{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:13:09Z","timestamp":1790356389074,"version":"4.1.0"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004386","name":"University of Malaya","doi-asserted-by":"publisher","award":["PV067-2025F"],"award-info":[{"award-number":["PV067-2025F"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cca.2026.121146","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:04:11Z","timestamp":1780787051000},"page":"121146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Biomarker-driven biosensing strategies for early risk stratification in severe dengue"],"prefix":"10.1016","volume":"591","author":[{"given":"Wei Yin","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Mei","family":"Khor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2026.121146_bb0005","series-title":"StatPearls [Internet]","article-title":"Dengue fever","author":"Schaefer","year":"2025"},{"issue":"7446","key":"10.1016\/j.cca.2026.121146_bb0010","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cca.2026.121146_bb0015","author":"World Health Organization"},{"key":"10.1016\/j.cca.2026.121146_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2025.107940","article-title":"Global dengue epidemic worsens with record 14 million cases and 9,000 deaths reported in 2024","volume":"158","author":"Haider","year":"2025","journal-title":"Int. J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.2034","article-title":"Upsurge of dengue outbreaks in several WHO regions: Public awareness, vector control activities, and international collaborations are key to prevent spread","volume":"7","author":"Sarker","year":"2024","journal-title":"Health Sci. Reports"},{"key":"10.1016\/j.cca.2026.121146_bb0030","series-title":"Dengue Guidelines for Diagnosis, Treatment, Prevention and Control","author":"World Health Organization","year":"2009"},{"key":"10.1016\/j.cca.2026.121146_bb0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.trac.2015.01.005","article-title":"An introduction to dengue-disease diagnostics","volume":"67","author":"Darwish","year":"2015","journal-title":"TrAC Trends Anal. Chem."},{"issue":"3","key":"10.1016\/j.cca.2026.121146_bb0040","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1016\/j.snb.2017.09.159","article-title":"Point-of-care tests: A review of advances in the emerging diagnostic tools for dengue virus infection","volume":"255","author":"Darwish","year":"2018","journal-title":"Sens. Actuators B"},{"issue":"5","key":"10.1016\/j.cca.2026.121146_bb0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00281-017-0625-1","article-title":"Immune-mediated cytokine storm and its role in severe dengue","volume":"39","author":"Srikiatkhachorn","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0050","doi-asserted-by":"crossref","first-page":"15612","DOI":"10.1038\/s41598-025-99628-y","article-title":"Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome","volume":"15","author":"Jiravejchakul","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12929-015-0191-6","article-title":"Biomarkers of severe dengue disease\u2013a review","volume":"22","author":"John","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cca.2026.121146_bb0060","author":"Centers for Disease Control and Prevention (CDC)"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0065","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1038\/s41598-025-91099-5","article-title":"Kinetics of NS1 and anti-NS1 IgG following dengue infection reveals likely early formation of immune complexes in secondary infected patients","volume":"15","author":"Muller","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0070","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1186\/s12879-014-0570-8","article-title":"Dengue NS1 antigen as a marker of severe clinical disease","volume":"14","author":"Paranavitane","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cca.2026.121146_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105409","article-title":"Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1","volume":"109","author":"de Sousa","year":"2024","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.cca.2026.121146_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiph.2025.102982","article-title":"Dengue virus infection: A systematic review of pathogenesis, diagnosis and management","volume":"18","author":"Yang","year":"2025","journal-title":"J. Infect. Public Health."},{"issue":"2","key":"10.1016\/j.cca.2026.121146_bb0085","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jmii.2024.12.004","article-title":"Dengue virus non-structural protein 1 binding to thrombin as a dengue severity marker: Comprehensive patient analysis in south Taiwan","volume":"58","author":"Nanda","year":"2025","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.cca.2026.121146_bb0090","author":"Centers for Disease Control and Prevention (CDC)"},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jgeb.2025.100556","article-title":"Exploring the therapeutic potential of micrornas: targeted gene regulation strategies for enhanced cancer therapy","volume":"23","author":"Pandey","year":"2025","journal-title":"J. Genet. Eng. Biotechnol."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12929-019-0614-x","article-title":"Role of microRNAs in antiviral responses to dengue infection","volume":"27","author":"Wong","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cca.2026.121146_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.714409","article-title":"microRNAs, the link between dengue virus and the host genome","volume":"12","author":"Su","year":"2021","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0110","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/0004563215604001","article-title":"microRNA expression in blood of dengue patients","volume":"53","author":"Tambyah","year":"2016","journal-title":"Ann. Clin. Biochem."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0115","first-page":"1","article-title":"Circulating miR-1246 as a diagnostic and prognostic biomarker in dengue infection: a case\u2013control study","volume":"7","author":"Pradhan","year":"2025","journal-title":"J. Mol. Pathol."},{"issue":"10","key":"10.1016\/j.cca.2026.121146_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010836","article-title":"Discovery and validation of circulating miRNAs for the clinical prognosis of severe dengue","volume":"16","author":"Limothai","year":"2022","journal-title":"PLoS Neglect. Trop. Dis."},{"key":"10.1016\/j.cca.2026.121146_bb0125","article-title":"Role of microRNA 21 (miR-21) in dengue disease progression and cross talk with target proteins","volume":"121","author":"Datta","year":"2025","journal-title":"Comput. Biol. Chem."},{"issue":"23","key":"10.1016\/j.cca.2026.121146_bb0130","doi-asserted-by":"crossref","first-page":"12883","DOI":"10.3390\/ijms252312883","article-title":"MicroRNA Nobel Prize: Timely recognition and high anticipation of future products\u2014A prospective analysis","volume":"25","author":"Niazi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.cca.2026.121146_bb0135","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpha.2019.05.004","article-title":"Research advances in the detection of miRNA","volume":"9","author":"Ye","year":"2019","journal-title":"J. Pharm. Anal."},{"issue":"5","key":"10.1016\/j.cca.2026.121146_bb0145","first-page":"943","article-title":"Cytokine expression in dengue fever and dengue hemorrhagic fever patients with bleeding and severe hepatitis","volume":"102","author":"Imad","year":"2020","journal-title":"AJTMH"},{"key":"10.1016\/j.cca.2026.121146_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105312","article-title":"Dengue NS1 induces phospholipase A2 enzyme activity, prostaglandins, and inflammatory cytokines in monocytes","volume":"202","author":"Silva","year":"2022","journal-title":"Antivir. Res."},{"issue":"6","key":"10.1016\/j.cca.2026.121146_bb0155","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3390\/v17060807","article-title":"Role of extracellular vesicles in severe dengue: virus\u2013host interactions and biomarker potential","volume":"17","author":"Agudelo","year":"2025","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.cca.2026.121146_bb0160","first-page":"1975","article-title":"Pro-and anti-inflammatory cytokines signatures at different severity of dengue infection","volume":"13","author":"Prajapati","year":"2024","journal-title":"J. Family Med. Prim. Care"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0165","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s12964-024-01779-4","article-title":"Immunomodulation in dengue: towards deciphering dengue severity markers","volume":"22","author":"Dash","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0170","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2018.023","article-title":"Role of cytokines as molecular marker of dengue severity","volume":"10","author":"Sehrawat","year":"2018","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"issue":"8","key":"10.1016\/j.cca.2026.121146_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70511","article-title":"Risk stratification of dengue cases requiring hospitalization","volume":"97","author":"Anh","year":"2025","journal-title":"J. Med. Virol."},{"issue":"2","key":"10.1016\/j.cca.2026.121146_bb0180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijmmb.2022.01.010","article-title":"Pathophysiologic and prognostic role of proinflammatory and regulatory cytokines as a proinflammatory and regulatory cytokine in dengue fever","volume":"40","author":"Iyer","year":"2022","journal-title":"Indian J. Med. Microbiol."},{"issue":"8","key":"10.1016\/j.cca.2026.121146_bb0185","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.35975\/apic.v29i8.3039","article-title":"Novel insights into immune dysregulation and cytokine signatures in intensive care settings: bridging IL-6, IL-10, TNF-\u03b1 to endothelial, hepatic, and hematological dysfunction in severe dengue, a schematic meta-analysis","volume":"29","author":"Bukhari","year":"2025","journal-title":"Anaesth. Pain Intens. Care"},{"issue":"11","key":"10.1016\/j.cca.2026.121146_bb0190","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/pathogens12111362","article-title":"Viremia and inflammatory cytokines in dengue: interleukin-2 as a biomarker of infection, and interferon-\u03b1 and-\u03b3 as markers of primary versus secondary infection","volume":"12","author":"de Arruda","year":"2023","journal-title":"Pathogens"},{"issue":"5","key":"10.1016\/j.cca.2026.121146_bb0195","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/20477724.2024.2365581","article-title":"Distinct inflammatory markers in primary and secondary dengue infection: can cytokines CXCL5, CXCL9, and CCL17 act as surrogate markers?","volume":"118","author":"Mustafa","year":"2024","journal-title":"Pathog. Global Health"},{"issue":"11","key":"10.1016\/j.cca.2026.121146_bb0200","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/infdis\/jiac273","article-title":"The Cytokines CXCL10 and CCL2 and the kynurenine metabolite anthranilic acid accurately predict patients at risk of developing dengue with warning signs","volume":"226","author":"Jusof","year":"2022","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12918-017-0415-3","article-title":"Mathematical modelling and a systems science approach to describe the role of cytokines in the evolution of severe dengue","volume":"11","author":"Jayasundara","year":"2017","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.cca.2026.121146_bb0210","article-title":"An integrated biomarker panel for early computational prediction of dengue severity during the acute phase","volume":"282","author":"Nanda","year":"2025","journal-title":"Clin. Immunol."},{"issue":"5","key":"10.1016\/j.cca.2026.121146_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2468","article-title":"Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta-analysis","volume":"33","author":"Shukla","year":"2023","journal-title":"Rev. Med. Virol."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0220","first-page":"7463489","article-title":"Serum ferritin: a backstage weapon in diagnosis of dengue fever","volume":"2017","author":"Roy Chaudhuri","year":"2017","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"10.1016\/j.cca.2026.121146_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.nmni.2025.101582","article-title":"Ferritin's role in infectious diseases: Exploring pathogenic mechanisms and clinical implications","volume":"65","author":"Liao","year":"2025","journal-title":"New Microb. New Infect."},{"issue":"3","key":"10.1016\/j.cca.2026.121146_bb0230","first-page":"1072","article-title":"Serum ferritin as a prognostic indicator in adult dengue patients","volume":"104","author":"Suresh","year":"2020","journal-title":"AJTMH"},{"key":"10.1016\/j.cca.2026.121146_bb0235","series-title":"StatPearls [Internet]","article-title":"C-reactive protein: clinical relevance and interpretation","author":"Singh","year":"2026"},{"issue":"8","key":"10.1016\/j.cca.2026.121146_bb0240","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4103\/1995-7645.289440","article-title":"Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults","volume":"13","author":"Rao","year":"2020","journal-title":"Asian Pac J Trop Med"},{"issue":"3","key":"10.1016\/j.cca.2026.121146_bb0245","first-page":"810","article-title":"Role of C-reactive proteins and liver function tests in assessing the severity of dengue fever","volume":"71","author":"Khetpal","year":"2021","journal-title":"J. Pak. Med. Assoc."},{"issue":"3","key":"10.1016\/j.cca.2026.121146_bb0250","first-page":"444","article-title":"The usefulness of serum C-reactive protein and total bilirubin levels for distinguishing between dengue fever and malaria in returned travelers","volume":"90","author":"Kutsuna","year":"2014","journal-title":"AJTMH"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0255","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12916-020-1496-1","article-title":"C-reactive protein as a potential biomarker for disease progression in dengue: a multi-country observational study","volume":"18","author":"Vuong","year":"2020","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0260","first-page":"70","article-title":"Inflammatory mediators in dengue virus infection in children: interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2","volume":"65","author":"Juffrie","year":"2001","journal-title":"AJTMH"},{"key":"10.1016\/j.cca.2026.121146_bb0265","doi-asserted-by":"crossref","first-page":"072","DOI":"10.23937\/2469-5769\/1510072","article-title":"The usefulness of high sensitivity c-reactive protein (hs-CRP) to differentiate between severe and non-severe dengue in children","volume":"6","author":"Aaradhana","year":"2020","journal-title":"Int. J. Pediatr. Res."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008709","article-title":"Clinical findings and pro-inflammatory cytokines in dengue patients in Western India: a facility-based study","volume":"5","author":"Priyadarshini","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cca.2026.121146_bb0275","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.3390\/ijms22062879","article-title":"Cytokine signature of dengue patients at different severity of the disease","volume":"22","author":"Puc","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0280","article-title":"Utility of C-reactive protein levels for early prediction of dengue severity in adults","volume":"2015","author":"Chen","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"8","key":"10.1016\/j.cca.2026.121146_bb0285","article-title":"Role of IgM\/IgG ratio in distinguishing primary and secondary dengue viral infections: a cross-sectional study","volume":"16","author":"Kalra","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0290","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12879-015-1022-9","article-title":"Kurniawan, Immunoglobulin G (IgG) to IgM ratio in secondary adult dengue infection using samples from early days of symptoms onset","volume":"15","author":"Cucunawangsih","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cca.2026.121146_bb0295","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijid.2021.05.007","article-title":"Clinical evaluation of a developed paper-based Dengue NS1 rapid diagnostic test for febrile illness patients","volume":"107","author":"Prabowo","year":"2021","journal-title":"Int. J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0300","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1021\/acsomega.3c07856","article-title":"One-dimensional HKUST-1-decorated glassy carbon electrode for the sensitive electrochemical immunosensor of NS1 dengue virus serotype-3","volume":"9","author":"Dewi","year":"2023","journal-title":"ACS Omega"},{"issue":"15","key":"10.1016\/j.cca.2026.121146_bb0305","first-page":"868","article-title":"Development of a smartphone-based portable immunosensor with PVA coating for stable detection of dengue virus","volume":"36","author":"Kapse","year":"2025","journal-title":"J. Mater. Sci."},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0310","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/diagnostics4040165","article-title":"Screen printed carbon electrode based electrochemical immunosensor for the detection of dengue NS1 antigen","volume":"4","author":"Parkash","year":"2014","journal-title":"Diagnostics"},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0315","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00604-024-06259-7","article-title":"Point-of-care dengue detection: polydopamine-modified electrode for rapid NS1 protein testing for clinical samples","volume":"191","author":"Muttaqien","year":"2024","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.cca.2026.121146_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2018.04.032","article-title":"Development of a portable and disposable NS1 based electrochemical immunosensor for early diagnosis of dengue virus","volume":"1026","author":"Nawaz","year":"2018","journal-title":"Anal. Chim. Acta"},{"issue":"7","key":"10.1016\/j.cca.2026.121146_bb0325","first-page":"1","article-title":"Hybrid g-C\u2083N\u2084\/ZnO nanocomposites for enhanced electrochemical detection of dengue virus serotype 2 (DENV2) NS1 protein biomarker","volume":"192","author":"Tadi","year":"2025","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.cca.2026.121146_bb0330","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpba.2017.11.064","article-title":"Immunofluorescence\u2013based biosensor for the determination of dengue virus NS1 in clinical samples","volume":"149","author":"Darwish","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"19","key":"10.1016\/j.cca.2026.121146_bb0335","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1080\/03067319.2024.2447896","article-title":"PENSOR: a Xerox machine linked pencil-based dengue biosensor towards draw, detect & do-it-yourself approach","volume":"105","author":"Hasan","year":"2025","journal-title":"Int. J. Environ. Anal. Chem."},{"key":"10.1016\/j.cca.2026.121146_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.339817","article-title":"Advancement of dengue virus NS1 protein detection by 3D-nanoassembly complex gold nanoparticles utilizing competitive sandwich aptamer on disposable electrode","volume":"1207","author":"Khoris","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0345","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00604-023-06141-y","article-title":"Electrochemical capacitive dengue aptasensor using NS1 in undiluted human serum","volume":"191","author":"Bachour Junior","year":"2024","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.cca.2026.121146_bb0350","article-title":"Electrochemical aptasensor for NS1 detection: Towards a fast dengue biosensor","volume":"233","author":"Junior","year":"2021","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.cca.2026.121146_bb0355","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1039\/C7AY02131C","article-title":"Dengue serotyping with a label-free DNA sensor","volume":"10","author":"Chan","year":"2018","journal-title":"Anal. Methods"},{"issue":"2","key":"10.1016\/j.cca.2026.121146_bb0360","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1039\/C9NA00763F","article-title":"The detection and identification of dengue virus serotypes with quantum dot and AuNP regulated localized surface plasmon resonance","volume":"2","author":"Chowdhury","year":"2020","journal-title":"Nanoscale Adv."},{"issue":"3","key":"10.1016\/j.cca.2026.121146_bb0365","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/diagnostics9030074","article-title":"Visual detection of dengue-1 RNA using gold nanoparticle-based lateral flow biosensor","volume":"9","author":"Yrad","year":"2019","journal-title":"Diagnostics"},{"issue":"13","key":"10.1016\/j.cca.2026.121146_bb0370","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.3390\/s20133728","article-title":"A label-free impedimetric genosensor for the nucleic acid amplification-free detection of extracted RNA of dengue virus","volume":"20","author":"Wu","year":"2020","journal-title":"Sensors"},{"key":"10.1016\/j.cca.2026.121146_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.128677","article-title":"Fabrication of ultrasensitive electrochemical biosensor for dengue fever viral RNA Based on CRISPR\/Cpf1 reaction","volume":"326","author":"Lee","year":"2021","journal-title":"Sens. Actuators B"},{"issue":"18","key":"10.1016\/j.cca.2026.121146_bb0380","doi-asserted-by":"crossref","first-page":"11527","DOI":"10.1021\/acs.chemrev.0c00997","article-title":"Polymeric delivery of therapeutic nucleic acids","volume":"121","author":"Kumar","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cca.2026.121146_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.electacta.2026.148992","article-title":"Influence of immobilization strategies on RNA aptamer-based impedimetric detection of neomycin","volume":"570","author":"Adamicka","year":"2026","journal-title":"Electrochim. Acta"},{"issue":"10","key":"10.1016\/j.cca.2026.121146_bb0390","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1021\/acs.langmuir.4c04859","article-title":"Antifouling polymer coatings for bioactive surfaces","volume":"41","author":"Yang","year":"2025","journal-title":"Langmuir"},{"issue":"23","key":"10.1016\/j.cca.2026.121146_bb0395","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1007\/s00216-018-1201-9","article-title":"Antifouling and ultrasensitive biosensing interface based on self-assembled peptide and aptamer on macroporous gold for electrochemical detection of immunoglobulin E in serum","volume":"410","author":"Wang","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cca.2026.121146_bb0400","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fmed.2020.00456","article-title":"Design, bioanalytical, and biomedical applications of aptamer-based hydrogels","volume":"7","author":"Di","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.cca.2026.121146_bb0405","doi-asserted-by":"crossref","DOI":"10.1039\/D6CB00062B","article-title":"Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design","author":"Pan","year":"2026","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.cca.2026.121146_bb0410","article-title":"A novel and ultrasensitive high-surface porous carbon-based electrochemical biosensor for early detection of dengue virus","volume":"X 20","author":"Hegde","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0415","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12678-023-00847-6","article-title":"Electrochemical immunosensor based on Al-tcpp nanomaterial adsorption aggregation signal amplification for the detection of dengue virus NS1 protein","volume":"15","author":"Zhang","year":"2024","journal-title":"Electrocatalysis"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0420","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1039\/D4SD00335G","article-title":"In situ amplified colorimetric immunoassay coupled with a dual-enzyme-functionalized UiO-66 (Ce) framework for quantitative detection of the dengue virus","volume":"4","author":"Lin","year":"2025","journal-title":"Sens. Diagn."},{"key":"10.1016\/j.cca.2026.121146_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.162753","article-title":"Recent advances of HKUST-1 metal\u2013organic frameworks in the biomedical applications: A comprehensive review","volume":"513","author":"Kabir","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"44","key":"10.1016\/j.cca.2026.121146_bb0430","doi-asserted-by":"crossref","first-page":"10209","DOI":"10.1039\/C9SC03916C","article-title":"Improving MOF stability: approaches and applications","volume":"10","author":"Ding","year":"2019","journal-title":"Chem. Sci."},{"issue":"2","key":"10.1016\/j.cca.2026.121146_bb0435","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.nano.2016.08.009","article-title":"A novel method for dengue virus detection and antibody screening using a graphene-polymer based electrochemical biosensor","volume":"13","author":"Navakul","year":"2017","journal-title":"NBM"},{"key":"10.1016\/j.cca.2026.121146_bb0440","article-title":"Effect of nickel incorporation on the physicochemical properties and performance of HKUST-1-based MOF immunosensor for DENV-3 NS1 detection","volume":"6","author":"Lidiawati","year":"2025","journal-title":"Sens. Int."},{"issue":"7","key":"10.1016\/j.cca.2026.121146_bb0445","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/bios12070495","article-title":"Development of a rapid gold nanoparticle-based lateral flow immunoassay for the detection of dengue virus","volume":"12","author":"Martinez-Liu","year":"2022","journal-title":"Biosensors"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0450","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/diagnostics11010033","article-title":"Development and evaluation of an electrochemical biosensor for detection of dengue-specific IgM antibody in serum samples","volume":"11","author":"Parkash","year":"2020","journal-title":"Diagnostics"},{"issue":"4","key":"10.1016\/j.cca.2026.121146_bb0455","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/bios15040236","article-title":"Ultrasensitive peptide-based electrochemical biosensor for universal diagnostic of dengue","volume":"15","author":"Prado","year":"2025","journal-title":"Biosensors"},{"key":"10.1016\/j.cca.2026.121146_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125268","article-title":"Lateral flow immunoassay (LFIA) for dengue diagnosis: Recent progress and prospect","volume":"267","author":"Ma","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2026.121146_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.793882","article-title":"Peptide biomarkers for the diagnosis of dengue infection","volume":"13","author":"Falconi-Agapito","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0470","doi-asserted-by":"crossref","first-page":"17485","DOI":"10.1038\/s41598-023-44559-9","article-title":"Early biomarkers for prediction of severe manifestations of dengue fever: a systematic review and a meta-analysis","volume":"13","author":"Moallemi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2026.121146_bb0475","article-title":"In vitro analysis of VEGF-mediated endothelial permeability and the potential therapeutic role of Anti-VEGF in severe dengue","volume":"39","author":"Lim","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"issue":"11","key":"10.1016\/j.cca.2026.121146_bb0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050387","article-title":"Cellular and cytokine correlates of severe dengue infection","volume":"7","author":"Malavige","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.cca.2026.121146_bb0485","article-title":"A comprehensive review on electrochemical cytokine detection in sweat","volume":"5","author":"Ploner","year":"2024","journal-title":"Cell Rep. Phys. Sci."},{"issue":"24","key":"10.1016\/j.cca.2026.121146_bb0490","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.3390\/s21248491","article-title":"Recent advances in aptasensor for cytokine detection: A review","volume":"21","author":"Kim","year":"2021","journal-title":"Sensors"},{"issue":"2","key":"10.1016\/j.cca.2026.121146_bb0495","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3390\/s17020428","article-title":"Emerging cytokine biosensors with optical detection modalities and nanomaterial-enabled signal enhancement","volume":"17","author":"Singh","year":"2017","journal-title":"Sensors"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0500","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1038\/s41467-022-35278-2","article-title":"Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS2 diodes","volume":"13","author":"De Silva","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.cca.2026.121146_bb0505","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3390\/bios11100364","article-title":"Advances in nanotechnology-based biosensing of immunoregulatory cytokines","volume":"11","author":"Lohcharoenkal","year":"2021","journal-title":"Biosensors"},{"key":"10.1016\/j.cca.2026.121146_bb0510","series-title":"Leucocytes: Methods and Protocols","first-page":"15","article-title":"Detection and quantification of cytokines and other biomarkers","author":"Chiswick","year":"2011"},{"issue":"1","key":"10.1016\/j.cca.2026.121146_bb0515","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10753-016-0477-1","article-title":"Aptamers against pro-and anti-inflammatory cytokines: a review","volume":"40","author":"Boshtam","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.cca.2026.121146_bb0520","first-page":"56","article-title":"Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid","volume":"5","author":"Shinde","year":"2019","journal-title":"J. Cancer Metastasis Treat."},{"key":"10.1016\/j.cca.2026.121146_bb0525","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3389\/fbioe.2020.00695","article-title":"Metal-organic frameworks: a potential platform for enzyme immobilization and related applications","volume":"8","author":"Xia","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cca.2026.121146_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2025.108964","article-title":"A novel hybrid biosensor for miRNA detection based on peptide nucleic acids and molecularly imprinted polymers","volume":"165","author":"Abdel-Hamied","year":"2025","journal-title":"Bioelectrochemistry"},{"issue":"38","key":"10.1016\/j.cca.2026.121146_bb0535","doi-asserted-by":"crossref","first-page":"1901867","DOI":"10.1002\/smll.201901867","article-title":"Progress in miRNA detection using graphene material\u2013based biosensors","volume":"15","author":"Zhang","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.cca.2026.121146_bb0540","article-title":"Detection of plasma miR-223 by a novel label-free graphene oxide\/gold nanocomposite immunosensor in colorectal cancer patients: an electrochemical biosensor approach","volume":"X 14","author":"Akbari","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121146_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125854","article-title":"Metal-organic framework (MOF)-based biosensors for miRNA detection","volume":"273","author":"Gorgani","year":"2024","journal-title":"Talanta"},{"issue":"7","key":"10.1016\/j.cca.2026.121146_bb0550","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/chemosensors13070242","article-title":"Electrochemical strategies for MicroRNA quantification leveraging amplification and nanomaterials: a review","volume":"13","author":"Hunt","year":"2025","journal-title":"Chemosensors"},{"key":"10.1016\/j.cca.2026.121146_bb0555","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.apsusc.2014.10.167","article-title":"Indium tin oxide with zwitterionic interfacial design for biosensing applications in complex matrices","volume":"325","author":"Darwish","year":"2015","journal-title":"Appl. Surf. Sci."},{"issue":"16","key":"10.1016\/j.cca.2026.121146_bb0560","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1080\/03067319.2024.2357248","article-title":"Paper-based aptasensor for electrochemical detection of polyvalent antigen of dengue virus","volume":"105","author":"Hasan","year":"2025","journal-title":"Int. J. Environ. Anal. Chem."},{"key":"10.1016\/j.cca.2026.121146_bb0565","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.aca.2018.04.005","article-title":"An electrochemical peptide sensor for detection of dengue fever biomarker NS1","volume":"1026","author":"Lim","year":"2018","journal-title":"Anal. Chim. Acta"},{"issue":"9","key":"10.1016\/j.cca.2026.121146_bb0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222144","article-title":"Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1","volume":"14","author":"Kim","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2026.121146_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125376","article-title":"Site-specific imprinting of dengue virus non-structural 1 antigen on a polydopamine-based sensing film for early detection and prognosis of dengue","volume":"268","author":"Lim","year":"2024","journal-title":"Talanta"},{"issue":"24","key":"10.1016\/j.cca.2026.121146_bb0580","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1007\/s00216-021-03410-8","article-title":"Enhancing sensitivity of QCM for dengue type 1 virus detection using graphene-based polymer composites","volume":"413","author":"Navakul","year":"2021","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126003281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126003281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:23:22Z","timestamp":1786422202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126003281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":116,"alternative-id":["S0009898126003281"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121146","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarker-driven biosensing strategies for early risk stratification in severe dengue","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121146"}}