{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:20:08Z","timestamp":1789068008009,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cca.2026.121139","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:44:32Z","timestamp":1780415072000},"page":"121139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inflammatory biomarkers in chronic kidney disease"],"prefix":"10.1016","volume":"591","author":[{"given":"Ghaleb","family":"Oriquat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Hashim","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Qutayba","family":"Badraldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasur","family":"Rizaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargiza","family":"Abdusamiyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasim M.","family":"Salih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Adil","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cca.2026.121139_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12040548","article-title":"Emerging biomarkers for early detection of chronic kidney disease","volume":"12","author":"Mizdrak","year":"2022","journal-title":"J. Pers. Med."},{"issue":"10302","key":"10.1016\/j.cca.2026.121139_bb0010","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(21)00519-5","article-title":"Chronic kidney disease","volume":"398","author":"Kalantar-Zadeh","year":"2021","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cca.2026.121139_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13061423","article-title":"New and emerging biomarkers in chronic kidney disease","volume":"13","author":"Dopiera\u0142a","year":"2025","journal-title":"Biomedicines"},{"issue":"10075","key":"10.1016\/j.cca.2026.121139_bb0020","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.cca.2026.121139_bb0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/j.ajkd.2021.11.010","article-title":"Antifibrotic agents for the management of CKD: a review","volume":"80","author":"Ruiz-Ortega","year":"2022","journal-title":"Am. J. Kidney Dis."},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2026.121139_bb0030","doi-asserted-by":"crossref","first-page":"s03","DOI":"10.1590\/1806-9282.66.s1.3","article-title":"Chronic kidney disease","volume":"66","author":"Ammirati","year":"2020","journal-title":"Rev. Assoc. Med. Bras."},{"issue":"10","key":"10.1016\/j.cca.2026.121139_bb0035","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11906-022-01206-4","article-title":"Inflammation, lymphatics, and cardiovascular disease: amplification by chronic kidney disease","volume":"24","author":"Kon","year":"2022","journal-title":"Curr. Hypertens. Rep."},{"issue":"10","key":"10.1016\/j.cca.2026.121139_bb0040","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3390\/biomedicines11102746","article-title":"Novel therapeutic approaches in the management of chronic kidney disease","volume":"11","author":"D\u0105bek","year":"2023","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.cca.2026.121139_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26073072","article-title":"Targeting inflammatory imbalance in chronic kidney disease: focus on anti-inflammatory and resolution mediators","volume":"26","author":"Rispoli","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cca.2026.121139_bb0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/kidneydial5030039","article-title":"Biomarkers predicting major adverse cardiovascular events in end-stage kidney disease: a systematic review","volume":"5","author":"Davies","year":"2025","journal-title":"Kidney Dial."},{"issue":"9","key":"10.1016\/j.cca.2026.121139_bb0055","article-title":"A comprehensive review of biomarkers for chronic kidney disease in older individuals: current perspectives and future directions","volume":"16","author":"Gupta","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-024-00589-9","article-title":"Chronic kidney disease","volume":"11","author":"Romagnani","year":"2025","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.cca.2026.121139_bb0065","doi-asserted-by":"crossref","unstructured":"Ekanayaka E, Dahanayake D. Emerging biomarkers for early detection of chronic kidney disease of unknown etiology (CKDu): a mini review. Transl. Appl. Res. :171\u2013179.","DOI":"10.1201\/9781003774105-20"},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0070","article-title":"The efficacy of novel biomarkers for the early detection and management of acute kidney injury: a systematic review","volume":"20","author":"Yousef","year":"2025","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.cca.2026.121139_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040633","article-title":"Novel biomarkers of diabetic kidney disease","volume":"13","author":"Rico-Fontalvo","year":"2023","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.cca.2026.121139_bb0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000534447","article-title":"Chronic inflammation in chronic kidney disease","volume":"148","author":"Yan","year":"2024","journal-title":"Nephron"},{"issue":"7","key":"10.1016\/j.cca.2026.121139_bb0085","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.ekir.2021.04.023","article-title":"Chronic inflammation in chronic kidney disease progression: role of Nrf2","volume":"6","author":"Stenvinkel","year":"2021","journal-title":"Kidney Int Rep."},{"issue":"11","key":"10.1016\/j.cca.2026.121139_bb0090","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.2337\/dc22-0866","article-title":"Interleukin-6 and cardiovascular and kidney outcomes in patients with type 2 diabetes: new insights from CANVAS","volume":"45","author":"Koshino","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cca.2026.121139_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1397160","article-title":"Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis","volume":"11","author":"Muglia","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.cca.2026.121139_bb0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1265\/ehpm.24-00329","article-title":"Association of C-reactive protein to albumin ratio with all-cause and cardiovascular mortality in patients with chronic kidney disease stages 3\u20135","volume":"30","author":"Liu","year":"2025","journal-title":"Environ. Health Prev. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12882-015-0068-7","article-title":"Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease","volume":"16","author":"Lee","year":"2015","journal-title":"BMC Nephrol."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0110","doi-asserted-by":"crossref","first-page":"23587","DOI":"10.1038\/s41598-021-02864-1","article-title":"Effects of tumor necrosis factor-\u03b1 inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy","volume":"11","author":"Taguchi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2026.121139_bb0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cca.2020.03.040","article-title":"Bone, inflammation and chronic kidney disease","volume":"506","author":"Mazzaferro","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.cca.2026.121139_bb0120","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/ndt\/gfac290","article-title":"TNF or EGFR inhibition equally block AKI-to-CKD transition: opportunities for etanercept treatment","volume":"38","author":"Abdelmageed","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.cca.2026.121139_bb0125","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/labinvest.2011.42","article-title":"C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice","volume":"91","author":"Li","year":"2011","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/srep26740","article-title":"C-reactive protein promotes diabetic kidney disease in db\/db mice via the CD32b-Smad3-mTOR signaling pathway","volume":"6","author":"You","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cca.2026.121139_bb0135","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00011-024-01861-0","article-title":"Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults","volume":"73","author":"Huang","year":"2024","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.cca.2026.121139_bb0140","article-title":"Association between systemic inflammatory indicators with the survival of chronic kidney disease: a prospective study based on NHANES","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2026.121139_bb0145","doi-asserted-by":"crossref","first-page":"1329256","DOI":"10.3389\/fendo.2024.1329256","article-title":"Association between systemic inflammation response index and chronic kidney disease: a population-based study","volume":"15","author":"Li","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0150","article-title":"The association between nutritional-inflammatory status and chronic kidney disease prognosis: a population-based study","volume":"47","author":"Zhang","year":"2025","journal-title":"Ren. Fail."},{"issue":"2","key":"10.1016\/j.cca.2026.121139_bb0155","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2432541","article-title":"Inflammation-based scores predict chronic kidney disease progression in patients with chronic kidney disease and chronic heart failure","volume":"46","author":"Cai","year":"2024","journal-title":"Ren. Fail."},{"issue":"5","key":"10.1016\/j.cca.2026.121139_bb0160","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/aje\/kwz246","article-title":"Inflammatory markers and incidence of hospitalization with infection in chronic kidney disease: the chronic renal insufficiency cohort study","volume":"189","author":"Ishigami","year":"2020","journal-title":"Am. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.cca.2026.121139_bb0165","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/imj.15251","article-title":"Inflammation-based modified Glasgow prognostic score and renal outcome in chronic kidney disease patients: is there a relationship?","volume":"52","author":"Stefan","year":"2022","journal-title":"Intern. Med. J."},{"issue":"3","key":"10.1016\/j.cca.2026.121139_bb0170","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139927","article-title":"Biomarkers of inflammation and repair in kidney disease progression","volume":"131","author":"Puthumana","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.cca.2026.121139_bb0175","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/ndt\/gfac286","article-title":"Total cortical interstitial inflammation predicts chronic kidney disease progression in patients with lupus nephritis","volume":"38","author":"Duong","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cca.2026.121139_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2019.00206","article-title":"Alterations to the gut microbiota and their correlation with inflammatory factors in chronic kidney disease","volume":"9","author":"Li","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.cca.2026.121139_bb0185","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2399314","article-title":"Inflammatory indices and anemia in chronic kidney disease: correlation and survival analysis of the National Health and nutrition examination survey 2005\u20132018","volume":"46","author":"Fu","year":"2024","journal-title":"Ren. Fail."},{"issue":"8","key":"10.1016\/j.cca.2026.121139_bb0190","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tips.2023.06.001","article-title":"Targeting galectin-3 in inflammatory and fibrotic diseases","volume":"44","author":"Bouffette","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.cca.2026.121139_bb0195","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s11255-024-04026-4","article-title":"Association of serum galectin-3 levels with mortality and cardiovascular disease outcomes in hemodialysis patients: a systematic review and dose\u2013response meta-analysis","volume":"56","author":"Bellos","year":"2024","journal-title":"Int. Urol. Nephrol."},{"issue":"7","key":"10.1016\/j.cca.2026.121139_bb0200","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1177\/10815589241249991","article-title":"Association of suPAR, ST2, and galectin-3 with eGFR decline and mortality in patients with advanced heart failure with reduced ejection fraction","volume":"72","author":"Roehm","year":"2024","journal-title":"J. Invest. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ekir.2018.09.013","article-title":"Soluble ST2 and Galectin-3 and progression of CKD","volume":"4","author":"Alam","year":"2019","journal-title":"Kidney Int Rep."},{"key":"10.1016\/j.cca.2026.121139_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.119727","article-title":"Galectin-3 in chronic kidney disease","volume":"559","author":"Bellos","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121139_bb0215","first-page":"10","article-title":"Biomarkers of kidney failure and all-cause mortality in CKD","volume":"6","author":"Onoja","year":"2024","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.cca.2026.121139_bb0220","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/j.ajkd.2018.03.025","article-title":"GDF-15, galectin 3, soluble ST2, and risk of mortality and cardiovascular events in CKD","volume":"72","author":"Tuegel","year":"2018","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cca.2026.121139_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.639103","article-title":"Interleukin-18 in inflammatory kidney disease","volume":"8","author":"Hirooka","year":"2021","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.cca.2026.121139_bb0230","article-title":"Elevated serum interleukin-18 level is associated with all-cause mortality in stable hemodialysis patients independently of cardiac dysfunction","volume":"9","author":"Liu","year":"2014","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.cca.2026.121139_bb0235","doi-asserted-by":"crossref","DOI":"10.1172\/JCI190850","article-title":"Unveiling mechanisms underlying kidney function changes during sex hormone therapy","volume":"135","author":"van Eeghen","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.cca.2026.121139_bb0240","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1744-9987.2012.01141.x","article-title":"Novel inflammatory marker in dialysis patients: YKL-40","volume":"17","author":"Okyay","year":"2013","journal-title":"Ther. Apher. Dial."},{"issue":"5","key":"10.1016\/j.cca.2026.121139_bb0245","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00011-022-01574-2","article-title":"Inflammatory biomarkers in staging of chronic kidney disease: elevated TNFR2 levels accompanies renal function decline","volume":"71","author":"Lousa","year":"2022","journal-title":"Inflamm. Res."},{"issue":"10","key":"10.1016\/j.cca.2026.121139_bb0250","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1093\/ndt\/gfab294","article-title":"Novel biomarkers of inflammation, kidney function and chronic kidney disease in the general population","volume":"37","author":"Nano","year":"2022","journal-title":"Nephrol. Dial. Transplant."},{"issue":"2","key":"10.1016\/j.cca.2026.121139_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020257","article-title":"Proteomic analysis of human serum from patients with chronic kidney disease","volume":"10","author":"Romanova","year":"2020","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.cca.2026.121139_bb0260","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.ajkd.2021.09.018","article-title":"Associations of plasma biomarkers of inflammation, fibrosis, and kidney tubular injury with progression of diabetic kidney disease: a cohort study","volume":"79","author":"Gutierrez","year":"2022","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cca.2026.121139_bb0265","article-title":"Altered inflammatory cytokines and mcp-1 chemokine in patients with chronic renal failure","volume":"12","author":"Mahmoud","year":"2025","journal-title":"Labyrinth: Fayoum J. Sci. Interdiscip. Stud."},{"issue":"12","key":"10.1016\/j.cca.2026.121139_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2024.0474","article-title":"Correlation between serum biomarkers and disease progression of chronic kidney disease","volume":"85","author":"Xu","year":"2024","journal-title":"Br. J. Hosp. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0275","doi-asserted-by":"crossref","first-page":"173","DOI":"10.53771\/ijbpsa.2025.10.1.0068","article-title":"Determination of high-sensitivity C-reactive protein in chronic kidney disease patients in Al-Hawija general Hospital in Kirkuk City-Iraq","volume":"10","author":"Al-Quraghuli","year":"2025","journal-title":"Int J Biol Pharm Sci Arch."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/srep18332","article-title":"Usefulness of serum interleukin-18 in predicting cardiovascular mortality in patients with chronic kidney disease\u2013systems and clinical approach","volume":"5","author":"Formanowicz","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0285","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.cca.2026.121139_bb0290","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1038\/s41591-024-03043-1","article-title":"IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial","volume":"30","author":"Chertow","year":"2024","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.cca.2026.121139_bb0295","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jjcc.2023.05.006","article-title":"Efficacy and safety of interleukin-6 inhibition with ziltivekimab in patients at high risk of atherosclerotic events in Japan (RESCUE-2): a randomized, double-blind, placebo-controlled, phase 2 trial","volume":"82","author":"Wada","year":"2023","journal-title":"J. Cardiol."},{"issue":"1","key":"10.1016\/j.cca.2026.121139_bb0300","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/jamacardio.2025.4491","article-title":"Rationale, design, and baseline clinical characteristics of the ziltivekimab cardiovascular outcomes trial: interleukin-6 inhibition and atherosclerotic event rate reduction","volume":"11","author":"Ridker","year":"2026","journal-title":"JAMA Cardiol."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126003219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126003219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:14:35Z","timestamp":1786421675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126003219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":60,"alternative-id":["S0009898126003219"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121139","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory biomarkers in chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121139"}}