{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:25Z","timestamp":1792083565569,"version":"4.4.0"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.cca.2026.121257","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:42:29Z","timestamp":1785858149000},"page":"121257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The utilization of multiplex PCR with fragment analysis for carrier screening of spinal muscular atrophy"],"prefix":"10.1016","volume":"593","author":[{"given":"Kunvara","family":"Orachon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watcharapa","family":"Jaranasaksakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preyaporn","family":"Onsod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerapong","family":"Siriboonpiputtana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budsaba","family":"Rerkamnuaychoke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takol","family":"Chareonsirisuthigul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cca.2026.121257_bb0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/AOG.0000000000001952","article-title":"Carrier screening for genetic conditions","volume":"129","author":"ACOG committee opinion No. 691","year":"2017","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.cca.2026.121257_bb0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13023-017-0671-8","article-title":"Prevalence, incidence and carrier frequency of 5q-linked spinal muscular atrophy","volume":"12","author":"Verhaart","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"issue":"6","key":"10.1016\/j.cca.2026.121257_bb0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/jmg.15.6.409","article-title":"Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy","volume":"15","author":"Pearn","year":"1978","journal-title":"J. Med. Genet."},{"issue":"1\u20132","key":"10.1016\/j.cca.2026.121257_bb0020","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2008.08.015","article-title":"Evaluation of an in-house protocol for prenatal molecular diagnosis of SMA in Chinese","volume":"398","author":"Zeng","year":"2008","journal-title":"Clin. Chim. Acta"},{"issue":"7","key":"10.1016\/j.cca.2026.121257_bb0025","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/GIM.0b013e318220d523","article-title":"Technical standards and guidelines for spinal muscular atrophy testing","volume":"13","author":"Prior","year":"2011","journal-title":"Genet. Med."},{"issue":"11","key":"10.1016\/j.cca.2026.121257_bb0030","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/GIM.0b013e318188d069","article-title":"Carrier screening for spinal muscular atrophy","volume":"10","author":"Prior","year":"2008","journal-title":"Genet. Med."},{"issue":"8","key":"10.1016\/j.cca.2026.121257_bb0035","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s10072-019-03885-5","article-title":"Carrier frequency of spinal muscular atrophy in Thailand","volume":"40","author":"Dejsuphong","year":"2019","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.cca.2026.121257_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2025.1566417","article-title":"Prenatal carrier screening for spinal muscular atrophy among pregnant Thai women","volume":"12","author":"Tangshewinsirikul","year":"2025","journal-title":"Front. Med."},{"issue":"6","key":"10.1016\/j.cca.2026.121257_bb0045","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jmoldx.2026.03.003","article-title":"Performance evaluation of a PCR\/nanopore assay for carrier screening for cystic fibrosis, spinal muscular atrophy, and fragile X syndrome","volume":"28","author":"Martin","year":"2026","journal-title":"J. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.cca.2026.121257_bb0050","first-page":"180","article-title":"Genetic counseling and carrier screening in candidates for gamete donation at a Portuguese center","volume":"27","author":"Soares","year":"2023","journal-title":"JBRA Assisted Reproduction"},{"issue":"2","key":"10.1016\/j.cca.2026.121257_bb0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/gim.2013.84","article-title":"An Ashkenazi Jewish SMN1 haplotype specific to duplication alleles improves pan-ethnic carrier screening for spinal muscular atrophy","volume":"16","author":"Luo","year":"2014","journal-title":"Genet. Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:28:17Z","timestamp":1792081697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126004390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":11,"alternative-id":["S0009898126004390"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121257","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The utilization of multiplex PCR with fragment analysis for carrier screening of spinal muscular atrophy","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121257"}}