{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:13:50Z","timestamp":1778894030725,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cca.2026.120992","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:21:17Z","timestamp":1774970477000},"page":"120992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Circulating biomarkers in bladder cancer: emerging evidence and future directions for personalized therapy"],"prefix":"10.1016","volume":"588","author":[{"given":"Tareq Nayef","family":"AlRamadneh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Faisal","family":"Mutee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Kubaev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaxnoza","family":"Qayumova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasim M.","family":"Salih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Adil","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa","family":"Hussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/BLC-160075","article-title":"Circulating biomarkers in bladder cancer","volume":"2","author":"Nandagopal","year":"2016","journal-title":"Bladder Cancer"},{"key":"10.1016\/j.cca.2026.120992_bb0010","article-title":"Circulating tumor DNA: a revolutionary approach for early detection and personalized treatment of bladder cancer","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cca.2026.120992_bb0015","doi-asserted-by":"crossref","first-page":"100310","DOI":"10.1016\/j.jlb.2025.100310","article-title":"Liquid Biopsy: Current advancements in clinical practice for bladder cancer","volume":"8","author":"Crocetto","year":"2025","journal-title":"The journal of liquid biopsy"},{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040921","article-title":"Circulating tumor DNA and its prognostic role in management of muscle invasive bladder cancer: a narrative review of the literature","volume":"12","author":"Kapriniotis","year":"2024","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16040803","article-title":"New perspectives on the role of liquid biopsy in bladder cancer: applicability to precision medicine","volume":"16","author":"Alberca-del Arco","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.120992_bb0030","series-title":"Urologic Oncology: Seminars and Original Investigations","article-title":"Circulating biomarkers to guide systemic therapy for urothelial carcinoma","author":"Abbosh","year":"2016"},{"key":"10.1016\/j.cca.2026.120992_bb0035","article-title":"Emerging biomarkers in bladder cancer: translating molecular advances into precision oncology","volume":"23","author":"Ferro","year":"2025","journal-title":"Critical Reviews in Oncology\/Hematology"},{"issue":"9","key":"10.1016\/j.cca.2026.120992_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092514","article-title":"Liquid biopsy biomarkers in bladder cancer: a current need for patient diagnosis and monitoring","volume":"19","author":"Lodewijk","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.120992_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103577","article-title":"Liquid biopsy in bladder cancer: state of the art and future perspectives","volume":"170","author":"Crocetto","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.euo.2023.05.012","article-title":"Circulating tumor DNA as a predictive and prognostic biomarker in the perioperative treatment of muscle-invasive bladder cancer: a systematic review","volume":"7","author":"Crupi","year":"2024","journal-title":"Euro. Urol. Oncol."},{"issue":"9","key":"10.1016\/j.cca.2026.120992_bb0055","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41585-025-01023-9","article-title":"Circulating tumor DNA and circulating tumor cells in bladder cancer\u2014from discovery to clinical implementation","volume":"22","author":"Lindskrog","year":"2025","journal-title":"Nat. Rev. Urol."},{"issue":"6","key":"10.1016\/j.cca.2026.120992_bb0060","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.21037\/tau.2017.09.16","article-title":"The current status and clinical value of circulating tumor cells and circulating cell-free tumor DNA in bladder cancer","volume":"6","author":"Riethdorf","year":"2017","journal-title":"Transl. Androl. Urol."},{"issue":"10","key":"10.1016\/j.cca.2026.120992_bb0065","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.21037\/tcr-20-1990","article-title":"Review of noninvasive urinary biomarkers in bladder cancer","volume":"9","author":"Lee","year":"2020","journal-title":"Transl. Cancer Res."},{"issue":"8","key":"10.1016\/j.cca.2026.120992_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17081283","article-title":"Novel urinary biomarkers for the detection of bladder cancer","volume":"17","author":"Oyaert","year":"2025","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0075","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12957-024-03569-1","article-title":"The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis","volume":"22","author":"Long","year":"2024","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.cca.2026.120992_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1019391","article-title":"Urine exosomes as biomarkers in bladder cancer diagnosis and prognosis: from functional roles to clinical significance","volume":"12","author":"Lee","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16010160","article-title":"Cystoscopy accuracy in detecting bladder tumors: a prospective video-confirmed study","volume":"16","author":"Guldhammer","year":"2023","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.cca.2026.120992_bb0090","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/uro4030012","article-title":"Bladder cancer basic study and current clinical trials","volume":"4","author":"Godlewski","year":"2024","journal-title":"Uro"},{"issue":"12","key":"10.1016\/j.cca.2026.120992_bb0095","doi-asserted-by":"crossref","DOI":"10.5306\/wjco.v16.i12.113578","article-title":"Liquid biopsy in genitourinary cancers: diagnostic and prognostic implications","volume":"16","author":"Youssef","year":"2025","journal-title":"World J. Clin. Oncol."},{"issue":"15","key":"10.1016\/j.cca.2026.120992_bb0100","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.3390\/ijms23158597","article-title":"A liquid biopsy in bladder cancer\u2014the current landscape in urinary biomarkers","volume":"23","author":"Matuszczak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.cca.2026.120992_bb0105","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.3390\/cancers17213425","article-title":"Urinary biomarkers in bladder cancer: FDA-approved tests and emerging tools for diagnosis and surveillance","volume":"17","author":"Yang","year":"2025","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0110","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jmoldx.2024.01.006","article-title":"The clinical validity of urinary pellet DNA monitoring for the diagnosis of recurrent bladder cancer","volume":"26","author":"Abe","year":"2024","journal-title":"J. Mol. Diagn."},{"issue":"9","key":"10.1016\/j.cca.2026.120992_bb0115","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/oncolo\/oyae198","article-title":"High sensitivity ctDNA assays in genitourinary malignancies: current evidence and future directions","volume":"29","author":"Patel","year":"2024","journal-title":"Oncologist"},{"key":"10.1016\/j.cca.2026.120992_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108528","article-title":"CtDNA can detect minimal residual disease in curative treated non-small cell lung cancer patients using a tumor agnostic approach","volume":"203","author":"Rosenlund","year":"2025","journal-title":"Lung Cancer"},{"issue":"12","key":"10.1016\/j.cca.2026.120992_bb0125","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/iju.70215","article-title":"Current status and future perspectives of molecular residual disease testing in genitourinary cancers","volume":"32","author":"Kato","year":"2025","journal-title":"Int. J. Urol."},{"issue":"23","key":"10.1016\/j.cca.2026.120992_bb0130","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1158\/1078-0432.CCR-23-1860","article-title":"Circulating tumor DNA analysis in advanced urothelial carcinoma: insights from biological analysis and extended clinical follow-up","volume":"29","author":"Lindskrog","year":"2023","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.eururo.2024.05.014","article-title":"Whole-genome mutational analysis for tumor-informed detection of circulating tumor DNA in patients with urothelial carcinoma","volume":"86","author":"Nordentoft","year":"2024","journal-title":"Eur. Urol."},{"issue":"19","key":"10.1016\/j.cca.2026.120992_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911732","article-title":"Cell-free DNA as a prognostic biomarker for monitoring muscle-invasive bladder cancer","volume":"23","author":"Carrasco","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.cca.2026.120992_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316578","article-title":"Tumor-agnostic circulating tumor DNA testing for monitoring muscle-invasive bladder cancer","volume":"24","author":"Carrasco","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.120992_bb0150","article-title":"In patients with muscle-invasive bladder cancer undergoing radical cystectomy, dynamics of circulating tumor DNA following cystectomy: Association with patient outcomes","volume":"12","author":"Tasios","year":"2025","journal-title":"European Urology Focus"},{"issue":"2","key":"10.1016\/j.cca.2026.120992_bb0155","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.euo.2024.07.001","article-title":"Association of tumor-informed circulating tumor DNA detectability before and after radical cystectomy with disease-free survival in patients with bladder cancer","volume":"8","author":"Sfakianos","year":"2025","journal-title":"Euro. Urol. Oncol."},{"key":"10.1016\/j.cca.2026.120992_bb0160","article-title":"The Impact of Kidney, Liver, and Immune Function on Circulating Tumor DNA Detection in Muscle-invasive Bladder Cancer. European Urology","author":"Radif","year":"2025","journal-title":"Oncology."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s44276-025-00143-4","article-title":"Monitoring circulating tumor DNA by recurrent hotspot mutations in bladder cancer","volume":"3","author":"Tsukahara","year":"2025","journal-title":"BJC Rep."},{"key":"10.1016\/j.cca.2026.120992_bb0170","article-title":"Circulating tumor DNA analyses predict disease recurrence in non-muscle-invasive bladder cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0175","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41698-022-00345-w","article-title":"Urine cell-free DNA multiomics to detect MRD and predict survival in bladder cancer patients","volume":"7","author":"Chauhan","year":"2023","journal-title":"NPJ Precision Oncol."},{"issue":"8","key":"10.1016\/j.cca.2026.120992_bb0180","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/1878-0261.12729","article-title":"The effect of surgical trauma on circulating free DNA levels in cancer patients\u2014implications for studies of circulating tumor DNA","volume":"14","author":"Henriksen","year":"2020","journal-title":"Mol. Oncol."},{"issue":"5","key":"10.1016\/j.cca.2026.120992_bb0185","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/ijc.34964","article-title":"Beyond basics: key mutation selection features for successful tumor-informed ctDNA detection","volume":"155","author":"Nesic","year":"2024","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cca.2026.120992_bb0190","article-title":"Small extracellular vesicles as a multicomponent biomarker platform in urinary tract carcinomas","volume":"9","author":"Szeliski","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cca.2026.120992_bb0195","doi-asserted-by":"crossref","DOI":"10.1177\/17588359251349288","article-title":"Extracellular vesicles-derived extracellular RNA in bladder cancer: current progress and future prospects","volume":"17","author":"Chen","year":"2025","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"7","key":"10.1016\/j.cca.2026.120992_bb0200","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/kjm2.12845","article-title":"The value of urinary exosomal microRNA-21 in the early diagnosis and prognosis of bladder cancer","volume":"40","author":"Yang","year":"2024","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40364-026-00901-7","article-title":"Isolation and typing techniques for circulating tumor cells","volume":"14","author":"Wu","year":"2026","journal-title":"Biomark. Res."},{"issue":"10","key":"10.1016\/j.cca.2026.120992_bb0210","article-title":"Heterogeneity landscape of circulating tumor cells in clinical utility","volume":"8","author":"Alam","year":"2025","journal-title":"Adv. Ther."},{"issue":"35","key":"10.1016\/j.cca.2026.120992_bb0215","doi-asserted-by":"crossref","first-page":"59527","DOI":"10.18632\/oncotarget.18521","article-title":"The prognostic and diagnostic value of circulating tumor cells in bladder cancer and upper tract urothelial carcinoma: a meta-analysis of 30 published studies","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2026.120992_bb0220","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fonc.2017.00006","article-title":"Circulating tumor cells in genitourinary malignancies: an evolving path to precision medicine","volume":"7","author":"Hugen","year":"2017","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0225","doi-asserted-by":"crossref","first-page":"40909","DOI":"10.1038\/s41598-025-16000-w","article-title":"Small cell size circulating tumor cells predict the prognosis of high-risk nonmuscle invasive bladder cancer patients","volume":"15","author":"Wen","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.cca.2026.120992_bb0230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/1756287217742564","article-title":"Circulating tumor cells in genitourinary tumors","volume":"10","author":"Massari","year":"2018","journal-title":"Ther. Adv. Urol."},{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043902","article-title":"Recent advances in methods for circulating tumor cell detection","volume":"24","author":"Vidlarova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cca.2026.120992_bb0240","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.juro.2015.02.2951","article-title":"Circulating tumor cells as potential biomarkers in bladder cancer","volume":"194","author":"Alva","year":"2015","journal-title":"J. Urol."},{"issue":"7","key":"10.1016\/j.cca.2026.120992_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254433","article-title":"Prognostic value of circulating tumor cells in patients with bladder cancer: a meta-analysis","volume":"16","author":"Jiang","year":"2021","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.cca.2026.120992_bb0250","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2533449123","article-title":"Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer","volume":"123","author":"Galsky","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.cca.2026.120992_bb0255","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1158\/2159-8290.CD-18-0825","article-title":"Detection and surveillance of bladder cancer using urine tumor DNA","volume":"9","author":"Dudley","year":"2019","journal-title":"Cancer Discov."},{"issue":"5","key":"10.1016\/j.cca.2026.120992_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics15050628","article-title":"Recent exploration of solid cancer biomarkers hidden within urine or blood exosomes that provide fundamental information for future cancer diagnostics","volume":"15","author":"Hara","year":"2025","journal-title":"Diagnostics"},{"issue":"6","key":"10.1016\/j.cca.2026.120992_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13061032","article-title":"Circulating tumor cells predict response of neoadjuvant chemotherapy in patients with bladder cancer: a preliminary study","volume":"13","author":"Jhuo","year":"2023","journal-title":"Diagnostics"},{"issue":"6","key":"10.1016\/j.cca.2026.120992_bb0270","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1097\/JS9.0000000000001372","article-title":"Prognostic significance of circulating tumor DNA in urothelial carcinoma: a systematic review and meta-analysis","volume":"110","author":"Liu","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cca.2026.120992_bb0275","article-title":"Prognostic significance of circulating tumor DNA in urothelial carcinoma patients undergoing immune checkpoint inhibitor therapy: a systematic review and meta-analysis","volume":"16","author":"Ma","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2026.120992_bb0280","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2511885","article-title":"ctDNA-Guided Adjuvant Atezolizumab in Muscle-Invasive Bladder Cancer","author":"Powles","year":"2025","journal-title":"N Engl J Med"},{"issue":"18","key":"10.1016\/j.cca.2026.120992_bb0285","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1200\/JCO.18.02052","article-title":"Early detection of metastatic relapse and monitoring of therapeutic efficacy by ultradeep sequencing of plasma cell-free DNA in patients with urothelial bladder carcinoma","volume":"37","author":"Christensen","year":"2019","journal-title":"J. Clin. Oncol."},{"issue":"21","key":"10.1016\/j.cca.2026.120992_bb0290","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1158\/1078-0432.CCR-17-1140","article-title":"Circulating tumor DNA reveals clinically actionable somatic genome of metastatic bladder cancer","volume":"23","author":"Vandekerkhove","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0295","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41467-020-20493-6","article-title":"Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer","volume":"12","author":"Vandekerkhove","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cca.2026.120992_bb0300","article-title":"Genomic alteration and clinical significance of circulating tumor DNA in patients with advanced urothelial cancer: SCRUM-Japan monstar screen project","volume":"9","author":"Osawa","year":"2025","journal-title":"NPJ Precis. Oncol."},{"issue":"8_Supplement_1","key":"10.1016\/j.cca.2026.120992_bb0305","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2025-5888","article-title":"Urinary ctDNA tumor fraction monitoring enhances non-invasive assessment of molecular response in bladder-preserving treatment of muscle-invasive bladder cancer","volume":"85","author":"Deng","year":"2025","journal-title":"Cancer Research."},{"issue":"8_Supplement_2","key":"10.1016\/j.cca.2026.120992_bb0310","doi-asserted-by":"crossref","first-page":"CT101","DOI":"10.1158\/1538-7445.AM2025-CT101","article-title":"Abstract CT101: ctDNA-guided immunotherapy following cystectomy in patients with urothelial carcinoma: preliminary results from the TOMBOLA trial","volume":"85","author":"Dyrskj\u00f8t","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.cca.2026.120992_bb0315","article-title":"Real-world experience with a commercial circulating tumor DNA assay in non\u2013muscle-invasive bladder cancer","volume":"14","author":"Wang","year":"2025","journal-title":"European Urology Oncology"},{"issue":"5","key":"10.1016\/j.cca.2026.120992_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2025.104534","article-title":"Tumor-informed ctDNA assay to predict recurrence in locally advanced squamous-cell carcinoma of the head and neck (SCCHN)","volume":"10","author":"Honor\u00e9","year":"2025","journal-title":"ESMO open"},{"key":"10.1016\/j.cca.2026.120992_bb0325","unstructured":"J.A. Nowak, Q. Shi, T. Twombly, L.D. Pederson, C. Ma, J.P. Vaeyrynen, M.M. Zhao, Y. Takashima, A. Shergill, P. Kumar, F. Couture Prognostic and predictive role of circulating tumor DNA (ctDNA) in stage III colon cancer treated with celecoxib: Findings from CALGB (Alliance)\/SWOG 80702."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126001749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126001749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:48:37Z","timestamp":1778892517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126001749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":65,"alternative-id":["S0009898126001749"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.120992","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating biomarkers in bladder cancer: emerging evidence and future directions for personalized therapy","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.120992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120992"}}