{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:05:59Z","timestamp":1784019959279,"version":"3.55.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014786","name":"Northern Border University","doi-asserted-by":"publisher","award":["NBU-FFR-2026-146-04"],"award-info":[{"award-number":["NBU-FFR-2026-146-04"]}],"id":[{"id":"10.13039\/501100014786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.cca.2026.120894","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T23:30:52Z","timestamp":1771198252000},"page":"120894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Circulating integrins as biomarkers for bone metastasis in prostate cancer"],"prefix":"10.1016","volume":"586","author":[{"given":"Bandar Theyab","family":"Alenezi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah R.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zia Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayaa M.","family":"Alhuthali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani A.","family":"Alrehaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0005","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.juro.2010.03.034","article-title":"Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in Denmark (1999 to 2007)","volume":"184","author":"N\u00f8rgaard","year":"2010","journal-title":"J. Urol."},{"key":"10.1016\/j.cca.2026.120894_bb0010","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.2147\/CMAR.S168579","article-title":"The homogeneous and heterogeneous risk factors for the morbidity and prognosis of bone metastasis in patients with prostate cancer","volume":"10","author":"Guo","year":"2018","journal-title":"Cancer Manag. Res."},{"issue":"7","key":"10.1016\/j.cca.2026.120894_bb0015","doi-asserted-by":"crossref","first-page":"482","DOI":"10.21037\/atm.2020.03.55","article-title":"Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study","volume":"8","author":"Huang","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0020","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1038\/s41598-020-64073-6","article-title":"Prognosis of prostate cancer and bone metastasis pattern of patients: a SEER-based study and a local hospital based study from China","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/pcan.2011.7","article-title":"Mortality following bone metastasis and skeletal-related events among men with prostate cancer: a population-based analysis of US Medicare beneficiaries, 1999-2006","volume":"14","author":"Sathiakumar","year":"2011","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0030","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziaf081","article-title":"Epidemiology of bone metastasis in France between 2009 and 2018","volume":"9","author":"Marchal","year":"2025","journal-title":"JBMR Plus"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17020218","article-title":"Incidence and prevalence of bone metastases in different solid tumors determined by natural language processing of CT reports","volume":"17","author":"Long","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.120894_bb0040","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2147\/JHC.S456712","article-title":"A Multicenter retrospective study: impact of first-line treatment strategies on second-line efficacy and safety of regorafenib with or without PD-1 inhibitors in unresectable hepatocellular carcinoma","volume":"12","author":"Ma","year":"2025","journal-title":"J. Hepatocell Carcinoma"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0045","first-page":"146","article-title":"Whole-body bone scan for detecting bone metastasis in the prostate-specific membrane antigen positron emission tomography era: a retrospective cohort study of post-radical prostatectomy prostate Cancer patients","volume":"13","author":"Poenateetai","year":"2025","journal-title":"Asia Oceania J. Nucl. Med. Biol."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0050","doi-asserted-by":"crossref","first-page":"e2452971","DOI":"10.1001\/jamanetworkopen.2024.52971","article-title":"PSMA-PET\/CT findings in patients with high-risk biochemically recurrent prostate Cancer with no metastatic disease by conventional imaging","volume":"8","author":"Holzgreve","year":"2025","journal-title":"JAMA Netw. Open"},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0055","doi-asserted-by":"crossref","DOI":"10.36922\/arnm.4590","article-title":"68Ga-PSMA PET CT\/MRI in the initial diagnosis and staging of prostate cancer: a review","volume":"2","author":"Akinmuleya","year":"2024","journal-title":"ARNM"},{"issue":"3","key":"10.1016\/j.cca.2026.120894_bb0060","first-page":"297","article-title":"(68)ga-PSMA PET\/CT for the evaluation of metastasis in patients with prostate cancer: a systematic review and meta-analysis","volume":"25","author":"Zhou","year":"2022","journal-title":"Hell. J. Nucl. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228447","article-title":"Prediction of metastatic prostate cancer by prostate-specific antigen in combination with T stage and Gleason grade: Nationwide, population-based register study","volume":"15","author":"Thomsen","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.cca.2026.120894_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/893193","article-title":"Modern detection of prostate cancer\u2019s bone metastasis: is the bone scan era over?","volume":"2012","author":"Tombal","year":"2012","journal-title":"Adv. Urol."},{"issue":"3","key":"10.1016\/j.cca.2026.120894_bb0075","first-page":"371","article-title":"Total body MRI in early detection of bone metastasis and its indication in comparison to bone scan and other imaging techniques","volume":"68","author":"Luna","year":"2015","journal-title":"Archivos espanoles de urologia"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ctrv.2013.07.001","article-title":"Predicting the risk of bone metastasis in prostate cancer","volume":"40","author":"Briganti","year":"2014","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/biomedicines12010079","article-title":"The potential of extracellular matrix- and integrin adhesion complex-related molecules for prostate Cancer biomarker discovery","volume":"12","author":"Samar\u017eija","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cca.2026.120894_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2025.100305","article-title":"Blood and urine-based biomarkers in prostate cancer: current advances, clinical applications, and future directions","volume":"9","author":"Crocetto","year":"2025","journal-title":"J. Liquid Biopsy"},{"issue":"5","key":"10.1016\/j.cca.2026.120894_bb0100","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF00132982","article-title":"Specific alterations in the expression of alpha 3 beta 1 and alpha 6 beta 4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane","volume":"11","author":"Dedhar","year":"1993","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.cca.2026.120894_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1477-3163.48453","article-title":"Evaluation of the expression of integrins and cell adhesion molecules through tissue microarray in lymph node metastases of prostate cancer","volume":"8","author":"Pontes-Junior","year":"2009","journal-title":"J. Carcinogenesis"},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1158\/1541-7786.MCR-12-0551","article-title":"Targeting constitutively activated \u03b21 integrins inhibits prostate cancer metastasis","volume":"11","author":"Lee","year":"2013","journal-title":"Molecular Cancer Res.: MCR"},{"issue":"10","key":"10.1016\/j.cca.2026.120894_bb0115","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1210\/en.2002-220156","article-title":"Androgen modulation of adhesion and antiadhesion molecules in PC-3 prostate cancer cells expressing androgen receptor","volume":"143","author":"Evangelou","year":"2002","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.cca.2026.120894_bb0120","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/jcp.22455","article-title":"Leptin increases motility and integrin up-regulation in human prostate cancer cells","volume":"226","author":"Huang","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cca.2026.120894_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118209","article-title":"Revealing the role of bisphenol a on prostate cancer progression and identifying potential targets: a comprehensive analysis from population cohort to molecular mechanism","volume":"296","author":"Zhou","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"20","key":"10.1016\/j.cca.2026.120894_bb0130","first-page":"11369","article-title":"Comprehensive analysis of integrin \u03b1v\u03b23\/\u03b16\u03b21 in prognosis and immune escape of prostate cancer","volume":"15","author":"Liu","year":"2023","journal-title":"Aging"},{"issue":"7","key":"10.1016\/j.cca.2026.120894_bb0135","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/pros.21473","article-title":"Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases","volume":"72","author":"Colombel","year":"2012","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0140","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1091\/mbc.10.2.271","article-title":"alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression","volume":"10","author":"Lochter","year":"1999","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.cca.2026.120894_bb0145","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1091\/mbc.e05-11-1042","article-title":"A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5","volume":"17","author":"Winterwood","year":"2006","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.cca.2026.120894_bb0150","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbamcr.2014.03.005","article-title":"The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells","volume":"1843","author":"Chen","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cca.2026.120894_bb0155","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.24976\/Discov.Med.202537200.156","article-title":"TES7832-mediated selective inhibition of the scavenger receptor cysteine-rich domain of the transmembrane protease serine 2\/ERG gene fusion\u2014a novel and potential approach for suppressing the ERG-driven prostate Cancer","volume":"37","author":"Al Fayi","year":"2025","journal-title":"Discov. Med."},{"issue":"20","key":"10.1016\/j.cca.2026.120894_bb0160","doi-asserted-by":"crossref","first-page":"7927","DOI":"10.1158\/0008-5472.CAN-10-0194","article-title":"Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation","volume":"70","author":"McKenzie","year":"2010","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0165","first-page":"1987","article-title":"Severe combined immunodeficient-hu model of human prostate Cancer metastasis to human Bone1","volume":"59","author":"Nemeth","year":"1999","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.cca.2026.120894_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085143","article-title":"Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow","volume":"8","author":"Gakhar","year":"2013","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0175","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1158\/0008-5472.CAN-12-3264","article-title":"Definition of molecular determinants of prostate cancer cell bone extravasation","volume":"73","author":"Barthel","year":"2013","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.cca.2026.120894_bb0180","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10585-012-9561-6","article-title":"Integrin alpha2beta 1 (\u03b12\u03b21) promotes prostate cancer skeletal metastasis","volume":"30","author":"Sottnik","year":"2013","journal-title":"Clin. Exp. Metastasis"},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0185","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/19336918.2016.1212139","article-title":"Proteolytic fragments of fibronectin function as matrikines driving the chemotactic affinity of prostate cancer cells to human bone marrow mesenchymal stromal cells via the \u03b15\u03b21 integrin","volume":"11","author":"Joshi","year":"2017","journal-title":"Cell Adh. Migr."},{"issue":"21","key":"10.1016\/j.cca.2026.120894_bb0190","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1158\/0008-5472.CAN-17-0064","article-title":"Tenascin-C and integrin \u03b19 mediate interactions of prostate Cancer with the bone microenvironment","volume":"77","author":"San Martin","year":"2017","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.cca.2026.120894_bb0195","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1158\/1541-7786.MCR-19-0278","article-title":"A PSCA\/PGRN-NF-\u03baB-integrin-\u03b14 Axis promotes prostate Cancer cell adhesion to bone marrow endothelium and enhances metastatic potential","volume":"18","author":"Zhao","year":"2020","journal-title":"Molecular cancer research\u202f: MCR"},{"issue":"11","key":"10.1016\/j.cca.2026.120894_bb0200","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1158\/0008-5472.CAN-14-2155","article-title":"miR-25 modulates invasiveness and dissemination of human prostate Cancer cells via regulation of \u03b1v- and \u03b16-integrin expression","volume":"75","author":"Zoni","year":"2015","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0205","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.7150\/ijbs.91925","article-title":"GALNT12 suppresses the bone-specific prostate cancer metastasis by activating BMP pathway via the O-glycosylation of BMPR1A","volume":"20","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0210","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13045-017-0390-6","article-title":"Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression","volume":"10","author":"Chen","year":"2017","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.cca.2026.120894_bb0215","first-page":"4607","article-title":"Interleukin-8 promotes prostate cancer bone metastasis through upregulation of bone sialoprotein","volume":"17","author":"Liu","year":"2019","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0220","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1038\/s41598-018-25435-3","article-title":"Matrilysin\/MMP-7 cleavage of Perlecan\/HSPG2 complexed with Semaphorin 3A supports FAK-mediated stromal invasion by prostate Cancer cells","volume":"8","author":"Grindel","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0225","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1158\/1541-7786.MCR-08-0077","article-title":"Cadherin-11 promotes the metastasis of prostate cancer cells to bone","volume":"6","author":"Chu","year":"2008","journal-title":"Molecular cancer research\u202f: MCR"},{"issue":"6","key":"10.1016\/j.cca.2026.120894_bb0230","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1158\/1535-7163.MCT-13-0962","article-title":"Targeting integrin \u03b16 stimulates curative-type bone metastasis lesions in a xenograft model","volume":"13","author":"Landowski","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cca.2026.120894_bb0235","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jconrel.2024.07.067","article-title":"Nanomaterials for bone metastasis","volume":"373","author":"Hao","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.cca.2026.120894_bb0240","doi-asserted-by":"crossref","first-page":"80","DOI":"10.25259\/Cytojournal_44_2025","article-title":"Different metabolic paradigms and distribution of regulatory T cells between primary and lymph node metastasis prostate cancer","volume":"22","author":"Mei","year":"2025","journal-title":"Cytojournal"},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041223","article-title":"Bone cell activity in clinical prostate Cancer bone metastasis and its inverse relation to tumor cell androgen receptor activity","volume":"19","author":"Nordstrand","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cca.2026.120894_bb0250","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2025.01.006","article-title":"Identification, structure, and agonist design of an androgen membrane receptor","volume":"188","author":"Yang","year":"2025","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.cca.2026.120894_bb0255","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1359\/jbmr.2000.15.5.834","article-title":"Increased expression of bone sialoprotein in bone metastases compared with visceral metastases in human breast and prostate cancers","volume":"15","author":"Waltregny","year":"2000","journal-title":"Journal of bone and mineral research\u202f: the official journal of the American Society for Bone and Mineral Research"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0260","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/jir.2022.0172","article-title":"Analysis of immune and inflammatory microenvironment characteristics of noncancer end-stage liver disease","volume":"43","author":"Wang","year":"2023","journal-title":"J. Interferon Cytokine Res."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0265","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1186\/s12967-025-06865-w","article-title":"The CTSZ-TRA2A-IL32 axis defines a targetable macrophage-dependent pathway in metastatic prostate cancer","volume":"23","author":"Chen","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cca.2026.120894_bb0270","doi-asserted-by":"crossref","unstructured":"L. Li, Y. Sun, J. Luo, M. Liu, Circulating immune cells and risk of osteosarcoma: a mendelian randomization analysis, Front. Immunol. Volume 15\u20132024 (2024).","DOI":"10.3389\/fimmu.2024.1381212"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0275","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcb.22933","article-title":"Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells","volume":"112","author":"Grieco","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0280","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/sj.gt.3302456","article-title":"Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases","volume":"12","author":"Margheri","year":"2005","journal-title":"Gene Ther."},{"issue":"180","key":"10.1016\/j.cca.2026.120894_bb0285","doi-asserted-by":"crossref","first-page":"61","DOI":"10.24976\/Discov.Med.202436180.5","article-title":"<i>ALKBH5<\/i> suppresses autophagy in prostate Cancer cells via inhibiting m6A-modification of <i>TSPAN1<\/i> mRNA","volume":"36","author":"Xudong","year":"2024","journal-title":"Discov. Med."},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/genes12020182","article-title":"Long noncoding RNA HOXA11-AS and transcription factor HOXB13 modulate the expression of bone metastasis-related genes in prostate Cancer","volume":"12","author":"Misawa","year":"2021","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0295","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1158\/0008-5472.CAN-13-0275","article-title":"Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression","volume":"74","author":"Palmer","year":"2014","journal-title":"Cancer Res."},{"issue":"51","key":"10.1016\/j.cca.2026.120894_bb0300","doi-asserted-by":"crossref","first-page":"84645","DOI":"10.18632\/oncotarget.13175","article-title":"Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082300","article-title":"Exosomes-mediated transfer of Itga2 promotes migration and invasion of prostate Cancer cells by inducing epithelial-mesenchymal transition","volume":"12","author":"Gaballa","year":"2020","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0310","doi-asserted-by":"crossref","first-page":"1763594","DOI":"10.1080\/20013078.2020.1763594","article-title":"The \u03b1v\u03b26 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis","volume":"9","author":"Krishn","year":"2020","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0315","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13046-019-1317-6","article-title":"Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation","volume":"38","author":"Ciardiello","year":"2019","journal-title":"Journal of experimental & clinical cancer research : CR"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0320","doi-asserted-by":"crossref","first-page":"1761072","DOI":"10.1080\/20013078.2020.1761072","article-title":"Small extracellular vesicles modulated by \u03b1V\u03b23 integrin induce neuroendocrine differentiation in recipient cancer cells","volume":"9","author":"Quaglia","year":"2020","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0325","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1038\/s41598-023-29450-x","article-title":"Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs","volume":"13","author":"Garofano","year":"2023","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.cca.2026.120894_bb0330","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.ccell.2024.06.003","article-title":"Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution","volume":"42","author":"Casanova-Salas","year":"2024","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.cca.2026.120894_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12265","article-title":"Single vesicle analysis of CD47 association with integrins and tetraspanins on extracellular vesicles released by T lymphoblast and prostate carcinoma cells","volume":"11","author":"Kaur","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"13","key":"10.1016\/j.cca.2026.120894_bb0340","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/jnci\/90.13.1000","article-title":"Prognostic value of bone sialoprotein expression in clinically localized human prostate cancer","volume":"90","author":"Waltregny","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0345","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00261-016-0851-3","article-title":"Prostate cancer bone metastases on staging prostate MRI: prevalence and clinical features associated with their diagnosis","volume":"42","author":"Vargas","year":"2017","journal-title":"Abdominal radiology (New York)"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0350","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.eururo.2014.07.020","article-title":"Impact of the site of metastases on survival in patients with metastatic prostate Cancer","volume":"68","author":"Gandaglia","year":"2015","journal-title":"Eur. Urol."},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0355","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/pros.22625","article-title":"Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer","volume":"73","author":"Chen","year":"2013","journal-title":"Prostate"},{"issue":"23","key":"10.1016\/j.cca.2026.120894_bb0360","doi-asserted-by":"crossref","first-page":"12097","DOI":"10.18632\/oncotarget.2503","article-title":"E-selectin ligand-1 controls circulating prostate cancer cell rolling\/adhesion and metastasis","volume":"5","author":"Yasmin-Karim","year":"2014","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.cca.2026.120894_bb0365","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/pros.20799","article-title":"Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins","volume":"68","author":"Lai","year":"2008","journal-title":"Prostate"},{"issue":"12","key":"10.1016\/j.cca.2026.120894_bb0370","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1158\/0008-5472.CAN-09-3806","article-title":"High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer","volume":"70","author":"van den Hoogen","year":"2010","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.cca.2026.120894_bb0375","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/1878-0261.13653","article-title":"Identification of functional and diverse circulating cancer-associated fibroblasts in metastatic castration-na\u00efve prostate cancer patients","volume":"19","author":"Booijink","year":"2025","journal-title":"Mol. Oncol."},{"issue":"9","key":"10.1016\/j.cca.2026.120894_bb0380","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/bjc.2012.439","article-title":"Levels of a subpopulation of platelets, but not circulating endothelial cells, predict early treatment failure in prostate cancer patients after prostatectomy","volume":"107","author":"Wong","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2026.120894_bb0385","doi-asserted-by":"crossref","first-page":"1338420","DOI":"10.3389\/fendo.2024.1338420","article-title":"Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer","volume":"15","author":"Sun","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"16","key":"10.1016\/j.cca.2026.120894_bb0390","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/pros.22689","article-title":"Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression","volume":"73","author":"Ricci","year":"2013","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0395","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1200\/JCO.2006.05.6853","article-title":"Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis","volume":"25","author":"Shariat","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.cca.2026.120894_bb0400","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1002\/ijc.34457","article-title":"Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy","volume":"152","author":"Klusa","year":"2023","journal-title":"Int. J. Cancer"},{"issue":"18","key":"10.1016\/j.cca.2026.120894_bb0405","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1177\/1535370217728499","article-title":"Do the expressions of epithelial-mesenchymal transition proteins, periostin, integrin-\u03b14 and fibronectin correlate with clinico-pathological features and prognosis of metastatic castration-resistant prostate cancer?","volume":"242","author":"Konac","year":"2017","journal-title":"Exp. Biol. Med. (Maywood, N.J.)."},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0410","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221007","article-title":"Macrophages promote anti-androgen resistance in prostate cancer bone disease","volume":"220","author":"Li","year":"2023","journal-title":"J. Exp. Med."},{"issue":"45","key":"10.1016\/j.cca.2026.120894_bb0415","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1038\/s41388-024-03165-3","article-title":"The T\u03b2RI promotes migration and metastasis through thrombospondin 1 and ITGAV in prostate cancer cells","volume":"43","author":"Mu","year":"2024","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.cca.2026.120894_bb0420","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/carcin\/bgab083","article-title":"Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases","volume":"42","author":"Offermann","year":"2021","journal-title":"Carcinogenesis"},{"issue":"16","key":"10.1016\/j.cca.2026.120894_bb0425","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/pros.21029","article-title":"Adiponectin increases motility of human prostate cancer cells via adipoR, p38, AMPK, and NF-kappaB pathways","volume":"69","author":"Tang","year":"2009","journal-title":"The Prostate"},{"issue":"7","key":"10.1016\/j.cca.2026.120894_bb0430","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1359\/jbmr.090219","article-title":"Activin a enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer","volume":"24","author":"Kang","year":"2009","journal-title":"Journal of bone and mineral research\u202f: the official journal of the American Society for Bone and Mineral Research"},{"issue":"3","key":"10.1016\/j.cca.2026.120894_bb0435","doi-asserted-by":"crossref","first-page":"556","DOI":"10.7150\/jca.29481","article-title":"Prognostic significance of Young age and non-bone metastasis at diagnosis in patients with metastatic prostate Cancer: a SEER population-based data analysis","volume":"10","author":"Guo","year":"2019","journal-title":"J. Cancer"},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0440","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.euo.2018.04.013","article-title":"Increase in the annual rate of newly diagnosed metastatic prostate cancer: a contemporary analysis of the surveillance, epidemiology and end results database","volume":"1","author":"Bandini","year":"2018","journal-title":"Eur. Urol. Oncol."},{"issue":"5","key":"10.1016\/j.cca.2026.120894_bb0445","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.urolonc.2005.09.003","article-title":"Reduced incidence of bony metastasis at initial prostate cancer diagnosis: data from CaPSURE","volume":"24","author":"Ryan","year":"2006","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.cca.2026.120894_bb0450","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.critrevonc.2017.02.013","article-title":"Determinants of bone specific metastasis in prostate cancer","volume":"112","author":"Manca","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0455","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13046-018-0813-4","article-title":"Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K\/AKT signaling","volume":"37","author":"Tang","year":"2018","journal-title":"Journal of experimental & clinical cancer research : CR"},{"key":"10.1016\/j.cca.2026.120894_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbs.2025.109559","article-title":"Analyzing the impact of threshold strategies on cancer treatment using non-smooth models","volume":"390","author":"Wu","year":"2025","journal-title":"Math. Biosci."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0465","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41597-024-03551-2","article-title":"Integrated machine learning algorithms reveal a bone metastasis-related signature of circulating tumor cells in prostate cancer","volume":"11","author":"Ren","year":"2024","journal-title":"Sci. Data"},{"issue":"3","key":"10.1016\/j.cca.2026.120894_bb0470","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030380","article-title":"Circulating exosomal integrin \u03b23 is associated with intracranial failure and survival in lung cancer patients receiving cranial irradiation for brain metastases: a prospective observational study","volume":"13","author":"Chen","year":"2021","journal-title":"Cancers"},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0475","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1593\/neo.13762","article-title":"Circulating fibronectin controls tumor growth","volume":"15","author":"von Au","year":"2013","journal-title":"Neoplasia (N. Y.)."},{"key":"10.1016\/j.cca.2026.120894_bb0480","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canep.2019.05.013","article-title":"Incidence of skeletal-related events in patients with breast or prostate cancer-induced bone metastasis or multiple myeloma: a 12-year longitudinal nationwide healthcare database study","volume":"61","author":"Baek","year":"2019","journal-title":"Cancer Epidemiol."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0485","doi-asserted-by":"crossref","first-page":"17.e9","DOI":"10.1016\/j.urolonc.2014.09.010","article-title":"The burden of skeletal-related events in patients with prostate cancer and bone metastasis","volume":"33","author":"Roghmann","year":"2015","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.cca.2026.120894_bb0490","first-page":"335","article-title":"Prevalence of bone metastases and bone-targeting agent use among solid tumor patients in the United States","volume":"7","author":"Hernandez","year":"2015","journal-title":"Clin. Epidemiol."},{"issue":"3\u2013b Suppl","key":"10.1016\/j.cca.2026.120894_bb0495","first-page":"S1","article-title":"Evaluation of treatment patterns and costs in patients with prostate Cancer and bone metastases","volume":"25","author":"Wen","year":"2019","journal-title":"J. Manag. Care Spec. Pharm."},{"issue":"13","key":"10.1016\/j.cca.2026.120894_bb0500","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1158\/1078-0432.CCR-15-2512","article-title":"Differential effect on bone lesions of targeting integrins: randomized phase II trial of Abituzumab in patients with metastatic castration-resistant prostate Cancer","volume":"22","author":"Hussain","year":"2016","journal-title":"Clinical cancer research\u202f: an official journal of the American Association for Cancer Research"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0505","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10637-010-9573-5","article-title":"Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD\/PCF prostate cancer clinical trials consortium","volume":"30","author":"Alva","year":"2012","journal-title":"Invest. New Drugs"},{"issue":"6","key":"10.1016\/j.cca.2026.120894_bb0510","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1007\/s10637-010-9420-8","article-title":"Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium","volume":"29","author":"Bradley","year":"2011","journal-title":"Invest. New Drugs"},{"issue":"2","key":"10.1016\/j.cca.2026.120894_bb0515","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/annonc\/mds505","volume":"24","author":"Heidenreich","year":"2013","journal-title":"Annals Oncol.: Off. J. Eur. Soc. Med. Oncol."},{"issue":"4","key":"10.1016\/j.cca.2026.120894_bb0520","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1200\/JCO.2006.05.6853","article-title":"Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis","volume":"25","author":"Shariat","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cca.2026.120894_bb0525","article-title":"Integrin alpha V in urine: a novel noninvasive marker for prostate Cancer detection","volume":"10","author":"Zemskova","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cca.2026.120894_bb0530","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.matbio.2018.08.004","article-title":"Prostate cancer sheds the \u03b1v\u03b23 integrin in vivo through exosomes","volume":"77","author":"Krishn","year":"2019","journal-title":"Matrix Biol. : J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.cca.2026.120894_bb0535","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.matbio.2018.03.009","article-title":"Exosomal \u03b1v\u03b26 integrin is required for monocyte M2 polarization in prostate cancer","volume":"70","author":"Lu","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cca.2026.120894_bb0540","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v2i0.22097","article-title":"Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients","volume":"2","author":"Bijnsdorp","year":"2013","journal-title":"J. Extracell. Vesicles"},{"issue":"8","key":"10.1016\/j.cca.2026.120894_bb0545","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1074\/jbc.C114.617662","article-title":"The \u03b1v\u03b26 integrin is transferred intercellularly via exosomes*","volume":"290","author":"Fedele","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cca.2026.120894_bb0550","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13046-019-1317-6","article-title":"Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation","volume":"38","author":"Ciardiello","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.cca.2026.120894_bb0555","doi-asserted-by":"crossref","DOI":"10.1002\/jex2.64","article-title":"Integrins are enriched on aberrantly fucosylated tumour-derived urinary extracellular vesicles","volume":"1","author":"Islam","year":"2022","journal-title":"J. Extracellular Biol."},{"issue":"12","key":"10.1016\/j.cca.2026.120894_bb0560","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1158\/0008-5472.CAN-09-0354","article-title":"Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis","volume":"69","author":"Ports","year":"2009","journal-title":"Cancer Res."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126000768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126000768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:25:34Z","timestamp":1784017534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126000768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":112,"alternative-id":["S0009898126000768"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.120894","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating integrins as biomarkers for bone metastasis in prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.120894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120894"}}