{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:53:59Z","timestamp":1774065239064,"version":"3.50.1"},"reference-count":120,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Care Clinics"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.ccc.2011.04.001","type":"journal-article","created":{"date-parts":[[2011,7,10]],"date-time":"2011-07-10T17:26:45Z","timestamp":1310318805000},"page":"661-683","source":"Crossref","is-referenced-by-count":66,"title":["Biomarkers in Acute Lung Injury\u2014Marking Forward Progress"],"prefix":"10.1016","volume":"27","author":[{"given":"Nicolas","family":"Barnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine B.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9068","key":"10.1016\/j.ccc.2011.04.001_bib1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(05)61686-8","article-title":"Predicting ARDS: problems and prospects","volume":"349","author":"Hudson","year":"1997","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.ccc.2011.04.001_bib2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","year":"2000","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.ccc.2011.04.001_bib3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/thorax.58.11.983","article-title":"Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury","volume":"58","author":"Eisner","year":"2003","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1067\/mcp.2001.113989","article-title":"Biomarkers and surrogate endpoints: preferred definitions and conceptual framework","volume":"69","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.ccc.2011.04.001_bib5","author":"WHO International Programme on Chemical Safety"},{"key":"10.1016\/j.ccc.2011.04.001_bib6","author":"WHO International Programme on Chemical Safety"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/COH.0b013e32833ed177","article-title":"What are biomarkers?","volume":"5","author":"Strimbu","year":"2010","journal-title":"Curr Opin HIV AIDS"},{"issue":"10","key":"10.1016\/j.ccc.2011.04.001_bib8","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1164\/rccm.201001-0024WS","article-title":"Beyond mortality: future clinical research in acute lung injury","volume":"181","author":"Spragg","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.ccc.2011.04.001_bib9","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1097\/01.CCM.0000221922.08878.49","article-title":"Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury\/acute respiratory distress syndrome","volume":"35","author":"Ware","year":"2007","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.ccc.2011.04.001_bib10","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1097\/CCM.0b013e3181a02afc","article-title":"Biomarkers of sepsis","volume":"37","author":"Marshall","year":"2009","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jama.293.4.470","article-title":"Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial","volume":"293","author":"Willson","year":"2005","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1378\/chest.09-1484","article-title":"Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury","volume":"137","author":"Ware","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.ccc.2011.04.001_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1465-9921-6-62","article-title":"Serum biomarkers in acute respiratory distress syndrome an ailing prognosticator","volume":"6","author":"Tzouvelekis","year":"2005","journal-title":"Respir Res"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib14","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.4049\/jimmunol.172.4.2668","article-title":"Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression","volume":"172","author":"Olman","year":"2004","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.2008.061010","article-title":"Receiver-operating characteristic curve analysis in diagnostic, prognostic and predictive biomarker research","volume":"62","author":"Soreide","year":"2009","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.ccc.2011.04.001_bib16","author":"Zhu"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/cc6860","article-title":"Pro\/Con debate: is procalcitonin useful for guiding antibiotic decision making in critically ill patients?","volume":"12","author":"Shehabi","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.ccc.2011.04.001_bib18","unstructured":"Kaufman RA, Oakley-Brown H, Watkins R, et al. Strategic planning for success: aligning people, performance, and payoffs. 2003."},{"issue":"18","key":"10.1016\/j.ccc.2011.04.001_bib19","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0885066609332603","article-title":"The pathogenetic and prognostic value of biologic markers in acute lung injury","volume":"24","author":"Levitt","year":"2009","journal-title":"J\u00a0Intensive Care Med"},{"issue":"7047","key":"10.1016\/j.ccc.2011.04.001_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature03712","article-title":"Angiotensin-converting enzyme 2 protects from severe acute lung failure","volume":"436","author":"Imai","year":"2005","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1165\/rcmb.2008-0410OC","article-title":"Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome","volume":"41","author":"Tejera","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib23","doi-asserted-by":"crossref","first-page":"L426","DOI":"10.1152\/ajplung.00302.2004","article-title":"Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury","volume":"288","author":"Parsons","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.trsl.2006.07.009","article-title":"Rapid assay for plasma soluble E-selectin predicts the development of acute respiratory distress syndrome in patients with systemic inflammatory response syndrome","volume":"148","author":"Okajima","year":"2006","journal-title":"Transl Res"},{"issue":"5","key":"10.1016\/j.ccc.2011.04.001_bib25","doi-asserted-by":"crossref","first-page":"L713","DOI":"10.1152\/ajplung.90269.2008","article-title":"Recent advances in genetic predisposition to clinical acute lung injury","volume":"296","author":"Gao","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1165\/rcmb.F305","article-title":"Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management","volume":"33","author":"Matthay","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-2006-948290","article-title":"The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome","volume":"27","author":"Bastarache","year":"2006","journal-title":"Semin Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1183\/09031936.00098709","article-title":"Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio","volume":"35","author":"Ware","year":"2010","journal-title":"Eur Respir J"},{"issue":"5560","key":"10.1016\/j.ccc.2011.04.001_bib29","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1069492","article-title":"Systems biology: a brief overview","volume":"295","author":"Kitano","year":"2002","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib30","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1378\/chest.107.4.1062","article-title":"Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time","volume":"107","author":"Meduri","year":"1995","journal-title":"Chest"},{"issue":"10 Pt 1","key":"10.1016\/j.ccc.2011.04.001_bib31","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1164\/ajrccm.164.10.2104013","article-title":"Cytokine balance in the lungs of patients with acute respiratory distress syndrome","volume":"164","author":"Park","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib32","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1164\/ajrccm.155.4.9105096","article-title":"Circulating IL-1ra and IL-10 levels are increased but do not predict the development of acute respiratory distress syndrome in at-risk patients","volume":"155","author":"Parsons","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ccc.2011.04.001_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2466-4-6","article-title":"The clinical significance of serum and bronchoalveolar lavage inflammatory cytokines in patients at risk for Acute Respiratory Distress Syndrome","volume":"4","author":"Bouros","year":"2004","journal-title":"BMC Pulm Med"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib34","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/ajrccm.155.4.9105054","article-title":"Biological markers of acute lung injury: prognostic and pathogenetic significance","volume":"155","author":"Pittet","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.ccc.2011.04.001_bib35","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1164\/ajrccm\/145.5.1016","article-title":"High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis","volume":"145","author":"Suter","year":"1992","journal-title":"Am Rev Respir Dis"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00024382-200204000-00002","article-title":"A\u00a0prospective study of inflammation markers in patients at risk of indirect acute lung injury","volume":"17","author":"Takala","year":"2002","journal-title":"Shock"},{"issue":"8846","key":"10.1016\/j.ccc.2011.04.001_bib37","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0140-6736(93)90416-E","article-title":"Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups","volume":"341","author":"Donnelly","year":"1993","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib38","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1186\/cc8152","article-title":"Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion","volume":"13","author":"Cohen","year":"2009","journal-title":"Crit Care"},{"issue":"9","key":"10.1016\/j.ccc.2011.04.001_bib39","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/cc7153","article-title":"Bench-to-bedside review: angiopoietin signalling in critical illness - a future target?","volume":"13","author":"van Meurs","year":"2009","journal-title":"Crit Care"},{"issue":"12","key":"10.1016\/j.ccc.2011.04.001_bib41","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.it.2006.10.004","article-title":"Angiopoietins: a link between angiogenesis and inflammation","volume":"27","author":"Fiedler","year":"2006","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/path.1452","article-title":"Not just angiogenesis\u2014wider roles for the angiopoietins","volume":"201","author":"Jones","year":"2003","journal-title":"J\u00a0Pathol"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib43","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/SHK.0b013e31815dd92f","article-title":"Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury\/adult respiratory distress syndrome","volume":"29","author":"Gallagher","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.ccc.2011.04.001_bib44","first-page":"A1205","article-title":"Genome wide association (gwa) identifies functional susceptibility loci for trauma-induced acute lung injury","volume":"181","author":"Christie","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ccc.2011.04.001_bib45","first-page":"A3879","article-title":"Large scale genotyping in an African American trauma population identifies angiopoeitin-2 variants associated with ALI","volume":"179","author":"Meyer","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ccc.2011.04.001_bib46","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201005-0701OC","article-title":"ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio","author":"Meyer","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.ccc.2011.04.001_bib47","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/thx.2005.040204","article-title":"Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?","volume":"61","author":"Medford","year":"2006","journal-title":"Thorax"},{"issue":"22","key":"10.1016\/j.ccc.2011.04.001_bib48","doi-asserted-by":"crossref","first-page":"15732","DOI":"10.1074\/jbc.274.22.15732","article-title":"Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells","volume":"274","author":"Oh","year":"1999","journal-title":"J\u00a0Biol Chem"},{"issue":"12","key":"10.1016\/j.ccc.2011.04.001_bib49","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1161\/ATVBAHA.107.150482","article-title":"VEGF induces Tie2 shedding via a phosphoinositide 3-kinase\/Akt dependent pathway to modulate Tie2 signaling","volume":"27","author":"Findley","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1183\/09031936.05.00106604","article-title":"VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema","volume":"26","author":"Ware","year":"2005","journal-title":"Eur Respir J"},{"issue":"10","key":"10.1016\/j.ccc.2011.04.001_bib51","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/thx.2007.087387","article-title":"Angiopoietin-2, permeability oedema, occurrence and severity of ALI\/ARDS in septic and non-septic critically ill patients","volume":"63","author":"van der Heijden","year":"2008","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.ccc.2011.04.001_bib52","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00277-006-0085-5","article-title":"Von Willebrand factor and thrombosis","volume":"85","author":"Franchini","year":"2006","journal-title":"Ann Hematol"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib53","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1172\/JCI114733","article-title":"Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome","volume":"86","author":"Rubin","year":"1990","journal-title":"J\u00a0Clin Invest"},{"issue":"11","key":"10.1016\/j.ccc.2011.04.001_bib54","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s001340051054","article-title":"Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome","volume":"25","author":"Bajaj","year":"1999","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1164\/ajrccm.151.1.7812545","article-title":"von Willebrand factor antigen levels are not predictive for the adult respiratory distress syndrome","volume":"151","author":"Moss","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.ccc.2011.04.001_bib56","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1582-4934.2009.00811.x","article-title":"Leukocyte-endothelial interactions in inflammation","volume":"13","author":"Langer","year":"2009","journal-title":"J\u00a0Cell Mol Med"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib57","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4049\/jimmunol.150.2.644","article-title":"Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock","volume":"150","author":"Newman","year":"1993","journal-title":"J\u00a0Immunol"},{"issue":"8917","key":"10.1016\/j.ccc.2011.04.001_bib58","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(94)92995-5","article-title":"Role of selectins in development of adult respiratory distress syndrome","volume":"344","author":"Donnelly","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ccc.2011.04.001_bib59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-pathol-011110-130158","article-title":"The acute respiratory distress syndrome: pathogenesis and treatment","volume":"6","author":"Matthay","year":"2011","journal-title":"Annu Rev Pathol"},{"issue":"12","key":"10.1016\/j.ccc.2011.04.001_bib60","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/thx.2008.095588","article-title":"Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury","volume":"63","author":"Calfee","year":"2008","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib61","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1378\/chest.09-3082","article-title":"Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in ARDS","volume":"139","author":"Nakashima","year":"2011","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib62","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1513\/pats.200701-018AW","article-title":"Immunomodulatory roles of surfactant proteins A and D: implications in lung disease","volume":"4","author":"Pastva","year":"2007","journal-title":"Proc Am Thorac Soc"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000272047","article-title":"Pulmonary surfactant: an immunological perspective","volume":"25","author":"Chroneos","year":"2010","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib64","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1164\/ajrccm.160.6.9901117","article-title":"Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS","volume":"160","author":"Greene","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl 1","key":"10.1016\/j.ccc.2011.04.001_bib65","doi-asserted-by":"crossref","first-page":"90S","DOI":"10.1378\/chest.116.suppl_1.90S","article-title":"Serum surfactant protein-A levels predict development of ARDS in at-risk patients","volume":"116","author":"Greene","year":"1999","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib66","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1164\/ajrccm.164.4.2010111","article-title":"Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure","volume":"164","author":"Bersten","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib67","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2222.2000.00760.x","article-title":"Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker","volume":"30","author":"Broeckaert","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ccc.2011.04.001_bib68","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2466-9-49","article-title":"Plasma CC16 levels are associated with development of ALI\/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study","volume":"9","author":"Determann","year":"2009","journal-title":"BMC Pulm Med"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib69","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1378\/chest.08-2465","article-title":"Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury","volume":"135","author":"Kropski","year":"2009","journal-title":"Chest"},{"issue":"22","key":"10.1016\/j.ccc.2011.04.001_bib70","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1161\/CIRCULATIONAHA.107.187397","article-title":"Universal definition of myocardial infarction","volume":"116","author":"Thygesen","year":"2007","journal-title":"Circulation"},{"issue":"3 Pt 1","key":"10.1016\/j.ccc.2011.04.001_bib71","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination","volume":"149","author":"Bernard","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.ccc.2011.04.001_bib72","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1097\/CCM.0b013e31817d20bd","article-title":"Acute respiratory distress syndrome 40 years later: time to revisit its definition","volume":"36","author":"Phua","year":"2008","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib73","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/CCM.0b013e3181feb46a","article-title":"Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury\/acute respiratory distress syndrome","volume":"39","author":"Aman","year":"2011","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.ccc.2011.04.001_bib74","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1007\/s00134-010-1952-z","article-title":"The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?","volume":"36","author":"Creagh-Brown","year":"2010","journal-title":"Intensive Care Med"},{"issue":"9","key":"10.1016\/j.ccc.2011.04.001_bib75","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1164\/rccm.200509-1477OC","article-title":"Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury","volume":"173","author":"Uchida","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.ccc.2011.04.001_bib76","first-page":"1121","article-title":"Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis","volume":"68","author":"Fremont","year":"2010","journal-title":"J\u00a0Trauma"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib77","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.biocel.2007.07.015","article-title":"Bridging structure with function: structural, regulatory, and developmental role of laminins","volume":"40","author":"Tzu","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib78","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00134-009-1719-6","article-title":"Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury","volume":"36","author":"Katayama","year":"2010","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib79","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/CIRCRESAHA.109.200717","article-title":"Mechanisms of transendothelial migration of leukocytes","volume":"105","author":"Muller","year":"2009","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib80","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00134-008-1235-0","article-title":"Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury","volume":"35","author":"Calfee","year":"2009","journal-title":"Intensive Care Med"},{"issue":"Suppl 1","key":"10.1016\/j.ccc.2011.04.001_bib81","doi-asserted-by":"crossref","first-page":"83S","DOI":"10.1378\/chest.116.suppl_1.83S","article-title":"Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance","volume":"116","author":"Conner","year":"1999","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib82","doi-asserted-by":"crossref","first-page":"L20","DOI":"10.1152\/ajplung.00312.2002","article-title":"Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury","volume":"285","author":"Prabhakaran","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib83","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00003246-199902000-00036","article-title":"The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome","volume":"27","author":"Pugin","year":"1999","journal-title":"Crit Care Med"},{"issue":"3 Pt 1","key":"10.1016\/j.ccc.2011.04.001_bib84","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1164\/ajrccm.156.3.9701124","article-title":"Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance","volume":"156","author":"Chesnutt","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"5 Pt 1","key":"10.1016\/j.ccc.2011.04.001_bib85","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1164\/ajrccm.158.5.9801107","article-title":"Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment","volume":"158","author":"Meduri","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib86","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1165\/ajrcmb.23.2.3855","article-title":"Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins","volume":"23","author":"Dentener","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"10.1016\/j.ccc.2011.04.001_bib87","doi-asserted-by":"crossref","first-page":"e6818","DOI":"10.1371\/journal.pone.0006818","article-title":"Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis","volume":"4","author":"Villar","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ccc.2011.04.001_bib88","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1164\/rccm.200310-1434OC","article-title":"Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury","volume":"170","author":"Ware","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.CCM.0000149854.61192.DC","article-title":"Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury","volume":"33","author":"Parsons","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ccc.2011.04.001_bib90","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/978-0-387-89520-8_10","article-title":"Targeting the LIGHT-HVEM pathway","volume":"647","author":"Ware","year":"2009","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10.1016\/j.ccc.2011.04.001_bib91","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1164\/rccm.200902-0222OC","article-title":"Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome","volume":"180","author":"Chen","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib92","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1378\/chest.08-2413","article-title":"Plasma C-reactive protein levels are associated with improved outcome in ARDS","volume":"136","author":"Bajwa","year":"2009","journal-title":"Chest"},{"issue":"9","key":"10.1016\/j.ccc.2011.04.001_bib93","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/thx.2009.113464","article-title":"Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis","volume":"64","author":"Zhai","year":"2009","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib94","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1440-1843.2008.01293.x","article-title":"Procalcitonin is a valuable prognostic marker in ARDS caused by community-acquired pneumonia","volume":"13","author":"Tseng","year":"2008","journal-title":"Respirology"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib95","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa032193","article-title":"Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome","volume":"351","author":"Brower","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib96","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/cc6846","article-title":"Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury","volume":"12","author":"McClintock","year":"2008","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib97","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.ccc.2011.04.001_bib98","doi-asserted-by":"crossref","DOI":"10.1097\/CCM.0b013e318207ec3c","article-title":"Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury","author":"Calfee","year":"2011","journal-title":"Critical Care Medicine"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib99","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1378\/chest.10-0518","article-title":"Therapeutic potential of mesenchymal stem cells for severe acute lung injury","volume":"138","author":"Matthay","year":"2010","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib100","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1165\/rcmb.2009-0015OC","article-title":"Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells","volume":"43","author":"Burnham","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"7","key":"10.1016\/j.ccc.2011.04.001_bib101","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1164\/rccm.200410-1325OC","article-title":"Increased circulating endothelial progenitor cells are associated with survival in acute lung injury","volume":"172","author":"Burnham","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib102","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccm.2008.02.001","article-title":"Do newer monitors of exhaled gases, mechanics, and esophageal pressure add value?","volume":"29","author":"Owens","year":"2008","journal-title":"Clin Chest Med"},{"issue":"11","key":"10.1016\/j.ccc.2011.04.001_bib103","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0954-6111(03)00225-7","article-title":"Exhaled breath condensate acidification in acute lung injury","volume":"97","author":"Gessner","year":"2003","journal-title":"Respir Med"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib104","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1183\/09031936.05.00000505","article-title":"-308GA and TNFB polymorphisms in acute respiratory distress syndrome","volume":"26","author":"Gong","year":"2005","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/archinte.165.1.75","article-title":"The association of interleukin 6 haplotype clades with mortality in critically ill adults","volume":"165","author":"Sutherland","year":"2005","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1016\/j.ccc.2011.04.001_bib106","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1183\/09031936.06.00046405","article-title":"Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome","volume":"27","author":"Gong","year":"2006","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib107","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1378\/chest.125.1.203","article-title":"Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS","volume":"125","author":"Gong","year":"2004","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib108","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.CCM.0000251132.10689.F3","article-title":"Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome","volume":"35","author":"Gong","year":"2007","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.ccc.2011.04.001_bib109","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/01.CCM.0000256845.92640.38","article-title":"Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians","volume":"35","author":"Zhai","year":"2007","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib110","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1378\/chest.07-1117","article-title":"Variation in iron homeostasis genes between patients with ARDS and healthy control subjects","volume":"133","author":"Lagan","year":"2008","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib111","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1152\/physiolgenomics.90275.2008","article-title":"Discovery of the gene signature for acute lung injury in patients with sepsis","volume":"37","author":"Howrylak","year":"2009","journal-title":"Physiol Genomics"},{"issue":"6","key":"10.1016\/j.ccc.2011.04.001_bib112","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1165\/rcmb.2007-0354OC","article-title":"A\u00a0genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS","volume":"38","author":"Wang","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"10.1016\/j.ccc.2011.04.001_bib113","doi-asserted-by":"crossref","first-page":"e4380","DOI":"10.1371\/journal.pone.0004380","article-title":"Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development","volume":"4","author":"Wang","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib114","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2353\/ajpath.2006.050612","article-title":"Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)\/IGF-binding protein-3 pathway in acute lung injury","volume":"169","author":"Schnapp","year":"2006","journal-title":"Am J Pathol"},{"issue":"13","key":"10.1016\/j.ccc.2011.04.001_bib115","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1002\/pmic.200500693","article-title":"Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage","volume":"6","author":"de Torre","year":"2006","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib116","doi-asserted-by":"crossref","first-page":"L12","DOI":"10.1152\/ajplung.90558.2008","article-title":"Beyond fishing: the role of discovery proteomics in mechanistic lung research","volume":"296","author":"Ware","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib117","doi-asserted-by":"crossref","first-page":"L16","DOI":"10.1152\/ajplung.00044.2008","article-title":"Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs","volume":"295","author":"Gerszten","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib118","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1152\/ajplung.00375.2010","article-title":"Metabolomics of sepsis-induced acute lung injury: a new approach for biomarkers","volume":"300","author":"Lacy","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib119","first-page":"31","article-title":"1H-NMR-based metabolic signatures of clinical outcomes in trauma patients\u2013beyond lactate and base deficit","volume":"69","author":"Cohen","year":"2010","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.ccc.2011.04.001_bib120","doi-asserted-by":"crossref","first-page":"L4","DOI":"10.1152\/ajplung.00231.2010","article-title":"Metabolic consequences of sepsis-induced acute lung injury revealed by plasma (1)H-nuclear magnetic resonance quantitative metabolomics and computational analysis","volume":"300","author":"Stringer","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["Critical Care Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749070411000169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749070411000169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:15:18Z","timestamp":1686190518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0749070411000169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":120,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0749070411000169"],"URL":"https:\/\/doi.org\/10.1016\/j.ccc.2011.04.001","relation":{},"ISSN":["0749-0704"],"issn-type":[{"value":"0749-0704","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}