{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:53:24Z","timestamp":1790927604517,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.cca.2026.122856","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:04:01Z","timestamp":1790687041000},"page":"122856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adjustment and validation of convolutional neural network for indirect immunofluorescence interpretation of antinuclear and anti-neutrophil cytoplasmic antibodies: A multicenter study"],"prefix":"10.1016","volume":"594","author":[{"given":"Rulin","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzi","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2026.122856_bb0005","article-title":"The role of indirect immunofluorescence (IIF) and line immunoassay (LIA) in the diagnosis of autoimmune diseases and their clinical correlation: an observational study from a tertiary care center in Bihar","volume":"15","author":"Kumar","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.cca.2026.122856_bb0010","doi-asserted-by":"crossref","unstructured":"Hobson, P., Lovell, B. C., Percannella, G., Vento, M. & Wiliem, A. in Proceedings of the 2014 22nd International Conference on Pattern Recognition. 3233\u20133238 (IEEE Computer Society).","DOI":"10.1109\/ICPR.2014.557"},{"key":"10.1016\/j.cca.2026.122856_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1353965","article-title":"Automatic segmentation and classification for antinuclear antibody images based on deep learning","volume":"2023","author":"Xie","year":"2023","journal-title":"Comput. Intell. Neurosci."},{"key":"10.1016\/j.cca.2026.122856_bb0020","article-title":"Deep learning in computer vision: a critical review of emerging techniques and application scenarios","volume":"6","author":"Chai","year":"2021","journal-title":"Mach. Learn. Appl."},{"key":"10.1016\/j.cca.2026.122856_bb0025","article-title":"A review of convolutional neural network based methods for medical image classification","volume":"185","author":"Chen","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cca.2026.122856_bb0030","article-title":"Application of supervised machine learning to recognize competent level and mixed antinuclear antibody patterns based on ICAP international consensus","volume":"11","author":"Wu","year":"2021","journal-title":"Diagnostics (Basel)."},{"key":"10.1016\/j.cca.2026.122856_bb0035","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.patcog.2018.02.006","article-title":"A deeply supervised residual network for HEp-2 cell classification via cross-modal transfer learning","volume":"79","author":"Lei","year":"2018","journal-title":"Pattern Recogn."},{"key":"10.1016\/j.cca.2026.122856_bb0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neucom.2019.03.067","article-title":"Deeply supervised full convolution network for HEp-2 specimen image segmentation","volume":"351","author":"Xie","year":"2019","journal-title":"Neurocomputing"},{"key":"10.1016\/j.cca.2026.122856_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.110150","article-title":"Benchmarking HEp-2 cell segmentation methods in indirect immunofluorescence images - standard models to deep learning","volume":"192","author":"Iyer","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cca.2026.122856_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2026.120881","article-title":"Comparison of manual with artificial intelligence-aided interpretation of ANA HEp-2 IIF assay patterns in a clinical diagnostics lab","volume":"584","author":"Schmidt","year":"2026","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2026.122856_bb0055","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/651058","article-title":"Automated indirect immunofluorescence evaluation of antinuclear autoantibodies on HEp-2 cells","volume":"2012","author":"Voigt","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.cca.2026.122856_bb0060","first-page":"142","article-title":"Evaluation of a computer-aided microscope system and its anti-nuclear antibody test kit for indirect immunofluorescence assay (in Japanese)","volume":"64","author":"Hayashi","year":"2016","journal-title":"Rinsho Byori"},{"key":"10.1016\/j.cca.2026.122856_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cca.2019.08.018","article-title":"Evaluation of the automated indirect immunofluorescence test for anti-dsDNA antibodies","volume":"498","author":"Wu","year":"2019","journal-title":"Clin. Chim. Acta"},{"issue":"12","key":"10.1016\/j.cca.2026.122856_bb0070","first-page":"1143","article-title":"EUROPattern auto-reading system for the determination of anti-nuclear antibody (in Chinese)","volume":"32","author":"Jia","year":"2017","journal-title":"Lab. Med."},{"key":"10.1016\/j.cca.2026.122856_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3343\/alm.2017.37.3.240","article-title":"Performance of an automated fluorescence antinuclear antibody image analyzer","volume":"37","author":"Yoo","year":"2017","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.cca.2026.122856_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.607541","article-title":"Evaluation of a fully automated antinuclear antibody indirect immunofluorescence assay in routine use","volume":"11","author":"Choi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2026.122856_bb0085","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1515\/cclm-2017-0050","article-title":"Automated antinuclear immunofluorescence antibody analysis is a reliable approach in routine clinical laboratories","volume":"55","author":"Zheng","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2026.122856_bb0090","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/art.41773","article-title":"American College of Rheumatology\/Vasculitis Foundation guideline for the management of antineutrophil cytoplasmic antibody-associated vasculitis","volume":"73","author":"Chung","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cca.2026.122856_bb0095","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/annrheumdis-2019-215089","article-title":"Update of the EULAR recommendations for the management of systemic lupus erythematosus","volume":"78","author":"Fanouriakis","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2026.122856_bb0100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2026.122856_bb0105","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/hep.31065","article-title":"Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of Liver Diseases","volume":"72","author":"Mack","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2026.122856_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"American College of Rheumatology\/European League against Rheumatism classification criteria for primary Sjogren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cca.2026.122856_bb0115","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cca.2026.122856_bb0120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/annrheumdis-2021-221795","article-title":"American College of Rheumatology\/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis","volume":"81","author":"Robson","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2026.122856_bb0125","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/annrheumdis-2021-221796","article-title":"American College of Rheumatology\/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis","volume":"81","author":"Suppiah","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2026.122856_bb0130","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/annrheumdis-2021-221794","article-title":"American College of Rheumatology\/European Alliance of Associations for Rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis","volume":"81","author":"Grayson","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2026.122856_bb0135","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/annrheumdis-2018-214819","article-title":"European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus","volume":"78","author":"Aringer","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cca.2026.122856_bb0140","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1177\/0961203314559635","article-title":"EUROPattern suite technology for computer-aided immunofluorescence microscopy in autoantibody diagnostics","volume":"24","author":"Krause","year":"2015","journal-title":"Lupus"},{"key":"10.1016\/j.cca.2026.122856_bb0145","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.cca.2026.122856_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102588","article-title":"A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: a pilot study","volume":"19","author":"Infantino","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cca.2026.122856_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.638863","article-title":"Standardization and quality assessment under the perspective of automated computer-assisted HEp-2 immunofluorescence assay systems","volume":"12","author":"Cinquanta","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cca.2026.122856_bb0160","doi-asserted-by":"crossref","first-page":"R271","DOI":"10.1186\/ar4119","article-title":"Automated interpretation of ANCA patterns - a new approach in the serology of ANCA-associated vasculitis","volume":"14","author":"Knutter","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cca.2026.122856_bb0165","first-page":"127","article-title":"Automated versus conventional microscopic interpretation of antinuclear antibody indirect immunofluorescence test","volume":"49","author":"Park","year":"2019","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.cca.2026.122856_bb0170","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.autrev.2013.10.015","article-title":"Automated antinuclear immunofluorescence antibody screening: a comparative study of six computer-aided diagnostic systems","volume":"13","author":"Bizzaro","year":"2014","journal-title":"Autoimmun. Rev."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126020383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898126020383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:01:39Z","timestamp":1790924499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898126020383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":34,"alternative-id":["S0009898126020383"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2026.122856","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adjustment and validation of convolutional neural network for indirect immunofluorescence interpretation of antinuclear and anti-neutrophil cytoplasmic antibodies: A multicenter study","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2026.122856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122856"}}