{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:27Z","timestamp":1792083567120,"version":"4.4.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008982","name":"National Science Foundation of Sri Lanka","doi-asserted-by":"publisher","award":["NSF\/SCH\/2025\/12"],"award-info":[{"award-number":["NSF\/SCH\/2025\/12"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.cca.2026.121306","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:25:14Z","timestamp":1787786714000},"page":"121306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["RNA biosensors in oncology: Mechanisms, Cancer-specific applications, and a Hallmark-aligned clinical roadmap"],"prefix":"10.1016","volume":"593","author":[{"given":"A.","family":"Gamage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.L.P.B.","family":"Herath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M. Nalin","family":"de Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini M.","family":"de Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2026.121306_bb0005","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cca.2026.121306_bb0010","doi-asserted-by":"crossref","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2024;74:229\u201363. doi:https:\/\/doi.org\/10.3322\/caac.21834.","DOI":"10.3322\/caac.21834"},{"key":"10.1016\/j.cca.2026.121306_bb0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cca.2026.121306_bb0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41568-020-00306-0","article-title":"RNA in cancer","volume":"21","author":"Goodall","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cca.2026.121306_bb0025","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cell.2019.10.017","article-title":"The role of non-coding RNAs in oncology","volume":"179","author":"Slack","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cca.2026.121306_bb0030","doi-asserted-by":"crossref","unstructured":"Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat. Cell Biol. Nature Publishing Group; 2018;20:285\u201395. doi:https:\/\/doi.org\/10.1038\/s41556-018-0045-z.","DOI":"10.1038\/s41556-018-0045-z"},{"key":"10.1016\/j.cca.2026.121306_bb0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jobcr.2015.12.002","article-title":"Biosensors and their applications \u2013 a review","volume":"6","author":"Mehrotra","year":"2016","journal-title":"J. Oral. Biol. Craniofac. Res."},{"key":"10.1016\/j.cca.2026.121306_bb0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.copbio.2020.01.001","article-title":"RNA-based fluorescent biosensors for live cell imaging of small molecules and RNAs","volume":"63","author":"Su","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.cca.2026.121306_bb0045","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/annonc\/mdz227","article-title":"How liquid biopsies can change clinical practice in oncology","volume":"30","author":"Siravegna","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cca.2026.121306_bb0050","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Gerlinger","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2026.121306_bb0055","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1021\/ja311960g","article-title":"RNA-based fluorescent biosensors for live cell imaging of second messengers cyclic di-GMP and cyclic AMP-GMP","volume":"135","author":"Kellenberger","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cca.2026.121306_bb0060","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/10408363.2024.2321202","article-title":"DNA\/RNA-based electrochemical nanobiosensors for early detection of cancers","volume":"61","author":"Mikaeeli Kangarshahi","year":"2024","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.cca.2026.121306_bb0065","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1021\/acssynbio.9b00507","article-title":"Nucleic acid detection using CRISPR\/Cas biosensing technologies","volume":"9","author":"Aman","year":"2020","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cca.2026.121306_bb0070","article-title":"A small-molecule approach enables RNA aptamers to function as sensors for reactive inorganic targets","volume":"64","author":"Aggarwal","year":"2025","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.cca.2026.121306_bb0075","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.7150\/thno.76852","article-title":"m6A reader hnRNPA2B1 drives multiple myeloma osteolytic bone disease","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.cca.2026.121306_bb0080","doi-asserted-by":"crossref","first-page":"12142","DOI":"10.1021\/acs.analchem.6c01327","article-title":"Self-hybridization chain polymerization-driven transcriptional synthesis of fluorescent aptamers for one-step detection of cancer-associated RNA biomarkers","volume":"98","author":"Han","year":"2026","journal-title":"Anal. Chem. Soc."},{"key":"10.1016\/j.cca.2026.121306_bb0085","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1021\/acs.analchem.5c07694","article-title":"CRISPR\/Cas13a-engineered RNA-based fluorogenic biosensor for label-free quantification of RNA in colorectal tissues","volume":"98","author":"Xu","year":"2026","journal-title":"Anal. Chem. Soc."},{"key":"10.1016\/j.cca.2026.121306_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.343925","article-title":"Hand in hand catalytic hairpin assembly-based F\u00d6rster resonance energy transfer biosensor for simultaneous detection of multiple MicroRNAs from breast Cancer","volume":"1352","author":"Afshan","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121306_bb0095","doi-asserted-by":"crossref","first-page":"24625","DOI":"10.1021\/acs.analchem.5c04759","article-title":"Construction of a bifunctional single-quantum dot Nanosensor for enzyme-free detection of N6 -Methyladenosine demethylase in breast Cancer","volume":"97","author":"Liu","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0100","doi-asserted-by":"crossref","first-page":"18918","DOI":"10.1021\/acs.analchem.5c01039","article-title":"Multiplexed single-molecule detection of nucleic acid biomarkers with a distance-tuned single FRET pair","volume":"97","author":"Sethi","year":"2025","journal-title":"Anal. Chem. Soc."},{"key":"10.1016\/j.cca.2026.121306_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342962","article-title":"Ultrasensitive miRNA detection: a novel DNA nanomachine using split-type molecular beacons-mediated cascade amplification for cancer diagnostics","volume":"1319","author":"Huang","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121306_bb0110","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1039\/D4CC05440G","article-title":"A rolling circle amplification-based DNAzyme walker against intracellular degradation for imaging tumor cells\u2019 microRNA","volume":"61","author":"Yang","year":"2024","journal-title":"Chem Commun (Camb). Cambridge, England"},{"key":"10.1016\/j.cca.2026.121306_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/s13036-026-00641-0","article-title":"Amplification-free CRISPR\/Cas13a-based electrochemical biosensor for the detection of circulating tumor RNA using RNA-3Ag+ probes on Au porous-lattice nanoelectrode","volume":"20","author":"Lee","year":"2026","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.cca.2026.121306_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.139236","article-title":"Dual RPA-CRISPR\/Cas13a parallel detection of serum cell-free RNA and internal SDK1 m7G for diagnosis of early colorectal cancer metastasis","volume":"450","author":"Wu","year":"2026","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.cca.2026.121306_bb0125","article-title":"PRICE: direct and robust detection of microRNAs at single-nucleotide resolution","volume":"17","author":"Wang","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cca.2026.121306_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.139153","article-title":"Self-feedback DNAzyme circuit-powered label-free and signal-on CRISPR\/Cas12a electrochemical biosensor for ultrasensitive detection of liver cancer biomarkers","volume":"449","author":"Xiong","year":"2026","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.cca.2026.121306_bb0135","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/s41565-022-01179-0","article-title":"Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs","volume":"17","author":"Broto","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.cca.2026.121306_bb0140","article-title":"Autocatalytic Cas13a biosensor enabled by RNA-nanocircles for ultrasensitive RNA detection","volume":"3","author":"Deng","year":"2026","journal-title":"Npj Biosens. Nature Publishing Group"},{"key":"10.1016\/j.cca.2026.121306_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117468","article-title":"Cascaded logic gate-based electrochemical analysis of multiple miRNAs for cancer recognition","volume":"282","author":"Ma","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121306_bb0150","article-title":"Simultaneous electrochemical detection of miR-21 and miR-155 breast cancer biomarkers using a dual-signal aptasensor based on Cu\/Cd redox probes. Langmuir [Internet]","author":"Alemnezhad","year":"2026","journal-title":"Am. Chem. Soc."},{"key":"10.1016\/j.cca.2026.121306_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138905","article-title":"An electrochemical probe for the ultrasensitive detection of long non-coding RNA biomarkers","volume":"447","author":"Lin","year":"2026","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.cca.2026.121306_bb0160","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1039\/D5CC05842B","article-title":"A multiple signal-amplified electrochemiluminescence biosensor for ultrasensitive detection of bladder cancer-associated circRNA in urine","volume":"62","author":"Zhang","year":"2026","journal-title":"Chem. Commun. Royal Soc. Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0165","article-title":"Nanomaterial-mediated electrochemical and optical biosensors and their application in tumour marker detection","volume":"25","author":"Wang","year":"2025","journal-title":"Sensors. Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.cca.2026.121306_bb0170","article-title":"MXene-based electrochemical biosensors: advancing detection strategies for biosensing (2020\u20132024)","volume":"15","author":"Sengupta","year":"2025","journal-title":"Biosensors. Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.cca.2026.121306_bb0175","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1039\/D4MH00714J","article-title":"Peptide nucleic acid-clicked Ti3 C2 T x MXene for ultrasensitive enzyme-free electrochemical detection of microRNA biomarkers","volume":"11","author":"Ali","year":"2024","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.cca.2026.121306_bb0180","article-title":"Paper-based DNA biosensor for rapid and selective detection of miR-21","volume":"14","author":"Hunt","year":"2024","journal-title":"Biosensors. Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.cca.2026.121306_bb0185","article-title":"Recent advances in graphene-based field-effect transistor biosensors for disease biomarker detection and clinical prospects","volume":"16","author":"Nagpal","year":"2026","journal-title":"Biosensors. Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.cca.2026.121306_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127637","article-title":"An ultrasensitive flexible biosensor enabled by high-performance graphene field-effect transistors with defect-free van der Waals contacts for breast cancer miRNA fast detection","volume":"287","author":"Sun","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.cca.2026.121306_bb0195","article-title":"Engineering graphene field-effect transistor biosensors for disease biomarkers detection in liquid biopsy | request PDF","year":"2026","journal-title":"ResearchGate [Internet]."},{"key":"10.1016\/j.cca.2026.121306_bb0200","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-micro-091014-104306","article-title":"Riboswitch-mediated gene regulation: novel RNA architectures dictate gene expression responses","volume":"70","author":"Sherwood","year":"2016","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.cca.2026.121306_bb0205","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/15476286.2023.2234732","article-title":"Tapping the potential of synthetic riboswitches: reviewing the versatility of the tetracycline aptamer","volume":"20","author":"Kelvin","year":"2023","journal-title":"RNA Biol."},{"key":"10.1016\/j.cca.2026.121306_bb0210","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-38098-0","article-title":"Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system","volume":"14","author":"Vezeau","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cca.2026.121306_bb0215","article-title":"(PDF) Point-of-use detection of environmental fluoride via a cell-free riboswitch-based biosensor [internet]","year":"2026","journal-title":"ResearchGate"},{"key":"10.1016\/j.cca.2026.121306_bb0220","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1039\/D1CB00138H","article-title":"Cell-free riboswitches","volume":"2","author":"Tabuchi","year":"2021","journal-title":"RSC Chem. Biol. RSC"},{"key":"10.1016\/j.cca.2026.121306_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202401015","article-title":"Harnessing synthetic riboswitches for Tunable gene regulation in mammalian cells","volume":"26","author":"Khadake","year":"2025","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cca.2026.121306_bb0230","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1021\/acssynbio.4c00341","article-title":"Cell-free biosensors based on modular eukaryotic riboswitches that function in one pot at ambient temperature","volume":"13","author":"Ogawa","year":"2024","journal-title":"ACS Synth. Biol. Am. Chemical Soc."},{"key":"10.1016\/j.cca.2026.121306_bb0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrmicro2730","article-title":"Bacterial RNA thermometers: molecular zippers and switches","volume":"10","author":"Kortmann","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cca.2026.121306_bb0240","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1111\/cas.15068","article-title":"Reactive oxygen species in cancer: current findings and future directions","volume":"112","author":"Nakamura","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cca.2026.121306_bb0245","article-title":"Singlet oxygen-based photoelectrochemical detection of miRNAs in prostate cancer patients\u2019 plasma: a novel diagnostic tool for liquid biopsy","volume":"158","author":"Shanmugam","year":"2024","journal-title":"Bioelectrochemistry. Amsterdam, Netherlands"},{"key":"10.1016\/j.cca.2026.121306_bb0250","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41420-024-02097-x","article-title":"Dysregulation of tRNA methylation in cancer: mechanisms and targeting therapeutic strategies","volume":"10","author":"Yuan","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cca.2026.121306_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1169424","article-title":"CRISPR-Cas and catalytic hairpin assembly technology for target-initiated amplification detection of pancreatic cancer specific tsRNAs","volume":"11","author":"Wu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cca.2026.121306_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137693","article-title":"A dual-signal amplification strategy for electrochemical biosensing of transfer RNA-derived fragments targeting drug-resistant liver cancer","volume":"436","author":"Xie","year":"2025","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0265","article-title":"Exosomal tsRNA-Gly-5-0007 may be used as a diagnostic marker for colorectal cancer","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2026.121306_bb0270","author":"City of Hope Medical Center"},{"key":"10.1016\/j.cca.2026.121306_bb0275","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.cell.2014.10.002","article-title":"Toehold switches: de-novo-designed regulators of gene expression","volume":"159","author":"Green","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cca.2026.121306_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-024-06988-8","article-title":"Intelligent guide RNA: dual toehold switches for modulating luciferase in the presence of trigger RNA","volume":"7","author":"Hashemabadi","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cca.2026.121306_bb0285","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/acs.analchem.4c00510","article-title":"In vivo imaging MicroRNA with bright fluorescent RNA aptamer through target-mediated entropy-driven toehold exchange","volume":"96","author":"Gu","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0290","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1021\/acssensors.5c00758","article-title":"A toehold switch biosensor for versatile miRNA imaging and therapeutic application in living cells and acute liver injury mouse models","volume":"10","author":"Shi","year":"2025","journal-title":"ACS Sens."},{"key":"10.1016\/j.cca.2026.121306_bb0295","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.cell.2014.10.004","article-title":"Paper-based synthetic gene networks","volume":"159","author":"Pardee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cca.2026.121306_bb0300","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-020-01263-w","article-title":"The role of m6A, m5C and \u03a8 RNA modifications in cancer: novel therapeutic opportunities","volume":"20","author":"Nombela","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cca.2026.121306_bb0305","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41576-020-00295-8","article-title":"The epitranscriptome beyond m6A","volume":"22","author":"Wiener","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cca.2026.121306_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115966","article-title":"Demethylation-activated light-up dual-color RNA aptamersensor for label-free detection of multiple demethylases in lung tissues","volume":"247","author":"Liu","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121306_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202500105","article-title":"A fluorescent aptasensor for sensitive and selective determination of epigenetic cancer biomarker N1-methyladenosine in urine samples","volume":"31","author":"Ba\u011fda","year":"2025","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.cca.2026.121306_bb0320","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.900155","article-title":"Crosstalk of Exosomal non-coding RNAs in the tumor microenvironment: novel Frontiers","volume":"13","author":"Jia","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2026.121306_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117852","article-title":"Spherical nucleic acids-based nanomachines enable in situ tracing of exosomal lncRNA at the single-vesicle level","volume":"289","author":"Xiao","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121306_bb0330","doi-asserted-by":"crossref","first-page":"21098","DOI":"10.1021\/acs.analchem.5c04448","article-title":"An RCA-CRISPR-Enhanced SERS platform for ultrasensitive and single-nucleotide-resolved detection of Exosomal miRNA-21 in early lung Cancer","volume":"97","author":"Teng","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0335","article-title":"FRET imaging of glycoRNA on small extracellular vesicles enabling sensitive cancer diagnostics","volume":"16","author":"Ren","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cca.2026.121306_bb0340","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.1021\/acs.analchem.5c01156","article-title":"Multiplexed lncRNA analysis in breast cancer via cascade amplification reaction through fluorescent and electrochemical dual-signal output modalities","volume":"97","author":"Wang","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.118197","article-title":"Machine learning-assisted renewable and polarity-switchable photoelectrochemical biosensor for circRNA intelligent diagnosis","volume":"294","author":"Geng","year":"2026","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121306_bb0350","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-022-01543-7","article-title":"Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments","volume":"21","author":"Lone","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cca.2026.121306_bb0355","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1021\/jacsau.4c00989","article-title":"Electrochemical biosensors for cancer diagnosis: multitarget analysis to present molecular characteristics of tumor heterogeneity","volume":"4","author":"Cao","year":"2024","journal-title":"JACS Au"},{"key":"10.1016\/j.cca.2026.121306_bb0360","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1158\/1538-7445.AM2025-7113","article-title":"Abstract 7113: barriers to cancer diagnosis and treatment among women in low- and low-middle-income countries","volume":"85","author":"Antwi","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.cca.2026.121306_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344872","article-title":"Magnetic separation coupled with gold nanoparticle-assisted hybridization chain reaction for simultaneous detection of exomiR-21 and exomiR-155","volume":"1383","author":"Cheng","year":"2026","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121306_bb0370","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1039\/D5AN01292A","article-title":"Selective electrochemical discrimination of 3\u2032 isomiRs differing by two nucleotides","volume":"151","author":"Ojeda","year":"2026","journal-title":"Analyst"},{"key":"10.1016\/j.cca.2026.121306_bb0375","doi-asserted-by":"crossref","DOI":"10.1039\/D5LC01014D","article-title":"Point of care molecular cancer diagnostics","author":"Bhaskar","year":"2026","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2026.121306_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117681","article-title":"Current smartphone-assisted point-of-care cancer detection: towards supporting personalized cancer monitoring","volume":"174","author":"Le","year":"2024","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.cca.2026.121306_bb0385","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s00604-025-07523-0","article-title":"Smartphone-based biosensing: a review of optical imaging, microfluidic integration, and AI-enhanced analysis","volume":"192","author":"Avci","year":"2025","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.cca.2026.121306_bb0390","doi-asserted-by":"crossref","DOI":"10.1007\/s40820-024-01534-x","article-title":"Flexible graphene field-effect transistors and their application in flexible biomedical sensing","volume":"17","author":"Sun","year":"2025","journal-title":"Nano Micro Lett."},{"key":"10.1016\/j.cca.2026.121306_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117198","article-title":"Construction of a hierarchical DNA circuit for single-molecule profiling of locus-specific N6-methyladenosine-MALAT1 in clinical tissues","volume":"274","author":"Liu","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2026.121306_bb0400","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.7150\/thno.96163","article-title":"Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype","volume":"14","author":"Gao","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.cca.2026.121306_bb0405","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s43556-025-00340-0","article-title":"Multi-omics strategies for biomarker discovery and application in personalized oncology","volume":"6","author":"Jiang","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.cca.2026.121306_bb0410","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41571-025-01110-1","article-title":"The actionable transcriptome: a framework for incorporating RNA sequencing into precision oncology","volume":"23","author":"Johnson","year":"2026","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cca.2026.121306_bb0415","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1039\/D4LC00340C","article-title":"CRISPR for companion diagnostics in low-resource settings","volume":"24","author":"Qian","year":"2024","journal-title":"Lab Chip"},{"key":"10.1016\/j.cca.2026.121306_bb0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272308","article-title":"Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer","volume":"17","author":"Ali","year":"2022","journal-title":"PLoS One"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:29:33Z","timestamp":1792081773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126004882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":84,"alternative-id":["S0009898126004882"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121306","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA biosensors in oncology: Mechanisms, Cancer-specific applications, and a Hallmark-aligned clinical roadmap","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121306"}}