.1016\/j.cca.2025.120636_b11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1055\/s-0043-1768684","article-title":"Understanding the constraints and optimization of serum immunofixation electrophoresis and serum free light chains for detecting monoclonal proteins: A single-center experience","volume":"15","author":"Shastri","year":"2023","journal-title":"J. Lab. Physicians"},{"issue":"11","key":"10.1016\/j.cca.2025.120636_b12","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1182\/blood-2011-04-349175","article-title":"Incidence, clinical course, and prognosis of secondary monoclonal gammopathy of undetermined significance in patients with multiple myeloma","volume":"118","author":"Wadhera","year":"2011","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.cca.2025.120636_b13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/labmed\/lmab001","article-title":"Analysis of multiple bands on serum protein immunofixation electrophoresis: Challenge in interpretation of clonality in a patient with light chain\u2013predominant multiple myeloma","volume":"52","author":"Nwogbo","year":"2021","journal-title":"Lab. Med."},{"issue":"3","key":"10.1016\/j.cca.2025.120636_b14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41408-021-00444-0","article-title":"MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients","volume":"11","author":"Mellors","year":"2021","journal-title":"Blood Cancer J."},{"issue":"12","key":"10.1016\/j.cca.2025.120636_b15","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/clinchem\/hvae130","article-title":"Clonality determination by detecting unmodified monoclonal serum free light chains using on-probe extraction coupled with liquid chromatography-high-resolution mass spectrometry","volume":"70","author":"Yeung","year":"2024","journal-title":"Clin. Chem."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125005157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125005157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:32:43Z","timestamp":1766511163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125005157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"alternative-id":["S0009898125005157"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120636","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of monoclonal alpha heavy chains in the absence of other monoclonal proteins in a patient with a history of IgG- MGUS","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120636"}}