{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:52:10Z","timestamp":1790657530820,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cca.2026.121056","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:33:18Z","timestamp":1777995198000},"page":"121056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Free light chain EQA: Analytical variability with clinical consequences \u2013 Data from 25 Italian EQA exercises (2021\u20132025)"],"prefix":"10.1016","volume":"590","author":[{"given":"Fabio","family":"Pasotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Da Molin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bosoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Azzar\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Liga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Moriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Zaccaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Buoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2026.121056_bb0005","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/leu.2010.60","article-title":"Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma: IMWG consensus perspectives, risk factors for progression and guidelines for monitoring and management","volume":"24","author":"Rajkumar","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.cca.2026.121056_bb0010","article-title":"Indicators of profound hematologic response in AL amyloidosis: complete response remains the goal of therapy","volume":"2","author":"Dispenzieri","year":"2012","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.cca.2026.121056_bb0015","first-page":"123","article-title":"New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes","volume":"96","author":"Kumar","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.cca.2026.121056_bb0020","first-page":"e538","article-title":"IMWG guidelines for serum free light chain analysis in monoclonal gammopathies","volume":"15","author":"International Myeloma Working Group","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cca.2026.121056_bb0025","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1186\/s40001-025-02984-8","article-title":"Performance and comparison of FLCCheck: a novel serum free light chain assay for the auxiliary diagnosis of multiple myeloma","volume":"30","author":"Cao","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.cca.2026.121056_bb0030","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International myeloma working group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cca.2026.121056_bb0035","first-page":"173","article-title":"Recommendations for clinical use of serum free light chains in monoclonal gammopathies","volume":"46","author":"Graziani","year":"2022","journal-title":"Biochim Clin."},{"key":"10.1016\/j.cca.2026.121056_bb0040","first-page":"e1","article-title":"Recommendations for standardized reporting of serum free light chain results in clinical laboratories","volume":"62","author":"Tate","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0045","first-page":"201","article-title":"Harmonization issues in EQA schemes for free light chains","volume":"62","author":"Jassam","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0050","first-page":"420","article-title":"Analytical concordance between Siemens N latex FLC and binding site Freelite assays","volume":"60","author":"Bosmann","year":"2022","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0055","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1093\/ajcp\/aqab191.241","article-title":"Evaluation of the Siemens N latex free light chain assay and comparison to binding site Freelite assay","volume":"156","author":"Lin","year":"2021","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.cca.2026.121056_bb0060","article-title":"Comparison of Freelite and N latex serum free light chain assays","volume":"31","author":"Roccaforte","year":"2021","journal-title":"Biochem. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0065","first-page":"311","article-title":"Impact of method-specific differences in free light chain assays: results from a national EQA program","volume":"62","author":"Infusino","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0070","first-page":"423","article-title":"Method-dependent variability in EQA schemes: implications for clinical follow-up of monoclonal gammopathies","volume":"62","author":"Infusino","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0075","first-page":"125","article-title":"Commutability of external quality assessment materials for serum free light chains","volume":"62","author":"Tate","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0080","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1515\/cclm.2011.793","article-title":"Clinical comparison of new monoclonal antibody-based nephelometric assays for free light chain kappa and lambda to polyclonal antibody-based assays and immunofixation electrophoresis","volume":"50","author":"Hoedemakers","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0085","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1515\/cclm-2017-0339","article-title":"Evaluation of a new free light chain ELISA assay: bringing coherence with electrophoretic methods","volume":"56","author":"Jacobs","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clinbiochem.2022.10.003","article-title":"Accuracy of determination of free light chains (kappa and lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment","volume":"111","author":"Rollborn","year":"2023","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2026.121056_bb0095","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1515\/cclm-2015-0879","article-title":"Is accuracy of serum free light chain measurement achievable?","volume":"54","author":"Jacobs","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-022-00732-3","article-title":"Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: results of the iStopMM study","volume":"12","author":"Long","year":"2022","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.cca.2026.121056_bb0105","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41408-022-00751-0","article-title":"In response to: defining new reference intervals for serum free light chains in individuals with chronic kidney disease: results of the iStopMM study","volume":"12","author":"Minnema","year":"2022","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.cca.2026.121056_bb0110","article-title":"Revised free light chain reference intervals enhance risk stratification in monoclonal gammopathy of undetermined significance and reduce overdiagnosis","volume":"15","author":"Maeng","year":"2025","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.cca.2026.121056_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-019-0267-8","article-title":"Comparison of three different serum free light-chain assays\u2014implications on diagnostic and therapeutic monitoring of multiple myeloma","volume":"10","author":"Schieferdecker","year":"2020","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.cca.2026.121056_bb0120","first-page":"183","article-title":"Quality assurance and external quality assessment in clinical laboratories","volume":"54","author":"Panteghini","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0125","first-page":"98","article-title":"The importance of external quality assessment (EQA) schemes in laboratory medicine","volume":"466","author":"Ceriotti","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121056_bb0130","first-page":"2013","article-title":"External quality assessment (EQA): an essential tool for improving laboratory quality","volume":"411","author":"Plebani","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121056_bb0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clinbiochem.2018.02.004","article-title":"The role of external quality assessment in the verification of in vitro medical diagnostics","volume":"57","author":"Braga","year":"2018","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2026.121056_bb0140","first-page":"200","article-title":"Quality indicators in EQA","volume":"20","author":"Sciacovelli","year":"2010","journal-title":"Biochem. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0145","series-title":"Statistical methods for use in proficiency testing by interlaboratory comparison","author":"UNI ISO 13528","year":"2022"},{"key":"10.1016\/j.cca.2026.121056_bb0150","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1515\/cclm-2015-0067","article-title":"Defining analytical performance specifications: consensus statement from the 1st strategic conference of the European Federation of Clinical Chemistry and Laboratory Medicine","volume":"53","author":"Sandberg","year":"2015","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0155","first-page":"1212","article-title":"EQA data elaboration according to commutability principles: a regional experience","volume":"59","author":"Infusino","year":"2021","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.121056_bb0160","first-page":"431","article-title":"Why commutability matters in proficiency testing","volume":"64","author":"Miller","year":"2018","journal-title":"Clin. Chem."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812600238X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989812600238X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:31:49Z","timestamp":1783643509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989812600238X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"alternative-id":["S000989812600238X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121056","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Free light chain EQA: Analytical variability with clinical consequences \u2013 Data from 25 Italian EQA exercises (2021\u20132025)","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121056"}}