{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:26:29Z","timestamp":1793643989553,"version":"4.5.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2304400"],"award-info":[{"award-number":["2022YFC2304400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016126","name":"Beijing Hospital Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cca.2026.120867","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:29:13Z","timestamp":1769354953000},"page":"120867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasma ceramides decreased in Gilbert's syndrome associated with healthy blood lipid phenotypes: A cross-sectional study"],"prefix":"10.1016","volume":"584","author":[{"given":"Haitian","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cca.2026.120867_bb0005","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jhep.2021.06.010","article-title":"Bilirubin: the yellow hormone?","volume":"75","author":"V\u00edtek","year":"2021","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.plipres.2012.11.001","article-title":"Bilirubin and beyond: a review of lipid status in Gilbert\u2019s syndrome and its relevance to cardiovascular disease protection","volume":"52","author":"Bulmer","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cca.2026.120867_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.869579","article-title":"Association of Serum Bilirubin with Metabolic Syndrome and non-Alcoholic Fatty Liver Disease: a systematic review and Meta-analysis","volume":"13","author":"Liang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.cca.2026.120867_bb0020","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/jnnp-2024-334408","article-title":"Total bilirubin modified the association between diabetes and stroke: a cross-sectional study from NHANES 2011-2016","volume":"96","author":"Xia","year":"2025","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.aohep.2019.02.001","article-title":"Association between plasma bilirubin and mortality","volume":"18","author":"Vitek","year":"2019","journal-title":"Ann. Hepatol."},{"issue":"4","key":"10.1016\/j.cca.2026.120867_bb0030","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jhep.2023.06.004","article-title":"Gilbert\u2019s syndrome revisited","volume":"79","author":"V\u00edtek","year":"2023","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0035","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10408363.2018.1428526","article-title":"Diagnostic criteria and contributors to Gilbert\u2019s syndrome","volume":"55","author":"Wagner","year":"2018","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0040","first-page":"151","article-title":"Associations between Gilbert\u2019s syndrome and personality characteristics","volume":"43","author":"D\u00fczenli","year":"2021","journal-title":"Trends Psychiatry Psychother."},{"issue":"10","key":"10.1016\/j.cca.2026.120867_bb0045","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41580-024-00742-y","article-title":"Regulation of cellular and systemic sphingolipid homeostasis","volume":"25","author":"Kuo","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cca.2026.120867_bb0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in metabolism: key lipotoxic players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annu. Rev. Physiol."},{"issue":"18","key":"10.1016\/j.cca.2026.120867_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814015","article-title":"Circulating sphingolipids in insulin resistance, diabetes and associated complications","volume":"24","author":"Hammad","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.120867_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijid.2015.01.020","article-title":"Serum sphingomyelin has potential to reflect hepatic injury in chronic hepatitis B virus infection","volume":"33","author":"Zheng","year":"2015","journal-title":"International journal of infectious diseases\u202f: IJID\u202f: official publication of the International Society for Infectious Diseases."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0065","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00216-013-7479-8","article-title":"Lipidomic profiling of plasma in patients with chronic hepatitis C infection","volume":"406","author":"Qu","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cca.2026.120867_bb0070","first-page":"553","article-title":"The potential serum sphingolipid biomarkers for distinguishing Wilson disease","author":"Tang","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.120867_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154913","article-title":"Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert\u2019s syndrome individuals","volume":"125","author":"Hana","year":"2021","journal-title":"Metab. Clin. Exp."},{"issue":"10","key":"10.1016\/j.cca.2026.120867_bb0080","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.freeradbiomed.2012.03.002","article-title":"Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome","volume":"52","author":"Boon","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0085","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.atherosclerosis.2007.11.022","article-title":"Improved resistance to serum oxidation in Gilbert\u2019s syndrome: a mechanism for cardiovascular protection","volume":"199","author":"Bulmer","year":"2008","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.cca.2026.120867_bb0090","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4082\/kjfm.2017.38.6.352","article-title":"The relationship between the triglyceride to high-density lipoprotein cholesterol ratio and metabolic syndrome","volume":"38","author":"Shin","year":"2017","journal-title":"Korean journal of family medicine."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2310\/JIM.0000000000000044","article-title":"Triglyceride-to-high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men","volume":"62","author":"Vega","year":"2014","journal-title":"Journal of investigative medicine\u202f: the official publication of the American Federation for Clinical Research."},{"issue":"6","key":"10.1016\/j.cca.2026.120867_bb0100","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.17305\/bjbms.2022.7142","article-title":"Associations of non-HDL-C and triglyceride\/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults","volume":"22","author":"Akin","year":"2022","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"12","key":"10.1016\/j.cca.2026.120867_bb0105","first-page":"770","article-title":"Is elevated triglyceride high density lipoprotein cholesterol ratio a risk factor that causes acute coronary syndrome to appear earlier?","volume":"119","author":"Dogan","year":"2018","journal-title":"Bratislavske lekarske listy."},{"issue":"1","key":"10.1016\/j.cca.2026.120867_bb0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12933-024-02182-6","article-title":"Sex differences in the relationship between serum total bilirubin and risk of incident metabolic syndrome in community-dwelling adults: propensity score analysis using longitudinal cohort data over 16 years","volume":"23","author":"Kim","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"10","key":"10.1016\/j.cca.2026.120867_bb0115","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000245","article-title":"Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia","volume":"7","author":"Poynard","year":"2023","journal-title":"Hepatology communications."},{"issue":"1","key":"10.1016\/j.cca.2026.120867_bb0120","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1038\/s41598-021-87220-z","article-title":"Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.cca.2026.120867_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199594","article-title":"Sex hormones and metabolic dysfunction-associated Steatotic liver disease","volume":"26","author":"Weiskirchen","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.120867_bb0130","series-title":"Potential Therapeutic Targets for Atherosclerosis in Sphingolipid Metabolism. Clinical Science (London, England\u202f: 1979)","author":"Yu","year":"2019"},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0135","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db08-1228","article-title":"Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance","volume":"58","author":"Haus","year":"2009","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.cca.2026.120867_bb0140","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jhep.2021.04.013","article-title":"Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis","volume":"75","author":"Ooi","year":"2021","journal-title":"J. Hepatol."},{"issue":"25","key":"10.1016\/j.cca.2026.120867_bb0145","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/eurheartj\/ehw148","article-title":"Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol","volume":"37","author":"Laaksonen","year":"2016","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0150","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.atherosclerosis.2015.10.022","article-title":"Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: results of the ATHEROREMO-IVUS study","volume":"243","author":"Cheng","year":"2015","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0155","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yexcr.2015.02.025","article-title":"Revisiting the sphingolipid rheostat: evolving concepts in cancer therapy","volume":"333","author":"Newton","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0160","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/cvr\/cvp064","article-title":"Sphingosine-1-phosphate and modulation of vascular tone","volume":"82","author":"Igarashi","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0165","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.coph.2008.11.002","article-title":"Targeting sphingosine-1-phosphate signalling for cardioprotection","volume":"9","author":"Kennedy","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.cca.2026.120867_bb0170","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yjmcc.2017.07.004","article-title":"Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease","volume":"110","author":"Polzin","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.cca.2026.120867_bb0175","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2015.07.030","article-title":"Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate","volume":"64","author":"Nojima","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cca.2026.120867_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.594574","article-title":"Bilirubin nanoparticles reduce diet-induced hepatic steatosis, improve fat utilization, and increase plasma \u03b2-hydroxybutyrate","volume":"11","author":"Hinds","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.cca.2026.120867_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13020215","article-title":"Bilirubin nanoparticle treatment in obese mice inhibits hepatic ceramide production and remodels liver fat content","volume":"13","author":"Kipp","year":"2023","journal-title":"Metabolites"},{"issue":"8","key":"10.1016\/j.cca.2026.120867_bb0190","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00018-022-04401-3","article-title":"Contribution of specific ceramides to obesity-associated metabolic diseases","volume":"79","author":"Hammerschmidt","year":"2022","journal-title":"Cellular and molecular life sciences\u202f: CMLS."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126000495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126000495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:30:41Z","timestamp":1793640641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126000495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":38,"alternative-id":["S0009898126000495"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.120867","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma ceramides decreased in Gilbert's syndrome associated with healthy blood lipid phenotypes: A cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.120867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120867"}}