{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:49:06Z","timestamp":1776001746919,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["257545"],"award-info":[{"award-number":["257545"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cca.2025.120653","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:11:10Z","timestamp":1761300670000},"page":"120653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Residual cardiovascular risk is tracked by apolipoprotein B in coronary patients with elevated serum triglyceride levels: the ESC EORP EUROASPIRE IV survey"],"prefix":"10.1016","volume":"579","author":[{"given":"Jaana","family":"Leivisk\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouko","family":"Sundvall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Jauhiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornelia","family":"Kotseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e2le","family":"Tokg\u00f6zo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljko","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"De Bacquer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2025.120653_bb0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.atherosclerosis.2019.03.014","article-title":"Management of dyslipidaemia in patients with coronary heart disease: results from the ESC-EORP EUROASPIRE V survey in 27 countries","volume":"285","author":"De Backer","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cca.2025.120653_bb0010","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1177\/2047487315569401","article-title":"EUROASPIRE IV: a European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries","volume":"23","author":"Kotseva","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.cca.2025.120653_bb0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-nutr-062222-020716","article-title":"Biosynthesis and metabolism of ApoB-containing lipoproteins","volume":"44","author":"Bor\u00e9n","year":"2024","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.cca.2025.120653_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025858","article-title":"Physiological bases for the superiority of apolipoprotein B over low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol as a marker of cardiovascular risk","volume":"11","author":"Glavinovic","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cca.2025.120653_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/01.CIR.102.2.179","article-title":"Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men?","volume":"102","author":"Lemieux","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2025.120653_bb0030","doi-asserted-by":"crossref","first-page":"9693","DOI":"10.1038\/s41598-019-46187-8","article-title":"Visceral adiposity index (VAI), lipid accumulation product (LAP), and product of triglycerides and glucose (TyG) to discriminate prediabetes and diabetes","volume":"9","author":"Ahn","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120653_bb0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-511X-13-38","article-title":"The association between \u201chypertriglyceridemic waist\u201d and sub-clinical atherosclerosis in a multiethnic population: a cross-sectional study","volume":"13","author":"Gasevic","year":"2014","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.cca.2025.120653_bb0040","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12967-016-1020-8","article-title":"Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study","volume":"14","author":"Zheng","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cca.2025.120653_bb0045","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.amjmed.2005.11.015","article-title":"Contemporary management of dyslipidemia in high-risk patients: targets still not met","volume":"119","author":"Yan","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cca.2025.120653_bb0050","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/dom.13070","article-title":"PCSK9 in context: a contemporary review of an important biological target for the prevention and treatment of atherosclerotic cardiovascular disease","volume":"20","author":"Page","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cca.2025.120653_bb0055","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0140-6736(14)61177-6","article-title":"Triglycerides and cardiovascular disease","volume":"384","author":"Nordestgaard","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2025.120653_bb0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/eurheartj\/ehz785","article-title":"Clinical review on triglycerides","volume":"41","author":"Laufs","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cca.2025.120653_bb0065","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3390\/nu5030981","article-title":"Hypertriglyceridemia","volume":"5","author":"Brahm","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.cca.2025.120653_bb0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.298.3.299","article-title":"Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women","volume":"298","author":"Nordestgaard","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.cca.2025.120653_bb0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrcardio.2017.31","article-title":"Hypertriglyceridaemia and risk of coronary artery disease","volume":"14","author":"Reiner","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cca.2025.120653_bb0080","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jacc.2012.08.1026","article-title":"Remnant cholesterol as a causal risk factor for ischemic heart disease","volume":"61","author":"Varbo","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cca.2025.120653_bb0085","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1001\/jamacardio.2019.3780","article-title":"Apolipoprotein B particles and cardiovascular disease: a narrative review","volume":"4","author":"Sniderman","year":"2019","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.cca.2025.120653_bb0090","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinchem\/32.2.283","article-title":"Improved estimation of cholesteryl ester transfer\/exchange activity in serum or plasma","volume":"32","author":"Groener","year":"1986","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2025.120653_bb0095","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ymeth.2004.11.006","article-title":"Determination of human plasma phospholipid transfer protein mass and activity","volume":"36","author":"Jauhiainen","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.cca.2025.120653_bb0100","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1016\/S0021-9258(19)62718-3","article-title":"Human plasma lecithin-cholesterol acyltransferase. An elucidation of the catalytic mechanism","volume":"261","author":"Jauhiainen","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cca.2025.120653_bb0105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0021-9150(01)00594-9","article-title":"Dietary determinants of serum paraoxonase activity in healthy humans","volume":"160","author":"Kleemola","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cca.2025.120653_bb0110","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1194\/jlr.M002618","article-title":"Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample","volume":"51","author":"Robciuc","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2025.120653_bb0115","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/00365513.2017.1379608","article-title":"ANGPTL3 serum concentration and rare genetic variants in Finnish population","volume":"77","author":"Tikka","year":"2017","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"2016","key":"10.1016\/j.cca.2025.120653_bb0120","first-page":"207","volume":"252","author":"Authors\/Task Force Members","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cca.2025.120653_bb0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12933-015-0296-y","article-title":"Patients with coronary artery disease and diabetes need improved management: a report from the EUROASPIRE IV survey: a registry from the EuroObservational research Programme of the European Society of Cardiology","volume":"14","author":"Gyberg","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cca.2025.120653_bb0130","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apolipoproteins, and risk of vascular disease","volume":"302","author":"Di","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.cca.2025.120653_bb0135","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1001\/jama.2012.366","article-title":"Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis","volume":"307","author":"Boekholdt","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.cca.2025.120653_bb0140","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1307095","article-title":"TG and HDL working group of the exome sequencing project, national heart, lung, and blood institute, loss-of-function mutations in APOC3, triglycerides, and coronary disease","volume":"371","author":"Crosby","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2025.120653_bb0145","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/eurheartj\/ehs431","article-title":"Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction","volume":"34","author":"Jorgensen","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cca.2025.120653_bb0150","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1161\/CIRCULATIONAHA.117.032318","article-title":"Triglyceride-rich lipoprotein cholesterol and risk of cardiovascular events among patients receiving statin therapy in the treating to new targets (TNT) trial","volume":"138","author":"Vallejo-Vaz","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2025.120653_bb0155","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1177\/2047487315569411","article-title":"Apolipoprotein B improves risk assessment of future coronary heart disease in the Framingham heart study beyond LDL-C and non-HDL-C","volume":"22","author":"Pencina","year":"2015","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.cca.2025.120653_bb0160","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1177\/2047487315580892","article-title":"Coronary heart disease prediction: apolipoprotein B shows its might again -but still in vain?","volume":"22","author":"Kovanen","year":"2015","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.cca.2025.120653_bb0165","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/ATVBAHA.117.310269","article-title":"Nonfasting triglycerides, low-density lipoprotein cholesterol, and heart failure risk: two cohort studies of 113 554 individuals","volume":"38","author":"Varbo","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cca.2025.120653_bb0170","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1016\/j.jacl.2024.08.013","article-title":"Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: an expert clinical consensus from the national lipid association","volume":"18","author":"Soffer","year":"2024","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.cca.2025.120653_bb0175","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1111\/dom.16335","article-title":"Discordance between serum cholesterol concentration and atherogenic lipoprotein particle number in people with metabolic disease: a systematic review","volume":"27","author":"Witt","year":"2025","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cca.2025.120653_bb0180","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1017\/S0954422416000147","article-title":"Nutritional management of hyperapoB","volume":"29","author":"Lamantia","year":"2016","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.cca.2025.120653_bb0185","doi-asserted-by":"crossref","first-page":"8741","DOI":"10.1038\/srep08741","article-title":"HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2025.120653_bb0190","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1056\/NEJMoa1701329","article-title":"Cardiovascular and metabolic effects of ANGPTL3 antisense oligonucleotides","volume":"377","author":"Graham","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2025.120653_bb0195","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1612790","article-title":"Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease","volume":"377","author":"Dewey","year":"2017","journal-title":"N. Engl. J. Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125005327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898125005327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:40:43Z","timestamp":1773294043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898125005327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"alternative-id":["S0009898125005327"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2025.120653","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Residual cardiovascular risk is tracked by apolipoprotein B in coronary patients with elevated serum triglyceride levels: the ESC EORP EUROASPIRE IV survey","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2025.120653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120653"}}