{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:13:11Z","timestamp":1789992791352,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014980","name":"Wannan Medical College","doi-asserted-by":"publisher","award":["WK2023ZQNZ27"],"award-info":[{"award-number":["WK2023ZQNZ27"]}],"id":[{"id":"10.13039\/501100014980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2018jxtd153"],"award-info":[{"award-number":["2018jxtd153"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2024cxcysj185"],"award-info":[{"award-number":["2024cxcysj185"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2019jxxms066"],"award-info":[{"award-number":["2019jxxms066"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["GXXT-2020-22"],"award-info":[{"award-number":["GXXT-2020-22"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2024jsmszs044"],"award-info":[{"award-number":["2024jsmszs044"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.cca.2026.121342","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:18:33Z","timestamp":1789168713000},"page":"121342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolic and liver enzyme correlates of serum alpha-fetoprotein in a large health check-up population"],"prefix":"10.1016","volume":"594","author":[{"given":"Lu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Adaeze","family":"Ezeokafor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cca.2026.121342_bb0005","first-page":"127","article-title":"Alpha-fetoprotein: a review","volume":"15","author":"Crandall","year":"1981","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"issue":"2","key":"10.1016\/j.cca.2026.121342_bb0010","first-page":"84","article-title":"The clinical significance of human alpha-fetoprotein","volume":"8","author":"Yachnin","year":"1978","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1089-3261(05)70158-6","article-title":"The role of serum alpha-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma","volume":"5","author":"Johnson","year":"2001","journal-title":"Clin. Liver Dis."},{"issue":"4","key":"10.1016\/j.cca.2026.121342_bb0020","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0168-8278(00)00053-2","article-title":"Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status","volume":"34","author":"Trevisani","year":"2001","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/jama.1975.03260010040018","article-title":"Alpha-fetoprotein in noneoplastic hepatic disorders","volume":"233","author":"Bloomer","year":"1975","journal-title":"Jama"},{"issue":"33","key":"10.1016\/j.cca.2026.121342_bb0030","doi-asserted-by":"crossref","first-page":"11865","DOI":"10.3748\/wjg.v20.i33.11865","article-title":"Association between serum alpha-fetoprotein levels and fatty liver disease: a cross-sectional study","volume":"20","author":"Xu","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cca.2026.121342_bb0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12944-016-0256-x","article-title":"Association between alpha-fetoprotein and metabolic syndrome in a Chinese asymptomatic population: a cross-sectional study","volume":"15","author":"Chen","year":"2016","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.cca.2026.121342_bb0040","first-page":"98","article-title":"Serum alpha-fetoprotein and its lectin reactivity in liver diseases: a review","volume":"20","author":"Wu","year":"1990","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"9","key":"10.1016\/j.cca.2026.121342_bb0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00432-004-0572-9","article-title":"Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature","volume":"130","author":"Qin","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.cca.2026.121342_bb0050","first-page":"101","article-title":"Liver regeneration","volume":"93","author":"Michalopoulos","year":"2005","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"issue":"5","key":"10.1016\/j.cca.2026.121342_bb0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2613.2006.00485.x","article-title":"Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury","volume":"87","author":"Kuhlmann","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.cca.2026.121342_bb0060","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.12659\/MSM.901861","article-title":"Reference intervals of alpha-fetoprotein and carcinoembryonic antigen in the apparently healthy population","volume":"22","author":"Zhang","year":"2016","journal-title":"Medical Sci. Monitor\u202f: Int. Medical J. Exp. Clin. Res."},{"issue":"3","key":"10.1016\/j.cca.2026.121342_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/003655101300133649","article-title":"Alpha-fetoprotein in plasma and serum of healthy adults: preanalytical, analytical and biological sources of variation and construction of age-dependent reference intervals","volume":"61","author":"Christiansen","year":"2001","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0070","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/17474124.2025.2607008","article-title":"Guideline comparison for fatty liver disease: European (EASL-EASD-EASO) and Asian (APASL) perspectives","volume":"20","author":"Abenavoli","year":"2026","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cca.2026.121342_bb0080","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.freeradbiomed.2023.09.020","article-title":"Targeting gamma-glutamyl transpeptidase: a pleiotropic enzyme involved in glutathione metabolism and in the control of redox homeostasis","volume":"208","author":"Mitri\u0107","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-024-03889-x","article-title":"Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review","volume":"99","author":"Svobodov\u00e1","year":"2025","journal-title":"Arch. Toxicol."},{"issue":"15","key":"10.1016\/j.cca.2026.121342_bb0090","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000042078","article-title":"Influence of triglycerides on the link between gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease in nonobese Chinese adults: a secondary cohort study","volume":"104","author":"Chen","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.cca.2026.121342_bb0095","series-title":"Care and Treatment of Persons with Chronic Hepatitis B Infection","author":"Guidelines for the Prevention","year":"2015"},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0100","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jhep.2018.03.018","article-title":"EASL clinical practice guidelines: management of alcohol-related liver disease","volume":"69","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cca.2026.121342_bb0105","series-title":"Elecsys AFP: AFP Alpha-Fetoprotein\u2014Method Sheet for Cobas e Analyzers. Mannheim, Germany","author":"Roche Diagnostics GmbH","year":"2023"},{"issue":"19","key":"10.1016\/j.cca.2026.121342_bb0110","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.cca.2026.121342_bb0115","doi-asserted-by":"crossref","DOI":"10.2147\/DMSO.S575645","article-title":"Association between platelet parameters and metabolic syndrome in residents of Wuhu, China: a mediation analysis of insulin resistance","volume":"19","author":"Zhou","year":"2026","journal-title":"Diabetes Metab. Syndr. Obes."},{"issue":"9403","key":"10.1016\/j.cca.2026.121342_bb0120","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","year":"2004","journal-title":"Lancet (London, England)."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13048-025-01961-3","article-title":"Investigating the association between systemic immune-inflammation index and female fertility: a retrospective cohort study","volume":"19","author":"Yao","year":"2026","journal-title":"J. Ovarian Res."},{"issue":"5","key":"10.1016\/j.cca.2026.121342_bb0130","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cca.2026.121342_bb0135","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000539371","article-title":"EASL-EASD-EASO clinical practice guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","volume":"17","year":"2024","journal-title":"Obes. Facts"},{"issue":"5","key":"10.1016\/j.cca.2026.121342_bb0140","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology (Baltimore, Md)."},{"issue":"20","key":"10.1016\/j.cca.2026.121342_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011128","article-title":"The interplay between insulin resistance, inflammation, oxidative stress, base excision repair and metabolic syndrome in nonalcoholic fatty liver disease","volume":"22","author":"Ziolkowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2026.121342_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1231420","article-title":"Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice","volume":"13","author":"Ma","year":"2023","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.cca.2026.121342_bb0155","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease","volume":"77","author":"Rinella","year":"2023","journal-title":"Hepatology (Baltimore, Md)."},{"issue":"4","key":"10.1016\/j.cca.2026.121342_bb0160","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1515\/cclm-2021-0283","article-title":"Within- and between-subject biological variation data for tumor markers based on the European biological variation study","volume":"60","author":"Co\u015fkun","year":"2022","journal-title":"Clin. Chem. Lab. Med."},{"issue":"4","key":"10.1016\/j.cca.2026.121342_bb0165","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1515\/cclm-2021-0725","article-title":"Critical review and meta-analysis of biological variation estimates for tumor markers","volume":"60","author":"Marques-Garcia","year":"2022","journal-title":"Clin. Chem. Lab. Med."},{"issue":"4","key":"10.1016\/j.cca.2026.121342_bb0170","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12072-009-9156-8","article-title":"Serum \u03b1-fetoprotein levels in liver steatosis","volume":"3","author":"Babal\u0131","year":"2009","journal-title":"Hepatol. Int."},{"issue":"11","key":"10.1016\/j.cca.2026.121342_bb0175","first-page":"1536","article-title":"Alpha fetoprotein levels and its relationship with histopathological findings in patients with non-alcoholic fatty liver disease","volume":"17","author":"Kara","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.cca.2026.121342_bb0180","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3748\/wjg.v28.i2.216","article-title":"Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma","volume":"28","author":"Hanif","year":"2022","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.cca.2026.121342_bb0185","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jvh.13886","article-title":"CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes","volume":"30","author":"Ning","year":"2023","journal-title":"J. Viral Hepat."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0190","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40842-024-00187-4","article-title":"From adiposity to steatosis: metabolic dysfunction-associated steatotic liver disease, a hepatic expression of metabolic syndrome - current insights and future directions","volume":"10","author":"Basil","year":"2024","journal-title":"Clin Diabetes Endocrinol."},{"issue":"5","key":"10.1016\/j.cca.2026.121342_bb0195","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cmet.2024.04.006","article-title":"Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease","volume":"36","author":"Bo","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/liv.15099","article-title":"Gamma-Glutamyl transferase (\u03b3-GT) - an old dog with new tricks?","volume":"42","author":"Brennan","year":"2022","journal-title":"Liver Int.: Official J. Int. Association Study Liver."},{"issue":"2","key":"10.1016\/j.cca.2026.121342_bb0205","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/jir.2022.0172","article-title":"Analysis of immune and inflammatory microenvironment characteristics of noncancer end-stage liver disease","volume":"43","author":"Wang","year":"2023","journal-title":"J. Interferon Cytokine Res.: The Official J. Int. Society For Interferon Cytokine Res."},{"issue":"12","key":"10.1016\/j.cca.2026.121342_bb0210","article-title":"Lipid metabolism in MASLD and MASH: from mechanism to the clinic","volume":"6","author":"Carli","year":"2024","journal-title":"JHEP reports\u202f: innovation in hepatology."},{"issue":"10","key":"10.1016\/j.cca.2026.121342_bb0215","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41575-023-00832-w","article-title":"Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis","volume":"20","author":"Sharma","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.cca.2026.121342_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/edm2.70132","article-title":"Metabolic dysfunction-associated Steatotic liver disease (MASLD): mechanisms, clinical implications and therapeutic advances","volume":"8","author":"Miller","year":"2025","journal-title":"Endocrinology, Diabetes & Metabolism."},{"key":"10.1016\/j.cca.2026.121342_bb0225","doi-asserted-by":"crossref","DOI":"10.1007\/s10557-026-07866-7","article-title":"The nonlinear relationship between serum uric acid and cardiovascular disease risk: mechanistic insights and clinical implications","author":"Hou","year":"2026","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.cca.2026.121342_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2025.101397","article-title":"Liver aging: underlying mechanisms and therapeutic strategies","volume":"105","author":"Zhong","year":"2025","journal-title":"Mol. Asp. Med."},{"issue":"12","key":"10.1016\/j.cca.2026.121342_bb0235","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.molmed.2024.05.013","article-title":"Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease","volume":"30","author":"Cherubini","year":"2024","journal-title":"Trends Mol. Med."},{"issue":"19","key":"10.1016\/j.cca.2026.121342_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199594","article-title":"Sex hormones and metabolic dysfunction-associated steatotic liver disease","volume":"26","author":"Weiskirchen","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.cca.2026.121342_bb0245","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41575-024-00974-5","article-title":"Hepatic immune regulation and sex disparities","volume":"21","author":"Burra","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.cca.2026.121342_bb0250","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5301\/JBM.2011.6364","article-title":"Reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen in Chinese Han ethnic males from the Fangchenggang area male health and examination survey","volume":"26","author":"Qin","year":"2011","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.cca.2026.121342_bb0255","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.clinbiochem.2017.11.002","article-title":"Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults: sub-analysis of a prospective multi-center study","volume":"52","author":"Yan","year":"2018","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2026.121342_bb0260","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ymeth.2021.08.001","article-title":"NetAUC: a network-based multi-biomarker identification method by AUC optimization","volume":"198","author":"Li","year":"2022","journal-title":"Methods (San Diego, Calif)."},{"issue":"Pt 2","key":"10.1016\/j.cca.2026.121342_bb0265","article-title":"Pan-cancer analysis identifies adhesion G protein-coupled receptor G6 as a potential prognostic and immunotherapeutic biomarker with its functional validation","volume":"334","author":"Zhu","year":"2025","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126005243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126005243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:38:12Z","timestamp":1789990692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126005243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":53,"alternative-id":["S0009898126005243"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121342","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic and liver enzyme correlates of serum alpha-fetoprotein in a large health check-up population","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121342"}}