{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:20:26Z","timestamp":1792981226708,"version":"4.5.0"},"reference-count":143,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["24011101105"],"award-info":[{"award-number":["24011101105"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cca.2026.121013","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:47:24Z","timestamp":1776523644000},"page":"121013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Emerging biomarkers for early detection of colorectal cancer"],"prefix":"10.1016","volume":"589","author":[{"given":"Reem A.","family":"Qannita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruba A.","family":"Zenati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Y.","family":"Abuhelwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.Y.","family":"Alqudah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen M.","family":"Aleidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"El-Huneidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Abu-Gharbieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab M.","family":"AlShareef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karem H.","family":"Alzoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Bustanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Semreen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2026.121013_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","author":"Xi","year":"2021","journal-title":"Transl. Oncol."},{"issue":"3","key":"10.1016\/j.cca.2026.121013_bb0010","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cca.2026.121013_bb0015","article-title":"Colorectal cancer statistics, 2020","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cca.2026.121013_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092025","article-title":"A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis","author":"Sawicki","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.121013_bb0025","doi-asserted-by":"crossref","DOI":"10.5114\/pg.2018.81072","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","author":"Rawla","year":"2019","journal-title":"Gastroenterol. Rev."},{"key":"10.1016\/j.cca.2026.121013_bb0030","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.37509","article-title":"Colon cancer screening methods: 2023 update","author":"Jayasinghe","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.cca.2026.121013_bb0035","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.1003894","article-title":"The evolving landscape of colonoscopy: recent developments and complication management","author":"Patel","year":"2024","journal-title":"Colonoscopy - Diagnostic Therapeutic Adv."},{"key":"10.1016\/j.cca.2026.121013_bb0040","article-title":"The effectiveness of FOBT vs. FIT: a meta-analysis on colorectal cancer screening test","author":"Mousavinezhad","year":"2016","journal-title":"Med. J. Islam Repub. Iran 30"},{"key":"10.1016\/j.cca.2026.121013_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics11061113","article-title":"Computer-aided detection false positives in colonoscopy","author":"Hsieh","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.cca.2026.121013_bb0050","first-page":"1287","author":"Lavin","year":"2014","journal-title":"New England J."},{"issue":"2","key":"10.1016\/j.cca.2026.121013_bb0055","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.gastro.2019.06.043","article-title":"Strategies for colorectal cancer screening","volume":"158","author":"Ladabaum","year":"2020","journal-title":"Gastroenterology"},{"issue":"April","key":"10.1016\/j.cca.2026.121013_bb0060","article-title":"Untargeted LC-MS\/MS- based metabolomics profiling of colorectal cancer cell lines reveals potential hypoxia-associated biomarkers","volume":"263","author":"Nimer","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.cca.2026.121013_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.csbj.2018.10.002","article-title":"Techniques of using circulating tumor DNA as a liquid biopsy component in cancer management","author":"Elazezy","year":"2018","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.cca.2026.121013_bb0070","doi-asserted-by":"crossref","DOI":"10.1200\/PO.21.00289","article-title":"Genomic landscape of advanced solid tumors in circulating tumor DNA and correlation with tissue sequencing: a single institutions experience","author":"Gerratana","year":"2022","journal-title":"JCO Precis. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41571-019-0187-3","article-title":"Liquid biopsy and minimal residual disease \u2014 latest advances and implications for cure","author":"Pantel","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113343","article-title":"The polemic diagnostic role of TP53 mutations in liquid biopsies from breast, colon and lung cancers","author":"Garrido-Navas","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.121013_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/10408363.2019.1700902","article-title":"Early detection of cancer using circulating tumor DNA: biological, physiological and analytical considerations","author":"Bronkhorst","year":"2020","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12010099","article-title":"Use of circulating tumour DNA (ctDNA) for measurement of therapy predictive biomarkers in patients with cancer","author":"Duffy","year":"2022","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.cca.2026.121013_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi8618","article-title":"Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: current research, opportunities, and challenges","author":"Sanz-Garcia","year":"2022","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.cca.2026.121013_bb0100","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jamaoncol.2019.0528","article-title":"Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages i to III colorectal cancer","volume":"5","author":"Hospital","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0105","series-title":"HHS Public Access","first-page":"1415","volume":"25","author":"Parikh","year":"2020"},{"key":"10.1016\/j.cca.2026.121013_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2022.06.134","article-title":"miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: a spotlight on signaling pathways interplay \u2014 a review","author":"Elrebehy","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.cca.2026.121013_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311023","article-title":"MicroRNA biomarkers as promising tools for early colorectal cancer screening\u2014a comprehensive review","author":"Santos","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2022.154290","article-title":"The function of miR-145 in colorectal cancer progression; an updated review on related signaling pathways","author":"Mozammel","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.cca.2026.121013_bb0125","doi-asserted-by":"crossref","DOI":"10.53388\/2023623024","article-title":"Exploring stool-based microrna-92a as a potential biomarker for colorectal cancer diagnosis","author":"Jian","year":"2023","journal-title":"Cancer Adv."},{"issue":"20","key":"10.1016\/j.cca.2026.121013_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011060","article-title":"Advances in microRNAs as emerging biomarkers for colorectal cancer early detection and diagnosis","volume":"25","author":"\u017ddralevi\u0107","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12123657","article-title":"Non-coding RNAs as mediators of epigenetic changes in malignancies","author":"Kumar","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.121013_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110648","article-title":"Omics technologies for improved diagnosis and treatment of colorectal cancer: technical advancement and major perspectives","author":"Dalal","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cca.2026.121013_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2015.4","article-title":"The role of MicroRNAs in human cancer","author":"Peng","year":"2016","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cca.2026.121013_bb0150","article-title":"Prognostic role of microRNA-21 in colorectal cancer: a meta-analysis","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2026.121013_bb0155","doi-asserted-by":"crossref","DOI":"10.3892\/or.2014.3614","article-title":"Clinical significance of microRNA-21 as a biomarker in each dukes stage of colorectal cancer","author":"Fukushima","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cca.2026.121013_bb0160","doi-asserted-by":"crossref","DOI":"10.1136\/gut.2011.239236","article-title":"Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps","author":"Wu","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.cca.2026.121013_bb0165","article-title":"MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection","author":"Chang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2026.121013_bb0170","article-title":"Identification of stool miR-135b-5p as a non-invasive diaognostic biomarker in later tumor stage of colorectal cancer","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0175","article-title":"MicroRNA expression profile reveals miR-17-92 and miR-143-145 cluster in synchronous colorectal cancer","author":"Meng","year":"2015","journal-title":"Med. (United States)"},{"key":"10.1016\/j.cca.2026.121013_bb0180","doi-asserted-by":"crossref","DOI":"10.3892\/mco.2013.61","article-title":"Plasma miR-200c and miR-18a as potential biomarkers for the detection of colorectal carcinoma","author":"Zhang","year":"2013","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0185","article-title":"MiR-17-5p promotes the invasion and migration of colorectal cancer by regulating HSPB2","author":"Yu","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0190","doi-asserted-by":"crossref","DOI":"10.1158\/1055-9965.EPI-13-0512","article-title":"Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test","author":"Koga","year":"2013","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.cca.2026.121013_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/onc.2014.348","article-title":"MiR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II\/III colorectal cancer","author":"Gao","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.cca.2026.121013_bb0200","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-021-08729-0","article-title":"Circulating MiR-1290 as a potential diagnostic and disease monitoring biomarker of human gastrointestinal tumors","author":"Xu","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0205","doi-asserted-by":"crossref","DOI":"10.4149\/neo_2020_200924N1018","article-title":"MiR-1246 shuttling from fibroblasts promotes colorectal cancer cell migratio","author":"Si","year":"2021","journal-title":"Neoplasma"},{"key":"10.1016\/j.cca.2026.121013_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2021.799060","article-title":"The High Ratio of the Plasma miR-96 \/ miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer","volume":"8","author":"Chen","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cca.2026.121013_bb0215","article-title":"MiR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1","author":"Li","year":"2019","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.cca.2026.121013_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13174355","article-title":"The Molecular Networks of Micrornas and their Targets in the Drug Resistance of colon Carcinoma","author":"Crudele","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.121013_bb0225","doi-asserted-by":"crossref","DOI":"10.2147\/OTT.S134252","article-title":"miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: A systematic review and meta-analysis","author":"Ye","year":"2017","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.cca.2026.121013_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-021-00780-4","article-title":"KRAS Mutation: From Undruggable to Druggable in cancer","author":"Huang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cca.2026.121013_bb0235","series-title":"Research progress on KRAS mutations in colorectal cancer","author":"Cefal\u00ec","year":"2021"},{"key":"10.1016\/j.cca.2026.121013_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.103916","article-title":"An Empirical Review on the Resistance Mechanisms of Epidermal Growth Factor Receptor Inhibitors and Predictive Molecular Biomarkers in Colorectal cancer","author":"Bhattacharya","year":"2023","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"10.1016\/j.cca.2026.121013_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/s41416-022-02017-9","article-title":"The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis","author":"Faulkner","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-019-1694-1","article-title":"The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity","author":"Canon","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cca.2026.121013_bb0255","article-title":"Presence of concurrent TP53 mutations is necessary to predict poor outcomes within the SMAD4 mutated subgroup of metastatic colorectal cancer","author":"Wang","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.cca.2026.121013_bb0260","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-025-06566-4","article-title":"P53 in colorectal cancer: from a master player to a privileged therapy target","volume":"23","author":"Yan","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cca.2026.121013_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14081889","article-title":"Colorectal cancer diagnosis: the obstacles we face in determining a non-invasive test and current advances in biomarker detection","author":"Kamel","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cca.2026.121013_bb0270","article-title":"TP53 mutation and MET amplification in circulating tumor DNA analysis predict disease progression in patients with advanced gastric cancer","author":"Li","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.cca.2026.121013_bb0275","series-title":"TP53 mutations in human cancers: origins, consequences, and clinical use","author":"Olivier","year":"2010"},{"key":"10.1016\/j.cca.2026.121013_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2014.01.021","article-title":"Mutant p53 in cancer: New Functions and Therapeutic Opportunities","author":"Muller","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cca.2026.121013_bb0285","doi-asserted-by":"crossref","DOI":"10.1038\/nrc.2017.109","article-title":"Targeting mutant p53 for efficient cancer therapy","author":"Bykov","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(22)00408-9","article-title":"APC mutations as a predictive marker of endometrial cancer immunotherapy: a retrospective cohort study","author":"Li","year":"2022","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.biochi.2018.11.003","article-title":"Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives","author":"Aghabozorgi","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.cca.2026.121013_bb0300","doi-asserted-by":"crossref","DOI":"10.21037\/atm-20-5622","article-title":"The relationship between KRAS gene mutation and intestinal flora in tumor tissues of colorectal cancer patients","author":"Sui","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.cca.2026.121013_bb0305","article-title":"Analysis of KRAS, NRAS, and BRAF mutations, microsatellite instability, and relevant prognosis effects in patients with early colorectal cancer: a cohort study in east asia","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0310","article-title":"Mutation analysis of tp53 tumor suppressor gene in colorectal cancer in patients from Iran (Kerman province), Iran","volume":"139-144","author":"Nejad","year":"2012","journal-title":"J. Basic Med. Sci.15"},{"key":"10.1016\/j.cca.2026.121013_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","author":"Vousden","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cca.2026.121013_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14133252","article-title":"A RAS-independent biomarker panel to reliably predict response to MEK inhibition in colorectal cancer","author":"Pfohl","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cca.2026.121013_bb0325","article-title":"The structural basis for ras activation of PI3K\u03b1 lipid kinase","author":"Zhang","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.cca.2026.121013_bb0330","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04430-y","article-title":"Aspirin sensitivity of PIK3CA-mutated colorectal cancer: potential mechanisms revisited","author":"Hall","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0335","series-title":"BRAF mutant colorectal cancer as a distinct subset of colorectal cancer: clinical characteristics, clinical behavior, and response to targeted therapies","author":"Clarke","year":"2015"},{"key":"10.1016\/j.cca.2026.121013_bb0340","article-title":"Progression-free survival remains poor over sequential lines of systemic therapy in patients with BRAF-mutated colorectal cancer","author":"Morris","year":"2014","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0345","article-title":"Genomic alteration characterization in colorectal cancer identifies a prognostic and metastasis biomarker: FAM83A|IDO1","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0350","article-title":"Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells","author":"Testa","year":"2018","journal-title":"Med. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8100414","article-title":"Genetic alterations of metastatic colorectal cancer","author":"Testa","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.cca.2026.121013_bb0360","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-021-08535-8","article-title":"Clinical significance of FBXW7 tumor suppressor gene mutations and expression in human colorectal cancer: a systemic review and meta-analysis","author":"Shang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0365","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-017-0169-y","article-title":"TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells","author":"Fricke","year":"2017","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.cca.2026.121013_bb0370","article-title":"Loss of MMR and TGFBR2 increases the susceptibility to microbiota-dependent inflammation-associated colon cancer","author":"Tosti","year":"2022","journal-title":"CMGH"},{"key":"10.1016\/j.cca.2026.121013_bb0375","doi-asserted-by":"crossref","DOI":"10.2478\/raon-2019-0033","article-title":"KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer-practical implications for the clinician","author":"Afr\u01ces\u00e2nie","year":"2019","journal-title":"Radiol. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0380","doi-asserted-by":"crossref","DOI":"10.14740\/gr1167","article-title":"A systematic literature review and meta-analysis describing the prevalence of KRAS, NRAS , and BRAF gene mutations in metastatic colorectal cancer","author":"Levin-Sparenberg","year":"2020","journal-title":"Gastroenterol. Res."},{"key":"10.1016\/j.cca.2026.121013_bb0385","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019505","article-title":"Epigenetic determinants of cancer","author":"Baylin","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cca.2026.121013_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2015.04.021","article-title":"An adenine code for DNA: a second life for N6-methyladenine","author":"Heyn","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cca.2026.121013_bb0395","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.900590","article-title":"Diagnostic value of methylated septin9 for colorectal cancer screening: a meta-analysis","author":"Yan","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.cca.2026.121013_bb0400","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-9-133","article-title":"Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer","author":"Warren","year":"2011","journal-title":"BMC Med."},{"key":"10.1016\/j.cca.2026.121013_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2017.09.003","article-title":"Colorectal cancer: epigenetic alterations and their clinical implications","author":"Puccini","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA) - Rev. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0410","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v16.i28.3553","article-title":"Promoter methylation status of hMLH1, MGMT, and CDKN2A\/p16 in colorectal adenomas","author":"Psofaki","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cca.2026.121013_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.tig.2013.11.004","article-title":"Mining cancer methylomes: prospects and challenges","author":"Stirzaker","year":"2014","journal-title":"Trends Genet."},{"key":"10.1016\/j.cca.2026.121013_bb0420","doi-asserted-by":"crossref","DOI":"10.1007\/s12253-019-00663-8","article-title":"Histone modifications and their role in colorectal cancer (Review)","author":"Qin","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.cca.2026.121013_bb0425","article-title":"A DNA methylation signature for the prediction of tumour recurrence in stage II colorectal cancer","author":"Li","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0430","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s12013-025-01683-9","article-title":"The gut microbiome and colorectal cancer: an integrative review of the underlying mechanisms","author":"Karam","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cca.2026.121013_bb0435","doi-asserted-by":"crossref","DOI":"10.3390\/cells10081934","article-title":"The role of DNA damage response in dysbiosis-induced colorectal cancer","author":"Rivas-Dom\u00ednguez","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cca.2026.121013_bb0440","article-title":"The role of fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management","author":"Sun","year":"2019","journal-title":"Chronic Dis. Transl. Med."},{"key":"10.1016\/j.cca.2026.121013_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fbrio.2023.1229077","article-title":"A tale of two bacteria \u2013 Bacteroides Fragilis, Escherichia Coli, and colorectal cancer","author":"Lichtenstern","year":"2023","journal-title":"Front. Bacteriol."},{"key":"10.1016\/j.cca.2026.121013_bb0450","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176201","article-title":"Gut microbiota and colon cancer: a role for bacterial protein toxins?","author":"Fiorentini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0455","article-title":"Gut microbiota-derived short-chain fatty acids and colorectal cancer: ready for clinical translation?","author":"Hou","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cca.2026.121013_bb0460","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071775","article-title":"Butyrate and the intestinal epithelium: modulation of proliferation and inflammation in homeostasis and disease","author":"Salvi","year":"2021","journal-title":"Cells"},{"issue":"May","key":"10.1016\/j.cca.2026.121013_bb0465","article-title":"Exploring gut microbial metabolites as key players in inhibition of cancer progression: mechanisms and therapeutic implications","volume":"288","author":"Yin","year":"2024","journal-title":"Microbiol. Res."},{"issue":"2","key":"10.1016\/j.cca.2026.121013_bb0470","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/1878-0261.13700","article-title":"Detection of colorectal-cancer-associated bacterial taxa in fecal samples using next-generation sequencing and 19 newly established qPCR assays","volume":"19","author":"Senthakumaran","year":"2025","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2014.12.020","article-title":"Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery","author":"Patel","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"10","key":"10.1016\/j.cca.2026.121013_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105071","article-title":"Metabolomics and proteomics in prostate cancer research: overview, analytical techniques, data analysis, and recent clinical applications","volume":"25","author":"Al-Daffaie","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0485","doi-asserted-by":"crossref","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cca.2026.121013_bb0490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103466","article-title":"Proteomic characterization of colorectal cancer cells versus normal-derived colon mucosa cells: approaching identification of novel diagnostic protein biomarkers in colorectal cancer","author":"Ludvigsen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0495","doi-asserted-by":"crossref","DOI":"10.4240\/wjgs.v12.i12.468","article-title":"Carbohydrate antigen 19-9 \u2014 tumor marker: Past, present, and future","author":"Lee","year":"2020","journal-title":"World J. Gastrointest. Surg."},{"key":"10.1016\/j.cca.2026.121013_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","author":"Raffetto","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cca.2026.121013_bb0505","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13246226","article-title":"Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer","author":"Pezeshkian","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.cca.2026.121013_bb0510","series-title":"From Enzyme to Predictors: Serine Proteases in cancer Diagnosis and Prognosis","author":"Bose","year":"2024"},{"key":"10.1016\/j.cca.2026.121013_bb0515","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.30326","article-title":"The role of heat shock proteins in metastatic colorectal cancer: a review","author":"Javid","year":"2022","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cca.2026.121013_bb0520","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13174407","article-title":"Heat shock proteins 27, 70, and 110: expression and prognostic significance in colorectal cancer","author":"Hrudka","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cca.2026.121013_bb0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113698","article-title":"Beyond liquid biopsy: toward non-invasive assays for distanced cancer diagnostics in pandemics","author":"Ferrara","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121013_bb0530","doi-asserted-by":"crossref","DOI":"10.1080\/14789450.2020.1763174","article-title":"Analytical techniques for multiplex analysis of protein biomarkers","author":"Van Gool","year":"2020","journal-title":"Expert Rev. Proteomics"},{"issue":"1","key":"10.1016\/j.cca.2026.121013_bb0535","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-025-04107-w","article-title":"Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK biobank and ESTHER cohorts","volume":"23","author":"Seum","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.cca.2026.121013_bb0540","series-title":"Emerging non-invasive biomarkers for early detection of gastrointestinal cancers","volume":"17","author":"Singh","year":"2025"},{"issue":"1","key":"10.1016\/j.cca.2026.121013_bb0545","first-page":"1","article-title":"Altered metabolic profiles in colon and rectal cancer","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.cca.2026.121013_bb0550","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147722","article-title":"The utility of lipidomic analysis in colorectal cancer diagnosis and prognosis\u2014a systematic review of recent literature","volume":"25","author":"Klekowski","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cca.2026.121013_bb0555","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.ccell.2024.07.005","article-title":"Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers","volume":"42","author":"Sun","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.cca.2026.121013_bb0560","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41416-025-02997-4","article-title":"Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and mendelian randomisation analyses","volume":"133","author":"Yuan","year":"2025","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0565","doi-asserted-by":"crossref","DOI":"10.12998\/wjcc.v11.i27.6318","article-title":"Characteristics of amino acid metabolism in colorectal cancer","author":"Xu","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.cca.2026.121013_bb0570","doi-asserted-by":"crossref","DOI":"10.1038\/s41416-018-0357-6","article-title":"Alterations in serum amino-acid profile in the progression of colorectal cancer: associations with systemic inflammation, tumour stage and patient survival","author":"Sirni\u00f6","year":"2019","journal-title":"Br. J. Cancer"},{"issue":"12","key":"10.1016\/j.cca.2026.121013_bb0575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo14120708","article-title":"The potential of metabolomics in colorectal cancer prognosis","volume":"14","author":"Fu","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.cca.2026.121013_bb0580","article-title":"Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2026.121013_bb0585","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4935","article-title":"Serum nuclear magnetic resonance metabolomics analysis of human metastatic colorectal cancer: biomarkers and pathway analysis","author":"Trist\u00e1n","year":"2023","journal-title":"NMR Biomed."},{"key":"10.1016\/j.cca.2026.121013_bb0590","doi-asserted-by":"crossref","DOI":"10.3892\/ol.2023.13944","article-title":"Metabolomic analysis of gut metabolites in patients with colorectal cancer: association with disease development and outcome","author":"Xie","year":"2023","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cca.2026.121013_bb0595","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.32076","article-title":"Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: the DACHS study","author":"Zaimenko","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0600","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11030129","article-title":"Targeted plasma metabolic profiles and risk of recurrence in stage ii and iii colorectal cancer patients: results from an international cohort consortium","author":"Ose","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.cca.2026.121013_bb0605","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.114.103804","article-title":"Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study","author":"Liesenfeld","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2026.121013_bb0610","doi-asserted-by":"crossref","DOI":"10.1021\/acs.analchem.6b00885","article-title":"Combining NMR and LC\/MS using backward variable elimination: metabolomics analysis of colorectal cancer, polyps, and healthy controls","author":"Deng","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2026.121013_bb0615","doi-asserted-by":"crossref","DOI":"10.1007\/s00535-016-1261-6","article-title":"Serum metabolomics analysis for early detection of colorectal cancer","author":"Uchiyama","year":"2017","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.cca.2026.121013_bb0620","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.30829","article-title":"Global and targeted serum metabolic profiling of colorectal cancer progression","author":"Long","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.cca.2026.121013_bb0625","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55952-8","article-title":"Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer","author":"Mart\u00edn-Bl\u00e1zquez","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2026.121013_bb0630","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051142","article-title":"Integrative analysis of fecal metagenomics and metabolomics in colorectal cancer","author":"Clos-Garcia","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cca.2026.121013_bb0635","article-title":"Metabolomic comparison of patients with colorectal cancer at different anticancer treatment stages","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cca.2026.121013_bb0640","article-title":"Elucidating tumor-stromal metabolic crosstalk in colorectal cancer through integration of constraint-based models and LC-MS metabolomics","author":"Wang","year":"2022","journal-title":"Metab. Eng."},{"key":"10.1016\/j.cca.2026.121013_bb0645","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2023.13106","article-title":"Metabolomics analyses of cancer tissue from patients with colorectal cancer","author":"Kang","year":"2023","journal-title":"Mol. Med. Rep."},{"issue":"17","key":"10.1016\/j.cca.2026.121013_bb0650","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13175202","article-title":"Stage-specific plasma metabolomic profiles in colorectal cancer","volume":"13","author":"Ishizaki","year":"2024","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.cca.2026.121013_bb0655","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/1878-0261.13791","article-title":"Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer","volume":"19","author":"Hu","year":"2025","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.cca.2026.121013_bb0660","first-page":"1","article-title":"Serum metabolomics to identify molecular subtypes and predict XELOX efficacy in colorectal cancer","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2026.121013_bb0665","article-title":"A plasma metabolite-based test to detect minimal residual disease in post-surgery colorectal cancer patients","author":"Zhou","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.cca.2026.121013_bb0670","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-019-0230-y","article-title":"Epigenetics of colorectal cancer: biomarker and therapeutic potential","author":"Jung","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cca.2026.121013_bb0675","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020852","article-title":"Novel diagnostic biomarkers in colorectal cancer","author":"Zygulska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121013_bb0680","doi-asserted-by":"crossref","DOI":"10.1080\/14737140.2021.1882858","article-title":"Colorectal cancer screening and diagnosis: omics-based technologies for development of a non-invasive blood-based method","author":"Gallardo-G\u00f3mez","year":"2021","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"10.1016\/j.cca.2026.121013_bb0685","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaa010","article-title":"Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine","author":"Ahmed","year":"2020","journal-title":"Database"},{"key":"10.1016\/j.cca.2026.121013_bb0690","series-title":"Emerging biomarkers for early cancer detection and diagnosis\u00a0: challenges , innovations , and clinical perspectives","author":"Zafar","year":"2025"},{"key":"10.1016\/j.cca.2026.121013_bb0695","series-title":"Liquid biopsies come of age: towards implementation of circulating tumour DNA","author":"Wan","year":"2017"},{"key":"10.1016\/j.cca.2026.121013_bb0700","series-title":"Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer","first-page":"317","author":"Church","year":"2014"},{"key":"10.1016\/j.cca.2026.121013_bb0705","series-title":"Risk-Predictive and Diagnostic Biomarkers for Colorectal Cancer\u00a0; a Systematic Review of Studies Using Pre-Diagnostic Blood Samples Collected in Prospective Cohorts and Screening Settings","first-page":"1","author":"Settings","year":"2021"},{"key":"10.1016\/j.cca.2026.121013_bb0710","series-title":"HHS public access","first-page":"1350","volume":"21","author":"Soneson","year":"2016"},{"key":"10.1016\/j.cca.2026.121013_bb0715","first-page":"71","article-title":"Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries","volume":"82","author":"Id","year":"2019","journal-title":"PLoS One"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126001956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126001956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:16:22Z","timestamp":1781511382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126001956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":143,"alternative-id":["S0009898126001956"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121013","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging biomarkers for early detection of colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121013"}}