{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:51Z","timestamp":1792083591465,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.cca.2026.121307","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:55:33Z","timestamp":1787759733000},"page":"121307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development and validation of a generalizable M-protein screening model using routine laboratory indicators: a multicenter retrospective study"],"prefix":"10.1016","volume":"593","author":[{"given":"Hou-Long","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.cca.2026.121307_bb0005","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/jamaoncol.2018.2128","article-title":"Global burden of multiple myeloma: a systematic analysis for the global burden of disease study 2016","volume":"4","author":"Cowan","year":"2018","journal-title":"JAMA Oncol."},{"issue":"11","key":"10.1016\/j.cca.2026.121307_bb0010","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1056\/NEJMra1011442","article-title":"Multiple myeloma","volume":"364","author":"Palumbo","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.cca.2026.121307_bb0015","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","volume":"20","author":"Kumar","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"10","key":"10.1016\/j.cca.2026.121307_bb0020","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/qjmed\/hcm077","article-title":"Multiple myeloma: causes and consequences of delay in diagnosis","volume":"100","author":"Kariyawasan","year":"2007","journal-title":"QJM"},{"key":"10.1016\/j.cca.2026.121307_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.clinbiochem.2017.05.001","article-title":"Laboratory testing for monoclonal gammopathies: focus on monoclonal gammopathy of undetermined significance and smoldering multiple myeloma","volume":"51","author":"Willrich","year":"2018","journal-title":"Clin. Biochem."},{"issue":"3","key":"10.1016\/j.cca.2026.121307_bb0030","first-page":"105","article-title":"Screening panels for monoclonal gammopathies: time to change","volume":"30","author":"Katzmann","year":"2009","journal-title":"Clin. Biochem. Rev."},{"issue":"6","key":"10.1016\/j.cca.2026.121307_bb0035","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1515\/cclm-2015-1031","article-title":"Monitoring multiple myeloma patients treated with daratumumab: teasing out monoclonal antibody interference","volume":"54","author":"McCudden","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"issue":"427","key":"10.1016\/j.cca.2026.121307_bb0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cca.2013.08.018","article-title":"Serum free light chains in clinical laboratory diagnostics","volume":"1","author":"Jenner","year":"2014","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.cca.2026.121307_bb0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/leu.2008.307","article-title":"International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders","volume":"23","author":"Dispenzieri","year":"2009","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.cca.2026.121307_bb0050","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/annonc\/mdt118","article-title":"Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia","volume":"24","author":"Ludwig","year":"2013","journal-title":"Ann. Oncol."},{"issue":"5","key":"10.1016\/j.cca.2026.121307_bb0055","doi-asserted-by":"crossref","first-page":"e340","DOI":"10.1016\/S2352-3026(22)00069-2","article-title":"Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study","volume":"9","author":"El-Khoury","year":"2022","journal-title":"Lancet Haematol."},{"issue":"11","key":"10.1016\/j.cca.2026.121307_bb0060","article-title":"Employment of artificial intelligence based on routine laboratory results for the early diagnosis of multiple myeloma","volume":"29","author":"Yan","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.cca.2026.121307_bb0065","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/ijlh.13806","article-title":"Routine blood biomarkers for the detection of multiple myeloma using machine learning","volume":"44","author":"Fan","year":"2022","journal-title":"Int. J. Lab. Hematol."},{"issue":"577","key":"10.1016\/j.cca.2026.121307_bb0070","article-title":"Construction of a machine learning-based screening model for IgD myeloma","volume":"1","author":"Zhou","year":"2025","journal-title":"Clin. Chim. Acta"},{"issue":"8","key":"10.1016\/j.cca.2026.121307_bb0075","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1016\/j.ekir.2025.05.007","article-title":"Machine learning for monoclonal Gammopathies of renal significance risk stratification using clinical and pathology data","volume":"10","author":"Cazzaniga","year":"2025","journal-title":"Kidney Int Rep."},{"issue":"5","key":"10.1016\/j.cca.2026.121307_bb0080","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/bjh.17933","article-title":"Accurate classification of plasma cell dyscrasias is achieved by combining artificial intelligence and flow cytometry","volume":"196","author":"Clichet","year":"2022","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.cca.2026.121307_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.beha.2025.101641","article-title":"Precursor plasma cell disorders: classification, risk stratification, and emerging role of early interception","volume":"38","author":"Mouhieddine","year":"2025","journal-title":"Best Pract. Res. Clin. Haematol."},{"issue":"13","key":"10.1016\/j.cca.2026.121307_bb0090","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121307_bb0095","doi-asserted-by":"crossref","DOI":"10.1080\/16078454.2024.2352686","article-title":"Prevalence of monoclonal gammopathy of undetermined significance in Shenzhen, China","volume":"29","author":"Xu","year":"2024","journal-title":"Hematology"},{"issue":"12","key":"10.1016\/j.cca.2026.121307_bb0100","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1515\/cclm-2023-0326","volume":"61","author":"C\u00e1rdenas","year":"2023","journal-title":"Clin. Chem. Lab. Med."},{"issue":"5","key":"10.1016\/j.cca.2026.121307_bb0105","doi-asserted-by":"crossref","first-page":"575","DOI":"10.5858\/arpa.2020-0794-CP","article-title":"Laboratory detection and initial diagnosis of monoclonal Gammopathies","volume":"146","author":"Keren","year":"2022","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.cca.2026.121307_bb0110","series-title":"Timely diagnosis of myeloma in populations with comorbidities and health disparities","author":"Mikhael","year":"2024"},{"issue":"9","key":"10.1016\/j.cca.2026.121307_bb0115","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/ajh.27422","article-title":"Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management","volume":"99","author":"Rajkumar","year":"2024","journal-title":"Am. J. Hematol."},{"issue":"27","key":"10.1016\/j.cca.2026.121307_bb0120","article-title":"Beyond comparing machine learning and logistic regression in clinical prediction modelling: shifting from model debate to data quality","volume":"5","author":"Hu","year":"2025","journal-title":"J. Med. Internet Res."},{"issue":"1","key":"10.1016\/j.cca.2026.121307_bb0125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12916-019-1466-7","article-title":"Topic group \u2018evaluating diagnostic tests and prediction models\u2019 of the STRATOS initiative. Calibration: the Achilles heel of predictive analytics","volume":"17","author":"Van Calster","year":"2019","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121307_bb0130","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41746-025-01766-0","article-title":"Development and validation of an interpretable risk prediction model for the early classification of thalassemia","volume":"8","author":"Lai","year":"2025","journal-title":"NPJ Digit Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126004894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:31:21Z","timestamp":1792081881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126004894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":26,"alternative-id":["S0009898126004894"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121307","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a generalizable M-protein screening model using routine laboratory indicators: a multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121307"}}