{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:03:11Z","timestamp":1789902191694,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016015","name":"Universit\u00e4tsspital Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca PLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim International GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016946","name":"Singulex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013348","name":"Innosuisse Swiss Innovation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk AS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.cca.2026.121346","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:49:50Z","timestamp":1789721390000},"page":"121346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Diagnostic and prognostic performance of heart-type fatty acid\u2013binding protein in functionally relevant coronary artery disease"],"prefix":"10.1016","volume":"594","author":[{"given":"Evangelos","family":"Tsianakas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seval","family":"Kul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Nafaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koray","family":"Durak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Lopez-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Hur\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Koechlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Strebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Haaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Zellweger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2026.121346_bb0005","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.suc.2022.01.007","article-title":"Epidemiology of coronary artery disease","volume":"102","author":"Duggan","year":"2022","journal-title":"Surg. Clin. N. Am."},{"key":"10.1016\/j.cca.2026.121346_bb0010","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/eurheartj\/ehaf289","article-title":"Acute coronary syndromes: mechanisms, challenges, and new opportunities","volume":"46","author":"Kraler","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cca.2026.121346_bb0015","doi-asserted-by":"crossref","DOI":"10.1093\/ehjqcco\/qcw043","article-title":"Permanent work disability in patients \u226450 years old after percutaneous coronary intervention and coronary artery bypass grafting (the CRAGS study)","author":"Lautam\u00e4ki","year":"2016","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.cca.2026.121346_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics\u20142021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2026.121346_bb0025","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1093\/eurheartj\/ehad583","article-title":"Economic burden of cardiovascular diseases in the European Union: a population-based cost study","volume":"44","author":"Luengo-Fernandez","year":"2023","journal-title":"Eur. Heart J."},{"issue":"2024","key":"10.1016\/j.cca.2026.121346_bb0030","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"ESC guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cca.2026.121346_bb0035","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2012.11.056","article-title":"Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing","volume":"61","author":"Rozanski","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cca.2026.121346_bb0040","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ehjci\/jeag076","article-title":"Temporal trends in pretest probability and normal scan rates in myocardial perfusion imaging: a 24-year experience from a Swiss tertiary referral center (between 2000 and 2024)","volume":"27","author":"Frey","year":"2026","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.cca.2026.121346_bb0045","doi-asserted-by":"crossref","first-page":"482","DOI":"10.7326\/M14-0296","article-title":"Physician decision making and trends in the use of cardiac stress testing in the United States: an analysis of repeated cross-sectional data","volume":"161","author":"Ladapo","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cca.2026.121346_bb0050","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s00392-022-01992-6","article-title":"Gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and cardiovascular risk in patients with suspected functionally relevant coronary artery disease (fCAD)","volume":"111","author":"Amrein","year":"2022","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.cca.2026.121346_bb0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/1354750X.2022.2038269","article-title":"Soluble urokinase plasminogen activator receptor and functionally relevant coronary artery disease: a prospective cohort study","volume":"27","author":"Walter","year":"2022","journal-title":"Biomarkers"},{"key":"10.1016\/j.cca.2026.121346_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117582","article-title":"Diagnostic and prognostic value of H-ficolin for functionally relevant coronary artery disease","volume":"551","author":"Isayeva","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121346_bb0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/1354750X.2023.2172211","article-title":"Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes","volume":"28","author":"Amrein","year":"2023","journal-title":"Biomarkers"},{"key":"10.1016\/j.cca.2026.121346_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.7326\/M19-0080","article-title":"Using high-sensitivity cardiac troponin for the exclusion of inducible myocardial ischemia in symptomatic patients: a cohort study","volume":"172","author":"Walter","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cca.2026.121346_bb0075","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1373\/clinchem.2018.286971","article-title":"Direct comparison of cardiac troponin T and I using a uniform and a sex-specific approach in the detection of functionally relevant coronary artery disease","volume":"64","author":"Mueller","year":"2018","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2026.121346_bb0080","first-page":"185","article-title":"Incremental value of heart-type fatty acid-binding protein in suspected acute myocardial infarction early after symptom onset","volume":"5","author":"Schoenenberger","year":"2016","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.cca.2026.121346_bb0085","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/heartjnl-2012-303325","article-title":"Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction","volume":"99","author":"Reiter","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.cca.2026.121346_bb0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01270583","article-title":"Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man","volume":"116","author":"Kleine","year":"1992","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cca.2026.121346_bb0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0009-9120(91)90571-U","article-title":"Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction","volume":"24","author":"Tanaka","year":"1991","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2026.121346_bb0100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0002-9343(03)00325-5","article-title":"Use of a whole blood rapid panel test for heart-type fatty acid\u2013binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests","volume":"115","author":"Seino","year":"2003","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cca.2026.121346_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ahj.2015.11.010","article-title":"Clinical benefit of high-sensitivity cardiac troponin I in the detection of exercise-induced myocardial ischemia","volume":"173","author":"Lee","year":"2016","journal-title":"Am. Heart J."},{"key":"10.1016\/j.cca.2026.121346_bb0110","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.cca.2026.121346_bb0115","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-082440","article-title":"Dealing with continuous variables and modelling non-linear associations in healthcare data: practical guide","volume":"390","author":"Lopez-Ayala","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.cca.2026.121346_bb0120","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat. Med."},{"key":"10.1016\/j.cca.2026.121346_bb0125","author":"Harrell"},{"key":"10.1016\/j.cca.2026.121346_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejim.2025.106694","article-title":"Growth differentiation factor-15 in patients presenting with acute chest pain: diagnostic and prognostic utility","author":"Crisanti","year":"2026","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.cca.2026.121346_bb0135","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/CIRCULATIONAHA.115.017719","article-title":"Introduction to the analysis of survival data in the presence of competing risks","volume":"133","author":"Austin","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2026.121346_bb0140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijcard.2018.10.029","article-title":"Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease","volume":"275","author":"Walter","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cca.2026.121346_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.119668","article-title":"Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease","volume":"558","author":"Isayeva","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.121346_bb0150","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.clinbiochem.2015.12.005","article-title":"Direct comparison of cardiac troponin I and cardiac troponin T in the detection of exercise-induced myocardial ischemia","volume":"49","author":"Sou","year":"2016","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2026.121346_bb0155","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.amjmed.2015.01.009","article-title":"Incremental value of a single high-sensitivity cardiac troponin I measurement to rule out myocardial ischemia","volume":"128","author":"Tanglay","year":"2015","journal-title":"Am. J. Med."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126005280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126005280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:50:12Z","timestamp":1789901412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126005280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":31,"alternative-id":["S0009898126005280"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.121346","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic and prognostic performance of heart-type fatty acid\u2013binding protein in functionally relevant coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.121346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121346"}}