{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:44Z","timestamp":1792083584695,"version":"4.4.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012472","name":"Education and Scientific Research Project of Shanghai","doi-asserted-by":"publisher","award":["QWJ2023-11"],"award-info":[{"award-number":["QWJ2023-11"]}],"id":[{"id":"10.13039\/501100012472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","award":["2023YXZD02"],"award-info":[{"award-number":["2023YXZD02"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202340050"],"award-info":[{"award-number":["202340050"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["QKY2025-5"],"award-info":[{"award-number":["QKY2025-5"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.cca.2026.121259","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T05:52:59Z","timestamp":1785995579000},"page":"121259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated DIA proteomics of tissue and exudate reveals screening markers for early detection of ulcerative colitis and colorectal cancer"],"prefix":"10.1016","volume":"593","author":[{"given":"Qian","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cca.2026.121259_bb0005","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","article-title":"Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.cca.2026.121259_bb0010","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. N. Am."},{"issue":"2","key":"10.1016\/j.cca.2026.121259_bb0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.canlet.2013.07.032","article-title":"Chronic ulcerative colitis and colorectal cancer","volume":"345","author":"Rogler","year":"2013","journal-title":"Cancer Lett."},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0020","article-title":"Identifying neutrophil-associated subtypes in ulcerative colitis and confirming neutrophils promote colitis-associated colorectal cancer","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.cca.2026.121259_bb0025","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/CM9.0000000000002514","article-title":"Chemoprevention of colorectal cancer in general population and high-risk population: a systematic review and network meta-analysis","volume":"136","author":"Ma","year":"2023","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0030","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13287-022-02811-5","article-title":"The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer","volume":"13","author":"Guo","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"11","key":"10.1016\/j.cca.2026.121259_bb0035","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2025-103637","article-title":"Folate exposures and risk of colorectal cancer: an umbrella review of meta-analyses of observational studies and randomised controlled trials","volume":"15","author":"Li","year":"2025","journal-title":"BMJ Open"},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0040","article-title":"Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites","volume":"85","author":"Wu","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0045","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41467-018-07841-3","article-title":"Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response","volume":"10","author":"Haberman","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.cca.2026.121259_bb0050","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2024.5474","article-title":"Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (review)","volume":"55","author":"Qiu","year":"2024","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.cca.2026.121259_bb0055","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.gendis.2022.03.010","article-title":"Cancer genes and cancer stem cells in tumorigenesis: evolutionary deep homology and controversies","volume":"9","author":"Niculescu","year":"2022","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.cca.2026.121259_bb0060","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.cgh.2024.06.050","article-title":"Modern advanced therapies for inflammatory bowel diseases: practical considerations and positioning","volume":"23","author":"Fudman","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.cca.2026.121259_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2024.100219","article-title":"Diet, food, and nutritional exposures and inflammatory bowel disease or progression of disease: an umbrella review","volume":"15","author":"Christensen","year":"2024","journal-title":"Adv. Nutr."},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0070","article-title":"MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis","volume":"74","author":"Yao","year":"2021","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0075","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/15548627.2021.1909406","article-title":"How autophagy controls the intestinal epithelial barrier","volume":"18","author":"Foerster","year":"2021","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.cca.2026.121259_bb0080","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41596-022-00771-x","article-title":"Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications","volume":"18","author":"Malinovska","year":"2022","journal-title":"Nat. Protoc."},{"issue":"8052","key":"10.1016\/j.cca.2026.121259_bb0085","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41586-025-08584-0","article-title":"Mass-spectrometry-based proteomics: from single cells to clinical applications","volume":"638","author":"Guo","year":"2025","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cca.2026.121259_bb0090","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/17460441.2023.2293153","article-title":"Ultra-high-throughput mass spectrometry in drug discovery: fundamentals and recent advances","volume":"19","author":"Williams","year":"2023","journal-title":"Expert Opin. Drug Discov."},{"issue":"173","key":"10.1016\/j.cca.2026.121259_bb0095","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0055-2024","article-title":"Pathophysiology and genomics of bronchiectasis","volume":"33","author":"Perea","year":"2024","journal-title":"Eur. Respir. Rev."},{"issue":"10","key":"10.1016\/j.cca.2026.121259_bb0100","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/ueg2.12655","article-title":"Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence","volume":"12","author":"Cannarozzi","year":"2024","journal-title":"United European Gastroenterol J"},{"issue":"9","key":"10.1016\/j.cca.2026.121259_bb0105","article-title":"Integrating multi-omics to unravel host-microbiome interactions in inflammatory bowel disease","volume":"5","author":"Zhang","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-82992-6","article-title":"Cytokines and inflammatory biomarkers and their association with post-operative delirium: a meta-analysis and systematic review","volume":"15","author":"Mosharaf","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cca.2026.121259_bb0115","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/1751-2980.12593","article-title":"Chinese consensus on chronic gastritis (2017, Shanghai)","volume":"19","author":"Fang","year":"2018","journal-title":"J. Dig. Dis."},{"issue":"4","key":"10.1016\/j.cca.2026.121259_bb0120","doi-asserted-by":"crossref","first-page":"G430","DOI":"10.1152\/ajpgi.00405.2011","article-title":"An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants","volume":"302","author":"Gustafsson","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"9","key":"10.1016\/j.cca.2026.121259_bb0125","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1021\/acs.jproteome.5c00316","article-title":"Plasma-derived extracellular vesicle proteomics","volume":"24","author":"Tan","year":"2025","journal-title":"J. Proteome Res."},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0130","article-title":"Data-independent acquisition mass spectrometry-based proteomics and software tools: a glimpse in 2020","volume":"20","author":"Zhang","year":"2020","journal-title":"Proteomics"},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0135","article-title":"Urinary proteomics for noninvasive monitoring of biomarkers of chronic mountain sickness in a young adult population using data-independent acquisition (DIA)-based mass spectrometry","volume":"302","author":"Fan","year":"2024","journal-title":"J. Proteome"},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12859-022-04594-1","article-title":"MonaGO: a novel gene ontology enrichment analysis visualisation system","volume":"23","author":"Xin","year":"2022","journal-title":"BMC Bioinform."},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0145","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0150","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2021.1923910","article-title":"Cldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrity","volume":"10","author":"Wang","year":"2021","journal-title":"Oncoimmunology"},{"issue":"9","key":"10.1016\/j.cca.2026.121259_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2024.07.028","article-title":"Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis","volume":"32","author":"Guo","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0160","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.apsb.2024.11.014","article-title":"Facilitation of mucosal healing by estrogen receptor \u03b2 in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells","volume":"15","author":"Guo","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0165","article-title":"SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis","volume":"327","author":"Yaxian","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.cca.2026.121259_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101469","article-title":"Prostaglandin E(2) and Akt promote stemness in Apc mutant Dclk1+ cells to give rise to colitis-associated cancer","volume":"19","author":"Good","year":"2025","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0175","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cca.2021.07.001","article-title":"Proteomic screening of potential N-glycoprotein biomarkers for colorectal cancer by TMT labeling combined with LC-MS\/MS","volume":"521","author":"Gong","year":"2021","journal-title":"Clin. Chim. Acta"},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0180","article-title":"Tucidinostat ameliorates DSS-induced ulcerative colitis by inhibiting cellular senescence, modulating the p53 signaling pathway and cell cycle, and restoring the gut microbiota-metabolite axis","volume":"171","author":"Xu","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"16","key":"10.1016\/j.cca.2026.121259_bb0185","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1038\/s41388-020-1225-4","article-title":"MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism","volume":"39","author":"Olou","year":"2020","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.cca.2026.121259_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167213","article-title":"Loss of cytidine deaminase expression as a potential attempt to counteract the process of carcinogenesis by reducing basal PARP-1 activity and increasing tau levels","volume":"1870","author":"Amor-Gu\u00e9ret","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0195","article-title":"Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors","volume":"555","author":"Onclercq-Delic","year":"2022","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.cca.2026.121259_bb0200","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-026-10156-4","article-title":"The ATP-adenosine axis as a driver of tumor-associated macrophage reprogramming in colorectal cancer: mechanistic insights into immune evasion and therapeutic vulnerabilities","volume":"22","author":"Albukhari","year":"2026","journal-title":"Purinergic Signal"},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0205","doi-asserted-by":"crossref","DOI":"10.1186\/s41065-022-00259-4","article-title":"Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis","volume":"159","author":"Li","year":"2022","journal-title":"Hereditas"},{"issue":"7","key":"10.1016\/j.cca.2026.121259_bb0210","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1158\/0008-5472.CAN-22-3219","article-title":"Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs","volume":"84","author":"Lumeau","year":"2024","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.cca.2026.121259_bb0215","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1007\/s12602-024-10425-x","article-title":"Intestinal Goblet Cell-Expressed Reg4 Ameliorates Intestinal Inflammation Potentially by Restraining Pathogenic Escherichia coli Infection","volume":"17","author":"Lu","year":"2024","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0220","article-title":"Identification and immunoinfiltration analysis of key genes in ulcerative colitis using WGCNA","volume":"12","author":"Ni","year":"2024","journal-title":"PeerJ"},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0225","article-title":"REG4 promotes the proliferation and anti-apoptosis of cancer","volume":"10","author":"Zheng","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"0","key":"10.1016\/j.cca.2026.121259_bb0230","article-title":"All-trans retinoic acid enhances the anti-tumour effects of fimaporfin-based photodynamic therapy","volume":"155","author":"Wong","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.cca.2026.121259_bb0235","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41416-024-02735-2","article-title":"Tumour cell-derived serglycin promotes IL-8 secretion of CAFs in gastric cancer","volume":"131","author":"Li","year":"2024","journal-title":"Br. J. Cancer"},{"issue":"23","key":"10.1016\/j.cca.2026.121259_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222313156","article-title":"Depletion of lipocalin 2 (LCN2) in mice leads to dysbiosis and persistent colonization with segmented filamentous bacteria","volume":"22","author":"Kl\u00fcber","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cca.2026.121259_bb0245","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-026-02316-z","article-title":"LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate\/MCT1\/AMPK\/mTOR axis","volume":"31","author":"Chen","year":"2026","journal-title":"Apoptosis"},{"issue":"9","key":"10.1016\/j.cca.2026.121259_bb0250","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/ibd\/izad050","article-title":"Identification of Lipocalin 2 as a potential ferroptosis-related gene in ulcerative colitis","volume":"29","author":"Deng","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"issue":"7","key":"10.1016\/j.cca.2026.121259_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167279","article-title":"Lipocalin-2-mediated intestinal epithelial cells pyroptosis via NF-\u03baB\/NLRP3\/GSDMD signaling axis adversely affects inflammation in colitis","volume":"1870","author":"Yang","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"5","key":"10.1016\/j.cca.2026.121259_bb0260","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/ijc.35205","article-title":"Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: results from the EPIC cohort","volume":"156","author":"Reichmann","year":"2024","journal-title":"Int. J. Cancer"},{"issue":"15","key":"10.1016\/j.cca.2026.121259_bb0265","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303037120","article-title":"Phase transition of tensin-1 during the focal adhesion disassembly and cell division","volume":"120","author":"Lee","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"13","key":"10.1016\/j.cca.2026.121259_bb0270","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/jcmm.17714","article-title":"The molecular and clinical role of tensin 1\/2\/3 in cancer","volume":"27","author":"Mainsiouw","year":"2023","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121259_bb0275","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1038\/s41598-021-91154-x","article-title":"Transcriptomic landscape of early age onset of colorectal cancer identifies novel genes and pathways in Indian CRC patients","volume":"11","author":"Singh","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:31:01Z","timestamp":1792081861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126004419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":55,"alternative-id":["S0009898126004419"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121259","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated DIA proteomics of tissue and exudate reveals screening markers for early detection of ulcerative colitis and colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121259"}}